CN215273558U

CN215273558U - Mouse pressure after-load model threaded blood vessel penetrating tool

Info

Publication number: CN215273558U
Application number: CN202121145335.4U
Authority: CN
Inventors: 肖晓琳; 马晓芳; 李艳霞; 边希云
Original assignee: 5th Central Hospital Of Tianjin
Current assignee: 5th Central Hospital Of Tianjin
Priority date: 2021-05-26
Filing date: 2021-05-26
Publication date: 2021-12-24
Anticipated expiration: 2031-05-26

Abstract

The utility model provides a mouse pressure afterload model area line blood vessel instrument of wearing, including handle, blood vessel hook, coupling assembling, the blood vessel hook passes through coupling assembling and can dismantle with the handle and be connected, all be equipped with the line chamber that runs through in handle and the blood vessel hook, the silk thread stretches out from blood vessel hook free end in proper order through the line chamber of handle and blood vessel hook. Wear inside cavity that is equipped with the intercommunication of vascular instrument, the silk thread passes from the cavity, can not receive the interference of silk thread among the experimenter operation process, help improving the operation precision, effectively reduce the emergence probability that mouse aorta broke and pneumothorax among the operation process, the handle passes through coupling assembling with the blood vessel hook and can dismantle and be connected, connect convenient and fast, the dismouting can be accomplished fast to the experimenter, is convenient for wash or change.

Description

Mouse pressure after-load model threaded blood vessel penetrating tool

Technical Field

The utility model belongs to wear the vascular apparatus field, especially, relate to a mouse pressure afterload model area line instrument of wearing blood vessel.

Background

Cardiovascular disease is one of the most common diseases in clinic, with high morbidity and mortality worldwide. At present, cardiovascular patients in China are 2.9 hundred million, and heart failure patients reach 450 ten thousand. Heart failure is a pathological syndrome of cardiovascular diseases developing to the late stage, mainly manifested by the decrease of ventricular blood pumping function, and failing to meet the metabolic needs of body tissues. The pathogenesis of heart failure is not clear at present. Therefore, establishing animal disease models of heart failure helps to enhance understanding of the pathogenesis of heart failure.

The construction of a mouse stress afterload model is a common method for studying heart failure. Generally, a 27gauge needle is tied to the aortic arch by a silk thread and the needle is immediately withdrawn to narrow the aortic arch to a uniform size. The aortic arch constriction causes blood outflow obstruction in the heart, the afterload of the heart is increased, pathological myocardial remodeling such as myocardial hypertrophy appears after four weeks, and chronic heart failure can develop after about eight weeks. However, due to the limited space of the thoracic cavity of the mouse, the common apparatus has difficulty in threading the silk thread through the aortic arch without causing excessive traction or rupture bleeding of the blood vessel, and the improper apparatus is also easy to cause pneumothorax of the mouse when being threaded.

SUMMERY OF THE UTILITY MODEL

In view of this, the utility model aims at providing a mouse pressure afterload model area line blood vessel instrument to make things convenient for the experimenter to carry out the operation of wearing the blood vessel to the mouse, reduce the emergence probability that the mouse aorta broke and pneumothorax in the operation process simultaneously.

In order to achieve the above purpose, the technical scheme of the utility model is realized like this:

the utility model provides a mouse pressure afterload model area line blood vessel instrument of wearing, includes handle, blood vessel hook, coupling assembling, the blood vessel hook passes through coupling assembling and can dismantle with the handle and be connected, all be equipped with the line chamber that runs through in handle and the blood vessel hook, the silk thread stretches out from blood vessel hook free end in proper order through the line chamber of handle and blood vessel hook.

Preferably, coupling assembling includes that the chucking connects and transition joint, the chucking connects and locates handle one end and chucking and connect and handle integrated into one piece, the transition joint can be dismantled with the blood vessel hook and be connected, and the transition joint can be dismantled with the chucking and be connected.

Preferably, the section of the clamping joint is trapezoidal, and the inner diameter of the end, close to the outside, of the clamping joint is larger than that of the other end of the clamping joint.

Preferably, the transition joint is cylindrical, and the outer diameter of the transition joint is smaller than the inner diameter of the outer end of the clamping joint and larger than the inner diameter of the outer end of the clamping joint.

Preferably, the inner diameter of one end of the transition joint connected with the blood vessel hook is smaller than that of the other end.

Preferably, the middle part of the handle is provided with a finger groove.

Preferably, the handle is made of polypropylene.

Preferably, the blood vessel hook is the L type, and the blood vessel hook includes linkage segment and interlude section, the linkage segment can be dismantled with the transition joint and be connected.

Preferably, the length of the connecting section is greater than that of the penetrating section, and an included angle between the connecting section and the penetrating section is 90 degrees.

Preferably, the length of the thread extending from the blood vessel hook is more than or equal to 1 cm.

Compared with the prior art, mouse pressure after-load model threaded vessel penetrating tool has the following advantages:

(1) the blood vessel puncture tool is internally provided with the communicated cavity, the silk thread passes through the cavity, and the experimenter cannot be interfered by the silk thread in the operation process, thereby being beneficial to improving the operation precision and effectively reducing the occurrence probability of aortic rupture and pneumothorax of a mouse in the operation process;

(2) the handle and the blood vessel hook of the utility model are detachably connected through the connecting component, the connection is convenient and fast, and the experimenter can quickly complete the disassembly and the assembly, thereby being convenient for cleaning or replacing;

(3) the handle of the utility model is integrally injection molded by polypropylene, has light weight and high strength and is convenient to hold;

(4) the inner cavity of the blood vessel puncture tool is provided with a plurality of inclined planes for leading the silk thread to pass through, the silk thread can smoothly pass through the inner cavity, and the operation efficiency is improved;

(5) blood vessel penetrating tool simple structure, the processing cost is low, is suitable for mass production, has extensive use prospect.

Drawings

The accompanying drawings, which form a part hereof, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention without undue limitation. In the drawings:

fig. 1 is a schematic structural view of a mouse pressure post-load model threaded vascular puncture tool according to an embodiment of the present invention;

fig. 2 is a schematic top view of the mouse pressure post-load model vascular puncture tool with thread according to the embodiment of the present invention;

fig. 3 is a schematic view of a connection structure of the transition joint and the blood vessel hook according to the embodiment of the present invention.

Description of reference numerals:

1. a handle; 2. a blood vessel hook; 3. a silk thread; 4. clamping the joint; 5. a transition joint.

Detailed Description

It should be noted that, in the present invention, the embodiments and features of the embodiments may be combined with each other without conflict.

In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.

The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

The utility model discloses a mouse pressure afterload model threading blood vessel instrument, including handle 1, blood vessel hook 2, chucking joint 4 and transition joint 5, handle 1 and chucking joint 4 are polymer polypropylene integrated injection moulding, the middle part of handle 1 and chucking joint 4 is equipped with the cavity that runs through along length direction, silk thread 3 passes from the cavity in proper order, in addition also can store silk thread 3 in the cavity of handle 1, the silk thread 3 can not stretch out at the handle 1 rear end, interference to operating personnel is reduced, the silk thread 3 that the comprehensive function of this embodiment used is 7-0 silk thread 3, blood vessel hook 2 in this embodiment is connected with transition joint 5 interference fit, also can be through threaded connection, transition joint 5 is the cylinder, by the material preparation that has certain rigidity and intensity, blood vessel hook 2 in this embodiment is bent by the needle-like structure of certain rigidity and intensity and forms, the bending angle is 90 degrees, the length of one section of the vascular hook 2 connected with the transition joint 5 is larger than that of the other section, the middle part of the needle-shaped structure is provided with a thread through hole which penetrates along the length direction, the silk thread 3 which penetrates out of the clamping joint 4 sequentially penetrates through the inner cavity of the transition joint 5 and the thread through hole in the vascular hook 2 and finally extends out of the tail end of the vascular hook 2, the extending length of the silk thread 3 is not less than 1cm, and an experimenter can conveniently hold the silk thread 3 which extends out of the tail end of the vascular hook 2 by using micro-forceps after the vascular threading step is completed.

Specifically, 4 cross-sections of chucking joint are trapezoidal, be close to 1 one end of handle for the narrow limit, the other end is the broadside, 4 inner walls of chucking joint are the inclined plane, the internal diameter that leans on outer one end is greater than the internal diameter of the other end, the external diameter of crossover joint 5 is less than the internal diameter that chucking joint 4 leans on outer one end and is greater than the internal diameter that chucking joint 4 leans on outer one end, 5 surfaces of crossover joint have certain roughness, along with crossover joint 5 inserts chucking joint 4, the internal diameter that chucking joint 4 diminishes gradually, crossover joint 5 connects 4 with the chucking and is connected inseparabler, make chucking

joint

4 and 5 fastening connection of crossover joint through interference fit.

Specifically, the internal diameter that transition joint 5 and vessel hook 2 are connected one end is less than the internal diameter of the other end, because the external diameter is the same, the lateral wall thickness that transition joint 5 and vessel hook 2 are connected one end is less than the lateral wall thickness of the other end promptly, the inside inclined plane that is of transition joint 5, on the one hand, when silk thread 3 passes, can play the guide effect, make silk thread 3 get into vessel hook 2 smoothly, on the other hand, when transition joint 5 inserts chucking and connects 4, deformation takes place easily for thinner lateral wall, it is inseparabler with the connection of chucking joint 4 inner wall.

Specifically, 1 middle part of handle is equipped with the finger groove, and the finger groove makes 1 middle part of handle be the platykurtic, and the experimenter of being convenient for holds, still is equipped with anti-skidding line on the finger groove in this embodiment, prevents that handle 1 from droing from the operating personnel hand.

The steps of performing the vessel-piercing operation using the vessel-piercing tool in this embodiment are as follows:

after anesthetizing the experimental mice, the neck and chest of the mice were shaved off with a razor, and then the mice were fixed to the mouse table in a supine position. Trachea intubation was performed and then connected to a well-established mouse ventilator while iodophors disinfected the exposed skin of the mice. The neck is cut longitudinally by an ophthalmological scissors, the skin is incised, neck muscles are separated bluntly by an ophthalmological forceps, the trachea is exposed, an opening of about 2mm is formed along the longitudinal direction of the sternum handle after the neck muscles are separated to the sternum handle, the thoracic cavity is separated bluntly, and the thymus is poked to expose the aortic arch after the thymus is found. The experimenter holds the handle 1 of the threading blood vessel tool, lightly threads the blood vessel hook 2 through the aortic arch, after the 7-0 silk thread 3 in the threading blood vessel tool bypasses the aortic arch, the silk thread 3 is dragged by the micro forceps, the threading blood vessel tool is lightly pulled out along the original path, the 7-0 silk thread 3 is cut off at a proper position, and the residual 7-0 silk thread 3 in the threading blood vessel tool can be continuously used for the next experiment. The 27gauge needle is tied tightly with the aortic arch by 7-0 silk thread 3 which bypasses the aortic arch, and the 27gauge needle is immediately drawn out to complete the narrowing of the aortic arch. Finally, the sternal pedicle and the skin cut open of the mouse are sutured, and the ventilator is stopped after the consciousness of the mouse is restored.

The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A mouse load model after pressure is with line blood vessel threading instrument which characterized in that: including handle, blood vessel hook, coupling assembling, the blood vessel hook passes through coupling assembling and can dismantle with the handle and be connected, all be equipped with the line chamber that runs through in handle and the blood vessel hook, the silk thread stretches out from blood vessel hook free end through the line chamber of handle and blood vessel hook in proper order.

2. The mouse load after pressure model threaded vessel crossing tool according to claim 1, wherein: coupling assembling includes that the chucking connects and transition joint, the chucking connects and locates handle one end and chucking and connect and handle integrated into one piece, the transition joint can be dismantled with the blood vessel hook and be connected, and the transition joint can be dismantled with the chucking and be connected.

3. The mouse load after pressure model threaded vessel crossing tool according to claim 2, wherein: the section of the clamping joint is trapezoidal, and the inner diameter of one end, close to the outside, of the clamping joint is larger than that of the other end of the clamping joint.

4. The mouse load after pressure model corded vessel crossing tool of claim 3, wherein: the transition joint is cylindrical, and the outer diameter of the transition joint is smaller than the inner diameter of the outer end of the clamping joint and larger than the inner diameter of the outer end of the clamping joint.

5. The mouse load after pressure model corded vessel crossing tool of claim 4, wherein: the inner diameter of one end of the transition joint connected with the blood vessel hook is smaller than that of the other end of the transition joint.

6. The mouse load after pressure model threaded vessel crossing tool according to claim 1, wherein: the middle part of the handle is provided with a finger groove.

7. The mouse load after pressure model threaded vessel crossing tool according to claim 1, wherein: the handle is made of polypropylene.

8. The mouse load after pressure model threaded vessel crossing tool according to claim 1, wherein: the blood vessel hook is the L type, and the blood vessel hook is including linkage segment and interlude section, the linkage segment can be dismantled with transition joint and be connected.

9. The mouse load after pressure model threaded vessel crossing tool of claim 8, wherein: the length of the connecting section is greater than that of the inserting section, and the included angle between the connecting section and the inserting section is 90 degrees.

10. The mouse load after pressure model threaded vessel crossing tool according to claim 1, wherein: the length of the silk thread extending out of the blood vessel hook is more than or equal to 1 cm.