CN215375218U - Continuous mass spectrum sampling device and mass spectrum detection equipment - Google Patents
Continuous mass spectrum sampling device and mass spectrum detection equipment Download PDFInfo
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- CN215375218U CN215375218U CN202022965215.0U CN202022965215U CN215375218U CN 215375218 U CN215375218 U CN 215375218U CN 202022965215 U CN202022965215 U CN 202022965215U CN 215375218 U CN215375218 U CN 215375218U
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Abstract
The utility model discloses a continuous mass spectrum sampling device and mass spectrum detection equipment. The continuous mass spectrum sampling device comprises a sample feeding mechanism, a sample application mechanism and a position detection mechanism; send appearance mechanism to go up the order and be provided with a plurality of samples and send appearance groove, send appearance mechanism to have application of sample end and recovery end, send appearance mechanism can with the sample send appearance groove to carry to mass spectrum check out test set's detection area, application of sample mechanism sets up the top of application of sample end is in order to be used for to each the sample send appearance inslot application of sample, position detection mechanism sets up in predetermined position and is used for detecting whether the sample in the sample send appearance groove reaches mass spectrum check out test set's detection area and gives a appearance mechanism and send and pause and send a sample signal. When the continuous mass spectrum sampling device is used for mass spectrum sampling, a sample carrying table does not need to be frequently replaced, and continuous detection of a large batch of samples can be met; the consistency of sample introduction positions can be ensured, and human errors are reduced; automatic sampling and sample introduction processes can be realized; cross contamination between samples can be effectively reduced or eliminated.
Description
Technical Field
The utility model relates to the field of mass spectrometry detection, in particular to a continuous mass spectrometry sampling device and mass spectrometry detection equipment.
Background
The in-situ ionization mass spectrometry is a mass spectrometry emerging in recent decades, and compared with the traditional mass spectrometry, the in-situ ionization mass spectrometry has the most obvious difference that the complex sample pretreatment and pre-separation processes are not needed, the object to be detected can be only analyzed directly in the normal pressure environment, and the method has the characteristics of being direct, rapid, real-time, in-situ, high-flux and the like, is particularly suitable for detection of a large number of samples, and has been widely developed and applied in the fields of biology, environment, food and the like.
At present, most of the sample injection devices commonly used in the in-situ ionization mass spectrometry technology adopt slide sample injection, card sample injection, distributed capillary, a traveling type sample injection platform (such as 1 × 12 holes and 6 × 6 holes) and the like, and can respectively satisfy the analysis of a single sample and a plurality of samples. However, in response to the increasingly large demand for detection volume in the market, the sample feeding device described above has the following disadvantages: 1. the sample carrying device can bear a small amount of samples, needs to be replaced manually frequently, and cannot meet continuous detection of large-batch samples. 2. The automation degree is low, and the programmed detection process is difficult to realize. 3. The isolation degree between samples is low, and cross contamination is easy to generate. 4. The manual intervention operation is more, and the human error is easy to generate.
SUMMERY OF THE UTILITY MODEL
Based on this, it is necessary to provide a continuous mass spectrometer sampling device. When the continuous mass spectrum sampling device is used for mass spectrum sampling, a sample carrying table does not need to be frequently replaced, and continuous detection of a large batch of samples can be met; the consistency of sample introduction positions can be ensured, and human errors are reduced; automatic sampling and sample introduction processes can be realized; cross contamination between samples can be effectively reduced or eliminated.
A continuous mass spectrum sampling device comprises a sample feeding mechanism, a sample application mechanism and a position detection mechanism; send appearance mechanism to go up the order and be provided with a plurality of samples and send appearance groove, send appearance mechanism to have application of sample end and recovery end, send appearance mechanism be used for with the sample send appearance groove to carry to mass spectrum check out test set's detection area, application of sample mechanism sets up the top of application of sample end is in order to be used for to each the sample send appearance inslot application of sample, position detection mechanism sets up in predetermined position and is used for detecting whether the sample in the sample send appearance groove reaches mass spectrum check out test set's detection area and gives and send the appearance mechanism and send and pause and send a signal of sending.
In one embodiment, the sample feeding mechanism comprises a sample feeding belt and a sample feeding driving component, wherein a plurality of sample feeding grooves arranged in sequence are arranged on the sample feeding belt, and the sample feeding driving component is connected to the sample feeding belt and used for driving the sample feeding belt to move.
In one of them embodiment, send appearance mechanism still includes first rotation wheel and second and rotate the wheel, first rotation wheel with the second rotates the relative setting of wheel, first rotation wheel and the second rotates the wheel and passes through sample send appearance area to connect, send appearance drive unit connect in first rotation wheel and/or the second rotates the wheel in order to be used for the drive first rotation wheel with the second rotates the wheel and rotates, first rotation wheel is used for placing the part that the sample sent appearance area not application of sample, the second rotates the wheel and is used for batching sample send appearance area application of sample back and the part that mass spectrum detected.
In one embodiment, the sample feeding mechanism further includes a pressing wheel, the pressing wheel is disposed opposite to the second rotating wheel, the pressing wheel is movably disposed, a gap for a sample feeding belt to pass through is formed between the pressing wheel and the second rotating wheel, and the pressing wheel is matched with the second rotating wheel to assist the second rotating wheel in rolling up a part of the sample feeding belt subjected to sample feeding and subjected to mass spectrometry detection.
In one embodiment, the sample feeding driving part is connected to the second rotating wheel.
In one embodiment, the continuous mass spectrometry sampling device further comprises a tensioning mechanism, the tensioning mechanism comprises at least two tensioning limiting columns, the tensioning limiting columns are arranged between the first rotating wheel and the second rotating wheel, and the tensioning limiting columns are used for tensioning the sample conveying belt.
In one embodiment, the sample feeding grooves on the sample feeding belt are sequentially distributed along the length direction of the sample feeding belt, and adjacent sample feeding grooves on the sample feeding belt are spaced apart from each other and have equal intervals.
In one embodiment the deposition mechanism is spaced from the position detection mechanism.
In one embodiment, the pitch between the spotting mechanism and the position detection mechanism is equal to the pitch between adjacent sample presentation wells.
The mass spectrum detection equipment comprises the continuous mass spectrum sampling device.
The continuous mass spectrum sampling device has the following beneficial effects:
(1) when the continuous mass spectrum sampling device is used for mass spectrum sampling, a sample carrying platform does not need to be frequently replaced, continuous sampling can be realized through a sample conveying belt, continuous detection of a large number of samples can be met, when detection is carried out, the sample conveying mechanism drives the sample conveying belt to move for a preset distance, the distance can enable a sample conveying groove on the sample conveying belt to move to a sample application mechanism, the sample application mechanism applies samples to the sample conveying groove, the sample conveying mechanism drives the sample conveying belt to move to a position detection mechanism after the samples are applied, when the position detection mechanism detects that the samples in the sample conveying groove reach a detection area of mass spectrum detection equipment, the position detection mechanism sends a sample conveying suspension signal to the sample conveying mechanism, the sample conveying mechanism stops driving the sample conveying belt to move, and the samples are detected by the mass spectrum detection equipment.
(2) In the continuous mass spectrum sampling device, the distances between the adjacent sample feeding grooves are equal, so that the consistency of sample feeding positions can be ensured, and the human error is reduced.
(3) The continuous mass spectrum sampling device provided by the utility model realizes actions of automatic sampling and automatic sampling, has high automation degree, reduces manual participation and improves detection efficiency.
(4) The continuous mass spectrum sampling device of the utility model arranges the interval between the adjacent sample feeding grooves and also arranges the interval between the sample application mechanism and the position detection mechanism, thereby effectively reducing or eliminating the cross contamination between samples.
Drawings
FIG. 1 is a schematic view of a continuous mass spectrometer sampling device according to embodiment 1 of the present invention;
fig. 2 is a schematic view of a continuous mass spectrometry sample injection device according to embodiment 2 of the present invention.
Description of the reference numerals
10. A continuous mass spectrum sample introduction device; 100. a sample feeding mechanism; 110. a sample delivery belt; 120. a first rotating wheel; 130. a second rotating wheel; 140. a pinch roller; 200. a sample application mechanism; 300. a position detection mechanism; 400. a tensioning mechanism; 410. tensioning the limiting column.
Detailed Description
To facilitate an understanding of the utility model, the utility model will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
In the description of the present invention, it should be understood that the terms used in the present invention are used in the description of the present invention, and it should be understood that the directions or positional relationships indicated by the terms "center", "upper", "lower", "bottom", "inner", "outer", etc. in the present invention are based on the directions or positional relationships shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
It should be understood that the terms "first", "second", etc. are used herein to describe various information, but the information should not be limited to these terms, which are only used to distinguish one type of information from another. For example, "first" information may also be referred to as "second" information, and similarly, "second" information may also be referred to as "first" information, without departing from the scope of the present invention.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "connected" and "connected" are to be interpreted broadly, e.g., as being fixed or detachable or integrally connected; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening elements, or they may be in communication within two elements, i.e., when an element is referred to as being "secured to" another element, it may be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the utility model herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the utility model. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
Referring to fig. 1, a continuous mass spectrometer sampling device 10 is provided according to an embodiment of the present invention.
A continuous mass spectrometry sample introduction device 10 comprises a sample feeding mechanism 100, a sample application mechanism 200 and a position detection mechanism 300.
The sample feeding mechanism 100 is provided with a plurality of sample feeding grooves in sequence. The sample feeding mechanism 100 has a sample application end and a collection end. The sample feeding mechanism 100 can transport the sample feeding groove to the detection area of the mass spectrometry detection apparatus.
The sample application mechanism 200 is disposed above the sample application end for applying a sample to each sample application slot.
The position detection mechanism 300 is provided at a predetermined position for detecting whether the sample in the sample well reaches the detection region of the mass spectrometry detection apparatus and sending a sample pause signal to the sample feeding mechanism 100.
In one embodiment, the sample presentation mechanism 100 includes a sample presentation belt 110 and a presentation drive component. The sample presentation drive means are not shown in both fig. 1 and fig. 2. The sample presentation belt 110 is provided with a plurality of sample presentation grooves arranged in series, the sample presentation grooves being provided on the front surface of the sample presentation belt 110, the sample presentation grooves being located on the upper surface of the sample presentation belt 110 in the direction shown in fig. 1. The sample transport driving unit is connected to the sample transport belt 110 for driving the sample transport belt 110 to move. The sample sending driving part can be a driving motor. During sample feeding, continuous sample feeding can be realized through the sample feeding belt 110, continuous detection of a large number of samples can be met, during detection, the sample feeding mechanism 100 drives the sample feeding belt 110 to move for a preset distance, the distance can enable a sample feeding groove on the sample feeding belt 110 to move to the sample application mechanism 200, the sample application mechanism 200 applies samples to the sample feeding groove, after sample application is finished, the sample feeding mechanism 100 drives the sample feeding belt 110 to move to the position detection mechanism 300, when the position detection mechanism 300 detects that a sample in the sample feeding groove reaches a detection area of mass spectrum detection equipment, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move, and the sample is detected by the mass spectrum detection equipment at the position.
In one embodiment, the sample presentation mechanism 100 further comprises a first rotating wheel 120 and a second rotating wheel 130. The first rotating wheel 120 is disposed opposite to the second rotating wheel 130. The first rotating wheel 120 and the second rotating wheel 130 are connected by a sample feeding belt 110, and a feeding driving unit is connected to the first rotating wheel 120 and/or the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130 to rotate. The first rotating wheel 120 is used for taking up the part of the sample-feeding belt 110 which is not applied with the sample, and the second rotating wheel 130 is used for taking up the part of the sample-feeding belt 110 which is applied with the sample and is detected by the mass spectrometry. When the sample feeding belt 110 is not used, the sample feeding belt 110 may be wound, the entire sample feeding belt 110 may be sleeved on the first rotating wheel 120, and when the sample feeding belt 110 is used, the head of the sample feeding belt 110 is pulled to the second rotating wheel 130, and when the sample feeding driving member drives the second rotating wheel 130 to rotate, the sample feeding belt 110 on the first rotating wheel 120 may be driven to release.
In one embodiment, the sample presentation mechanism 100 further includes a pinch roller 140. The pressing wheel 140 is opposite to the second rotating wheel 130, the pressing wheel 140 is movably arranged, a gap for the sample conveying belt 110 to pass through is formed between the pressing wheel 140 and the second rotating wheel 130, and the pressing wheel 140 is matched with the second rotating wheel 130 to assist the second rotating wheel 130 to roll the part of the sample conveying belt 110 which is subjected to sample adding and is subjected to mass spectrum detection.
In one embodiment, the sample presentation drive member is coupled to the second rotating wheel 130. The first rotating wheel 120 is driven as a driven wheel to perform sample feeding.
In one embodiment, the continuous mass spectrometer sampling device 10 further comprises a tensioning mechanism 400. The tensioning mechanism 400 includes at least two tensioning limiting posts 410, the tensioning limiting posts 410 are disposed between the first rotating wheel 120 and the second rotating wheel 130, and the tensioning limiting posts 410 are used for tensioning the sample presentation belt 110. Referring to the orientation shown in fig. 1, the position of the tension limiting columns 410 is a little higher than the positions of the first rotating wheel 120 and the second rotating wheel 130 in the height direction, so that the two tension limiting columns 410 can tension the sample belt 110.
In one embodiment, the sample presentation grooves on the sample presentation belt 110 are sequentially distributed along the length of the sample presentation belt 110. The sample feeding belt 110 has a gap between adjacent sample feeding grooves and the gap between adjacent sample feeding grooves is equal. Because the distances between the adjacent sample feeding grooves are equal, the consistency of sample feeding positions can be ensured, and the human error is reduced.
In one embodiment, the deposition mechanism 200 is spaced from the position detection mechanism 300. The continuous mass spectrum sampling device 10 of the utility model is provided with an interval between the adjacent sample feeding grooves and an interval between the sample application mechanism 200 and the position detection mechanism 300, thereby effectively reducing or eliminating the cross contamination between samples.
In one embodiment, the spacing between the deposition mechanism 200 and the position detection mechanism 300 is equal to the spacing between adjacent sample presentation wells.
In one embodiment, the continuous mass spectrometer sampling device 10 further comprises a support, wherein the spotting mechanism 200 and the position detection mechanism 300 are disposed on the support. In addition, the first rotating wheel 120, the second rotating wheel 130 and the tension limiting column 410 are all arranged on a bracket, and at this time, the whole continuous mass spectrometry sampling device 10 is integrated on one bracket, so that the mass spectrometry detection equipment can be conveniently installed. The stent is not shown in either of figures 1 and 2.
An embodiment of the present invention provides a mass spectrometry detection apparatus.
A mass spectrum detection device comprises the continuous mass spectrum sampling device 10.
Example 1
The embodiment provides a continuous mass spectrometry sample introduction device 10.
Referring to fig. 1, a continuous mass spectrometry sampling device 10 includes a sample feeding mechanism 100, a sample application mechanism 200, a tensioning mechanism 400, and a position detection mechanism 300.
The sample feeding mechanism 100 is provided with a plurality of sample feeding grooves in sequence. The sample application grooves of the sample application belt 110 are sequentially distributed along the longitudinal direction of the sample application belt 110. The sample feeding belt 110 has a gap between adjacent sample feeding grooves and the gap between adjacent sample feeding grooves is equal.
The sample feeding mechanism 100 has a sample application end and a collection end. The sample feeding mechanism 100 can transport the sample feeding groove to the detection area of the mass spectrometry detection apparatus.
The sample application mechanism 200 is disposed above the sample application end for applying a sample to each sample application slot.
The position detection mechanism 300 is provided at a predetermined position and is used to detect whether the sample in the sample well reaches the detection region of the mass spectrometry detection apparatus and to transmit a sample pause signal to the sample feed mechanism 100. When the position detection mechanism 300 detects that the sample in the sample feed slot reaches the detection area of the mass spectrometry detection device, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move, where the sample is detected by the mass spectrometry detection device.
The deposition mechanism 200 and the position detection mechanism 300 have a space therebetween. The pitch between the spotting mechanism 200 and the position detecting mechanism 300 is equal to the pitch between the adjacent sample loading wells.
The sample transport mechanism 100 includes a sample transport belt 110 and a sample transport driving unit. The sample feeding belt 110 is provided with a plurality of sample feeding grooves arranged in sequence, and the sample feeding driving part is connected to the sample feeding belt 110 for driving the sample feeding belt 110 to move. The sample feeding driving part is a driving motor.
The sample transport mechanism 100 further includes a first rotating wheel 120 and a second rotating wheel 130. The first rotating wheel 120 is disposed opposite to the second rotating wheel 130. The first rotating wheel 120 and the second rotating wheel 130 are connected by a sample feeding belt 110, and a feeding driving member is connected to the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130 to rotate. The first rotating wheel 120 is used for taking up the part of the sample-feeding belt 110 which is not applied with the sample, and the second rotating wheel 130 is used for taking up the part of the sample-feeding belt 110 which is applied with the sample and is detected by the mass spectrometry.
The sample presentation mechanism 100 also includes a pinch roller 140. The pressing wheel 140 is opposite to the second rotating wheel 130, the pressing wheel 140 is movably arranged, a gap for the sample conveying belt 110 to pass through is formed between the pressing wheel 140 and the second rotating wheel 130, and the pressing wheel 140 is matched with the second rotating wheel 130 to assist the second rotating wheel 130 to roll the part of the sample conveying belt 110 which is subjected to sample adding and is subjected to mass spectrum detection.
The tensioning mechanism 400 comprises two tensioning limiting columns 410, the two tensioning limiting columns 410 are arranged between the first rotating wheel 120 and the second rotating wheel 130, one of the tensioning limiting columns 410 is close to the first rotating wheel 120, the other tensioning limiting column 410 is close to the second rotating wheel 130, and the tensioning limiting column 410 is used for supporting and tensioning the sample conveying belt 110, so as to facilitate the sample loading of the sample application mechanism 200 and the detection of the position detection mechanism 300.
Example 2
The embodiment provides a continuous mass spectrometry sample introduction device 10.
Referring to fig. 2, a continuous mass spectrometry sampling device 10 includes a sample feeding mechanism 100, a sample deposition mechanism 200, and a position detection mechanism 300.
The sample feeding mechanism 100 is provided with a plurality of sample feeding grooves in sequence. The sample application grooves of the sample application belt 110 are sequentially distributed along the longitudinal direction of the sample application belt 110. The sample feeding belt 110 has a gap between adjacent sample feeding grooves and the gap between adjacent sample feeding grooves is equal.
The sample feeding mechanism 100 has a sample application end and a collection end. The sample feeding mechanism 100 can transport the sample feeding groove to the detection area of the mass spectrometry detection apparatus.
The sample application mechanism 200 is disposed above the sample application end for applying a sample to each sample application slot.
The position detection mechanism 300 is provided at a predetermined position and is used to detect whether the sample in the sample well reaches the detection region of the mass spectrometry detection apparatus and to transmit a sample pause signal to the sample feed mechanism 100. When the position detection mechanism 300 detects that the sample in the sample feed slot reaches the detection area of the mass spectrometry detection device, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move, where the sample is detected by the mass spectrometry detection device.
The deposition mechanism 200 and the position detection mechanism 300 have a space therebetween. The pitch between the spotting mechanism 200 and the position detecting mechanism 300 is equal to the pitch between the adjacent sample loading wells.
The sample transport mechanism 100 includes a sample transport belt 110 and a sample transport driving unit. The sample feeding belt 110 is provided with a plurality of sample feeding grooves arranged in sequence, and the sample feeding driving part is connected to the sample feeding belt 110 for driving the sample feeding belt 110 to move. The sample feeding driving part is a driving motor.
Referring to fig. 2, the sample feeding mechanism 100 further includes a first rotating wheel 120, a second rotating wheel 130, and a pressing wheel 140. The first rotating wheel 120 is disposed opposite to the second rotating wheel 130. The first rotating wheel 120 and the second rotating wheel 130 are connected by a sample feeding belt 110, and a feeding driving member is connected to the second rotating wheel 130 for driving the first rotating wheel 120 and the second rotating wheel 130 to rotate. The first rotating wheel 120 is used for taking up the part of the sample-feeding belt 110 which is not applied with the sample, and the second rotating wheel 130 is used for taking up the part of the sample-feeding belt 110 which is applied with the sample and is detected by the mass spectrometry.
Referring to fig. 2, the pressing wheel 140 is opposite to the second rotating wheel 130, the pressing wheel 140 is movably disposed, a gap for the sample-transporting belt 110 to pass through is formed between the pressing wheel 140 and the second rotating wheel 130, the pressing wheel 140 is matched with the second rotating wheel 130 to assist the second rotating wheel 130 to roll up a portion of the sample-transporting belt 110 after sample application and subjected to mass spectrometry, and the pressing wheel 140 is used for pressing the sample-transporting belt 110 on the second rotating wheel 130.
The tensioning mechanism 400 comprises two tensioning limiting columns 410, the two tensioning limiting columns 410 are arranged between the first rotating wheel 120 and the second rotating wheel 130, one of the tensioning limiting columns 410 is close to the first rotating wheel 120, the other tensioning limiting column 410 is close to the second rotating wheel 130, and the tensioning limiting column 410 is used for supporting and tensioning the sample conveying belt 110, so as to facilitate the sample loading of the sample application mechanism 200 and the detection of the position detection mechanism 300.
In summary, the continuous mass spectrometry sample injection device 10 of the present invention has the following beneficial effects:
(1) when the continuous mass spectrum sampling device 10 is used for mass spectrum sampling, a sample carrying table does not need to be frequently replaced, continuous sample feeding can be realized through the sample feeding belt 110, can meet the continuous detection of a large number of samples, when in detection, the sample feeding mechanism 100 drives the sample feeding belt 110 to move for a preset distance, the distance can enable the sample feeding groove on the sample feeding belt 110 to move to the sample application mechanism 200, the sample application mechanism 200 applies the sample to the sample feeding groove, after the sample application is finished, the sample feeding mechanism 100 drives the sample feeding belt 110 to move to the position detection mechanism 300, when the position detection mechanism 300 detects that the sample in the sample-sending well reaches the detection region of the mass spectrometry detection apparatus, the position detection mechanism 300 sends a sample feeding suspension signal to the sample feeding mechanism 100, and the sample feeding mechanism 100 stops driving the sample feeding belt 110 to move, where the sample is detected by the mass spectrometry detection device.
(2) In the continuous mass spectrum sampling device 10, the distances between the adjacent sample feeding grooves are equal, so that the consistency of sample feeding positions can be ensured, and the human error is reduced.
(3) The continuous mass spectrum sampling device 10 realizes the actions of automatic sampling and automatic sampling, has high automation degree, reduces manual participation and improves the detection efficiency.
(4) The continuous mass spectrum sampling device 10 of the utility model is provided with an interval between the adjacent sample feeding grooves and an interval between the sample application mechanism 200 and the position detection mechanism 300, thereby effectively reducing or eliminating the cross contamination between samples.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the present invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A continuous mass spectrum sampling device is characterized by comprising a sample feeding mechanism, a sample application mechanism and a position detection mechanism; send appearance mechanism to go up the order and be provided with a plurality of samples and send appearance groove, send appearance mechanism to have application of sample end and recovery end, send appearance mechanism be used for with the sample send appearance groove to carry to mass spectrum check out test set's detection area, application of sample mechanism sets up the top of application of sample end is in order to be used for to each the sample send appearance inslot application of sample, position detection mechanism sets up in predetermined position and is used for detecting whether the sample in the sample send appearance groove reaches mass spectrum check out test set's detection area and gives and send the appearance mechanism and send and pause and send a signal of sending.
2. The continuous mass spectrometry sample introduction device according to claim 1, wherein the sample introduction mechanism comprises a sample introduction belt and a sample introduction driving component, the sample introduction belt is provided with a plurality of sample introduction grooves arranged in sequence, and the sample introduction driving component is connected to the sample introduction belt for driving the sample introduction belt to move.
3. The continuous mass spectrometry sampling device of claim 2, wherein the sample feeding mechanism further comprises a first rotating wheel and a second rotating wheel, the first rotating wheel and the second rotating wheel are arranged oppositely, the first rotating wheel and the second rotating wheel are connected through the sample feeding belt, the sample feeding driving component is connected to the first rotating wheel and/or the second rotating wheel for driving the first rotating wheel and the second rotating wheel to rotate, the first rotating wheel is used for placing the part of the sample feeding belt which is not subjected to sample feeding, and the second rotating wheel is used for coiling the part of the sample feeding belt which is subjected to sample feeding and subjected to mass spectrometry detection.
4. The continuous mass spectrometry sample introduction device according to claim 3, wherein the sample introduction mechanism further comprises a pinch roller, the pinch roller is arranged opposite to the second rotating wheel, the pinch roller is movably arranged, a gap for a sample introduction belt to pass through is formed between the pinch roller and the second rotating wheel, and the pinch roller is matched with the second rotating wheel to assist the second rotating wheel to take up a part of the sample introduction belt after sample introduction and subjected to mass spectrometry detection.
5. The continuous mass spectrometry sample introduction device of claim 3, wherein the sample feeding driving part is connected to the second rotating wheel.
6. The continuous mass spectrometry sampling device of claim 3, further comprising a tensioning mechanism, wherein the tensioning mechanism comprises at least two tensioning limiting columns, the tensioning limiting columns are arranged between the first rotating wheel and the second rotating wheel, and the tensioning limiting columns are used for tensioning the sample conveying belt.
7. The continuous mass spectrometry sample introduction device according to any one of claims 2 to 6, wherein the sample introduction grooves on the sample introduction belt are sequentially distributed along the length direction of the sample introduction belt, adjacent sample introduction grooves on the sample introduction belt are spaced apart, and the distances between the adjacent sample introduction grooves are equal.
8. The continuous mass spectrometry sample introduction device of claim 7, wherein the deposition mechanism and the position detection mechanism are spaced apart.
9. The continuous mass spectrometry sample introduction device of claim 8, wherein the spacing between the sample application mechanism and the position detection mechanism is equal to the spacing between adjacent sample presentation wells.
10. A mass spectrometry detection apparatus comprising the continuous mass spectrometry sample introduction device of any one of claims 1 to 9.
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| CN114624315A (en) * | 2020-12-12 | 2022-06-14 | 广州禾信仪器股份有限公司 | Continuous mass spectrum sampling device and mass spectrum detection equipment |
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| CN114624315A (en) * | 2020-12-12 | 2022-06-14 | 广州禾信仪器股份有限公司 | Continuous mass spectrum sampling device and mass spectrum detection equipment |
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Address after: 510535 No. 16, Xinrui Road, Huangpu District, Guangzhou, Guangdong Patentee after: GUANGZHOU HEXIN INSTRUMENT Co.,Ltd. Address before: 510700 Room 102, building A3, 11 Kaiyuan Avenue, Huangpu District, Guangzhou City, Guangdong Province Patentee before: GUANGZHOU HEXIN INSTRUMENT Co.,Ltd. |