CN215350808U - Injection type liposome medicine carrying equipment - Google Patents
Injection type liposome medicine carrying equipment Download PDFInfo
- Publication number
- CN215350808U CN215350808U CN202120862735.0U CN202120862735U CN215350808U CN 215350808 U CN215350808 U CN 215350808U CN 202120862735 U CN202120862735 U CN 202120862735U CN 215350808 U CN215350808 U CN 215350808U
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- China
- Prior art keywords
- chamber
- injection type
- medicine carrying
- loading
- liposome
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Abstract
The utility model discloses injection type liposome medicine carrying equipment, which comprises an injector and a loading chamber; the two ends of the packing chamber are provided with a liquid inlet and a liquid outlet, and the top of the packing chamber is provided with a funnel-shaped exhaust pipe; the needle of the syringe is at the top center of the loading chamber. The liposome drug loading is carried out by using the equipment, and continuous liposome drug loading can be realized.
Description
Technical Field
The utility model relates to the field of pharmacy, in particular to a liposome drug loading device.
Background
Liposomes (liposomes) are an artificial membrane. The hydrophilic head of phospholipid molecule is inserted into water, the hydrophobic tail of liposome extends to air, and spherical liposome with double-layer lipid molecule with diameter of 25-1000nm is formed after stirring. Liposomes can be used for transgenosis, or for preparing drugs, and the drugs are delivered into the cell interior according to the biological definition by utilizing the characteristic that the liposomes can be fused with cell membranes: when amphiphilic molecules such as phospholipids and sphingolipids are dispersed in an aqueous phase, the hydrophobic tails of the molecules tend to cluster together, avoiding the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase, forming closed vesicles with a bilayer structure, known as liposomes.
Pharmaceutically defined liposomes (liposome): refers to a microvesicle formed by encapsulating a drug in a lipid bilayer. The commonly used liposome drug-loading method includes a film dispersion method, a multiple emulsion method, an injection method and the like. The injection method is to dissolve lipid and fat-soluble drugs into an organic solvent (oil phase), and then inject the oil phase into a constant-temperature water phase with the boiling point higher than that of the organic solvent at a constant speed to form liposome, thereby completing drug loading. The existing equipment for injecting liposome medicine carrying can only complete intermittent medicine carrying operation, and is not suitable for industrial production requirements.
Disclosure of Invention
The utility model provides injection type liposome drug loading equipment, which is used for carrying out liposome drug loading and can realize continuous liposome drug loading.
The technical scheme adopted by the utility model for solving the technical problems is as follows:
an injection type liposome drug loading device comprises an injector and a loading chamber; the two ends of the packing chamber are provided with a liquid inlet and a liquid outlet, and the top of the packing chamber is provided with a funnel-shaped exhaust pipe; the needle of the syringe is at the top center of the loading chamber.
The valve I of the liquid inlet of the packing chamber and the valve II of the liquid outlet of the packing chamber are one-way valves.
The operation process of the present invention is that certain amount of soybean lecithin, cholesterol and liposoluble medicine (such as camptothecine) are dissolved in ethanol and the mixture is injected into injector. Phosphate buffer solution with the temperature of 85 ℃ is added into a liquid inlet of the loading chamber, and a valve I and a valve II are adjusted to ensure that the liquid inflow speed is equal to the liquid outflow speed. And starting the injector to inject the liquid in the injector into the entrapment chamber at a constant speed, and collecting the liquid flowing out of a liquid outlet of the entrapment chamber to finish the liposome drug loading.
The utility model has the advantages that the organic solvent can be rapidly discharged in the entrapment chamber, and continuous liposome drug loading can be realized.
Drawings
The utility model is further illustrated with reference to the following figures and examples.
FIG. 1 is a schematic diagram of the apparatus of the present invention.
In the figure: 1. an injector; a needle head; 2. a packing chamber; 21. a liquid inlet; 211. a valve I; 22. a liquid outlet; 221. a valve II; 23. a funnel-shaped exhaust pipe.
Detailed Description
In order to make the technical means, innovative features, objectives and effects of the present invention apparent, the present invention will be further described with reference to the following detailed drawings.
An injection type liposome medicine carrying device shown in figure 1 comprises a syringe (1) and an entrapment chamber (2); two ends of the packing chamber (2) are provided with a liquid inlet (21) and a liquid outlet (22), and the top of the packing chamber (2) is provided with a funnel-shaped exhaust pipe (23); the needle (11) of the syringe (1) is positioned at the top center of the loading chamber (2).
The valve I (211) of the liquid inlet (21) of the entrapment chamber (2) and the valve II (221) of the liquid outlet (22) of the entrapment chamber (2) are one-way valves.
When the device is in operation, a certain amount of soybean lecithin, cholesterol and lipid soluble drug (such as camptothecin) are dissolved in ethanol and placed in a syringe. Phosphate buffer solution with the temperature of 85 ℃ is added into a liquid inlet of the loading chamber, and a valve I and a valve II are adjusted to ensure that the liquid inflow speed is equal to the liquid outflow speed. And starting the injector to inject the liquid in the injector into the entrapment chamber at a constant speed, and collecting the liquid flowing out of a liquid outlet of the entrapment chamber to finish the liposome drug loading.
Claims (2)
1. An injection type liposome medicine carrying device comprises an injector (1) and an entrapment chamber (2); the method is characterized in that: two ends of the packing chamber (2) are provided with a liquid inlet (21) and a liquid outlet (22), and the top of the packing chamber (2) is provided with a funnel-shaped exhaust pipe (23); the needle (11) of the syringe (1) is positioned at the top center of the loading chamber (2).
2. The apparatus of claim 1, wherein: the valve I (211) of the liquid inlet (21) of the entrapment chamber (2) and the valve II (221) of the liquid outlet (22) of the entrapment chamber (2) are one-way valves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120862735.0U CN215350808U (en) | 2021-04-25 | 2021-04-25 | Injection type liposome medicine carrying equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120862735.0U CN215350808U (en) | 2021-04-25 | 2021-04-25 | Injection type liposome medicine carrying equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215350808U true CN215350808U (en) | 2021-12-31 |
Family
ID=79627992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120862735.0U Expired - Fee Related CN215350808U (en) | 2021-04-25 | 2021-04-25 | Injection type liposome medicine carrying equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215350808U (en) |
-
2021
- 2021-04-25 CN CN202120862735.0U patent/CN215350808U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211231 |