CN215339892U - Immunochromatography multi-connection reagent card - Google Patents
Immunochromatography multi-connection reagent card Download PDFInfo
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- CN215339892U CN215339892U CN202121418130.9U CN202121418130U CN215339892U CN 215339892 U CN215339892 U CN 215339892U CN 202121418130 U CN202121418130 U CN 202121418130U CN 215339892 U CN215339892 U CN 215339892U
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- chromatography detection
- upper cover
- immunochromatography
- reagent card
- lower cover
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- 239000003153 chemical reaction reagent Substances 0.000 title claims abstract description 35
- 238000003317 immunochromatography Methods 0.000 title claims abstract description 30
- 238000001514 detection method Methods 0.000 claims abstract description 128
- 238000004587 chromatography analysis Methods 0.000 claims abstract description 97
- 239000007788 liquid Substances 0.000 claims description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 238000010521 absorption reaction Methods 0.000 claims description 6
- 238000005056 compaction Methods 0.000 claims description 6
- 230000036039 immunity Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 description 6
- 238000010586 diagram Methods 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 239000000020 Nitrocellulose Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920001220 nitrocellulos Polymers 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses an immunochromatography multi-connection reagent card which comprises an upper cover and a lower cover, wherein at least two chromatography detection channels are arranged between the upper cover and the lower cover; the chromatography detection channel comprises an effective chromatography detection channel and an ineffective chromatography detection channel, and satisfies the following conditions: m is more than or equal to 1 and less than or equal to N, N is more than or equal to 0 and less than or equal to N-1, and N is more than or equal to 2, wherein N is the total number of chromatography detection channels; m is the number of effective chromatography detection channels; n is the number of invalid chromatographic detection channels. According to the immunochromatography multi-connection reagent card, the plurality of chromatography detection channels are arranged between the upper cover and the lower cover, so that multi-channel chromatography detection can be realized at the same time, and the detection efficiency is improved; and the chromatography detection channels are divided into effective chromatography detection channels and ineffective chromatography detection channels, so that the number of the effective chromatography detection channels can be set according to the condition to carry out chromatography detection when the chromatography detection device is used, and the chromatography detection device is more flexible to use.
Description
Technical Field
The utility model belongs to the technical field of immunochromatography, and particularly relates to an immunochromatography multi-connected reagent card.
Background
The principle of immunochromatography (immunochromatography) is that a specific antibody is firstly fixed in a certain zone of a nitrocellulose membrane, after one end of the dried nitrocellulose membrane is immersed in a sample (urine or serum), the sample moves forwards along the membrane due to capillary action, when the sample moves to a region where the antibody is fixed, a corresponding antigen in the sample is specifically bound with the antibody, and the region can show a certain color if the region is stained by immune colloidal gold or immune enzyme, so that specific immunodiagnosis is realized.
Most of the existing immunochromatography reagent cards only have one detection channel, and the detection efficiency is low. An immunochromatographic reagent card disclosed in chinese patent publication No. CN211955504U, comprising: chromatography test paper; the lower shell is used for accommodating and supporting the chromatography test strip; the upper cover is detachably connected with the lower shell; a storage pool for accommodating a sample is arranged in the lower shell, a bayonet is formed in the side wall of the storage pool, and one end of the chromatographic test strip penetrates through the bayonet and extends into the storage pool; the upper cover is provided with an observation window and a sample adding port communicated with the storage pool, and the upper cover is also provided with a plurality of pressure columns at intervals for supporting the chromatography test paper strip. The immunochromatography reagent card can be only provided with one chromatography test strip, and can realize one-time chromatography detection.
Disclosure of Invention
In view of the above, the present invention provides an immunochromatography multi-linked reagent card having a plurality of detection channels, which can simultaneously implement a plurality of chromatographic detections.
In order to achieve the purpose, the utility model provides the following technical scheme:
an immunochromatography multi-connection reagent card comprises an upper cover and a lower cover, wherein at least two chromatography detection channels are arranged between the upper cover and the lower cover;
the chromatography detection channel comprises an effective chromatography detection channel and an ineffective chromatography detection channel, and satisfies the following conditions:
1≤m≤N
0≤n≤N-1
N≥2
wherein, N is the total number of chromatography detection channels; m is the number of effective chromatography detection channels; n is the number of invalid chromatographic detection channels.
Further, the chromatography detection channel comprises a test strip placement area positioned between the upper cover and the lower cover;
the lower cover is provided with liquid storage tanks which are arranged in one-to-one correspondence with the chromatography detection channels and are positioned at the liquid inlet ends of the corresponding test strip placing areas;
the upper cover is provided with an upper cover detection structure, and the upper cover detection structure and the effective chromatography detection channels are arranged in a one-to-one correspondence manner; the upper cover detection structure comprises a sample adding hole and an observation window, wherein the sample adding hole is positioned correspondingly to the liquid inlet end of the test strip placing area and communicated with the liquid storage tank, and the observation window is positioned correspondingly to the middle position of the test strip placing area.
Further, the upper cover detection structure further comprises air holes, and the air holes are located at the water absorption ends of the corresponding test strip placement areas.
Furthermore, the volume of the liquid storage tank is 70-300 muL.
Further, all the chromatography detection channels are arranged in parallel.
Furthermore, a thimble for preventing the shell from being clamped is arranged between the upper cover and the lower cover.
Furthermore, the outer side walls of the upper cover and the lower cover are provided with handheld anti-skid areas.
Further, the handheld anti-skid area is located at the other end opposite to the liquid inlet end of the test strip placement area.
Furthermore, an anti-pressing unit for preventing the test strip from being excessively pressed is arranged between the upper cover and the lower cover.
Further, the anti-compaction unit comprises anti-over-compaction columns which are arranged between two adjacent test strip placing areas and on two sides of all the test strip placing areas; the overpressure-preventing column is arranged on the upper cover or the lower cover, or the overpressure-preventing column is correspondingly arranged on the upper cover or the lower cover respectively.
The utility model has the beneficial effects that:
according to the immunochromatography multi-connection reagent card, the plurality of chromatography detection channels are arranged between the upper cover and the lower cover, so that multi-channel or multi-project chromatography detection can be realized at the same time, and the detection efficiency is improved; and the chromatography detection channels are divided into effective chromatography detection channels and ineffective chromatography detection channels, so that the number of the effective chromatography detection channels can be set according to the condition to carry out chromatography detection when the chromatography detection device is used, and the chromatography detection device is more flexible to use.
Through covering the liquid storage tank that sets up with chromatography detection channel one-to-one setting under, covering the upper cover detection structure that sets up with effective chromatography detection channel one-to-one setting on last, so, the lower cover of same structure can cooperate with the upper cover of isostructure not in order to constitute the reagent card that allies oneself with more that has different effective chromatography detection channel quantity to satisfy the operation requirement of different scenes.
Drawings
In order to make the object, technical scheme and beneficial effect of the utility model more clear, the utility model provides the following drawings for explanation:
FIG. 1 is a schematic structural diagram of an immunochromatography multi-linked reagent card in embodiment 1 of the present invention;
FIG. 2 is a schematic structural view of the present embodiment when the upper cover and the lower cover are laid flat;
FIG. 3 is a schematic structural diagram of an immunochromatography multi-linked reagent card in embodiment 2 of the present invention;
fig. 4 is a schematic structural view of the upper cover and the lower cover of the present embodiment when they are laid flat.
Description of reference numerals:
1-covering the upper cover; 2-lower cover; 3-a test strip placement area; 4-a liquid storage tank; 5-a sample addition hole; 6-observation window; 7-air holes; 8-a thimble; 9-hand-held antiskid zone; 10-overpressure prevention column.
Detailed Description
The present invention is further described with reference to the following drawings and specific examples so that those skilled in the art can better understand the present invention and can practice the present invention, but the examples are not intended to limit the present invention.
Example 1
Fig. 1 is a schematic structural diagram of an immunochromatography multi-linked reagent card in embodiment 1 of the present invention. The immunochromatography multi-connection reagent card comprises an upper cover 1 and a lower cover 2, wherein at least two chromatography detection channels are arranged between the upper cover 1 and the lower cover 2;
the chromatography detection channel comprises an effective chromatography detection channel and an ineffective chromatography detection channel, and satisfies the following conditions:
1≤m≤N
0≤n≤N-1
N≥2
wherein, N is the total number of chromatography detection channels; m is the number of effective chromatography detection channels; n is the number of invalid chromatographic detection channels.
Specifically, the chromatographic detection channel comprises a test strip placement zone 3 located between the upper cover 1 and the lower cover 2. Be equipped with liquid storage tank 4 on the lower cover 1 of this embodiment, liquid storage tank 4 sets up and is located the inlet liquid end that district 3 was placed to the test paper strip that corresponds with chromatography detection channel one-to-one. The upper cover 2 of the embodiment is provided with an upper cover detection structure, and the upper cover detection structure and the effective chromatography detection channels are arranged in a one-to-one correspondence manner; the upper cover detection structure comprises a sample adding hole 5 and an observation window 6, wherein the sample adding hole 5 is positioned at the liquid inlet end of the corresponding test strip placing area 3 and is communicated with the liquid storage tank 4, and the observation window 6 is positioned at the middle position of the corresponding test strip placing area 3. The sample adding hole 7 is used for dropwise adding detection liquid samples such as serum/plasma, whole blood, stool diluent, urine and the like into the liquid storage tank 6, and the sample adding hole 7 is in a water drop shape.
As shown in fig. 1-2, the number of the chromatography detection channels of the present embodiment is 3, wherein the number of the effective chromatography detection channels is 3, and the number of the ineffective chromatography detection channels is 0, that is, the number of the effective chromatography detection channels of the present embodiment is equal to the number of the chromatography detection channels. Of course, the number of chromatography detection channels can also be set to 2, 4 or more than 4 according to actual needs, and will not be described repeatedly.
The volume of the liquid storage tank 4 of the embodiment is 70-300 μ L, in the immunochromatography detection process, when the sample adding amount of the liquid sample is less, the chromatography is incomplete or the direct chromatography fails, when the sample adding amount of the liquid sample is excessive, the liquid sample overflows sample adding holes or forms a sample washing, and overflows the membrane surface of the observation area, so that the result interpretation is affected. In the embodiment, the volume of the liquid storage tank 4 is set to be compatible with 70-300 muL, so that the compatible volume range is larger.
Further, the upper cover detection structure of this embodiment still includes bleeder vent 7, and bleeder vent 7 is located the water absorption end in the test paper strip district 3 of placing that corresponds, and observation window 8 is located between corresponding application of sample hole 7 and bleeder vent 9. The air holes 7 play a role in balancing the internal and external air pressures of the reagent card in the detection process, and the influence of the internal and external pressure imbalance on the chromatographic detection of the reagent is avoided. By arranging the air holes 7 at the water absorption end of the test strip placement area 3, the water absorption end can be used for drying quickly, so that the influence of liquid at the water absorption end on the reagent background caused by the backflow to the membrane surface (because the membrane surface is directly exposed in the air and dries quickly) is prevented, the reagent result observation time is prolonged, and the background influence is reduced.
Further, a thimble 8 for preventing the shell from being clamped is arranged between the upper cover 1 and the lower cover 2, so that the shell is prevented from being clamped between the upper cover 1 and the lower cover 2.
Furthermore, the outer side walls of the upper cover 1 and the lower cover 2 are provided with handheld anti-skid areas 9, so that the holding is convenient. The handheld antiskid area 9 of this embodiment is located the other end relative with the feed liquor end that the district 3 was placed to the test paper strip, keeps away from the feed liquor end that the district 3 was placed to the test paper strip, avoids being stained with liquid on hand.
Further, all the chromatography detection channels of this embodiment are arranged in parallel. An anti-pressing unit for preventing the test strip from being pressed excessively is arranged between the upper cover 1 and the lower cover 2 of the embodiment. Specifically, the anti-compaction unit comprises anti-compaction columns 10 which are arranged between two adjacent test strip placing areas 3 and at two sides of all the test strip placing areas 3; the overpressure-preventing columns 10 are arranged on the upper cover 1 or the lower cover 2, or the upper cover 1 or the lower cover 2 are respectively and correspondingly provided with the overpressure-preventing columns 10. The upper cover 1 or the lower cover 2 of the present embodiment is correspondingly provided with an overpressure-proof column 10. By utilizing the limiting function of the overpressure-preventing column 10, the test strip can be prevented from being excessively compressed, so that the abnormal condition of the chromatographic state of the reagent during detection can be avoided, and the detection accuracy and reliability are improved.
According to the immunochromatography multi-connection reagent card, the plurality of chromatography detection channels are arranged between the upper cover and the lower cover, so that multi-channel chromatography detection can be realized at the same time, and the detection efficiency is improved; and the chromatography detection channels are divided into effective chromatography detection channels and ineffective chromatography detection channels, so that the number of the effective chromatography detection channels can be set according to the condition to carry out chromatography detection when the chromatography detection device is used, and the chromatography detection device is more flexible to use. Through covering the liquid storage tank that sets up with chromatography detection channel one-to-one setting under, covering the upper cover detection structure that sets up with effective chromatography detection channel one-to-one setting on last, so, the lower cover of same structure can cooperate with the upper cover of isostructure not in order to constitute the reagent card that allies oneself with more that has different effective chromatography detection channel quantity to satisfy the operation requirement of different scenes.
Example 2
Fig. 3 is a schematic structural diagram of an immunochromatography multi-linked reagent card in embodiment 2 of the present invention. The immunochromatography multi-connection reagent card comprises an upper cover 1 and a lower cover 2, wherein at least two chromatography detection channels are arranged between the upper cover 1 and the lower cover 2;
the chromatography detection channel comprises an effective chromatography detection channel and an ineffective chromatography detection channel, and satisfies the following conditions:
1≤m≤N
0≤n≤N-1
N≥2
wherein, N is the total number of chromatography detection channels; m is the number of effective chromatography detection channels; n is the number of invalid chromatographic detection channels.
Specifically, the chromatographic detection channel comprises a test strip placement zone 3 located between the upper cover 1 and the lower cover 2. Be equipped with liquid storage tank 4 on the lower cover 1 of this embodiment, liquid storage tank 4 sets up and is located the inlet liquid end that district 3 was placed to the test paper strip that corresponds with chromatography detection channel one-to-one. The upper cover 2 of the embodiment is provided with an upper cover detection structure, and the upper cover detection structure and the effective chromatography detection channels are arranged in a one-to-one correspondence manner; the upper cover detection structure comprises a sample adding hole 5 and an observation window 6, wherein the sample adding hole 5 is positioned at the liquid inlet end of the corresponding test strip placing area 3 and is communicated with the liquid storage tank 4, and the observation window 6 is positioned at the middle position of the corresponding test strip placing area 3. The sample adding hole 7 is used for dropwise adding detection liquid samples such as serum/plasma, whole blood, stool diluent, urine and the like into the liquid storage tank 6, and the sample adding hole 7 is in a water drop shape.
As shown in fig. 1 to 3, the number of the chromatography detection channels of the present embodiment is set to 3, wherein the number of the effective chromatography detection channels is 2, and the number of the ineffective chromatography detection channels is 1, and the 1 ineffective chromatography detection channel is located between the 2 effective chromatography detection channels. Of course, according to actual needs, the number of the effective chromatography detection channels can be set to 1, and the number of the ineffective chromatography detection channels can be set to 2, which are not described in detail again.
Other embodiments of this embodiment are the same as embodiment 1, and will not be described in detail.
The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. The equivalent substitution or change made by the technical personnel in the technical field on the basis of the utility model is all within the protection scope of the utility model. The protection scope of the utility model is subject to the claims.
Claims (10)
1. The utility model provides an immunity chromatography allies oneself with reagent card more, includes upper cover (1) and lower cover (2), its characterized in that: at least two chromatography detection channels are arranged between the upper cover (1) and the lower cover (2);
the chromatography detection channel comprises an effective chromatography detection channel and an ineffective chromatography detection channel, and satisfies the following conditions:
1≤m≤N
0≤n≤N-1
N≥2
wherein, N is the total number of chromatography detection channels; m is the number of effective chromatography detection channels; n is the number of invalid chromatographic detection channels.
2. The immunochromatography multi-linked reagent card of claim 1, wherein: the chromatography detection channel comprises a test strip placing area (3) positioned between the upper cover (1) and the lower cover (2);
a liquid storage tank (4) is arranged on the lower cover (1), the liquid storage tanks (4) are arranged in one-to-one correspondence with the chromatography detection channels and are positioned at the liquid inlet ends of the corresponding test strip placement areas (3);
an upper cover detection structure is arranged on the upper cover (1), and the upper cover detection structure and the effective chromatography detection channels are arranged in a one-to-one correspondence manner; upper cover detection structure includes application of sample hole (5) and observation window (6), application of sample hole (5) are located the correspondence the test paper strip place the feed liquor end of district (3) and with liquid storage tank (4) are linked together, observation window (6) are located the correspondence the test paper strip places the middle part position of district (3).
3. The immunochromatography multi-linked reagent card of claim 2, wherein: the upper cover detection structure further comprises air holes (7), and the air holes (7) are located at the water absorption ends of the test strip placement areas (3) correspondingly.
4. The immunochromatography multi-linked reagent card of claim 2, wherein: the volume of the liquid storage tank (4) is 70-300 muL.
5. The immunochromatography multi-linked reagent card of claim 2, wherein: all the chromatography detection channels are arranged in parallel.
6. The immunochromatography multi-linked reagent card of claim 1, wherein: and an ejector pin (8) for preventing the shell from being clamped is arranged between the upper cover (1) and the lower cover (2).
7. The immunochromatography multi-linked reagent card of claim 1, wherein: and hand-held anti-skid regions (9) are arranged on the outer side walls of the upper cover (1) and the lower cover (2).
8. The immunochromatography multi-linked reagent card of claim 7, wherein: and the handheld anti-skid area (9) is positioned at the other end opposite to the liquid inlet end of the test strip placing area (3).
9. The immunochromatography multi-linked reagent card of claim 5, wherein: an anti-compaction unit for preventing the test strip from being excessively compacted is arranged between the upper cover (1) and the lower cover (2).
10. The immunochromatography multi-linked reagent card of claim 9, wherein: the anti-compaction unit comprises anti-over-pressure columns (10) which are arranged between two adjacent test strip placing areas (3) and on two sides of all the test strip placing areas (3); the anti-over-pressure column (10) is arranged on the upper cover (1) or the lower cover (2), or the upper cover (1) or the lower cover (2) is respectively and correspondingly provided with the anti-over-pressure column (10).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121418130.9U CN215339892U (en) | 2021-06-24 | 2021-06-24 | Immunochromatography multi-connection reagent card |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121418130.9U CN215339892U (en) | 2021-06-24 | 2021-06-24 | Immunochromatography multi-connection reagent card |
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| Publication Number | Publication Date |
|---|---|
| CN215339892U true CN215339892U (en) | 2021-12-28 |
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Family Applications (1)
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| CN202121418130.9U Active CN215339892U (en) | 2021-06-24 | 2021-06-24 | Immunochromatography multi-connection reagent card |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116047062A (en) * | 2022-12-26 | 2023-05-02 | 科赫生物科技（北京）有限公司 | Multi-joint inspection quantum dot quantitative detection card and preparation method thereof |
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2021
- 2021-06-24 CN CN202121418130.9U patent/CN215339892U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116047062A (en) * | 2022-12-26 | 2023-05-02 | 科赫生物科技（北京）有限公司 | Multi-joint inspection quantum dot quantitative detection card and preparation method thereof |
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