CN215228747U - Rat trachea cannula assembly - Google Patents

Abstract

The utility model provides a rat trachea cannula subassembly, including outer sleeve pipe, inlayer sleeve pipe and guide wire. The outer layer sleeve is used as an oral cavity opening tube and is nested in the outer layer of the inner layer sleeve, and the outer layer sleeve comprises an opening end extending into the oral cavity and a holding end arranged on the outer side; the front end of the opening end is an inclined plane, and an included angle is also arranged between the tail end and the holding end. The inner casing is used as a breathing tube, the front end of the inner casing is provided with a certain angle and passivated corners, and the tail end of the inner casing is provided with a breathing machine connecting mechanism; the length of the guide steel wire is larger than that of the inner layer sleeve. The trachea cannula assembly can effectively realize quick intubation without tracheotomy, and avoids complex operation and additional damage to rats. The use result shows that the method has small damage to rats and high stable and reliable success rate, avoids additional damage caused by exposure of a plurality of wounds in the open-chest surgery, is beneficial to secondary or multiple open-chest surgeries and increases the survival rate of animals.

Description

Rat trachea cannula assembly

Technical Field

The utility model belongs to the technical field of rat trachea cannula, concretely relates to maintain mechanical respiration's rat trachea cannula subassembly when rat thorax opens operation.

Background

Acute myocardial infarction is myocardial necrosis caused by acute and persistent ischemia and hypoxia of coronary artery. The disease is clinically characterized by severe and persistent poststernal pain, rest and incomplete relief of nitrate medicines, and is accompanied by increased activity of serum myocardial enzyme and progressive electrocardiogram change, and arrhythmia, shock or heart failure can occur, and the disease can often endanger life. Acute myocardial infarction is the most common in europe and the united states, with about 150 million people in the united states per year. China has a remarkable rising trend in recent years, newly issues at least 50 ten thousand per year, and finds that the acute myocardial infarction is at least 200 ten thousand, so the research on the acute myocardial infarction is more and more emphasized. In animal experiments, rats are mostly used as research objects, and in the experiment of acute myocardial infarction modeling, the thoracic cavities of the rats need to be opened for operation.

When a thoracotomy operation is performed on a rat, negative pressure in the thoracic cavity of the rat cannot be maintained, and a breathing cannula is required. Because the tracheal diameter of the rat is small, the conventional rat respiratory intubation generally adopts a tracheotomy intubation method. In the process of establishing a rat myocardial infarction scar model, the trachea incision method is found to have the disadvantages of large wound area, more wounds, easy complication infection after operation, low survival rate and the like caused by aggravated damage during secondary intubation, and difficulty in establishing an experimental model.

SUMMERY OF THE UTILITY MODEL

The present invention has been made to solve the above problems. The inventor finds that a double cannula inserting method is invented by referring to a vascular catheter technology in the interventional cardiology technology through a plurality of experiments, a rat tracheal intubation component is formed, a tracheal incision operation is not needed, a respiratory tube can be directly inserted into the oral cavity through the pharyngeal portion, and therefore complex operation and multiple damage to the rat are avoided. In order to achieve the above object, the present invention provides the following technical solutions:

the utility model provides a rat trachea cannula subassembly has following technical characteristic: comprises an outer sleeve, an inner sleeve and a guide steel wire. The outer layer sleeve is used as an oral cavity opening tube and is nested in the outer layer of the inner layer sleeve, and the outer layer sleeve comprises an opening end extending into the oral cavity and a holding end arranged on the outer side; the front end of the opening end is set with a certain angle, and an included angle is also arranged between the tail end and the holding end. The inner casing is used as a breathing tube, the front end of the inner casing is provided with a certain angle and passivated corners, and the tail end of the inner casing is provided with a breathing machine connecting mechanism; the length of the guide steel wire is larger than that of the inner layer sleeve.

Further, the utility model provides an among the rat trachea cannula subassembly, outer sheathed tube struts end length and is 30mm, for the tapered structure.

Further, in the rat trachea cannula assembly provided by the utility model, the angle of the front end of the opening end is 30 degrees.

Further, in the rat trachea cannula assembly provided by the utility model, the tail end of the opening end and the included angle between the holding ends are 120 degrees.

Further, in the rat trachea cannula assembly provided by the utility model, the length of the inner casing is 8cm, the front end is trimmed by 45 degrees and the corners are passivated, the tail end is provided with the vent pipe interface, and 3-5 sealed inner grooves are arranged in the interface.

Further, the utility model provides an among the rat trachea cannula subassembly, the length of guide steel wire is 10cm, and the front end passivation is fillet and crooked, and the tail end is for holding the end.

Further, the utility model provides an among the rat trachea cannula subassembly, be provided with the scale on the guide steel wire, every interval 1cm sets up one.

The utility model provides a three structure can be special die sinking utensil batch production, also can self-control under emergency. The outer-layer sleeve is made of a laboratory 1mL standard suction head (tip) made of polypropylene materials, and is cut, heated and bent by 60 degrees according to a design pattern to form a holding end and a spreading end of a spreader, and the spreading end is simultaneously used as a breathing tube fixing structure; the respiratory tube is made of PVC intravenous infusion needle hose, a rear end infusion hose connector is reserved, 45-degree trimming and corner passivation are carried out at the front end, and the end part ventilation caliber is enlarged; the guide steel wire is made of a blood vessel guide steel wire for operation, the front end of the guide steel wire is burned to passivate the external coating, and the rear end of the guide steel wire is wrapped by adhesive tape with the length of 1cm to be used as a cannula holding end.

Action and effect of the utility model

The utility model provides a rat trachea cannula subassembly has following technological effect:

1. simple manufacture and low cost: the manufacturing materials can be selected from common biological laboratory equipment such as tip, transfusion hoses, guide steel wires and the like, and the manufacturing method is simple and convenient without professional tools and has low manufacturing cost.

2. The operation is simple and convenient, and the threshold is low: adopt the utility model discloses a when the subassembly carries out rat trachea cannula operation, only need combine frontal mirror (operation headlight), the accurate epiglottis cartilage location vocal cords of choosing can accomplish and put the pipe, does not have the breathing opportunity and masters the requirement, and the operation technique threshold is lower. However, when a common rat breathes at a intubation time, the elastic guide steel wire is inserted quickly after epiglottis and glottis are opened when the rat exhales, and technical and empirical requirements exist.

3. The fixed protection effect is good: the outer sleeve pipe makes things convenient for respiratory tube control depth of insertion and fixed, protects the respiratory tube simultaneously and does not receive the oppression of rat tongue tooth, ensures normally taking a breath, improves rat postoperative survival rate.

To sum up, this subassembly can effectively realize quick intubate, does not need the tracheotomy operation, has avoided complicated operation and to the extra damage of rat. The use result shows that the method has small damage to rats and high stable and reliable success rate, avoids additional damage caused by exposure of a plurality of wounds in the open-chest surgery, is beneficial to secondary or multiple open-chest surgeries and increases the survival rate of animals.

Drawings

Fig. 1 is a schematic structural diagram of a rat trachea cannula assembly in an embodiment of the present invention;

fig. 2 is a schematic diagram of a preparation structure of an outer casing according to an embodiment of the present invention;

fig. 3 is a schematic structural diagram of an inner casing according to an embodiment of the present invention;

fig. 4 is a schematic structural diagram of a guide wire in an embodiment of the present invention.

Detailed Description

The present invention will be described in detail with reference to the following embodiments and drawings. The following examples should not be construed, however, as limiting the scope of the invention.

Example 1 rat trachea cannula assembly structure

According to fig. 1, the rat trachea cannula assembly 100 comprises three parts, namely an outer sleeve 1, an inner sleeve 2 and a guide wire 3. The outer sleeve 1 is used as an oral cavity opening tube and is nested in the outer layer of the inner sleeve; the inner-layer sleeve 2 is used as a breathing tube and is arranged in the outer-layer sleeve 1 to be used as a breathing passage of a rat; the guiding steel wire 3 is used as a guide to guide the insertion of the breathing tube, the guiding steel wire is pulled out after the intubation is finished, and the rear end of the breathing tube is connected with a breathing mechanism to form a ventilation structure.

According to fig. 2, the outer sleeve 1 comprises two parts, a support end 11 which projects into the mouth and a grip end 12 which is arranged on the outside. The length of the opening end 11 is 30mm, the opening end is of a tapered structure, the angle of the front end is 30 degrees, the corners are passivated, and the included angle between the tail end and the holding end is 120 degrees.

According to the figure 3, the length of the inner-layer sleeve 2 is 8cm, the front end is trimmed at 45 degrees and corners are passivated so as to enlarge the ventilation caliber of the end part, and the tail end is provided with ventilation pipe interfaces (3-5 sealing inner grooves) so as to be conveniently connected with a breathing machine pipeline in a sealing mode. According to fig. 4, the length of the guide wire 3 is 10cm, the effective length is 9cm, the front end is passivated into a round angle and is bent, and the tail end is 1cm and is a holding end; furthermore, be provided with the scale on the guide steel wire, every interval 1cm sets up one, and the convenience is putting the pipe in-process, considers the contraposition pipe degree of depth.

The three structures in the implementation can be specially used for batch production of the mold, and can also be self-made in a laboratory. According to fig. 2, an outer sleeve 1 is made of a laboratory 1mL standard tip (tip) made of polypropylene, and the tip pipe is firstly cut according to a design pattern; then the tail end part is heated and bent by 60 degrees to form a holding end of the spreader; after the head end part is cut off by 15cm, the corner is trimmed at 45 degrees and passivated to be used as the head of the opening end which is simultaneously used as a breathing tube fixing structure.

The respiratory tube is made of PVC intravenous infusion needle hose, a rear end infusion hose connector is reserved, 45-degree trimming and corner passivation are carried out at the front end, and the end part ventilation caliber is enlarged; the guide steel wire is made of a blood vessel guide steel wire for operation, a steel wire of 10cm is cut out, the front end is burned to passivate an outer coating, and the rear end is wrapped with adhesive plaster of 1cm in length to be used as an intubation holding end.

Example 2 Experimental validation

1. Materials and methods

Animals: 28 SD rats (Shanghai B.K. company), 18 male and 10 female, 230g +/-20 g.

Rat endotracheal tube assembly prepared as described in example 1.

2. The method comprises the following operation steps:

(1) rat 3% sodium pentobarbital 50mg/kg intraperitoneal injection anesthesia, atropine 0.05mg/kg intramuscular injection to reduce respiratory tract secretion; after 10-15 minutes, the rat lies on the back, and the limbs and the head are fixed on the rat fixing wood board.

(2) The tongue of the rat is pulled out and picked up by tongue clamping forceps, the oral cavity opening tube is pushed into the oral cavity of the rat along the upper jaw of the rat by means of a frontal mirror, and the tip of the oral cavity opening tube is used for picking up epiglottis cartilage to expose the glottis.

(3) Inserting the guide wire into the respiratory tube with the tip exposed by about 1 cm; along the side wall of the distraction pipe, inserting the tip of the guide steel wire between the two vocal cords in the expiration gap of the rat; the front section of the respiratory tube faces downwards, the respiratory tube slides into the respiratory tract along the guide steel wire, the guide steel wire is slightly withdrawn after the respiratory tube reaches a proper depth (about 1cm), the other end of the respiratory tube is connected with a breathing machine, artificial respiration is carried out according to the indoor air and the tidal volume of 2ml/100g for 65 times/minute, and the intubation operation is finished.

3. Results

The 28 rats were subjected to intubation for 43 times in total, except for 1 drop during intubation surgery, respiratory failure death after reinsertion and 1 over-deep death due to anesthesia, intubation was successfully completed 41 times with a success rate of 95.3%.

The result shows that the method for intubation by adopting the assembly in the embodiment has small damage to rats, stability, reliability and high success rate, avoids additional damage caused by exposure of a plurality of wounds in the thoracotomy, is beneficial to secondary or multiple thoracotomy operations and increases the survival rate of animals. In the experiment, the fact that respiratory secretions are increased due to the fact that anesthesia is not deep and repeated intubation can be conducted is found, and due to the fact that the diameter of the breathing tube is small, the smoothness of respiration of a rat is seriously affected by excessive secretions, and therefore the fact that the anesthesia injection dosage and the intubation time are important to master is particularly important.

In summary, the rat trachea cannula assembly in this embodiment has the following technical effects:

1. simple manufacture and low cost: the preparation material can be selected from common biological laboratory equipment such as tip, transfusion hose, guide steel wire and the like, the preparation can be carried out without professional tools or industrial mold opening, the preparation can be realized by selecting laboratory materials, the method is simple and convenient, and the preparation cost is low.

2. The operation is simple and convenient, and the threshold is low: adopt the utility model discloses a when the subassembly carries out rat trachea cannula operation, only need combine frontal mirror (operation headlight), the accurate epiglottis cartilage location vocal cords of choosing can accomplish and put the pipe, does not have the breathing opportunity and masters the requirement, and the operation technique threshold is lower. When a common rat breathes at a intubation time, the elastic guide steel wire is inserted quickly after epiglottis and glottis are opened when the rat exhales, so that technical and empirical requirements exist and the rat can be mastered only by repeated practice.

3. The fixed protection effect is good: the outer sleeve pipe makes things convenient for respiratory tube control depth of insertion and fixed, protects the respiratory tube simultaneously and does not receive the oppression of rat tongue tooth, ensures normally taking a breath, improves rat postoperative survival rate.

To sum up, this subassembly can effectively realize quick intubate, does not need the tracheotomy operation, has avoided complicated operation and to the extra damage of rat. The use result shows that the method has small damage to rats and high stable and reliable success rate, avoids additional damage caused by exposure of a plurality of wounds in the open-chest surgery, is beneficial to secondary or multiple open-chest surgeries and increases the survival rate of animals.

The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the above embodiments, and that the foregoing embodiments and descriptions are provided only to illustrate the principles of the present invention without departing from the spirit and scope of the present invention. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (7)

1. A rat trachea cannula component is characterized by comprising an outer casing, an inner casing and a guide steel wire,

the outer-layer sleeve is used as an oral cavity opening tube, is nested in the outer layer of the inner-layer sleeve and comprises an opening end extending into the oral cavity and a holding end arranged on the outer side, the front end of the opening end is an inclined surface, and a certain angle is formed between the tail end and the holding end;

the inner casing is used as a breathing tube, the front end of the inner casing is provided with a certain angle and passivated corners, and the tail end of the inner casing is provided with a respirator connecting mechanism;

the length of the guide steel wire is larger than that of the inner layer sleeve.

2. A rat endotracheal tube assembly according to claim 1, characterized in that:

wherein, the length of the opening end of the outer casing is 30mm, and the outer casing is of a tapered structure.

3. A rat endotracheal tube assembly according to claim 2, characterized in that:

wherein the angle of the front end of the opening end is 30 degrees.

4. A rat endotracheal tube assembly according to claim 1, characterized in that:

wherein, the included angle between the tail end of the opening end and the holding end is 120 degrees.

5. A rat endotracheal tube assembly according to claim 1, characterized in that:

the length of the inner-layer sleeve is 8cm, the front end of the inner-layer sleeve is trimmed at 45 degrees and corners are passivated, the tail end of the inner-layer sleeve is provided with a vent pipe interface, and 3-5 sealed inner grooves are formed in the interface.

6. A rat endotracheal tube assembly according to claim 5, characterized in that:

wherein, the length of guide wire is 10cm, and the front end passivation is the fillet and is crooked, and the tail end is the end of gripping.

7. A rat endotracheal tube assembly according to claim 6, characterized in that:

wherein, be provided with the scale on the guide steel wire, every interval 1cm sets up one.

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