CN215155868U - Full-automatic partial shipment system of pipe that freezes - Google Patents

Abstract

The application discloses full-automatic cryopreserved pipe partial shipment system belongs to biology, medicine field. The automatic cap loading and unloading device comprises an operation table, a manipulator, automatic cap loading and unloading equipment, a divider turntable, a sample bag, a visual detection device and a waste liquid treatment device are installed on the upper portion of the operation table, an injection subpackaging device is arranged at the end portion of the manipulator, a plurality of freezing and storing boxes are evenly arranged on the upper portion of the divider turntable, a plurality of jacks used for placing freezing and storing tubes are arranged on the upper portions of the freezing and storing boxes, and the automatic cap loading and unloading equipment is located on the upper portions of the jacks. The application provides a pair of full-automatic pipe partial shipment system that freezes, through set up the robot hand on operation panel upper portion, the artificial operation that has significantly reduced has saved time and human cost, and simultaneously, operation panel upper portion has integrated the required equipment of partial shipment such as automatic upper and lower cover equipment, decollator carousel, visual detection device for each operation link's contact is inseparabler, and the degree of integrating is higher.

Description

Full-automatic partial shipment system of pipe that freezes

Technical Field

The application relates to the fields of biology and medicine, in particular to a full-automatic cryopreservation tube subpackaging system.

Background

At present, accurate medical treatment has become a focus of social attention, and the biological sample library plays an important role in the accurate medical treatment process of serious diseases such as malignant tumors, blood diseases, immune system diseases, metabolic diseases, cardiovascular and cerebrovascular diseases and the like. With the rapid development of the field of biological sample banks, people increasingly need the ability to quickly and efficiently pre-process liquid samples such as blood samples, urine samples, saliva and the like before downstream operations or sample storage.

The frozen tube is usually used for subpackaging samples when collecting and storing samples or performing research on subjects. However, the inventor finds that in the research process of the application, when the cryopreservation tube is used for split charging in the prior art, a manual operation mode is usually adopted, and the whole split charging process is complicated and has certain requirements on operation precision, so that the operation difficulty of workers is greatly increased, a large amount of time and labor cost are consumed, and the efficiency is low.

Disclosure of Invention

The application provides a full-automatic cryopreserved pipe partial shipment system to solve the problem that provides in the background art.

The utility model provides a full-automatic pipe partial shipment system that freezes deposits, includes the operation panel, manipulator, automatic upper and lower cover equipment, decollator carousel, sample bag, visual detection device and waste liquid treatment device are installed on operation panel upper portion, the manipulator tip is equipped with injection partial shipment device, decollator carousel upper portion is equipped with freezes deposits the box, freezes deposits box upper portion and evenly is equipped with the multiunit and is used for placing the jack that freezes deposits the pipe, automatic upper and lower cover equipment is located jack upper portion.

Preferably, the injection and distribution device is a syringe pump, and a syringe is installed on the syringe pump.

Preferably, an injector clamping station is arranged at the upper part of the operating platform, and a plurality of injectors are clamped at the injector clamping station.

Preferably, the injection dispensing device is a peristaltic pump, and the peristaltic pump is externally connected with a hose.

Preferably, a sample loading liquid station is arranged at the upper part of the operating platform, and frozen stock solution and/or detergent are/is filled in the sample loading liquid station.

Preferably, the upper part of the operating platform is provided with a mixing and shaking device.

Preferably, the mixing and shaking device is a shaking table.

Preferably, the robot hand is a six-axis robot hand, and the vision detection device adopts a CCD vision camera.

Preferably, the waste liquid treatment device comprises a waste liquid barrel and a waste material barrel.

Preferably, a biological safety cabinet or an ultra-clean workbench or a biological isolator is arranged outside the operating platform.

According to the technical scheme, the full-automatic frozen storage tube subpackage system has the advantages that the robot hand is arranged on the upper portion of the operating platform, manual operation procedures are greatly reduced, time and labor cost are saved, meanwhile, the equipment required for subpackage such as automatic upper and lower cover equipment, a divider turntable and a visual detection device is integrated on the upper portion of the operating platform, contact of each operation link is more compact, and the integration degree is higher.

Drawings

FIG. 1 is a front view of a fully automatic cryopreserved tubular racking system provided herein;

FIG. 2 is a perspective view of the fully automatic cryopreserved tubular racking system provided herein;

FIG. 3 is a cross-sectional view taken along line A-A in FIG. 1

Wherein: 10-an operation table, 20-a robot hand, 30-automatic upper and lower cover equipment, 40-a divider turntable, 401-a cryopreservation box, 50-a sample bag, 60-a visual detection device, 70-a waste liquid treatment device, 80-an injection pump, 801-an injector, 802-an injector clamping station, 90-a sample loading liquid station, 110-a shaking table and 111-a cryopreservation tube.

Detailed Description

The technical solutions in the embodiments will be described clearly and completely with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Referring to fig. 1 to 3, the present application provides a full-automatic cryopreservation tube subpackaging system, which comprises an operation table 10, wherein a robot 20, an automatic upper and lower cover device 30, a divider turntable 40, a sample bag 50, a visual detection device 60 and a waste liquid treatment device 70 are installed on the upper portion of the operation table 10. The positions of the robot arm 20, the automatic cap loading and unloading apparatus 30, the divider disk 40, the sample bag 50, the visual inspection device 60, and the waste liquid treatment device 70 may be moved and adjusted according to the actual operation, and the present application is not particularly limited.

Specifically, the robot hand 20 preferably adopts a six-axis robot hand, the outer surface of which is coated with a coating for resisting bacterial growth and is sterilized by VHP (Vaporized Hydrogen Peroxide) or other sterilization processes, so as to meet the requirements of GMP (GOOD MANUFACTURING practice) level a environment sterility and cleanliness, and meanwhile, the height of the six-axis robot hand can be flexibly adjusted during working, so that the six-axis robot hand has high applicability. The robot arm 20 is well known in the art and will not be described further herein.

Referring to fig. 3, the end of the robot 20 is provided with an injection dispensing device. In one embodiment, the syringe dispensing device is a syringe pump 80, the syringe pump 80 is preferably a split syringe pump, and a syringe 801 is mounted on the syringe pump 80; an injector clamping station 802 is arranged at the upper part of the operating platform 10, and a plurality of injectors 801 are clamped at the injector clamping station 802. When the injection pump 80 is used for subpackaging, in order to avoid sample pollution caused by repeated use of the same injector 801, a plurality of injectors 801 can be preset through setting the injector clamping station 802, so that the injectors can be conveniently and timely replaced during operation. In another embodiment, the injection subpackaging device adopts a peristaltic pump, the peristaltic pump is externally connected with a hose, and the hose is preferably a silica gel hose.

Referring to fig. 3, the divider rotating disc 40 is externally connected with a driving device to realize rotation, the upper part of the divider rotating disc is uniformly provided with a plurality of freezing boxes 401, the upper parts of the freezing boxes 401 are provided with a plurality of jacks for placing the freezing tubes 111, and the freezing tubes 111 are inserted into the jacks and fixed; the automatic capping and uncapping device 30 is located at an upper portion of the insertion hole, and is used for capping and uncapping the cryopreservation tube 111. The automatic capping apparatus 30 is well known in the art and will not be described further herein.

Referring to fig. 3, a sample liquid loading station 90 is arranged at the upper part of the operating platform 10, and frozen stock solution and/or detergent are/is filled in the sample liquid loading station 90; the upper part of the operation platform 10 is provided with a mixing and shaking device. Preferably, the mixing and shaking device is a shaking table 110. Through setting up and mixing the device and rocking the sample, can make frozen stock solution and detergent mix with the sample better.

The frozen stock solution is also called as frozen stock protective agent, the frozen stock solution is added into the sample to protect the sample cells from solution damage and ice crystal damage, the frozen stock solution is combined with water molecules in the sample to generate hydration, and the crystallization process of the weakened water increases the viscosity of the sample solution, thereby reducing the formation of the ice crystal, and meanwhile, the frozen stock solution can reduce the concentration of electrolyte in unfrozen solution inside and outside the sample cells by maintaining a certain molar concentration inside and outside the sample cells, so that the sample cells are protected from damage of solute; the detergent is used for cleaning impurities attached to a sample, for example, when the detergent is used for fat tissue subpackaging operation, the sodium lactate ringer injection is used as the detergent, fat is insoluble in the sodium lactate ringer injection, and impurities such as other blood are soluble in the sodium lactate ringer injection, so that the purpose of cleaning the impurities in the fat tissue can be achieved by injecting the sodium lactate ringer injection into the fat tissue sample and uniformly mixing the sodium lactate ringer injection with the fat tissue sample.

Preferably, the visual inspection device 60 employs a CCD vision camera; the waste liquid treatment apparatus 70 includes a waste liquid tank and a waste material tank. By arranging the visual detection device 60, the liquid level and the volume of the subpackage can be observed and detected in real time, and the subpackage precision is ensured; the waste barrel is used for recycling waste materials generated during subpackaging, such as used syringes, and the waste barrel is used for recycling waste liquid generated during subpackaging.

Preferably, a biosafety cabinet or clean bench or a biological isolator is arranged outside the operation table 10. By providing a biosafety cabinet or clean bench or bio-isolator externally, a cleaner and more sanitary working environment can be provided for the operation table 10.

The application provides a pair of full-automatic cryopreserved pipe partial shipment system's theory of operation as follows: firstly, liquid to be dispensed is placed in a sample bag 50; secondly, the divider rotating disc 40 rotates to move the freezing pipe 111 to the bottom of the automatic upper and lower cover equipment 30, and after the automatic upper and lower cover equipment 30 carries out the upper cover operation, the divider rotating disc 40 rotates again and outwards rotates the freezing pipe 111 out to the split charging station; then, the manipulator 20 operates the injection and sub-packaging device to sequentially sub-package the liquid to be sub-packaged into the cryopreservation tube 111; finally, the divider rotating disc 40 rotates to move the packed frozen tubes 111 to the bottom of the automatic upper and lower cover device 30, and the automatic upper and lower cover device 30 carries out lower cover operation, so that the frozen tubes packing operation can be completed.

Other embodiments of the present application will be apparent to those skilled in the art from consideration of the specification and practice of the application disclosed herein. This application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the application and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains. It is intended that the specification and examples be considered as exemplary only, with a true scope and spirit of the application being indicated by the following claims.

It will be understood that the present application is not limited to the precise arrangements described above and shown in the drawings and that various modifications and changes may be made without departing from the scope thereof. The scope of the application is limited only by the appended claims.

Claims (10)

1. The utility model provides a full-automatic pipe partial shipment system that freezes deposits, its characterized in that, includes operation panel (10), manipulator (20), automatic upper and lower cover equipment (30), decollator carousel (40), sample bag (50), visual detection device (60) and waste liquid treatment device (70) are installed on operation panel (10) upper portion, manipulator (20) tip is equipped with injection partial shipment device, decollator carousel (40) upper portion evenly is equipped with a plurality of boxes (401) that freezes, it is equipped with a plurality of jacks that are used for placing the pipe that freezes to deposit to freeze to deposit box (401) upper portion, automatic upper and lower cover equipment (30) are located jack upper portion.

2. The fully automatic cryopreservation tube dispensing system of claim 1, wherein the injection dispensing device is a syringe pump (80), and a syringe (801) is mounted on the syringe pump (80).

3. The full-automatic cryopreservation tube packaging system of claim 2, wherein a syringe clamping station (802) is arranged at the upper part of the operating platform (10), and a plurality of syringes (801) are clamped at the syringe clamping station (802).

4. The fully automatic cryopreservation tube dispensing system of claim 1, wherein the injection dispensing device is a peristaltic pump externally connected with a hose.

5. The full-automatic cryopreservation tube subpackaging system according to claim 1, wherein a sample loading liquid station (90) is arranged at the upper part of the operating platform (10), and the cryopreservation liquid and/or detergent are/is filled in the sample loading liquid station (90).

6. The full automatic cryopreservation tube dispensing system of claim 5, wherein a mixing and shaking device is arranged at the upper part of the operating platform (10).

7. The fully automated cryopreservation tube dispensing system of claim 6, wherein the mixing and shaking device is a shaker (110).

8. The fully automated cryopreservation tube racking system of claim 1, wherein the robot (20) is a six-axis robot and the vision inspection device (60) employs a CCD vision camera.

9. The fully automated cryopreservation tube dispensing system of claim 1, wherein the waste liquid treatment device (70) comprises a waste liquid barrel and a waste material barrel.

10. The fully automatic cryopreservation tube dispensing system of any one of claims 1 to 9, wherein a biosafety cabinet or an ultra clean bench or a biological isolator is arranged outside the operation table (10).

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