CN215118829U - Mass spectrum device based on multiple ion sources - Google Patents
Mass spectrum device based on multiple ion sources Download PDFInfo
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- CN215118829U CN215118829U CN202121429372.8U CN202121429372U CN215118829U CN 215118829 U CN215118829 U CN 215118829U CN 202121429372 U CN202121429372 U CN 202121429372U CN 215118829 U CN215118829 U CN 215118829U
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- 238000001819 mass spectrum Methods 0.000 title claims abstract description 29
- 238000004949 mass spectrometry Methods 0.000 claims abstract description 28
- 239000007921 spray Substances 0.000 claims abstract description 12
- 230000001154 acute effect Effects 0.000 claims abstract description 6
- 238000012544 monitoring process Methods 0.000 claims description 5
- 150000002500 ions Chemical class 0.000 description 84
- 239000000523 sample Substances 0.000 description 28
- 238000004458 analytical method Methods 0.000 description 7
- 239000002131 composite material Substances 0.000 description 5
- 238000010833 quantitative mass spectrometry Methods 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000002955 isolation Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000011002 quantification Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000008358 core component Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
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Abstract
The utility model provides a mass spectrum device based on a plurality of ion sources, the mass spectrum device based on a plurality of ion sources comprises a mass spectrometer, and the mass spectrometer is provided with a mass spectrum sample inlet; an included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source; a third central axis of a second outlet of a second ion source is parallel to the second central axis, the third central axis entering the mass spectrometry sample inlet without being blocked; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet. The utility model discloses a multiple mode's fast switch over.
Description
Technical Field
The utility model relates to a mass spectrometry, in particular to mass spectrum device based on a plurality of ion sources.
Background
The ion source is a key core component of the mass spectrometer, the development of the technology and products thereof continuously promotes the progress of mass spectrometry instruments and the expansion of application fields, and the utility model of a plurality of ionization technologies including the electrospray ion source accelerates the revolution of various subject research fields. The electrospray ion source has better stability and is a key component for quantitative mass spectrometry. The operation of electrospray can be described simply as: under the action of an electric field, the liquid forms a Taylor cone at the tip of the capillary, the liquid drops continuously generate coulomb explosion and are circulated in a reciprocating way, and finally gas-phase ions are obtained. Therefore, electrospray ion sources are a continuous ionization scheme.
Different from a continuous ionization scheme, the pulse direct current electrospray ion source forms an intermittent ionization strategy through a set direct current and alternating current high-voltage control technology to form a pulse gas-phase ion signal, can directly ionize a sample to be detected in an atmospheric pressure environment, and is an ideal means for rapid mass spectrometry.
However, in the conventional mass spectrometer, the switching between the quantitative mass spectrometry and the rapid mass spectrometry depends on the replacement of the ion source, the wiring of the gas circuit and the liquid circuit is complicated, and the process is time-consuming and labor-consuming. The utility model provides a combined type ion source design supports fast switch-over between the two sources, has had the quantitative mass spectrometry function of electrospray ion source and the fast mass spectrometry function of pulse direct current electrospray ion source concurrently, can shorten instrument operating time by a wide margin, is showing promotion mass spectrum detection efficiency.
SUMMERY OF THE UTILITY MODEL
For solving not enough among the above-mentioned prior art scheme, the utility model provides a mass spectrum device based on a plurality of ion sources.
The utility model aims at realizing through the following technical scheme:
a plurality of ion source based mass spectrometry apparatus comprising a mass spectrometer having a mass spectrometry sample inlet; the multiple ion source based mass spectrometry apparatus further comprises:
the included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;
a second ion source having a second outlet with a third central axis parallel to the second central axis, the third central axis unobstructed for entry into the mass spectrometry sample inlet; the second ion source adopts a pulse direct current spray ion source; the first distance between the first outlet and the sample inlet is greater than the second distance between the second outlet and the sample inlet
Compared with the prior art, the utility model discloses the beneficial effect who has does:
1. the quantitative and rapid analysis functions are realized;
the composite ion source uses an electrospray ion source and a pulse direct current spray ion source, and has the functions of quantitative mass spectrometry and rapid mass spectrometry;
2. the analysis efficiency is high;
under different working modes, the electrospray ion source and the pulse direct current spray ion source are rapidly switched, if the drawer design is utilized, the pulse direct current spray ion source rapidly enters into work, the operation time of an instrument can be greatly shortened, and the mass spectrum detection efficiency is remarkably improved.
Drawings
The disclosure of the present invention will become more readily understood with reference to the accompanying drawings. As is readily understood by those skilled in the art: these drawings are only intended to illustrate the technical solution of the present invention and are not intended to limit the scope of the present invention. In the figure:
fig. 1 is a schematic structural diagram of a mass spectrometer arrangement based on multiple ion sources according to an embodiment of the present invention.
Detailed Description
Fig. 1 and the following description depict alternative embodiments of the invention to teach those skilled in the art how to make and reproduce the invention. For explaining the technical solution of the present invention, some conventional aspects have been simplified or omitted. Those skilled in the art will appreciate variations or substitutions from these embodiments that will be within the scope of the invention. Those skilled in the art will appreciate that the features described below can be combined in various ways to form multiple variations of the invention. Accordingly, the present invention is not limited to the following alternative embodiments, but is only limited by the claims and their equivalents.
Example 1:
fig. 1 is a schematic structural diagram of a mass spectrometer apparatus based on multiple ion sources according to embodiment 1 of the present invention, and as shown in fig. 1, the mass spectrometer apparatus based on multiple ion sources includes:
a mass spectrometer having a mass spectrometry sample inlet;
the included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;
a second ion source having a second outlet with a third central axis parallel to the second central axis, the third central axis unobstructed for entry into the mass spectrometry sample inlet; the second ion source adopts a pulse direct current spray ion source; the first distance between the first outlet and the sample inlet is greater than the second distance between the second outlet and the sample inlet, and if the first distance and the second distance are respectively greater than 3mm and less than 15 mm.
To improve the workability, further, the first central axis and the second central axis intersect, and the third central axis and the second central axis are collinear.
In order to prevent the substance to be detected from diffusing into the atmosphere with the airflow, further, the mass spectrometry apparatus further includes:
the space that the cage enclosed keeps apart with atmospheric environment, mass spectrum introduction port, first ion source and second ion source set up respectively in the cage.
In order to shorten the working time, further, the mass spectrometry device further comprises:
a drawer within which the second ion source is disposed such that the second ion source is within the enclosure and in the atmospheric environment at intervals with the drawer.
In order to adjust the operating states of the two ion sources, the mass spectrometer further comprises:
a control module to operate the first ion source and the second ion source temporally.
In order to monitor whether the first ion source, the second ion source and the probe thereof are in the working position, a position sensor is further arranged and used for monitoring whether the first ion source and the second ion source are in the set position.
The utility model discloses mass spectrum device's based on a plurality of ion sources operating mode does:
in an analysis mode of pursuing quantification, only a first ion source works in the composite ion source, an included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;
in an analysis mode of pursuing speed, only a second ion source works in the composite ion source, a third central axis of a second outlet of the second ion source is parallel to the second central axis, and the third central axis enters the mass spectrum sample inlet without being blocked; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet.
In order to prevent the substance to be detected from diffusing into the atmosphere with the airflow, further, the mass spectrometry apparatus further includes:
the space that the cage enclosed keeps apart with atmospheric environment, mass spectrum introduction port, first ion source and second ion source set up respectively in the cage.
In order to shorten the working time, further, the mass spectrometry device further comprises:
a drawer within which the second ion source is disposed such that the second ion source is within the enclosure and in the atmospheric environment at intervals with the drawer.
Example 2:
according to the utility model discloses a plurality of ion source based mass spectrum device's application example.
In this application example, as shown in fig. 1, the first ion source and the second ion source are disposed in an isolation hood, and the drawer is disposed in the isolation hood, so that when the probe is installed, the second ion source is in an atmospheric environment, and when the probe is installed, the drawer is in the isolation hood;
the first central axis is intersected with the second central axis, the included angle between the first central axis and the second central axis is 60 degrees, the third central axis and the second central axis are collinear, and the first central axis, the second central axis and the third central axis are positioned in the same vertical plane; the first distance is 10mm, and the second distance is 8 mm;
the method comprises the steps that three position monitoring sensors are arranged, each monitoring sensor comprises a light source and a detector, when a monitored object is located at a set position, light emitted by the light source is blocked by the monitored object and cannot enter the detector, when the monitored object is not located at the set position, light emitted by the light source cannot be blocked by the monitored object and enters the detector, and whether the monitored object is installed in place or not is determined according to light intensity received by the detector. In this way, three position monitoring sensors are used to determine whether the probes and drawers of the first ion source, second ion source, respectively, are in place.
A control module for operating the first and second ion sources in time division, rather than simultaneously.
The utility model discloses mass spectrum device's based on a plurality of ion sources operating mode does:
in an analysis mode of pursuing quantification, only a first ion source works in the composite ion source, an included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;
in an analysis mode of pursuing speed, only a second ion source works in the composite ion source, a third central axis of a second outlet of the second ion source is parallel to the second central axis, and the third central axis enters the mass spectrum sample inlet without being blocked; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet.
In an analysis mode for pursuing speed, the specific steps are as follows:
pulling out a drawer of the pulse direct current spray ion source;
a probe for placing a pulse direct current spray ion source;
closing a drawer of the pulsed direct current spray ion source;
mass spectrometry was initiated.
Claims (7)
1. A plurality of ion source based mass spectrometry apparatus comprising a mass spectrometer having a mass spectrometry sample inlet; characterized in that the mass spectrometry apparatus based on multiple ion sources further comprises:
the included angle between a first central axis of a first outlet of the first ion source and a second central axis of the mass spectrum sample inlet is an acute angle, and the first central axis enters the mass spectrum sample inlet without being blocked; the first ion source adopts an electrospray ion source;
a second ion source having a second outlet with a third central axis parallel to the second central axis, the third central axis unobstructed for entry into the mass spectrometry sample inlet; the second ion source adopts a pulse direct current spray ion source; and a first distance between the first outlet and the sample inlet is greater than a second distance between the second outlet and the sample inlet.
2. The multiple ion source-based mass spectrometry apparatus of claim 1, wherein the first and second distances are each greater than 3mm and less than 15 mm.
3. The multiple ion source-based mass spectrometry apparatus of claim 1, wherein the first and second central axes intersect, and the third and second central axes are collinear.
4. The multiple ion source-based mass spectrometry apparatus of claim 1, further comprising:
the space that the cage enclosed keeps apart with atmospheric environment, mass spectrum introduction port, first ion source and second ion source set up respectively in the cage.
5. The multiple ion source based mass spectrometry apparatus of claim 4, further comprising:
a drawer within which the second ion source is disposed such that the second ion source is within the enclosure and in the atmospheric environment at intervals with the drawer.
6. The multiple ion source-based mass spectrometry apparatus of claim 1, further comprising:
a control module to operate the first ion source and the second ion source temporally.
7. The multiple ion source-based mass spectrometry apparatus of claim 1, further comprising:
a position sensor for monitoring whether the first and second ion sources are in a set position.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121429372.8U CN215118829U (en) | 2021-06-25 | 2021-06-25 | Mass spectrum device based on multiple ion sources |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121429372.8U CN215118829U (en) | 2021-06-25 | 2021-06-25 | Mass spectrum device based on multiple ion sources |
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| Publication Number | Publication Date |
|---|---|
| CN215118829U true CN215118829U (en) | 2021-12-10 |
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| CN202121429372.8U Active CN215118829U (en) | 2021-06-25 | 2021-06-25 | Mass spectrum device based on multiple ion sources |
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| CN (1) | CN215118829U (en) |
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2021
- 2021-06-25 CN CN202121429372.8U patent/CN215118829U/en active Active
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Address after: West side of 1st floor, 1st floor, Building A, No. 288 Jingu Middle Road (East), Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee after: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region after: China Address before: Room 304, D Building, Kexin Building, 655 Xueshi Road, Yinzhou District, Ningbo City, Zhejiang Province, 315000 Patentee before: CHINA INNOVATION INSTRUMENT Co.,Ltd. Country or region before: China |
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