CN215065654U

CN215065654U - Solid phase extraction instrument

Info

Publication number: CN215065654U
Application number: CN202121252524.1U
Authority: CN
Inventors: 段云威; 贾来; 樊孝俊
Original assignee: Beijing Youxing Keyi Technology Development Co ltd
Current assignee: Beijing Youxing Keyi Technology Development Co ltd
Priority date: 2021-06-04
Filing date: 2021-06-04
Publication date: 2021-12-07
Anticipated expiration: 2031-06-04

Abstract

The utility model provides a solid phase extraction appearance includes: a frame; the flow path system is at least partially arranged on the rack and comprises an injection pump assembly, a first multi-way valve, a first three-way valve, a butt joint assembly and a gas assembly, wherein the injection pump assembly is connected with a first interface of the first multi-way valve through a first pipeline, the first interface of the first multi-way valve can be respectively communicated with a second interface of the first multi-way valve, a third interface of the first multi-way valve and a fourth interface of the first multi-way valve in a switching mode, the second interface of the first multi-way valve is connected with the first interface of the first three-way valve through a second pipeline, the second interface of the first three-way valve is connected with the butt joint assembly through a third pipeline, and the gas assembly is connected with the third interface of the first three-way valve. The technical scheme of the utility model the lower problem of efficiency when the solid phase extraction appearance among the prior art uses has been solved effectively.

Description

Solid phase extraction instrument

Technical Field

The utility model relates to a technical field of detector particularly, relates to a solid phase extraction appearance.

Background

With the increasing strength of the country on food safety and environmental protection, various toxic and harmful substances need to be accurately detected on a large number of food and environmental samples, and the content of some substances is very small and needs to be detected by a solid phase extraction instrument.

According to the use characteristics of the solid phase extraction instrument, the flow path system in the prior art is simple to set, and only one set of experiment instrument can be used for one set of experiment, so that the use efficiency of the solid phase extraction instrument is greatly reduced.

SUMMERY OF THE UTILITY MODEL

The main object of the utility model is to provide a solid phase extraction appearance to the lower problem of efficiency when solving the solid phase extraction appearance among the prior art and using.

In order to achieve the above object, according to the present invention, there is provided a solid phase extraction apparatus comprising: a frame; the flow path system is at least partially arranged on the rack and comprises an injection pump assembly, a first multi-way valve, a first three-way valve, a butt joint assembly and a gas assembly, the injection pump assembly is connected with a first interface of the first multi-way valve through a first pipeline, the first multi-way valve at least comprises the first interface of the first multi-way valve, the second interface of the first multi-way valve, the third interface of the first multi-way valve and the fourth interface of the first multi-way valve, the first interface of the first multi-way valve can be respectively switched and communicated with the second interface of the first multi-way valve, the third interface of the first multi-way valve and the fourth interface of the first multi-way valve, the second interface of the first multi-way valve is connected with the first interface of the first three-way valve through a second pipeline, the second interface of the first three-way valve is connected with the butt joint component through a third pipeline, and the gas component is connected with the third interface of the first three-way valve.

Further, the docking head assembly includes: the luer connector comprises a convex luer lock device and a concave luer lock device; the mounting frame structure is mounted on the rack and comprises a first driving part, a first mounting seat, a second driving part and a second mounting seat, the first driving part is connected with the first mounting seat and can drive the first mounting seat to move in the vertical direction, the second driving part is arranged on the first mounting seat and can be movably connected with the second mounting seat, the second driving part is fixed on the second mounting seat and can drive the second mounting seat to move in the horizontal direction, the concave luer lock device is mounted on the second mounting seat, and the convex luer lock device is arranged on the rack; the mounting frame structure can drive the convex luer lock device and the concave luer lock device to have a separated state and a sealing installation state.

Furthermore, the luer connector comprises a convex luer lock device, a first concave luer lock device and a second concave luer lock device, the first concave luer lock device is connected with the vacuum pump, and the second concave luer lock device is connected with the dehydration small column.

Further, the first multiplex valve includes: a supporting seat; the valve body comprises a liquid inlet channel and a plurality of liquid outlet channels; the valve core is provided with a communication channel and arranged on the supporting seat and can rotate along with the supporting seat; the valve body is matched with the valve core, the communicating channel is always communicated with the liquid inlet channel, and the liquid inlet channel and the liquid outlet channels are switched and communicated by the rotation of the valve core.

Furthermore, the surface of the valve body is abutted against the surface of the valve core, the outlet of the liquid inlet channel is positioned on the rotating axis of the valve core, and the communicating channel is a flow channel groove arranged on one side of the valve core, which faces the valve body.

Furthermore, the supporting seat is of a rod-shaped structure and comprises a first rod section and a second rod section which are coaxially connected, the diameter of the first rod section is larger than that of the second rod section, an installation groove is formed in the first end face of the first rod section, the thickness of the valve core is larger than the height of the installation groove, and the first end of the second rod section is connected with the second end face of the first rod section.

Further, first multiple unit valve still includes the casing, and the casing is the tubular structure, and the one end that the valve body was kept away from to the casing has the protruding edge that extends to the center pin, and the diameter of first pole section and the internal diameter looks adaptation of casing, the diameter of first pole section is greater than the diameter in the hole that the protruding edge of casing encloses, and the diameter of second pole section and the diameter looks adaptation in the hole that the protruding edge of casing encloses.

Furthermore, the first multi-way valve also comprises an elastic piece which is propped against between the first rod section and the convex edge of the shell so as to apply acting force on the valve body to the valve core.

Furthermore, the first multi-way valve is a plurality of, and the butt joint subassembly and first three-way valve are all a plurality ofly with first multi-way valve one-to-one, and the syringe pump subassembly includes a plurality of syringe pumps with a plurality of first multi-way valve one-to-one.

Further, the syringe pump assembly comprises: a drive motor; and the transmission structure is connected with the driving motor, and the plungers of the plurality of injection pumps are connected with the transmission structure, so that the driving motor drives the plungers of the plurality of injection pumps to move simultaneously.

Use the technical scheme of the utility model, solid phase extraction appearance when using, the injection pump subassembly is when absorbing sample and/or solvent, through the switching of first multiple unit valve, just can realize the switching between different samples or different solvents, and need not change equipment. The purging, cleaning and other works of the flow path system can be realized through the cutting of the first three-way valve of the gas assembly. According to the method, the experiment efficiency is greatly improved through reasonable arrangement of the flow path system. The technical scheme of the utility model the lower problem of efficiency when the solid phase extraction appearance among the prior art uses has been solved effectively.

Drawings

The accompanying drawings, which form a part of the present application, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention and not to limit the invention. In the drawings:

fig. 1 shows a schematic structural view of a flow path system of a solid phase extractor according to the present invention;

FIG. 2 shows a schematic structural view of a docking head assembly of the solid phase extractor of FIG. 1;

FIG. 3 is a schematic diagram showing a first multi-way valve of the solid phase extractor of FIG. 1; and

FIG. 4 shows a schematic diagram of the syringe pump assembly of the solid phase extractor of FIG. 1.

Wherein the figures include the following reference numerals:

10. a frame; 20. a flow path system; 21. an injection pump assembly; 211. a drive motor; 212. a transmission structure; 22. a first multiplex valve; 221. a supporting seat; 222. a valve body; 223. a valve core; 23. a first three-way valve; 24. a docking head assembly; 241. a luer fitting; 242. a mounting frame structure; 25. and a gas assembly.

Detailed Description

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may also be oriented 90 degrees or at other orientations and the spatially relative descriptors used herein interpreted accordingly.

Exemplary embodiments according to the present application will now be described in more detail with reference to the accompanying drawings. These exemplary embodiments may, however, be embodied in many different forms and should not be construed as limited to only the embodiments set forth herein. It is to be understood that these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the concept of the exemplary embodiments to those skilled in the art, in the drawings, the thicknesses of layers and regions are exaggerated for clarity, and the same devices are denoted by the same reference numerals, and thus the description thereof will be omitted.

As shown in fig. 1 to 4, the solid phase extractor of the present embodiment includes: a housing 10 and a flow path system 20. The flow path system 20 is at least partially disposed on the rack 10, the flow path system 20 includes an injector pump assembly 21, a first multiplex valve 22, a first three-way valve 23, a butt joint assembly 24 and a gas assembly 25, the injector pump assembly 21 is connected to a first interface of the first multiplex valve 22 through a first pipeline, the first multiplex valve 22 includes at least a first interface of the first multiplex valve 22, a second interface of the first multiplex valve 22, a third interface of the first multiplex valve 22 and a fourth interface of the first multiplex valve 22, the first interface of the first multiplex valve 22 is in switching communication with the second interface of the first multiplex valve 22, the third interface of the first multiplex valve 22 and the fourth interface of the first multiplex valve 22, respectively, the second interface of the first multiplex valve 22 is connected to the first interface of the first three-way valve 23 through a second pipeline, the second interface of the first three-way valve 23 is connected to the butt joint assembly 24 through a third pipeline, the gas module 25 is connected to the third port of the first three-way valve 23.

By applying the technical scheme of the embodiment, when the solid phase extraction apparatus is used, the injection pump assembly can realize the switching between different samples or different solvents through the switching of the first multi-way valve when absorbing the samples and/or the solvents, and the equipment does not need to be replaced. The purging, cleaning and other works of the flow path system can be realized through the cutting of the first three-way valve of the gas assembly. According to the method, the experiment efficiency is greatly improved through reasonable arrangement of the flow path system. The technical scheme of this embodiment has solved the lower problem of efficiency when the solid phase extraction appearance among the prior art uses effectively. The gas module 25 is fed with nitrogen.

In the solution of the present embodiment, the butt joint assembly 24 includes: a luer fitting 241 and a mounting bracket structure 242. Luer fitting 241 includes a male luer lock device and a female luer lock device. Mounting bracket structure 242 is installed in frame 10, mounting bracket structure 242 includes first drive division, first mount pad, second drive division and second mount pad, first drive division links to each other with first mount pad, first drive division can drive first mount pad and remove in vertical direction, the second drive division sets up on first mount pad, the second drive division links to each other with the second mount pad is movably, the second drive division is fixed on the second mount pad, the second drive division can drive the second mount pad and remove along the horizontal direction, the lock device is luer to the concave surface is installed on the second mount pad, the lock device is luer to the convex surface sets up on frame 10. The mounting bracket structure 242 may actuate the male luer lock device to have a disengaged state and a sealed installation state with the female luer lock device. The installation position of the convex luer lock device is higher than that of the concave luer lock device. The accuracy of experiment can be improved through luer connection's connection, and the drive of first drive division has realized that luer lock device and the luer lock device can be in separation state and seal installation state are luer to the convex surface, and the drive of second drive division has realized that luer lock device and the centering of luer lock device are luer to the concave surface, and then has guaranteed the reliability of luer lock device and the connection of luer lock device is luer to the concave surface. The technical scheme of the utility model the solid phase extraction appearance among the prior art has been solved effectively because the great problem of experiment test error that the butt joint leads to.

In the technical solution of this embodiment, the luer connector 241 includes a male luer lock device, a first female luer lock device and a second female luer lock device, the first female luer lock device is connected to the vacuum pump, and the second female luer lock device is connected to the dehydration column. The structure further improves the service efficiency of the solid phase extractor, and for example, when vacuum pumping is needed, the solid phase extractor can be connected with a vacuum pump. When the device is required to be connected with the dewatering small column, the second concave surface luer lock device is replaced. In addition, the number of the luer fittings of the present embodiment is plural, and the plural luer fittings are disposed on the second mounting seat at intervals.

In the technical scheme of this embodiment, first drive division includes first driving motor and first drive screw, and first drive screw links to each other with first driving motor's output shaft, and first mount pad has first screw hole, and first drive screw is with first screw hole looks adaptation. The structure can realize that the movement of the convex luer lock device in the vertical direction is relatively accurate, and the structure is compact and the service cycle is long. The above structure may be replaced with a timing belt, but the effect is not as good as that of the present embodiment.

In the technical scheme of this embodiment, the second driving portion includes a second driving motor and a second driving screw, an output shaft of the second driving motor is connected to the second driving screw, the first mounting seat has a second threaded hole, and the second driving screw is matched with the second threaded hole. The structure is compact, the service cycle is long, and the movement is accurate. It should be noted that the axis of the second driving screw is perpendicular to the mounting vertical plate.

In the technical scheme of this embodiment, first mount pad includes riser, first diaphragm and second diaphragm, and first diaphragm is located the top of first riser and at the ascending middle part of horizontal direction, and first screw hole is located on first diaphragm and the axis of first screw hole sets up along vertical direction. The structure has lower processing cost and convenient arrangement.

In the technical scheme of this embodiment, first mount pad still includes the second diaphragm, and the second diaphragm is located the lower part of riser and is the horizontal direction setting, is provided with the slide rail structure with second mount pad matched with on the second diaphragm. The structure has lower processing cost and convenient arrangement.

In the technical scheme of the embodiment, the second mounting seat comprises a first slide rail; the bottom surface of the second transverse plate is connected with a limiting plate with a first sliding chute. The structure has lower processing cost and lower later maintenance cost. Specifically, the limiting plate is detachably connected with the second transverse plate through screws. As another possible embodiment, the bottom surface of the second horizontal plate is provided with a first sliding groove. It should be noted that there may be a plurality of second transverse plates, for example, the vertical plate has three spaced connecting legs, the second transverse plate is three transverse plates, and the widths of the three transverse plates are the same as the widths of the connecting legs.

In the solution of the present embodiment, the first multiplex valve 22 includes: a support seat 221, a valve body 222, and a valve spool 223. The valve body 222 includes an inlet channel and a plurality of outlet channels. The valve core 223 is provided with a communication channel, and the valve core 223 is arranged on the supporting seat 221 and can rotate along with the supporting seat 221. The valve body 222 is matched with the valve core 223, the communication channel is always communicated with the liquid inlet channel, and the liquid inlet channel and the liquid outlet channels are switched and communicated by the rotation of the valve core 223. The valve core is driven to rotate by rotation of the supporting seat, the liquid inlet channel is communicated with different liquid outlet channels by rotation of the valve core, and therefore functions realized by a plurality of valves can be realized by one switching valve, and the number of the valves is greatly saved. The technical scheme of this embodiment has solved the problem that the pipeline of solid phase extraction appearance among the prior art is complicated, and the volume is great effectively. The first multi-way valve 22 is also called a switching valve, the switching valve is not a one-way valve, the liquid inlet channel and the liquid outlet channel can be exchanged according to the requirement, namely the liquid inlet channel can also be used for discharging liquid, and the liquid outlet channel can also be used for feeding liquid. The inlet of the liquid inlet channel is the first interface, the outlet of the liquid outlet channels is the second interface of the first multi-way valve 22, and the like, and the present embodiment includes 11 liquid outlet channels.

In the technical solution of this embodiment, the surface of the valve body 222 abuts against the surface of the valve core 223, the outlet of the liquid inlet channel is located on the rotation axis of the valve core 223, and the communication channel is a channel groove disposed on one side of the valve core 223 facing the valve body 222. The structure is compact, the number of parts is small, the processing cost is low, and the use is convenient.

Specifically, the starting point of the flow channel groove is located at the center of the axis of the valve element, the end point of the flow channel groove extends to the inlet of the liquid outlet channel, the valve element rotates by different angles, the flow channel groove can be communicated with different liquid outlet channels, but the flow channel groove is always communicated with the outlet of the liquid inlet channel, sealing is achieved through extrusion between the valve element and the valve body, and a sealing structure can be arranged for sealing. It should be noted that the flow channel groove may also pass through the axis of the spool.

In the technical scheme of this embodiment, the inlet of each liquid outlet channel is located on one side of the valve body facing the valve core, and the outlet of each liquid outlet channel is located on the circumferential side wall of the valve body. The structure is convenient to be connected with an external pipeline. The inlets of the liquid outlet channels are positioned on the same circumference taking the axis as the center.

In the technical scheme of this embodiment, the support seat 221 is a rod-shaped structure, the support seat 221 includes a first rod segment and a second rod segment that are coaxially connected, a diameter of the first rod segment is greater than a diameter of the second rod segment, a first end surface of the first rod segment is provided with a mounting groove, a thickness of the valve element 223 is greater than a height of the mounting groove, and a first end of the second rod segment is connected with a second end surface of the first rod segment. The diameter of the first rod section is larger than that of the second rod section, so that the supporting seat can be prevented from being separated from the shell, and in addition, parts such as a spring, a bearing, a gasket and the like can be conveniently arranged. The first terminal surface of first pole section is provided with mounting groove, has made things convenient for the installation of case, and specifically, mounting groove includes the screens groove that the circumference outside of circular recess and circular recess extends, makes the supporting seat drive the case easily like this.

In the technical solution of this embodiment, the switching valve further includes a housing, the housing is a tubular structure, one end of the housing, which is far away from the valve body 222, has a convex edge extending towards the central axis, the diameter of the first rod section is adapted to the inner diameter of the housing, the diameter of the first rod section is greater than the diameter of the hole surrounded by the convex edge of the housing, and the diameter of the second rod section is adapted to the diameter of the hole surrounded by the convex edge of the housing. The structure is convenient for arranging parts such as springs and the like, so that the structure is compact.

The structure enables the supporting seat to move along the axial direction of the supporting seat, so that the valve core is provided with extrusion acting force which abuts against the valve body.

In the technical solution of this embodiment, the switching valve further includes an elastic member, and the elastic member abuts against between the first rod section and the convex edge of the housing to apply an acting force to the valve body 222 to the valve spool 223.

In the technical scheme of this embodiment, the elastic component is the dish spring, and the dish spring includes first dish spring and second dish spring, and first dish spring and second dish spring all become the horn mouth form, and the one end that first dish spring diameter is little supports and props up on the protruding edge of casing, and the one end that the diameter is little of second dish spring supports and props up on the surface of first pole section towards the protruding edge of casing, and the one end that the diameter is big of first dish spring and the one end that the diameter is big of second dish spring support mutually. The structure is convenient to set and easy to install. It should be noted that the disc spring may further include a third disc spring, a fourth disc spring, and the like. The first disc spring and the second disc spring are both approximately plate-shaped, so that the contact area of the first disc spring with the shell and the second disc spring is large, and the second disc spring indirectly abuts against the surface of the first rod section facing the convex edge of the shell.

In the technical solution of this embodiment, the switching valve further includes a bearing, and the bearing is disposed between the elastic member and the first rod section. The bearing is a plane bearing, so that the friction force is greatly reduced. A gasket is arranged between the disc spring and the convex edge of the shell, and a gasket is arranged between the bearing and the first rod section. The switching valve also comprises a valve cover, and the valve cover is connected with the shell through a screw to fix the extrusion valve body. The supporting seat is made of brass so as to facilitate heat transfer.

In the technical solution of this embodiment, the switching valve further includes a driving portion, and the driving portion drives the supporting seat to rotate. The switching valve also comprises a transmission part, and the driving part is connected with the supporting seat through the transmission part. The structure is convenient for adjusting the distance. The driving part is a driving motor, an output shaft of the driving motor is connected with the transmission part, the transmission part comprises a transmission rod, the transmission rod comprises a first transmission rod section and a second transmission rod section, the first transmission rod section is of a hollow structure, and the output shaft of the driving motor is at least partially positioned in the hollow structure of the first transmission rod section and is connected with the hollow structure through a screw. The transmission part further comprises a transmission cylinder, the second transmission rod section is at least partially positioned in the transmission cylinder, the supporting seat is at least partially positioned in the transmission cylinder, and the transmission cylinder is connected with the second transmission rod section and the supporting seat through screws.

In the technical solution of this embodiment, the switching valve further includes a code wheel and a photoelectric switch, the code wheel is disposed on the transmission portion and can rotate with the transmission portion, and the photoelectric switch is disposed corresponding to the code wheel to determine the communication of the communication channel. Taking the liquid outlet channel as an example, the coded disc is provided with a notch, each notch corresponds to the liquid outlet channel, and each notch corresponds to the liquid inlet channel, so that the positioning is more accurate. The hollow-out arranged on the code disc is used for detecting and judging which liquid outlet channel is connected with the communication channel.

In the technical scheme of the embodiment, the code disc is also provided with a calibration structure. The calibration structure is also hollow, and the hollow parts are hollow long gaps. The protective cover is a cylindrical structure, a first end of the protective cover is connected with the shell, a second end of the protective cover is connected with the driving motor, and the photoelectric switch is installed on the protective cover and is also an opening of the calibration structure.

In the technical solution of this embodiment, the number of the first multi-way valves 22 is multiple, the butt joint assembly 24 and the first three-way valve 23 are both multiple one-to-one corresponding to the first multi-way valves 22, and the syringe pump assembly 21 includes multiple syringe pumps one-to-one corresponding to the multiple first multi-way valves 22.

In the solution of the present embodiment, the syringe pump assembly 21 includes: a drive motor 211 and a transmission structure 212. The transmission structure 212 is connected with the driving motor 211, and the plungers of the plurality of syringe pumps are connected with the transmission structure 212, so that the driving motor 211 drives the plungers of the plurality of syringe pumps to move simultaneously.

Specifically, in the solution of the present embodiment, there are 6 syringe pumps, and six first multiplex valves 22. Each first multi-way valve 22 includes a main inlet C, a sample outlet with a first serial number, a sample outlet with a second serial number, a vent or suction port with a third serial number, solvent outlets with fourth to ninth serial numbers, a single solvent outlet with a eleventh serial number, and a ten-position reserve outlet with a fourth serial number.

The technical scheme of this embodiment still includes second multiple unit valve and third multiple unit valve, and the second multiple unit valve is connected between gas subassembly and first three-way valve, and the second multiple unit valve is an inlet and six ways, and six ways correspond six first three-way valves 23 and are linked together, and the gas circuit subassembly still includes pressure sensor for measure the pressure of gas circuit subassembly. The third multi-way valve is also provided with one inlet and six outlets, the vacuum pump is connected with the inlet of the third multi-way valve, the inlet at the moment is an outlet, and the six outlets are respectively connected with the six first concave luer lock devices.

The rack comprises an installation vertical plate, the first driving part is installed on the rack, a second sliding rail is arranged on the installation vertical plate, and a second sliding groove is formed in the first installation seat. The structure has lower processing cost and convenient operation. Specifically, the solid phase extraction instrument further comprises a control structure, wherein the control structure is electrically connected with the first driving part and the second driving part, and the control structure controls the first driving part and the second driving part to work. The concave luer lock device is arranged on the rack, the connection is convenient, and the concave luer lock device is arranged on the mounting vertical plate. The rack is provided with a third driving part, a sliding rail structure is arranged between the concave luer lock device and the rack, and the third driving part is connected with the concave luer lock device to drive the concave luer lock device to move in the vertical direction. Specifically, the installation riser is provided with the slide rail, and the concave surface luer lock device is provided with the spout.

Injection pump assembly 21, comprising: drive structure, transmission structure and a plurality of syringe pumps. The transmission structure is connected with the driving structure. The plungers of the plurality of syringe pumps are all connected with the transmission structure, so that the driving structure drives the plungers of the plurality of syringe pumps to move simultaneously. The driving structure drives the transmission structure, and the transmission structure is connected with the plurality of injection pumps, so that the simultaneous movement of the plurality of injection pumps driven by one driving structure can be realized. The technical scheme of this embodiment has solved the problem that the solid phase extraction appearance among the prior art's driving motor is more, and the volume is great effectively.

In the technical scheme of this embodiment, drive structure includes driving motor, and driving motor's output shaft links to each other with transmission structure. The structure has lower cost and convenient arrangement.

In the technical scheme of this embodiment, drive structure includes hold-in range and transmission shaft, and the hold-in range all is connected with driving motor's output shaft and transmission shaft. The structure is convenient to set. The output shaft of the driving motor is provided with a synchronous belt wheel, the transmission shaft is also provided with a synchronous belt wheel, two ends of the synchronous belt are respectively connected with the two synchronous belt wheels, a tension wheel can be further arranged as required, or the driving motor and the transmission shaft can be moved to adjust the tightness of the synchronous belt.

In the technical scheme of this embodiment, transmission structure still includes the connecting block, and the connecting block has the screw hole, and the transmission shaft is the threaded rod, and the threaded rod is worn to establish in the screw hole and can drive the connecting block removal with the screw hole looks adaptation of connecting block by the threaded rod, and the connecting block links to each other with the plunger of a plurality of syringe pumps. The structure of the connecting block driven by the threads of the transmission shaft is compact.

In the technical scheme of this embodiment, injection pump subassembly still includes the mount, and driving motor and transmission shaft are all fixed on the mount, and mount and connecting block have slide and the slide rail of mutually supporting. The arrangement of the fixing frame facilitates the fixing of the injection pump assembly with external connection, an internal driving motor and the like.

In the technical scheme of this embodiment, the axis of the output shaft of the driving motor is parallel to the axis of the transmission shaft. The structure is convenient to set. The mount includes two flat boards and four stands, and two flat boards set up respectively at the both ends of four stands, and the both ends of transmission shaft are located two flat boards respectively, and the one end of transmission shaft spreads out the flat board in order to set up synchronous pulley. Two upright posts close to the driving motor are provided with slide rails, and the connecting block is provided with a slide groove matched with the slide rails. The structure makes the movement of the connecting block relatively smooth.

The frame includes the mounting panel, is provided with a plurality of slot holes on the mounting panel, and the connecting block includes the connecting block main part and sets up the connecting rod in the connecting block main part, and each connecting rod passes each slot hole respectively one-to-one, and a plurality of syringe pumps set up with a plurality of slot hole one-to-one. The structure is compact, and the occupied volume is smaller. Specifically, the pipe system (flow path system) includes a plurality of liquid inlet pipes and a plurality of second three-way valves that are arranged in one-to-one correspondence with the plurality of liquid inlet pipes, the plurality of liquid inlet pipes are arranged in one-to-one correspondence with the plurality of injection pumps, a first interface of the second three-way valve is communicated with a liquid outlet of the injection pump, a second interface of the second three-way valve is communicated with the pipe system, and a third interface of the second three-way valve is communicated with a liquid inlet of the injection pump. The structure can realize that the injection pumps needing to work are communicated with the pipeline system through the switching of the second three-way valve when the plurality of injection pumps do not need to work, and the injection pumps not needing to work are pumped back to the original reagent container, so that the structure greatly improves the use flexibility of the solid phase extraction instrument. The pipeline system is provided with a switching valve, i.e. a first multi-way valve 22.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

It should be noted that the terms "first," "second," and the like in the description and claims of this application and in the drawings described above are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are, for example, capable of operation in sequences other than those illustrated or otherwise described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A solid phase extractor, comprising:

a frame (10);

a flow path system (20), the flow path system (20) being at least partially disposed on the rack (10), the flow path system (20) including an injector pump assembly (21), a first multiplex valve (22), a first three-way valve (23), a butt joint assembly (24) and a gas assembly (25), the injector pump assembly (21) being connected to a first interface of the first multiplex valve (22) through a first pipeline, the first multiplex valve (22) including at least a first interface of the first multiplex valve (22), a second interface of the first multiplex valve (22), a third interface of the first multiplex valve (22) and a fourth interface of the first multiplex valve (22), the first interface of the first multiplex valve (22) being switchable to the second interface of the first multiplex valve (22), the third interface of the first multiplex valve (22) and the fourth interface of the first multiplex valve (22), respectively, the second interface of the first multi-way valve (22) is connected with the first interface of the first three-way valve (23) through a second pipeline, the second interface of the first three-way valve (23) is connected with the butt joint assembly (24) through a third pipeline, and the gas assembly (25) is connected with the third interface of the first three-way valve (23).

2. The solid phase extractor of claim 1 wherein the docking assembly (24) comprises:

a luer fitting (241), the luer fitting (241) comprising a male luer lock device and a female luer lock device;

a mounting frame structure (242), wherein the mounting frame structure (242) is mounted on the rack (10), the mounting frame structure (242) includes a first driving portion, a first mounting seat, a second driving portion and a second mounting seat, the first driving portion is connected to the first mounting seat, the first driving portion can drive the first mounting seat to move in a vertical direction, the second driving portion is disposed on the first mounting seat, the second driving portion is movably connected to the second mounting seat, the second driving portion is fixed on the second mounting seat, the second driving portion can drive the second mounting seat to move in a horizontal direction, the concave luer lock device is mounted on the second mounting seat, and the convex luer lock device is disposed on the rack (10);

the mounting bracket structure (242) may drive the male luer lock device and the female luer lock device to have a disengaged state and a sealed installation state.

3. The solid phase extractor of claim 2, wherein said luer fitting (241) comprises a male luer lock device, a first female luer lock device and a second female luer lock device, said first female luer lock device is connected to a vacuum pump, and said second female luer lock device is connected to a dehydration column.

4. The solid phase extractor of claim 1, wherein the first multiplex valve (22) comprises:

a support base (221);

the valve body (222), the valve body (222) includes the inlet channel and a plurality of outlet channels;

the valve core (223) is provided with a communication channel, and the valve core (223) is arranged on the supporting seat (221) and can rotate along with the supporting seat (221);

the valve body (222) is matched with the valve core (223), the communication channel is always communicated with the liquid inlet channel, and the liquid inlet channel and the liquid outlet channels are switched and communicated by the rotation of the valve core (223).

5. The solid phase extraction apparatus according to claim 4, wherein the surface of the valve body (222) is abutted against the surface of the valve core (223), the outlet of the liquid inlet channel is located on the rotation axis of the valve core (223), and the communication channel is a channel groove provided on the side of the valve core (223) facing the valve body (222).

6. The solid phase extractor of claim 5, wherein the supporting base (221) is a rod-shaped structure, the supporting base (221) comprises a first rod section and a second rod section which are coaxially connected, the diameter of the first rod section is larger than that of the second rod section, a mounting groove is formed on a first end face of the first rod section, the thickness of the valve core (223) is larger than the height of the mounting groove, and a first end of the second rod section is connected with a second end face of the first rod section.

7. The solid phase extraction apparatus of claim 6, wherein the first multi-way valve further comprises a housing, the housing is a cylindrical structure, one end of the housing away from the valve body (222) has a convex edge extending towards the central axis, the diameter of the first rod section is matched with the inner diameter of the housing, the diameter of the first rod section is larger than the diameter of the hole surrounded by the convex edge of the housing, and the diameter of the second rod section is matched with the diameter of the hole surrounded by the convex edge of the housing.

8. The solid phase extractor of claim 7, wherein the first multi-way valve further comprises an elastic member abutting between the first rod section and the ledge of the housing to apply a force to the valve body (222) to the valve core (223).

9. The solid phase extractor according to any one of claims 1 to 8, wherein the first multiplex valve (22) is plural, the docking head assembly (24) and the first three-way valve (23) are each plural in one-to-one correspondence with the first multiplex valve (22), and the syringe pump assembly (21) includes plural syringe pumps in one-to-one correspondence with the plural first multiplex valves (22).

10. The solid phase extractor of claim 9, wherein the syringe pump assembly (21) comprises:

a drive motor (211);

the transmission structure (212) is connected with the driving motor (211), and the plungers of the multiple syringe pumps are connected with the transmission structure (212), so that the driving motor (211) drives the plungers of the multiple syringe pumps to move simultaneously.