CN215017195U - Rodent experimental animal flashlight electroretinogram detection auxiliary device - Google Patents
Rodent experimental animal flashlight electroretinogram detection auxiliary device Download PDFInfo
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- CN215017195U CN215017195U CN202120235859.6U CN202120235859U CN215017195U CN 215017195 U CN215017195 U CN 215017195U CN 202120235859 U CN202120235859 U CN 202120235859U CN 215017195 U CN215017195 U CN 215017195U
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Abstract
An auxiliary device for detecting flashing electroretinogram of rodent experimental animals. The method is characterized in that: the detection table comprises a base, a lower cushion block and an elastic pressing plate, wherein the lower cushion block is fixed at the front end of the base and is used for being cushioned below the chin of the animal, and two ends of the elastic pressing plate are connected with two sides of the base and are used for being pressed above the cranium of the animal; the cornea electrode comprises a circular ring part, an elastic connecting part, a fixed connecting part and a lead connecting part which are connected in sequence, and is fixedly connected with the elastic pressing plate through the fixed connecting part. Its advantage lies in, through lower cushion and elastic pressing plate, not only can conveniently realize the position location of animal, can keep animal head position fixed moreover, and the cornea electrode is installed on elastic pressing plate for the cornea electrode can follow the elastic pressing plate direction and extend to the front from the back, thereby can more conveniently accurately correspond its ring portion with animal cornea and contact, and not only easy operation is convenient, and the accurate oppression that does not have of contact improves the experiment success rate.
Description
Technical Field
The utility model relates to a rodent experimental animals flashlight retina electrogram detects auxiliary device.
Background
Flashlight electroretinogram is a recognized test item capable of objectively evaluating retinal function, and is widely used in aspects of ophthalmic clinical diagnosis, curative effect evaluation, judicial identification and the like. In the field of basic research, flashing electroretinogram detection of rodent experimental animals (such as rats and mice) is also common in recent years. However, the laboratory test of the animals is difficult to obtain the stable and reliable result like the clinical test; the reason is that the recording electrode is difficult to keep good and stable contact with the cornea of the animal.
In clinical human testing, almost all use a standardized contact lens electrode (also known as a JET electrode) that is sized and curved for most people. When in detection, the JET electrode can be adsorbed on the cornea, thereby ensuring that the annular metal coating layer on the concave surface of the contact lens can keep good contact with the cornea. In this case, the bioelectrical signal induced by the flash stimulation can be sufficiently collected and transmitted by the corneal electrode, thereby ensuring the stability and reliability of the detection result. Rodents have much smaller eyeballs than humans, and JET electrodes are therefore completely unsuitable. Researchers typically purchase or manufacture a special recording electrode that is wound from a thin wire into a ring that matches the size of an animal's cornea for contact with the cornea to collect bioelectrical signals.
Animal testing to achieve the desired results, the metal ring must be in uniform contact with the cornea and not be able to stress the cornea. In order to achieve the purpose, the current common method is to fix the recording electrode on an adjusting rod, the rod is provided with a sliding joint, the metal ring of the electrode is close to the cornea through the position and the direction of the adjusting rod, and finally the best contact between the metal ring and the cornea is achieved. Since the rodent eyeball is originally small, the above operation of placing the recording electrode is not easy, and furthermore, in order not to destroy the dark adaptation state of the retina, the examiner often needs to perform the operation under the weak red light condition in a dark room. When a new animal is replaced for detection each time, experimenters need to readjust the position and the direction of the recording electrode, so that the metal ring can be in good contact with the cornea of the animal each time, and the experimental result is unstable and poor in repeatability.
Like the animal vision electrophysiological examination platform that chinese utility model patent (CN 202960816U) disclosed, set up 6 holes on its testing platform, during the experiment, fix the animal with the mode of ligature through four fixed orificess in rear end earlier, then fix the cornea electrode through two holes in front end, make the position relatively fixed of animal and cornea electrode to improve the accuracy.
However, in the animal visual electrophysiological examination table, the cornea electrode is disposed at a position in front of the animal, and the position and angle of the cornea electrode are not easily adjusted, so that it is difficult to ensure that the circular ring portion of the cornea electrode makes good contact with the animal cornea.
SUMMERY OF THE UTILITY MODEL
In order to overcome the deficiency of the background art, the utility model provides a rodent experimental animals flashing retina electrogram detects auxiliary device.
The utility model discloses the technical scheme who adopts: a rodent experimental animal flashlight electroretinogram detection auxiliary device comprises a detection table and a cornea electrode; the detection table comprises a base, a lower cushion block and an elastic pressing plate, the lower cushion block is fixed at the front end of the base and used for being cushioned below the chin of the animal, and two ends of the elastic pressing plate are connected with two sides of the base and used for being pressed above the skull of the animal; the cornea electrode comprises a circular ring part, an elastic connecting part, a fixed connecting part and a lead connecting part which are connected in sequence, and is fixedly connected with the elastic pressing plate through the fixed connecting part.
The cornea electrode is integrally formed by bending metal wires.
The fixed connecting parts are in a plurality of continuous S shapes and are attached to the elastic pressing plate through adhesive tapes.
The fixed connection part is at least wrapped with a layer of medical adhesive plaster.
The cornea electrode adopts a fine silver wire with the purity of 99.99 percent.
The base is made of organic glass materials.
The bottom of base is equipped with the rubber callus on the sole.
The elastic pressing plate is made of an elastic arched hard paper board.
Screw holes are formed in two side edges of the base, through holes are formed in two ends of the elastic pressing plate, and the elastic pressing plate and the base are fixed through screws.
The lower cushion block is a foam block and is fixed at the front end of the base by double faced adhesive tape.
The utility model has the advantages that: scheme more than adopting, through lower cushion and elastic pressing plate, not only can conveniently realize the position location of animal, can keep animal head position fixed moreover, the cornea electrode is installed on elastic pressing plate for the cornea electrode can follow the elastic pressing plate direction and extend to the front from the back, thereby can more conveniently accurately correspond the contact with its ring portion and animal cornea, and not only easy operation is convenient, and the accurate no oppression of contact improves the experiment success rate moreover.
Drawings
Fig. 1 is a schematic structural view of the rodent experimental animal flashlight electroretinogram detection auxiliary device in the embodiment of the invention.
Fig. 2 is a schematic structural diagram of the detection table according to the embodiment of the present invention.
Fig. 3 is a schematic structural diagram of a corneal electrode according to an embodiment of the present invention.
Detailed Description
The embodiments of the present invention will be further explained with reference to the accompanying drawings:
as shown in the figure, the auxiliary device for detecting the flashlight electroretinogram of the rodent experimental animal comprises a detection table and a cornea electrode 1, wherein the detection table comprises a base 2, a lower cushion block 3 and an elastic pressing plate 4.
The base 2 is made of organic glass materials, and the organic glass materials not only can not reduce the body temperature of the animals in anesthesia to influence the detection result, but also can not influence light sources from all directions to effectively stimulate the retinas of the animals. The base 2 is of a cuboid structure, the length of the base is 25cm, the width of the base is 8cm, the thickness of the base is 0.8-1.0cm, and a rubber foot pad 21 is arranged at the bottom of the base 2.
The lower cushion block 3 is fixed at the front end of the base 2 and is used for being cushioned below the chin of the animal. The height of the lower cushion block 3 is 0.5-1.5cm, which is determined by the body type of the animal, for example, the lower cushion block with the height of 0.5cm is generally adopted by a mouse, and the lower cushion block with the height of 1.0-1.5cm is adopted by a rat. Wherein, the lower cushion block can directly adopt a foam block and is fixedly stuck at the front end of the base 2 through a double-sided adhesive tape, the cost is low, and the manufacture is convenient.
Two ends of the elastic pressing plate 4 are connected with two sides of the base 2, and the elastic pressing plate 4 is matched with the animal skull top and used for pressing the animal skull top. Elastic pressing plate 4 adopts elastic bow-shaped hard board, 2 both sides limits of base are equipped with screw 22, elastic pressing plate 4 both ends are equipped with the through-hole, elastic pressing plate 4 passes through the screw fixation with base 2.
The cornea electrode 1 is formed by integrally bending a metal wire with the diameter of 0.2mm, such as a fine silver wire with the purity of 99.99%, and the cornea electrode 1 comprises a circular ring part 11, an elastic connecting part 12, a fixed connecting part 13 and a lead connecting part 14 which are sequentially connected.
The circular part 11 is used for contacting with the animal cornea, and the diameter of the circular part is determined according to the size of the animal cornea, if a circular part with the diameter of 0.2-0.3cm is generally adopted by a mouse, a circular part with the diameter of 0.4-0.6cm is adopted by a rat.
An elastic connecting part 12 of 2-3cm is formed between the circular ring part 11 and the fixed connecting part 13, and the circular ring part is uniformly buckled on the animal cornea with slight force without pressing the animal cornea because of good elastic performance of the circular ring part.
Fixed connection portion 13 is used for being connected with elastic pressing plate 4, and is concrete, fixed connection portion 13 is a plurality of continuous S-shaped, fixed connection portion 13 at least parcel has the medical adhesive tape of one deck to reserve an adhesive tape, paste on elastic pressing plate 4 through the adhesive tape, the structure of its S-shaped can guarantee that cornea electrode 1 can establish through the stable subsides of adhesive tape and can not produce the removal at elastic pressing plate 4, in order to ensure that the detection experiment is accurate reliable.
The corneal electrode 1 terminates in a lead connection 14 for connection to a lead.
As shown in figure 1, when a flash electroretinogram detection experiment of a rodent experimental animal is carried out, the chin of the animal is padded on the lower cushion block 3, the elastic pressure plate 4 is pressed on the cranium of the animal, wherein, the front edge of the elastic pressure plate 4 is preferably flush with the connecting line of the front edges of the two ears of the animal, and the elastic pressure plate 4 has better elastic performance, so the elastic pressure plate can be matched with the lower cushion block 3 to realize the reliable fixation of the head position of the animal, and the elastic pressure plate 4 can be tightly attached to the cranium of the animal, so the elastic pressure plate 4 can be kept at an angle position corresponding to the contour of the cranium of the animal. The fixed connection part 13 of the cornea electrode 1 is fixed on the elastic pressing plate 4 through an adhesive tape, therefore, the cornea electrode 1 can keep an angle consistent with the elastic pressing plate 4, so that the angle position of the circular ring part 11 at the front end of the cornea electrode 1 corresponds to the animal cornea, the optimal contact between the circular ring part 11 and the animal cornea can be achieved, and the animal cornea can not be oppressed, not only the operation is extremely simple and convenient, but also the success rate of the experiment is greatly improved, and the cornea electrode is particularly suitable for beginners of related animal experiments.
In the description of the present invention, it should be noted that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplification of the description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art. In addition, in the description of the present invention, "a plurality" means two or more unless otherwise specified.
The skilled person should understand that: although the present invention has been described in accordance with the above embodiments, the inventive concept is not limited to this embodiment, and any modification of the inventive concept will be included in the scope of the patent claims.
Claims (10)
1. A rodent experimental animal flashlight electroretinogram detection auxiliary device comprises a detection table and a cornea electrode (1); the method is characterized in that:
the detection table comprises a base (2), a lower cushion block (3) and an elastic pressing plate (4), wherein the lower cushion block (3) is fixed at the front end of the base (2) and is used for being cushioned below the chin of an animal, and two ends of the elastic pressing plate (4) are connected with two sides of the base (2) and are used for being pressed above the cranium of the animal;
the cornea electrode (1) comprises a circular ring part (11), an elastic connecting part (12), a fixed connecting part (13) and a lead connecting part (14) which are connected in sequence, and is fixedly connected with the elastic pressing plate (4) through the fixed connecting part (13).
2. The rodent experimental animal flashlight electroretinogram detection aid of claim 1, wherein: the cornea electrode (1) is integrally formed by bending metal wires.
3. The rodent experimental animal flashlight electroretinogram detection aid of claim 2, wherein: the fixed connecting parts (13) are in a plurality of continuous S shapes and are attached to the elastic pressing plate (4) through adhesive tapes.
4. The rodent experimental animal flashlight electroretinogram detection aid of claim 3, wherein: the fixed connection part (13) is at least wrapped with a layer of medical adhesive plaster.
5. The rodent experimental animal flashlight electroretinogram detection aid of claim 2, wherein: the cornea electrode (1) adopts a fine silver wire with the purity of 99.99 percent.
6. The rodent experimental animal flashlight electroretinogram detection aid of claim 1, wherein: the base (2) is made of organic glass material.
7. The rodent experimental animal flashlight electroretinogram detection aid of claim 1 or 6, wherein: the bottom of the base (2) is provided with a rubber foot pad (21).
8. The rodent experimental animal flashlight electroretinogram detection aid of claim 1, wherein: the elastic pressing plate (4) is made of an elastic arched hard board.
9. The rodent experimental animal flashlight electroretinogram detection aid of claim 8, wherein: screw holes (22) are formed in two side edges of the base (2), through holes are formed in two ends of the elastic pressing plate (4), and the elastic pressing plate (4) is fixed with the base (2) through screws.
10. The rodent experimental animal flashlight electroretinogram detection aid of claim 1, wherein: the lower cushion block (3) is a foam block and is fixed at the front end of the base (2) by a double-faced adhesive tape.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202120235859.6U CN215017195U (en) | 2021-01-28 | 2021-01-28 | Rodent experimental animal flashlight electroretinogram detection auxiliary device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202120235859.6U CN215017195U (en) | 2021-01-28 | 2021-01-28 | Rodent experimental animal flashlight electroretinogram detection auxiliary device |
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| CN215017195U true CN215017195U (en) | 2021-12-07 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114403905A (en) * | 2021-12-31 | 2022-04-29 | 中国人民解放军联勤保障部队第九〇〇医院 | Rodential experimental animal visual electrophysiological detection arrangement platform |
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2021
- 2021-01-28 CN CN202120235859.6U patent/CN215017195U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114403905A (en) * | 2021-12-31 | 2022-04-29 | 中国人民解放军联勤保障部队第九〇〇医院 | Rodential experimental animal visual electrophysiological detection arrangement platform |
| CN114403905B (en) * | 2021-12-31 | 2024-03-19 | 中国人民解放军联勤保障部队第九〇〇医院 | Rodent experimental animal vision electrophysiology detection placement platform |
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