CN214967100U - Multifunctional experimental mouse enema and gastric lavage drug delivery device - Google Patents
Multifunctional experimental mouse enema and gastric lavage drug delivery device Download PDFInfo
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- CN214967100U CN214967100U CN202023211301.9U CN202023211301U CN214967100U CN 214967100 U CN214967100 U CN 214967100U CN 202023211301 U CN202023211301 U CN 202023211301U CN 214967100 U CN214967100 U CN 214967100U
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Abstract
The utility model discloses a multi-functional laboratory mouse enema lavage device of dosing belongs to experimental apparatus technical field. The administration device comprises an injector and an administration device, wherein the administration device comprises a detachable drug guide tube, a metal pipeline connected with the drug guide tube, a sleeve sleeved on the metal pipeline and attached with a metal plug, and an adjusting device capable of adjusting the length of an inserted needle. The utility model discloses a dual-purpose device of enema gavage, adjustable pipeline length is applicable to rat, mouse, convenient to use.
Description
Technical Field
The utility model belongs to the technical field of experimental apparatus, concretely relates to multi-functional laboratory mouse enema lavage device of dosing.
Background
Enema administration and gavage administration of laboratory mice are indispensable parts of pharmacological research and intestinal disease research. At present, no enemator special for experimental mice is available in the market, and a part of researchers select a catheter, a gastric lavage needle or a venous blood taking needle as the enemator. These enemators present the following problems:
the intestinal mucosa of the experimental mouse is easy to damage due to the intestinal mucosa of the experimental mouse, so that the experimental mouse can die in the experimental period to cause experimental failure;
secondly, the experimental mouse receives enema administration after being more than anaesthetized, and because the anal sphincter is relaxed after anaesthetizing, the experimental mouse often leaks liquid after enema;
the existing laboratory mouse enemators are all single-hole enemators, and the drugs are in single-side contact with intestinal mucosa of the laboratory mouse, so that the absorption of the drugs is influenced;
fourthly, the existing enemator has no scales, cannot adjust the length and is easy to cause the intestinal tract of the laboratory mouse to be too deep or too shallow.
The special laboratory mouse stomach irrigators are available on the market, but are all ordinary metal needles, the stomach irrigation depth cannot be adjusted, and the needle insertion depth can be judged only through the experience of a user.
SUMMERY OF THE UTILITY MODEL
Therefore, a simple and controllable universal device for enema and gastric perfusion of laboratory mice needs to be provided. In order to achieve the purpose, the technical scheme provided by the inventor is as follows:
the utility model provides a multi-functional laboratory mouse enema lavage device of dosing, includes syringe 7 and ware of dosing, the ware of dosing including being provided with detachable medicine guide tube 1, telescopic metal pipeline 2, the cover that is connected with medicine guide tube 1 on metal pipeline 2 and with sleeve pipe 4 of metal stopper 3 to and the adjusting device 5 of the adjustable pipeline length of setting between metal pipeline 2 and sleeve pipe 4.
The administration device is connected with an injector 7 through a connector 6 at one end of the metal pipeline 2. The other end interface of the metal pipeline 2 is connected with the medicine guide pipe 1. In order to make the connection secure, the interface may be provided as a threaded interface.
The length of the medicine guide tube 1 is 2-4cm, and the diameter is 0.5-2 mm.
The medicine guide tube 1 is a silica gel medicine guide tube provided with a blind end 8 and a liquid outlet 9, or a metal medicine guide tube with a single liquid outlet 9. The diameter of the liquid outlet 9 can be set to be 0.5-2 mm. The enema can be made of silica gel drug-guiding tube with multiple liquid outlets. Considering that the tongue obstructs when the stomach is irrigated, the single liquid outlet metal medicine guide tube can be used for the stomach irrigation.
The number of the liquid outlets 9 of the silica gel medicine guide tube 1 is 8-12, and the silica gel medicine guide tube 1 is uniformly distributed around the tube wall close to the blind end 8.
The adjusting device 5 comprises an adjusting block 10, an adjusting groove 11 and a fixer 12. The adjusting groove 11 is arranged on the sleeve 4.
8-10 pairs of fixing devices 12 are symmetrically arranged on two sides of the adjusting groove 11, the distance between every two adjacent fixing devices 12 on each side is set to be 0.5cm or 1cm, and the minimum distance between the fixing devices 12 at the symmetrical positions is consistent with the size of the thinnest part of the adjusting block 10.
The length of the metal pipeline 2 is 6-10 cm. The length of the metal pipeline can be adjusted by the adjusting device 5.
The adjusting block 10 is arranged in the middle of the adjusting groove 11 and comprises a pressing type adjusting block with a spring structure 13 or a rotary type adjusting block with a thread structure 14.
The pressing type adjusting block 10 is I-shaped, the top of the pressing type adjusting block is a pressing part, the bottom of the pressing type adjusting block is connected with one end of a spring 13, and the other end of the spring 13 is connected to the metal pipeline 2.
The adjustment mode of the pressing type adjusting device is that the adjusting block 10 is pressed to open the fixing device 12, the adjusting block 10 slides in the adjusting groove 11, when the required length is reached, the adjusting block 10 is loosened, the fixing device 12 is closed, the adjusting block 10 is clamped, and the length of the adjusting block is fixed. The adjustment groove 11 and the holder 12 may have a saw-toothed structure as a whole.
The rotary adjusting block 10 is in a screw shape. The screw neck comprises a thread formation 14 and the lower end of the screw head comprises a portion of the thread formation 14, the overall length of the thread formation 14 being no less than the thickness of the sleeve 4.
The rotary adjusting device is adjusted by rotating the adjusting block 10, loosening the adjusting block 10 upwards to the thin part at the lower end, adjusting the length of the metal pipeline 2 in a vertical sliding manner, and screwing the adjusting block 10 downwards to the thick part at the middle (namely the lower end of the head of the screw) after the required length is reached, so that the adjusting block is fixed on the fixer 12 at the corresponding position and the metal pipeline 2 is fixed at the same time. The adjusting groove 11 and the holder 12 may be formed as a bead-like structure as a whole, and the width of the thinner portion thereof is the same as the diameter of the thinner portion of the lower end of the adjusting block 10.
Different from the prior art, the technical scheme has the advantages that:
(1) the device has multiple functions, and is a dual-purpose device for enema and gastric perfusion formed by the replaceable medicine guide tube, thereby being suitable for not only mice but also rats;
(2) compared with the traditional enemator, the device can avoid damaging the intestinal tract of the experimental mouse with the help of the lubricant;
(3) the metal plug structure can effectively prevent liquid from leaking out of the anus of the experimental mouse during clystering, and plays a role in indicating the insertion depth of the medicine guide pipe during gavage;
(4) the liquid can be fully contacted with the intestinal tract of the laboratory mouse through the plurality of liquid outlets;
(5) the length of the pipeline can be adjusted by the adjusting device attached with the scale marks, so that the liquid can directly reach the action part according to the requirement.
Drawings
FIG. 1 is a schematic structural view of a drug delivery device according to an embodiment;
FIG. 2 is a schematic view of a drug delivery tube according to an embodiment, wherein a is a silicone drug delivery tube with multiple liquid outlets of an enema set, and b is a metal drug delivery tube with a single liquid outlet of a gastric lavage set;
FIG. 3 is a schematic structural view of a press type adjustable dispenser according to an embodiment, wherein a is a front view of the dispenser, b is a left view of the dispenser, and c is a sectional view of a press portion A-A;
fig. 4 is a schematic structural view of a rotary adjustment dispenser according to an embodiment, wherein a is a front view of the dispenser, b is a left view of the dispenser, and c is a sectional view of a rotating portion a-a.
Description of reference numerals:
1. medicine guide tube
2. Metal pipeline
3. Metal plug
4. Sleeve pipe
5. Adjusting device
6. Screw joint
7. Syringe with a needle
8. Blind end of silica gel drug-guiding tube
9. Liquid outlet
10. Regulating block
11. Adjusting groove
12. Fixing device
13. Spring structure
14. Thread structure
Detailed Description
To explain technical contents, structural features, and objects and effects of the technical solutions in detail, the following detailed description is given with reference to the accompanying drawings in conjunction with the embodiments.
Example 1
Please refer to fig. 1, fig. 2 and fig. 3 for the present embodiment.
A multifunctional experimental rat enema and gastric lavage administration device comprises a syringe 7 and an administration device, as shown in figure 1. The medicine feeder is provided with a detachable medicine guide pipe 1, a telescopic metal pipeline 2 connected with the medicine guide pipe 1, a sleeve 4 which is sleeved on the metal pipeline 2 and is attached with a metal plug 3, and an adjusting device 5 which is arranged between the metal pipeline 2 and the sleeve 4 and can adjust the length of the pipeline.
The administration device is connected with an injector 7 through a connector 6 at one end of the metal pipeline 2. The other end interface of the metal pipeline 2 is connected with the medicine guide pipe 1. In order to make the connection secure, the interface may be provided as a threaded interface.
During clystering, in order to avoid damaging intestinal tracts, a silica gel medicine guide tube 1 with a plurality of liquid outlets is selected to be connected into a metal pipeline 2. The drug guiding tube 1 is provided with a blind end 8 and a liquid outlet 9, as shown in fig. 2 a. The number of the liquid outlets 9 is 8, and the liquid outlets are uniformly distributed on the periphery of the tube wall of the silica gel drug guiding tube 1 close to the blind end 8.
When the stomach is irrigated, the metal medicine guide tube 1 with a single liquid outlet 9 is selected to be connected into the metal pipeline 2, and the metal medicine guide tube 1 is shown as figure 2 b.
The length of the medicine guide tube 1 is set to be 3cm, and the diameter is 0.5-2 mm. The length of the metal pipeline 2 is 6-10 cm. The length of the metal pipeline 2 can be adjusted by an adjusting device 5. The adjustment device 5 comprises an adjustment block 10, an adjustment slot 11 and a holder 12, as shown in fig. 3a, 3 b.
The adjusting groove 11 is arranged on the sleeve 4, 10 pairs of fixing devices 12 are symmetrically arranged on two sides of the adjusting groove 11, the distance between every two adjacent fixing devices 12 on each side is set to be 0.5cm, and the minimum distance between the fixing devices 12 in the symmetrical positions is consistent with the size of the thinnest part of the adjusting block 10.
The adjusting block 10 is arranged in the middle of the adjusting groove 11 and is a pressing type adjusting block with a spring structure 13. The push-type adjusting block 10 is shaped like an i, the top is a push portion, the bottom is connected to one end of a spring 13, and the other end of the spring 13 is connected to the metal pipeline 2, as shown in fig. 3 c.
The adjustment mode of the pressing type adjusting device 5 is that the adjusting block 10 is pressed to open the fixing device 12, the adjusting block 10 is vertically slid in the adjusting groove 11, when the adjusting block 10 slides to the required length, the adjusting block 10 is loosened, the fixing device 12 is closed, and the adjusting block 10 is clamped to fix the length. The adjustment groove 11 and the holder 12 may have a saw-toothed structure as a whole.
When mice are clystered, a silica gel drug guide tube 1 with the diameter of 1-1.2mm is selected. Firstly, a silica gel medicine guide tube 1 with a plurality of liquid outlets is connected to a metal pipeline 2; then pressing the adjusting block 10 to open the fixer 12, sliding up and down to adjust the length of the metal pipeline 2, adjusting the distance between the interface (i.e. liquid inlet) of the drug guide tube 1 and the top end of the metal plug 3 by 1-2cm (properly adjusting the size according to the shape of the mouse), then loosening the adjusting block 10, closing the fixer 12, and fixing the adjusting block 10 on the fixer 12 at the corresponding position; then, the medicine guide tube 1 extends into the intestinal tract from the anus of the mouse, and the metal plug 3 covers the anus opening of the mouse to prevent subsequent liquid from leaking. Connect syringe 7 into hickey 6, promote syringe 7, liquid is through metal pipeline 2, reaches silica gel drug guide tube 1, and liquid slowly gets into in the mouse intestinal from a plurality of liquid outlets 9 afterwards. At this time, the depth of the enema was about 4 to 5 cm.
When a rat is clystered, a silica gel drug guide tube 1 with the diameter of 1.5-1.6mm is selected, and the length of the metal pipeline 2 is adjusted until the distance between the interface (namely a liquid inlet) of the drug guide tube 1 and the top end of the metal plug 3 is 5-6cm (the size is properly adjusted according to the shape of the rat). At this time, the depth of the enema was about 8-9cm in the rats.
When the mouse is perfused with stomach, a metal drug guide tube 1 with the diameter of 1-1.2mm is selected. Firstly, a metal medicine guide pipe 1 with a single liquid outlet is connected to a metal pipeline 2; then pressing the adjusting block 10 to open the fixer 12, sliding up and down to adjust the length of the metal pipeline 2, adjusting the distance between the interface (i.e. liquid inlet) of the drug guide tube 1 and the top end of the metal plug 3 by 1-1.5cm (properly adjusting according to the shape and size of the mouse), then loosening the adjusting block 10, closing the fixer 12, and fixing the adjusting block 12 on the fixer 12 at the corresponding position; then, the medicine guide tube 1 is extended into the oral cavity of the mouse and enters the esophagus, and the metal plug 3 covers the periphery of the lip of the mouth of the mouse at the moment, so that the needle is prevented from being inserted too deeply. The syringe 7 is connected to the threaded connector 6, the syringe 7 is pushed, liquid passes through the metal pipeline 2 and reaches the metal medicine guide tube 1, and then the liquid slowly enters the mouse esophagus from the liquid outlet 9 at the top of the medicine guide tube 1. At this time, the depth of gavage was about 4-4.5cm in the mice.
When a rat is subjected to intragastric administration, the metal drug guide tube 1 with the diameter of 1.5-1.6mm is selected, and the length of the metal pipeline 2 is adjusted to the position that the interface (namely a liquid inlet) of the drug guide tube 1 is 3.5-4.5cm away from the top end of the metal plug 3 (the metal pipeline is properly adjusted according to the shape and the size of the rat). At this time, the depth of gavage was about 6.5-7.5cm in the rats.
The diameter of the medicine guide tube 1 is selected by the following method: the diameter of the drug delivery tube can be selected from 0.5-0.8mm for young mice (weight less than 30g), 1-1.2mm for mice (weight 30-60g), 1.5-1.8mm for rats (weight 400-500g), and 2mm for super rats (weight 500-600 g).
Example 2
Please refer to fig. 1, fig. 2 and fig. 4 for the present embodiment.
A multifunctional experimental rat enema and gastric lavage administration device comprises a syringe 7 and an administration device, as shown in figure 1. The medicine feeder is provided with a detachable medicine guide pipe 1, a telescopic metal pipeline 2 connected with the medicine guide pipe 1, a sleeve 4 which is sleeved on the metal pipeline 2 and is attached with a metal plug 3, and an adjusting device 5 which is arranged between the metal pipeline 2 and the sleeve 4 and can adjust the length of the pipeline.
The administration device is connected with an injector 7 through a connector 6 at one end of the metal pipeline 2. The other end interface of the metal pipeline 2 is connected with the medicine guide pipe 1.
During clystering, a silica gel medicine guide tube 1 with multiple liquid outlets is selected to be connected into a metal pipeline 2. The drug guiding tube 1 is provided with a blind end 8 and a liquid outlet 9, as shown in fig. 2 a. The number of the liquid outlets 9 is 12, and the liquid outlets are uniformly distributed on the periphery of the tube wall of the silica gel drug guiding tube 1 close to the blind end 8.
When the stomach is irrigated, the metal medicine guide tube 1 with a single liquid outlet 9 is selected to be connected into the metal pipeline 2, and the metal medicine guide tube 1 is shown as figure 2 b.
The length of the medicine guide tube 1 is set to be 4cm, and the diameter is 0.5-2 mm. The length of the metal pipeline 2 is 6-10 cm. The length of the metal pipeline 2 can be adjusted by an adjusting device 5. The adjustment device 5 comprises an adjustment block 10, an adjustment slot 11 and a holder 12, as shown in fig. 4a, 4 b.
The adjusting groove 11 is arranged on the sleeve 4, 8 pairs of fixing devices 12 are symmetrically arranged on two sides of the adjusting groove 11, the distance between every two adjacent fixing devices 12 on each side is set to be 1cm, and the minimum distance between the fixing devices 12 at the symmetrical positions is consistent with the size of the thinnest part of the adjusting block 10.
The adjusting block 10 is arranged in the middle of the adjusting groove 11 and is a rotary adjusting block with a thread structure 14. The rotary adjusting block 10 is in the shape of a screw, the neck of the screw comprises a thread structure 14, the lower end of the head of the screw comprises a part of the thread structure 14, and the total length of the thread structure 14 is not less than the thickness of the sleeve 4, as shown in fig. 4 c.
The rotary adjusting device 5 is adjusted by rotating the adjusting block 10 on the adjusting groove 11, loosening the adjusting block 10 upwards to the thin part at the lower end, adjusting the length of the metal pipeline 2 in a vertical sliding manner, and screwing the adjusting block 10 downwards to the thick part at the middle (namely the lower end of the head of the screw) after the required length is reached, so that the adjusting block is fixed on the fixer 12 at the corresponding position and the metal pipeline 2 is fixed at the same time. The adjusting groove 11 and the holder 12 may be formed in a bead shape as a whole, and the width of the thinner portion thereof is the same as the diameter of the thinner portion of the lower end of the adjusting block 10.
When mice are clystered, a silica gel drug guide tube 1 with the diameter of 1.4-1.5mm is selected. Firstly, a silica gel medicine guide tube 1 with a plurality of liquid outlets is connected to a metal pipeline 2; then the adjusting block 10 on the adjusting groove 11 is rotated, the adjusting block 10 is unscrewed upwards to the thin part at the lower end, the length of the metal pipeline 2 is adjusted in a vertical sliding mode, after the distance between the interface (namely the liquid inlet) of the medicine guide pipe 1 and the top end of the metal plug 3 is adjusted to be 1-2cm (the size is properly adjusted according to the shape and the size of a mouse), the adjusting block 10 is screwed downwards to the thick part in the middle, and the medicine guide pipe is fixed on a fixer 12 at a corresponding position; then, the medicine guide tube 1 extends into the intestinal tract from the anus of the mouse, and the metal plug 3 covers the anus opening of the mouse to prevent subsequent liquid from leaking. The syringe 7 is connected into the interface 6, the syringe 7 is pushed, liquid passes through the metal pipeline 2 and reaches the silica gel drug guide tube 1, and then the liquid slowly enters the intestinal tract of the mouse from the plurality of liquid outlets 9. At this time, the depth of the enema was about 5 to 6 cm.
When a rat is clystered, a silica gel drug guide tube 1 with the diameter of 1.8-2mm is selected, and the length of the metal pipeline 2 is adjusted until the distance between the interface (namely a liquid inlet) of the drug guide tube 1 and the top end of the metal plug 3 is 5-6cm (the size is properly adjusted according to the shape of the rat). At this time, the depth of the enema was about 9-10cm in the rats.
When the mouse is gavaged, a metal drug guide tube 1 with the diameter of 0.5-0.8mm is selected. Firstly, a metal medicine guide pipe 1 with a single liquid outlet is connected to a metal pipeline 2; then the adjusting block 10 on the adjusting groove 11 is rotated, the adjusting block 10 is unscrewed upwards to the thin part at the lower end, the length of the metal pipeline 2 is adjusted in a vertical sliding mode, after the distance between the interface (namely the liquid inlet) of the medicine guide pipe 1 and the top end of the metal plug 3 is adjusted to be 1cm (the size is properly adjusted according to the shape of a mouse), the adjusting block 10 is screwed downwards to the thick part in the middle, and the medicine guide pipe is fixed on a fixer 12 at a corresponding position; then, the medicine guide tube 1 is extended into the oral cavity of the mouse and enters the esophagus, and the metal plug 3 covers the periphery of the lip of the mouth of the mouse at the moment, so that the needle is prevented from being inserted too deeply. The syringe 7 is connected to the interface 6, the syringe 7 is pushed, the liquid passes through the metal pipeline 2 and reaches the metal medicine guide tube 1, and then the liquid slowly enters the mouse esophagus from the liquid outlet 9 at the top of the medicine guide tube 1. At this time, the depth of gavage was about 5 cm.
When a rat is subjected to intragastric administration, the metal drug guide tube 1 with the diameter of 1.5-1.6mm is selected, and the length of the metal pipeline 2 is adjusted until the distance from the interface (namely a liquid inlet) of the drug guide tube 1 to the top end of the metal plug 3 is 4-5cm (the size is properly adjusted according to the shape of the rat). At this time, the depth of gavage was about 8-9cm in the rats.
It should be noted that, although the above embodiments have been described herein, the scope of the present invention is not limited thereby. Therefore, based on the innovative concept of the present invention, the changes and modifications of the embodiments described herein, or the equivalent structure or equivalent process changes made by the contents of the specification and the drawings of the present invention, directly or indirectly apply the above technical solutions to other related technical fields, all included in the scope of the present invention.
Claims (9)
1. The utility model provides a multi-functional laboratory mouse enema lavage device of dosing, includes syringe and ware of dosing, its characterized in that: the medicine feeder comprises a detachable medicine guide pipe, a metal pipeline connected with the medicine guide pipe, a sleeve pipe sleeved on the metal pipeline and attached with a metal plug, and an adjusting device capable of adjusting the length of the metal pipeline; the medicine feeder is connected with the injector through a connector arranged at one end of the metal pipeline.
2. The multifunctional laboratory mouse enema and gastric lavage drug delivery device of claim 1, which is characterized in that: the medicine guide tube is a silica gel medicine guide tube provided with a blind end and a liquid outlet, or a metal medicine guide tube with a single liquid outlet.
3. The multifunctional laboratory mouse enema and gastric lavage drug delivery device according to claim 1 or 2, characterized in that: the length of the medicine guide tube is 2-4cm, and the diameter of the medicine guide tube is 3-5 mm.
4. The multifunctional laboratory mouse enema and gastric lavage drug delivery device of claim 2, which is characterized in that: the number of the liquid outlets of the silica gel medicine guide tube is 8-12, and the silica gel medicine guide tube is uniformly distributed around the tube wall of the silica gel medicine guide tube close to the blind end.
5. The multifunctional laboratory mouse enema and gastric lavage drug delivery device of claim 2 or 4, which is characterized in that: the diameter of the liquid outlet is 0.5-2 mm.
6. The multifunctional laboratory mouse enema and gastric lavage drug delivery device of claim 1, which is characterized in that: the adjusting device comprises an adjusting block, an adjusting groove and a fixer, wherein the adjusting groove is arranged on the sleeve.
7. The multifunctional laboratory mouse enema and gastric lavage drug delivery device of claim 6, wherein: the adjusting block is arranged in the middle of the adjusting groove and comprises a pressing type adjusting block with a spring structure or a rotary type adjusting block with a thread structure.
8. The multifunctional laboratory mouse enema and gastric lavage drug delivery device of claim 6, wherein: 8-10 pairs of fixing devices are symmetrically arranged on two sides of the adjusting groove, the distance between every two adjacent fixing devices on each side is set to be 0.5cm or 1cm, and the minimum distance between the fixing devices at the symmetrical positions is consistent with the size of the thinnest part of the adjusting block.
9. The multifunctional laboratory mouse enema and gastric lavage drug delivery device of claim 1, which is characterized in that: the length of the metal pipeline is 6-10 cm.
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| CN202023211301.9U CN214967100U (en) | 2020-12-28 | 2020-12-28 | Multifunctional experimental mouse enema and gastric lavage drug delivery device |
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| CN202023211301.9U CN214967100U (en) | 2020-12-28 | 2020-12-28 | Multifunctional experimental mouse enema and gastric lavage drug delivery device |
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