CN209269976U - Nodal and rectal drug delivery device for mice - Google Patents

Abstract

The utility model relates to a kind of syringe accessory devices, more particularly to a kind of mouse knot, rectum medicine applying apparatus, belong to medical instruments field, including dosage control syringe and perfusion tube, dosage controls syringe and is made of screw rod core, dosage control nut, rubber plug, housing, spiral interface；Infusion apparatus is made of spiral interface, liquid-transport pipe-line, hollow out liquid-transport pipe-line；Dosage control nut is set on screw rod core, can be moved up and down by the screw thread of screw rod wicking surface；Screw rod wicking surface has volume scale；Screw rod core is connect with rubber plug, is pushed and is driven rubber plug to move in housing when screw rod core；Dosage syringe spiral interface is connect with infusion apparatus spiral interface.Big (small) mouse colon medical fluid is given using the present apparatus, has the characteristics that dosage is accurate, medical fluid is evenly distributed, anti-medical fluid flows back, operating efficiency is high；In addition, the present apparatus also has many advantages, such as that structure is simple, easy to operate, low manufacture cost.

Description

Nodal and rectal drug delivery device for mice

technical field

The utility model relates to an auxiliary device for a syringe, in particular to a device for administering drugs to rats and rectums, and belongs to the field of medical instruments.

Background technique

In the prior art, traditional syringes and common infusion tubes are used for intestinal administration in large (small) mice, but the effect is not good. The main disadvantages are the following two aspects:

1. Inaccurate dosing.

①Traditional syringes usually set the dose marking line on the syringe, and align the specific part of the piston rod core with the preset dose marking line on the syringe during use. However, it is difficult to accurately push the piston rod core to the predetermined position due to visual errors such as looking up or looking down during operation, which cannot meet the needs of precise drug administration, especially in the scientific research process with rats and mice as research objects. The dose is small (100μL or less), so errors in traditional syringes when pushing a specific part of the piston rod to align with the dose mark on the barrel can lead to changes in the administered dose, thereby affecting the accuracy of scientific research.

②In the process of pushing the piston rod core of the traditional syringe, it is difficult to push it to the designated scale at one time, which may easily lead to inconsistent dosage.

2. The liquid medicine is unevenly distributed and easy to reflux.

In the early stage of the test, ordinary infusion tubes were used to implement intestinal administration, because the drug was poured into the intestinal tract from the broken end of the infusion tube under the pressure of the syringe, and the liquid medicine was concentrated in a certain area of the intestinal tract, resulting in excessive local drug dosage; or With the withdrawal of the infusion tube, the intestinal tract will reflux, and even overflow to the outside of the anus, resulting in inaccurate administration sites and insufficient drug dosage.

3. Low efficiency or waste of liquid medicine.

In order to ensure the accuracy of the dosage, the traditional syringe can only absorb the dose once, and cannot continuously administer; in order to ensure the operation efficiency, the traditional syringe can absorb a large amount of liquid medicine, but the scale needs to be readjusted after administration, resulting in waste of liquid medicine .

Utility model content

In order to solve the above-mentioned defects existing in the prior art, the utility model provides a rat knot and rectal drug delivery device which can precisely control the drug dosage and effectively control the uniform distribution of the drug solution in the intestinal tract.

In order to achieve the above object, the technical solution adopted by the utility model is:

A drug delivery device for rats and rectums, comprising a dose control syringe and an infusion set, characterized in that: the dose control syringe is composed of a screw rod core, a dose control nut, a rubber plug, an outer jacket, and a spiral interface; the infusion set is composed of a spiral interface, an infusion It is composed of pipeline and hollow infusion pipeline; the dose control nut is sleeved on the screw core, which can move up and down through the thread on the surface of the screw core; there is a volume scale on the surface of the screw core; the screw core is connected with the rubber plug, and when the screw core is pushed The rubber stopper is driven to move in the jacket; the helical interface of the dosage syringe is connected with the helical interface of the infusion set; the helical interface of the infusion set, the infusion pipeline, and the hollow infusion pipeline are arranged in sequence.

The dose control nut is sleeved on the end of the screw core away from the rubber plug, one end of the screw core is connected to the rubber plug, and the other end of the screw core is away from the rubber plug.

The casing is the casing of the dose control syringe, and the screw core and the rubber stopper are located inside the casing; the screw interface is located at the end of the casing.

The screw interface of the infusion set, the infusion pipeline, and the hollow infusion pipeline are integrally formed, with a total length of 150 mm and an inner diameter of 1.5 mm; the wall thickness of the infusion pipeline and the hollow infusion pipeline is 0.25 mm.

The length of the hollow infusion pipeline is 10 mm; the top of the hollow infusion pipeline is a closed structure, and the surface of the top of the hollow infusion pipeline is smooth and curved.

The surface of the hollow infusion pipeline has uniform holes, the surface of the hollow infusion pipeline is the area other than the top of the hollow infusion pipeline, the diameter of the holes is 0.3 mm, and the interval between adjacent holes is 0.3 mm.

The screw core and the rubber plug are connected in a concave-convex manner; the dose control nut moves up and down through the thread on the surface of the screw core to adjust the advancing distance of the screw core.

The helical interface of the dosage syringe and the helical interface of the infusion set can be tightly connected through threads.

Compared with the prior art, the beneficial effects of the utility model are:

1) Dose control The dose control nut in the syringe can precisely control the dosage of the drug. When administering the drug, it is only necessary to push the screw core until it cannot be pushed, which can avoid repeated drug administration and dose deviation caused by visual errors; Pushing the screw rod core hard can make the medicinal liquid spray out from the hollow infusion tube, and the medicinal liquid can be distributed more evenly.

2) Dose control The dosage of the syringe is controlled by the dose control nut, and the minimum accurate dose is 0.02 mL, which is suitable for precise intestinal administration of rats and mice.

3) The dose control syringe and the infusion pipeline adopt a spiral interface, which is more tightly connected, which can prevent the infusion pipeline from falling off or leaking due to vigorously pushing the screw rod core.

4) The top of the hollow infusion pipeline is sealed and the hole design is adopted (the hole diameter is 0.3 mm, the hole spacing is 0.3 mm), which can make the liquid medicine be evenly distributed on the administration site, avoiding excessive or insufficient local drug dosage and when the dosage is large. The backflow of the liquid medicine caused by it; the top is airtight, smooth, and curved, which is conducive to the smooth entry of the infusion tube into the intestinal tract of experimental animals, avoiding physical damage and improving work efficiency.

5) The device can absorb a large amount of liquid medicine at one time, and use the dose control nut to achieve continuous and accurate drug administration for multiple times, effectively avoiding the loss of liquid medicine caused by repeated calibration and exhaust during the administration of multiple experimental animals, improving injection efficiency and saving cost.

6) The device has a simple structure and low cost.

Description of drawings

Fig. 1 is a schematic diagram of the planar structure of a dose control syringe;

Fig. 2 is a schematic diagram of the planar structure of the infusion tube;

Fig. 3 is a schematic diagram of the planar structure of the hollow infusion pipeline;

Fig. 4 is a three-dimensional schematic diagram of a hollow infusion pipeline;

5 is a schematic diagram of drug reflux in a traditional drug delivery method and a drug delivery method using the device of the present invention;

Fig. 6 is a schematic diagram of the change of the action site of the traditional drug delivery method and the drug delivery method using the device of the present invention.

Detailed ways

Below in conjunction with accompanying drawing and specific embodiment, the utility model is described further.

Referring to Figures 1-4, a nodal and rectal drug delivery device for mice consists of a dose control syringe (Figure 1) and an infusion tube (Figure 2). The dose injector is composed of five parts: a screw rod core 1, a dose control nut 2, a rubber plug 3, a jacket 4, and a screw interface 5;

The dose control nut 2 is sleeved on the screw core 1, and can move up and down through the thread on the surface of the screw core 1; the surface of the screw core has a volume scale, and the minimum scale is 0.02 mL.

The screw core 1 and the rubber plug 3 adopt a concave-convex connection (that is, one end of the screw core 1 is inserted into the concave part of the rubber plug), and pushing the screw core 1 can drive the rubber plug 3 to move in the jacket 4; the dosage control nut 2 passes through the screw core. 1 The surface thread moves up and down to control the advancing distance of the screw core 1.

The helical interface 5 of the dosage syringe and the helical interface 6 of the infusion set can be tightly connected through threads; slippage and liquid leakage are prevented.

The screw interface 6 of the infusion set, the infusion pipeline 7, and the hollowed-out infusion pipeline 8 are manufactured in one piece, with a total length of 150 mm and a uniform inner diameter of 1.5 mm; the wall thickness of the infusion pipeline 7 and the hollowed-out infusion pipeline 8 is 0.25 mm.

The length of the hollow infusion pipeline 8 is 10 mm; the top 9 of the hollow infusion pipeline 8 is a closed structure with a smooth and curved surface.

The surface holes 10 of the hollow infusion pipeline have a diameter of 0.3 mm, and the interval between the holes is 0.3 mm.

When using the device of the present utility model, 1) set the dose control nut 2 on the end of the screw core 1 away from the rubber plug, the dose control nut 2 is located outside the jacket and has a certain distance from the jacket; connect the screw core 1 and the rubber plug 3 and put it in the coat 4. 2) Lifting screw core 1 absorbs a certain amount of liquid medicine into the jacket 4 . 3) Connect the screw interface 5 of the dose control syringe with the screw interface 6 of the infusion set. 4) Push the screw core 1 to make the medicinal liquid enter the infusion pipeline 7 and fill the hollowed infusion pipeline 8. 5) Adjust the dosage control nut 2 to the corresponding scale, and push the screw core 1 hard to make the medicinal liquid pass through the infusion pipeline 7 from the hollowed infusion pipeline 8 Overflow (push the screw rod core 1 until the dose control nut 2 is in contact with the jacket 4, then it can no longer be pushed).

The specific implementation of the utility model for enteral administration of large (small) mice will be illustrated below with reference to the accompanying drawings.

①Sedate or anesthetize the fasted rats (small) according to the test requirements.

②Use a dose syringe to draw an appropriate amount of liquid medicine and connect it to the infusion tube, push the screw core to make the liquid medicine fully fill the infusion tube, and adjust the dose control nut to the specified scale.

③ After sedation or anesthesia, the large (small) rats were placed supine on the experimental operation table, and the infusion tube was slowly inserted into the rectum from the anus and gently pushed to the designated site.

④Fix the perianal skin by hand so that it is fully in contact with the infusion tube, and push the screw core until it cannot be pushed; after standing for 1 min, slowly take out the infusion tube from the intestinal tract.

⑤Put the big (small) mouse back into the cage.

Remark:

l The infusion tube is made of medical silicone tube, which is tasteless, non-toxic and less irritating to the body; it is resistant to cold, high temperature, weak acid and alkali; It is suitable for the drug administration of various components, and is easy to wash and can be used repeatedly.

l Due to the small diameter of the infusion tube and the hole diameter of the hollow infusion tube, it is not suitable for viscous liquid medicine.

Analysis of test results:

The applicant used TNBS (trinitrobenzene sulfonic acid) to prepare a large (small) mouse model of ulcerative colitis, and found that the modeling effect of the utility model was significantly better than that of the previous model using traditional syringes and infusion tubes. In the early stage, traditional syringes and ordinary infusion tubes are prone to backflow of liquid medicine, resulting in insufficient dose of liquid medicine or action of liquid medicine on non-designated parts; It is difficult to achieve a good and uniform modeling effect. The utility model has the advantages of accurate dosage, uniform distribution of medicinal liquid, difficult backflow, accurate action site and good modeling effect, which guarantees the accuracy of scientific research.

Experimental picture comparison instructions:

In Figure 5, the traditional way of drug administration is easy to reflux and pollute the perianal area, which can lead to insufficient dosage of the drug solution and inaccurate action sites. In Fig. 5, the medicinal liquid has no reflux after administration of the utility model, and the perianal area is clean.

In Figure 6, the traditional drug administration method changes the site of action after the reflux of the drug solution. The main lesion site changes from the colon to the rectum, and the large amount of drug solution in the rectum leads to local tissue hyperplasia and serious lesions, causing intestinal adhesions that are difficult to separate. The expected modeling effect of this study. After the administration of the utility model, the colon tissue is obviously swollen and thickened, which leads to a decrease in the emptying speed of the feces and accumulation of feces in the intestinal tract, which is the ideal modeling effect for this study. Figure 6 also provides pictures of the cecum, colon, and rectum of normal rats.

The utility model discloses a device for administering medicinal liquid to the nodules and rectums of large (small) rats, which comprises two parts, a dose control syringe and a transfusion pipeline. Experiments have proved that the use of this device to administer medicinal liquid to the colon of large (small) rats has the characteristics of accurate dosage, uniform distribution of medicinal liquid, prevention of backflow of medicinal liquid, and high operating efficiency; It has low advantages and is very practical for carrying out experimental research on intestinal diseases in large (small) mice.

The above is only a preferred embodiment of the utility model, it should be pointed out that for those of ordinary skill in the art, without departing from the principle of the utility model, some improvements and modifications can also be made. Retouching should also be regarded as the scope of protection of the present utility model.

Claims (4)

1. a kind of mouse knot, rectum medicine applying apparatus, including dosage control syringe and infusion apparatus, it is characterised in that: dosage control note Emitter is made of screw rod core, dosage control nut, rubber plug, housing, spiral interface；Infusion apparatus by spiral interface, liquid-transport pipe-line, Hollow out liquid-transport pipe-line composition；Dosage control nut is set on screw rod core, can be moved down on the screw thread by screw rod wicking surface It is dynamic；Screw rod wicking surface has volume scale；Screw rod core is connect with rubber plug, is pushed and is driven rubber plug to move in housing when screw rod core It is dynamic；Dosage syringe spiral interface is connect with infusion apparatus spiral interface；Infusion apparatus spiral interface, liquid-transport pipe-line, hollow out perfusion tube Road sequence is arranged；Dosage control nut is sheathed on the separate rubber plug end of screw rod core, and one end of screw rod core connects rubber plug, spiral The other end of bar core is far from rubber plug end；The housing is the shell that dosage controls syringe, and screw rod core, rubber plug are respectively positioned on In housing；Spiral interface is located at housing end；Hollow out liquid-transport pipe-line surface has uniform hole, and hollow out liquid-transport pipe-line surface is Region other than hollow out liquid-transport pipe-line top, 0.3 mm of hole diameter are spaced 0.3 mm between adjacent holes；Screw rod core and glue Plug is using concave-convex connection type；Dosage control nut is moved up and down by screw rod wicking surface screw thread to adjust pushing away for screw rod core Into distance；Hollow out liquid-transport pipe-line top is enclosed construction, and hollow out liquid-transport pipe-line top end surface is smooth, cambered；It need to be pushed away when administration Press screw rod core until it cannot push.

2. a kind of mouse knot according to claim 1, rectum medicine applying apparatus, it is characterised in that: infusion apparatus spiral interface, infusion Pipeline, building sky liquid-transport pipe-line are integrally formed, and total length is 150 mm, and internal diameter is 1.5 mm；Liquid-transport pipe-line, hollow out liquid-transport pipe-line Wall thickness is 0.25 mm.

3. a kind of mouse knot according to claim 1, rectum medicine applying apparatus, which is characterized in that hollow out liquid-transport pipe-line length is 10 mm。

4. a kind of mouse knot according to claim 1, rectum medicine applying apparatus, which is characterized in that dosage syringe spiral interface It is closely connect with infusion apparatus spiral interface by screw thread.