CN214915636U - Extractum inclusion compound mixing system - Google Patents

Abstract

The application provides an extract inclusion compound mixing system, relates to pharmacy technical field. The extractum inclusion compound mixing system comprises: an extract processing system, an inclusion compound processing system and an extract inclusion compound mixing and metering system. The mixing and metering system for the extractum inclusion compound comprises an inclusion compound dissolving device, a supernatant temporary storage device, a stirring and mixing device and a metering device. The extract processing system is used for supplying extract supernatant to the clathrate compound dissolving device and the supernatant temporary storage device. The inclusion compound treatment system is used for providing inclusion compound dry materials. The inclusion compound dissolving device supplies extract inclusion compounds to the stirring and mixing device, the supernatant temporary storage device supplies extract supernatant to the stirring and mixing device, the stirring and mixing device is used for outputting extract mixed liquid to the metering device, and the metering device is used for weighing the extract mixed liquid of a target amount. Compared with the manual operation of the existing process, the extract inclusion compound mixing system effectively improves the production efficiency, reduces the labor intensity of workers and improves the precision.

Description

Extractum inclusion compound mixing system

Technical Field

The application relates to the technical field of pharmacy, in particular to an extract clathrate compound mixing system.

Background

The inclusion compound technology is an ultra-micro drug carrier. The main carrier material is Cyclodextrin (CD), and the medicine molecules are included or embedded into the cylindrical structure of the cyclodextrin to form superfine particle dispersion. Therefore, the inclusion compound has good medicinal effect, easy absorption, slow drug release and low side effect. Especially, the volatile components in the traditional Chinese medicine are included, so that the preservation rate can be greatly improved, and the stability can be improved.

CN100342847C the invention is a new Xiangsha stomach nourishing preparation prepared by using optimized inclusion process route to perform inclusion on extracted volatile oil, adopting different excipients and other additives respectively and tabletting according to the traditional compression method, not only ensuring that the active ingredients of the medicine meet the medical requirements, but also ensuring that the medicine can be rapidly disintegrated and dispersed in the stomach and the active ingredients can be dissolved out in time, greatly reducing the stimulation to the stomach caused by the long-term difficulty in disintegration and dispersion of the medicine, and the Xiangsha stomach nourishing dispersible tablet can be disintegrated in water within 3 minutes at 15-25 ℃. Can be used for treating stomach discomfort caused by anorexia, acid regurgitation, dyspepsia, and gastralgia.

The invention discloses a preparation method of chimonanthus salicifolius formula granules, which comprises the following steps: step 1, smashing chimonanthus salicifolius stems and leaves into coarse powder, adding water into chimonanthus salicifolius for reflux extraction for 2-3 times, and meanwhile collecting volatile oil and combining extracting solutions; step 2, clathrating the volatile oil with beta-cyclodextrin, drying to obtain white powder clathrate, and concentrating and drying the extractive solution to obtain extract; and 3, uniformly mixing the extract and the inclusion compound, adding auxiliary materials for mixing, adding ethanol into the mixture added with the auxiliary materials to prepare a soft material, sieving the soft material by a No. 12-14 sieve to prepare granules, drying, and finally, respectively sieving by a No. 1 sieve and a No. 5 sieve to obtain the chimonanthus salicifolius formula granules. The method has simple steps, the content of active ingredients such as volatile oil, flavone and the like in the product is high, inactive ingredients such as plant fiber and the like are effectively removed, the stability is improved, and the product is easy to store and convenient to take.

At present, in the pharmaceutical process, the extractum which is decocted just now is separated, residues are removed, the extract liquid is reserved, the extract liquid is often mixed with a plurality of inclusion compounds which are prepared and synthesized by active ingredients, and the obtained mixture enters equipment such as a wet granulator and the like for granulation.

At present, the process is usually manufactured manually, and has high labor intensity and low precision.

SUMMERY OF THE UTILITY MODEL

The application aims to provide an extract inclusion compound mixing system which can solve the problems of high labor intensity and low precision of manual operation in the existing process.

The embodiment of the application is realized as follows:

an embodiment of the present application provides an extract clathrate mixing system, includes: an extract processing system, an inclusion compound processing system and an extract inclusion compound mixing and metering system;

the mixing and metering system for the extractum inclusion compound comprises an inclusion compound dissolving device, a supernatant temporary storage device, a stirring and mixing device and a metering device;

the extract processing system is used for separating extract supernatant from the extract, supplying the first extract supernatant to the clathrate compound dissolving device, and supplying the second extract supernatant to the supernatant temporary storage device;

the clathrate compound processing system is used for making clathrate compound dry materials and providing the clathrate compound dry materials to the clathrate compound dissolving device;

the clathrate compound dissolving device is used for mixing the first part of extract supernatant with the clathrate compound dry material to form an extract clathrate compound and supplying the extract clathrate compound to the stirring and mixing device, the supernatant temporary storage device is used for supplying the second part of extract supernatant to the stirring and mixing device, the stirring and mixing device is used for mixing the extract clathrate compound with the second part of extract supernatant to form an extract mixed solution and outputting the extract mixed solution to the metering device, and the metering device is used for weighing the target amount of the extract mixed solution.

The mutual matching of the extract processing system, the inclusion compound processing system and the extract inclusion compound mixing and metering system can remove most of manual labor, not only reduces the labor intensity of workers, but also avoids the influence on the proportioning precision caused by errors caused by manual operation by means of the automatic matching of the systems.

In addition, the extract clathrate mixing system provided by the embodiment of the application can also have the following additional technical characteristics:

in an optional embodiment of the present application, the clathrate compound dissolving device includes a first agitator tank, a crusher, and an auxiliary hoist, the auxiliary hoist is used for delivering the clathrate compound dry material bag provided by the clathrate compound processing system to the crusher, the crusher is used for crushing the clathrate compound dry material bag and enabling the clathrate compound dry material in the bag to enter the first agitator tank, and the first agitator tank is used for mixing the clathrate compound dry material and the first part of extract supernatant into the extract clathrate compound.

Supplementary lifting machine can transmit the inclusion compound of being packed for the breaker to by the breaker with the bag body breakage and release material, need not rely on the manual work to rip the bag body, and need not the manual stirring.

In the optional embodiment of this application, extract processing system includes extract loading attachment and extract processing apparatus, extract loading attachment is used for carrying the extract to extract processing apparatus, extract processing apparatus is used for separating the extract into extract residue and extract supernatant, extract processing apparatus can regard partly extract supernatant as first extract supernatant carry for inclusion compound ization device is regarded as the second part extract supernatant is carried for supernatant temporary storage device.

The extract treatment device can effectively separate the extract into extract residue and extract supernatant, and then a part of the extract supernatant can be temporarily stored through the supernatant temporary storage device, so that the subsequent preparation of the extract mixed liquid is facilitated. And the other part of extract supernatant can be directly supplied to the clathrate compound dissolving device, and can also be used for preparing extract mixed liquor.

In an optional embodiment of the application, the stirring and mixing device comprises a second stirring tank and a weighing device, the second stirring tank is used for mixing the extract inclusion compound with the second part of extract supernatant to form an extract mixed liquid and outputting the extract mixed liquid outwards, and the weighing device is arranged below the second stirring tank to weigh the mass of the second stirring tank and the content.

The weighing device can acquire the mass of second agitator tank and content to whether need to prepare the extractum mixed liquid again according to the volume of content.

In an optional embodiment of the present application, the metering device includes a third stirring tank for storing the extract mixture, and an electronic scale for weighing the third stirring tank and the extract mixture and weighing a target amount of the extract mixture.

And the third stirring tank can contain required extract mixed liquor, and the required extract mixed liquor is weighed by the electronic scale to determine whether the target quantity is reached or not, and then the extract mixed liquor can be supplied to equipment at other stations for subsequent operation.

In an alternative embodiment of the present application, the clathrate processing system includes a first clathrate material processing apparatus, a first included material processing apparatus, a first mixing apparatus, and a first inclusion material processing apparatus;

the first inclusion material processing device is used for preparing a first inclusion material liquid and conveying the first inclusion material liquid to the first mixing device, and the first inclusion material processing device is used for finely grinding a first inclusion material and conveying the processed first inclusion material to the first mixing device;

the first mixing device is used for mixing a first inclusion material liquid and a treated first inclusion material and conveying a first inclusion compound formed after mixing to the first inclusion compound treatment device, the first inclusion compound treatment device is used for separating the first inclusion compound into a first waste liquid and a first dry inclusion compound, and the first dry inclusion compound is supplied to the inclusion compound decomposition device.

The inclusion material and the inclusion material of the inclusion compound can be automatically processed and mixed, and then processed into the dry first inclusion compound material by the first inclusion compound processing device, and the preparation of the dry first inclusion compound material is not required to be carried out manually.

In an alternative embodiment of the present application, the first included material processing device comprises a feeding device and a refining device;

the refining device is used for processing the first inclusion material supplied by the feeding device to the preset size, and the feeding device is used for controlling the speed of supplying the first inclusion material to the refining device.

The feeding device can conveniently adjust the feeding speed of the included material according to the liquid inlet speed of the first inclusion material liquid in the first mixing device, and the feeding device does not need manual feeding according to experience, so that the preparation precision of the first inclusion compound is improved.

In an alternative embodiment of the present application, the clathrate processing system includes a second clathrate processing apparatus, a second included material processing apparatus, a second mixing apparatus, and a second clathrate processing apparatus;

the second inclusion material processing device is used for preparing a second inclusion material liquid and conveying the second inclusion material liquid to the second mixing device, and the second inclusion material processing device is used for finely grinding a second inclusion material and conveying the processed second inclusion material to the second mixing device;

the second mixing device is used for mixing a second inclusion material liquid with a second processed inclusion material and conveying a second inclusion compound formed after mixing to the second inclusion compound processing device, the second inclusion compound processing device is used for separating the second inclusion compound into a second waste liquid and a second dry inclusion compound, and the second dry inclusion compound is supplied to the inclusion compound dissolving device.

In an alternative embodiment of the present application, the clathrate processing system includes a clathrate processing apparatus for separating one or more clathrates into a waste stream and a dry material, and capable of providing the dry material to the clathrate dissolution apparatus.

The inclusion compound processing device can provide a solid-liquid separation function for different inclusion compounds, and unnecessary site occupation is reduced.

In an optional embodiment of the present application, the extract processing system further comprises a first flow meter, wherein the first flow meter is used for metering outflow of the first extract supernatant and the second extract supernatant;

the inclusion compound processing system includes an inclusion material processing device for mixing an inclusion material with a base liquid into an inclusion material liquid, and the inclusion material processing device includes a second flow meter for measuring a doping amount of the base liquid.

The flowmeter can be used for conveniently and accurately controlling the flow, and the accuracy of preparing various mixed liquids is improved.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained from the drawings without inventive effort.

Fig. 1 is a schematic diagram of an extract clathrate mixing system provided in an embodiment of the present application;

FIG. 2 is a schematic diagram of an extract clathrate compound mixing and metering system;

FIG. 3 is a schematic view of a metering device of the extract clathrate compound mixing and metering system;

FIG. 4 is a schematic diagram of an extract processing system;

FIG. 5 is a schematic diagram of a clathrate processing system;

FIG. 6 is a schematic diagram of a portion of a clathrate processing system making a first dry inclusion compound;

FIG. 7 is a schematic diagram of a portion of a clathrate processing system making a second dry material clathrate;

FIG. 8 is a process flow chart of the mixing of the inclusion compound of the extract.

Icon: 1000-extract clathrate compound mixing system; 100-extract processing system; 101-a first flow meter; 103-extract processing device; 200-a clathrate processing system; 201-a second flow meter; 211-first wrapping material handling means; 212-first enclosed material handling apparatus; 2121-a feeding device; 2122-refining device; 213-a first mixing device; 214-a first inclusion handling device; 221-a second packaging material handling device; 222-a second enclosed material handling apparatus; 223-a second mixing device; 224-a second inclusion compound treatment device; 300-extract inclusion compound mixing and metering system; 310-an inclusion compound formation device; 311-a first stirred tank; 312-a crusher; 313-auxiliary hoist; 320-stirring and mixing device; 321-a second stirring tank; 322-a weighing device; 330-a metering device; 331-a third agitator tank; 332-electronic scale; 340-a supernatant temporary storage device; 1001-diaphragm pump; 1002-pneumatic diaphragm pump; 1003-extract barrel; 1004-extract container; 1005-centrifugal pump; 1006-a purified water pipe; 1007-a feeding machine; 1008-hand held suction device; 1009-material bag; 1010-low liquid level detection; 1011-hopper; 2000-wet granulator.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments. The components of the embodiments of the present application, generally described and illustrated in the figures herein, can be arranged and designed in a wide variety of different configurations.

Thus, the following detailed description of the embodiments of the present application, presented in the accompanying drawings, is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, it need not be further defined and explained in subsequent figures.

In the description of the present application, it should be noted that the terms "inside", "outside", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings or orientations or positional relationships that the product conventionally places when used, and are only used for convenience of description and simplification of description, but do not indicate or imply that the device or element to which the reference is made must have a specific orientation, be constructed in a specific orientation, and be operated, and thus should not be construed as limiting the present application. Furthermore, the terms "first," "second," and the like are used merely to distinguish one description from another, and are not to be construed as indicating or implying relative importance.

In the description of the present application, it is also to be noted that, unless otherwise explicitly specified or limited, the terms "disposed" and "connected" are to be interpreted broadly, e.g., as being either fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.

Examples

Referring to fig. 1, an embodiment of the present application provides an extract clathrate mixing system 1000, including: an extract processing system 100, an inclusion compound processing system 200 and an extract inclusion compound mixing and metering system 300. It should be noted that the extract processing system 100, the inclusion compound processing system 200, and the extract inclusion compound mixing and metering system 300 are placed in the same floor in an actual site, fig. 1 shows the extract inclusion compound mixing system 1000 as a whole, but the inclusion compound processing system 200 is placed in different upper and lower positions, which cannot be understood as requiring layered placement of the systems, and a producer can perform facility planning according to the site and equipment conditions of the producer.

Referring to fig. 2, the system 300 for mixing and metering inclusion compound of extractum includes an inclusion compound dissolving device 310, a stirring and mixing device 320, a metering device 330 and a supernatant temporary storage device 340.

Referring to fig. 4, the extract processing system 100 is configured to separate the extract into extract supernatant, supply the first extract supernatant to the clathrate dissolving device 310, and supply the second extract supernatant to the stirring and mixing device 320.

Referring to fig. 5, the clathrate processing system 200 is configured to produce clathrate dry materials and provide the clathrate compound dry materials to the clathrate melting apparatus 310.

The clathrate compound dissolving device 310 mixes the first part of extract supernatant with the dry material of the clathrate compound to form the extract clathrate compound and supplies the extract clathrate compound to the stirring and mixing device 320, the stirring and mixing device 320 is used for mixing the extract clathrate compound with the second part of extract supernatant to form extract mixed liquid and outputting the extract mixed liquid to the metering device 330, and the metering device 330 is used for weighing the target amount of the extract mixed liquid.

It should be noted that, the first extract supernatant and the second extract supernatant are only described for distinction, and do not mean that the first extract supernatant and the second extract supernatant are only divided into two parts, but the extract supernatants may be distributed according to a specific formula proportion, and here, the extract supernatant to be mixed with the inclusion compound dry material is referred to as the first extract supernatant, and the extract supernatant to be mixed with the inclusion compound is referred to as the second extract supernatant.

In a simple aspect, the mutual cooperation of the extract processing system 100, the inclusion compound processing system 200 and the extract inclusion compound mixing and metering system 300 can eliminate most of manual labor, not only reduce the labor intensity of workers, but also avoid the influence of errors caused by manual operation on the proportioning precision by means of the automatic cooperation of the systems.

In order to improve the accuracy, the embodiment further configures a flow meter, so that, referring to fig. 2, the extract processing system 100 further includes a first flow meter 101, where the first flow meter 101 is configured to measure outflow amounts of a first extract supernatant and a second extract supernatant;

referring to FIGS. 6 and 7, the clathrate processing system 200 includes a clathrate material processing apparatus for mixing a clathrate material with a base liquid into a clathrate material liquid, and the clathrate material processing apparatus includes a second flow meter 201 for metering the amount of the base liquid (in this embodiment, purified water) to be mixed. Simply, the flowmeter can be convenient for accurate control flow, improves the precision of preparing all kinds of mixed liquid.

Specifically, referring to fig. 2, the clathrate compound dissolving device 310 of this embodiment includes a first stirring tank 311, a crusher 312, and an auxiliary elevator 313, where the auxiliary elevator 313 is configured to deliver the clathrate compound dry material bag 1009 provided by the clathrate compound processing system 200 to the crusher 312, the crusher 312 is configured to crush the clathrate compound dry material bag 1009 and enable the clathrate compound dry material in the bag to enter the first stirring tank 311, and the first stirring tank 311 is configured to mix the clathrate compound dry material and the first extract supernatant into the extract clathrate compound.

Supplementary lifting machine 313 can transmit the inclusion compound drier packed for breaker 312 to by breaker 312 with the broken and release material of bag body, need not rely on the manual work to rip the bag body, and need not the manual stirring. Generally speaking, the prepared clathrate compound dry materials need to be packed and then conveyed to the clathrate compound dissolving device 310, so that on one hand, the temporary storage and the flow of the materials are facilitated, on the other hand, the materials are also conveniently supplied according to the amount, the amount of the clathrate compound dry materials added into the first stirring tank 311 is easier to control, and the precision in preparing the extract clathrate compound is improved. Of course, if intermediate storage equipment and conveying equipment can be added to the dry clathrate compound produced by the clathrate compound processing system 200 and the dry clathrate compound can be conveyed in a certain amount, it is considered that the crusher 312 and the auxiliary elevator 313 are not used, and the selection is specifically performed according to the actual situation of the producer.

Referring to fig. 4, in particular, the extract processing system 100 of this embodiment includes an extract feeding device (both the extract barrel 1003 and the extract container 1004 in fig. 4 may be used as an extract feeding device) and an extract processing device 103, where the extract feeding device is configured to convey the extract to the extract processing device 103, the extract processing device 103 is configured to separate the extract into extract residue and extract supernatant, the extract processing device 103 is configured to convey a portion of the extract supernatant to the inclusion compound dissolving device 310 as a first extract supernatant, and convey another portion of the extract supernatant to the supernatant temporary storage device 340 as a second extract supernatant, and the supernatant temporary storage device 340 is configured to supply the second extract supernatant to the stirring and mixing device 320.

It should be noted that the supernatant buffer 340 used in this embodiment is also a stirring tank.

The extract processing device 103 can effectively separate the extract into extract residue and extract supernatant, and then can temporarily store a part of the extract supernatant through the supernatant temporary storage device 340, so as to facilitate the subsequent preparation of the extract mixed liquid. Another part of the extract supernatant can be directly provided to the clathrate dissolving device 310, and can also be used for preparing the extract mixed liquor.

Referring to fig. 2, the stirring and mixing device 320 includes a second stirring tank 321 and a weighing device 322, the second stirring tank 321 is used for mixing the extract clathrate with a second extract supernatant to form an extract mixed liquid and can output the extract mixed liquid outwards, and the weighing device 322 is disposed below the second stirring tank 321 to weigh the mass of the second stirring tank 321 and the content. The content is a substance contained in the second stirring tank 321, and since the extract inclusion compound and the extract supernatant exist in a certain proportion before all the materials are mixed into the extract mixed liquid, the content is generally referred to as the content for convenience of description. Of course, there are many stirring tanks used in this embodiment, and the substances in other stirring tanks may also be simply referred to as contents, which will not be described in detail below.

The weighing device 322 can obtain the mass of the second stirring tank 321 and the content, so as to determine whether to reconstitute the extract mixture according to the amount of the content.

Referring to fig. 3, the system 300 further includes a metering device 330, the metering device 330 includes a third stirring tank 331 and an electronic scale 332, the third stirring tank 331 is used for storing the extract mixture, and the electronic scale 332 is used for weighing the third stirring tank 331 and the extract mixture and weighing the extract mixture of a target amount. The third mixing tank 331 can contain the required extract mixture, and the target amount is determined by the weighing of the electronic scale 332, and then the extract mixture can be provided to other station equipment for subsequent operation.

It should be noted that the extract clathrate mixing and metering system 300 includes many components, and the metering device 330 is shown separately for convenience of illustration. In addition, the electronic scale 332 may be directly disposed below the third agitator tank 331, or as shown in fig. 3, the extract mixture is collected on the left side, and then the extract mixture is manually pushed onto the electronic scale 332 for weighing, so that there are few steps requiring manual intervention, and an AGV cart may be disposed below the third agitator tank 331 to automatically pull the extract mixture onto the electronic scale 332.

Alternatively, the third stirring tank 331 can be used for weighing in the explosion-proof area as shown in fig. 3, or can be directly pumped into the measuring hopper of the wet-process material preparing machine through the diaphragm pump 1001, or can be used for weighing and then delivering to the station where the wet-process material preparing machine is located for preparing the material.

With regard to the clathrate processing system 200, specifically:

referring to fig. 5 and 6, the clathrate processing system 200 includes a first inclusion material processing apparatus 211, a first inclusion material processing apparatus 212, a first mixing apparatus 213, and a first inclusion material processing apparatus 214;

the first inclusion material processing device 211 is used for preparing a first inclusion material liquid and can convey the first inclusion material liquid to the first mixing device 213, and the first included material processing device 212 is used for refining the first included material and can convey the processed first included material to the first mixing device 213;

the first mixing device 213 is for mixing the first inclusion material liquid with the treated first inclusion material and is capable of conveying the mixed first inclusion compound to the first inclusion compound treatment device 214, and the first inclusion compound treatment device 214 is for separating the first inclusion compound into a first waste liquid and a first dry inclusion compound, which is supplied to the inclusion compound formation device 310.

The inclusion material and the inclusion material of the inclusion compound can be automatically processed and mixed and then processed by the first inclusion compound processing device 214 into the dry first inclusion compound without manually preparing the dry first inclusion compound.

The first enclosed material handling device 212 includes a feeding device 2121 and a refining device 2122;

the refining device 2122 is used to process the first included material supplied by the feeding device 2121 to a size that meets a predetermined requirement, and the feeding device 2121 is used to control the speed at which the first included material is supplied to the refining device 2122.

The feeding device 2121 can conveniently adjust the feeding speed of the included material according to the liquid inlet speed of the first inclusion material liquid in the first mixing device 213, and the feeding is performed by experience without manpower, so that the preparation precision of the first inclusion compound is improved.

In the present embodiment, the first inclusion compound is a menthol inclusion compound, the first inclusion material used is beta-dextrin, and the first inclusion material is menthol. In detail, this embodiment employs a colloid mill as the refining device 2122 for refining the inclusion material such as menthol, and hereinafter, the volatile oil and ethanol are also refined by the colloid mill (the second inclusion material processing device 222 in fig. 7), and during the addition to the colloid mill, flow control is also employed to match the liquid inlet speed of the inclusion material liquid. It is understood that the colloid mill is selected for the included material used in the embodiment, if the included material of the inclusion compound is changed, a device such as a crusher can be selected as the refining device, and a person skilled in the art can select different devices according to the material, perform different treatments, such as changing the number of times of grinding or crushing, etc.

Referring to fig. 7, the clathrate processing system 200 includes a second wrapping material processing apparatus 221, a second inclusion material processing apparatus 222, a second mixing apparatus 223, and a second inclusion material processing apparatus 224;

the second wrapping material processing device 221 is configured to prepare a second wrapping material liquid and to be capable of delivering the second wrapping material liquid to the second mixing device 223, and the second inclusion material processing device 222 is configured to grind a second inclusion material and to be capable of delivering the processed second inclusion material to the second mixing device 223;

the second mixing device 223 is used to mix the second inclusion material liquid with the treated second inclusion material and is capable of conveying the second inclusion compound formed after mixing to the second inclusion compound treatment device 224, the second inclusion compound treatment device 224 is used to separate the second inclusion compound into a second waste liquid and a second dry inclusion compound material, and the second dry inclusion compound material is supplied to the inclusion compound formation device 310.

The second inclusion compound in the embodiment is a volatile oil inclusion compound, the first inclusion material is beta dextrin, and the second inclusion material is volatile oil and ethanol.

While the inclusion compound treatment devices (214/224 in fig. 5 and 6) are used for different inclusion compounds, alternatively, corresponding treatment devices can be configured for different inclusion compounds, and as in the present embodiment, one inclusion compound treatment device can be used to serve different inclusion compounds together, i.e., the inclusion compound treatment device can be used to separate one or more inclusion compounds into waste liquid and dry material, and can provide the dry material to the inclusion compound dissolution device 310. The common inclusion compound treatment device can provide a solid-liquid separation function for different inclusion compounds, and unnecessary site occupation is reduced. The clathrate compound processing device can be a centrifuge, or other equipment capable of realizing solid-liquid separation, such as a screening machine.

It is understood that the present embodiment mainly exemplifies two kinds of clathrates according to the recipe, when the recipe is different, there may be more or less clathrates, and the kinds of clathrates may be different, and the corresponding inclusion material processing device, mixing device, clathrate processing device, and the like may be selected accordingly to form the adapted clathrate processing system 200. This embodiment is by way of example only and should not be construed as limiting.

In addition, the production of various inclusion compounds is automated, the inclusion compounds can be processed simultaneously, the aim of improving efficiency can be achieved without simply increasing human hands, and the labor intensity of workers is reduced to a certain extent.

The principle of the embodiment is as follows:

based on the mixing system 1000 of the embodiment, a person skilled in the art can prepare the extract mixed liquid formed by mixing the extractum and the inclusion compound according to the process flow chart of the extractum and inclusion compound mixing shown in fig. 8.

In fig. 8, the liquid material is mainly conveyed by means of a pneumatic diaphragm pump 1002, and a series of valves are configured on a conveying pipeline so that pipelines at different positions can be switched on and off according to different processes, and the valves can be arranged by those in the art according to conditions, which is not described herein again. The solid-liquid separation of the liquid material is carried out by a centrifuge. In addition, it should be noted that, in fig. 8, the stirring tanks are numbered to facilitate understanding of the flow, and the corresponding relationships between the corresponding stirring tanks and the devices in the system in this embodiment are as follows: the stirring tank A corresponds to the first stirring tank 311, the stirring tank B corresponds to the supernatant temporary storage device 340, the stirring and mixing tank C corresponds to the first composite material processing device 211, the stirring and mixing tank D corresponds to the first mixing device 213, the stirring and mixing tank E corresponds to the second composite material processing device 221, the stirring and mixing tank F corresponds to the second mixing device 223, the stirring tank G corresponds to the second stirring tank 321, and the stirring tank H corresponds to the third stirring tank 331. In addition, each stirring tank can be used for stirring the contents in a pneumatic stirring mode, and the low liquid level detection 1010 can be arranged on each stirring tank to determine whether the amount of the contents is insufficient.

Referring to fig. 4, firstly, the extract can be sucked from the extract barrel 1003 or the extract container 1004 through the pneumatic diaphragm pump 1002 and is delivered to the extract processing device 103 (centrifuge), then the extract supernatant is pumped through the centrifugal pump 1005, and during pumping, the first flowmeter 101 determines whether the pumped amount meets the requirement. One third of the extract supernatant is conveyed to a stirring liquid tank A, and two thirds of the extract supernatant is conveyed to a stirring tank B.

Referring to fig. 5 and 6, at the same time, the beta-dextrin is delivered from the material bag 1009 to the agitation mixing tank C through the feeding machine 1007 or the hand-held suction device 1008, and the purified water pipe 1006 is added into the agitation mixing tank C according to the formulation ratio under the cooperation of the second flow meter 201, and the mixing is started after the target value is reached, and then the mixing is stopped after the predetermined time. The menthol can be poured into a feeding device 2121 manually or mechanically for vibration feeding, the menthol is processed by a colloid mill and then is conveyed into a stirring and mixing tank D, the solution of the menthol and beta dextrin is primarily mixed in the stirring tank D and then is circulated to the colloid mill, the solution is circularly ground to reach the formula requirement, the solution is conveyed to a centrifugal machine under the pumping of a pneumatic diaphragm pump 1002, and after solid-liquid separation, the inclusion compound dry material left in the centrifugal machine is packed. The preparation of the menthol inclusion compound dry material is aimed at.

Referring to fig. 5 and 7, at the same time, beta-dextrin may be manually added into the agitator mixing tank E, and purified water is also added into the agitator mixing tank E according to the formula ratio by using the purified water pipe 1006 in cooperation with the second flowmeter 201. The volatile oil and the ethanol are manually poured into a hopper 1011, and are sent into a colloid mill by the hopper 1011 under the condition of controlling the flow rate, then are primarily mixed with the solution of the beta dextrin and are circulated into the colloid mill for grinding, when the grinding meets the requirement, the mixture is sent into a centrifuge by a pneumatic diaphragm pump 1002, and after solid-liquid separation, the dry inclusion compound materials remained in the centrifuge are packed. The preparation of the volatile oil inclusion compound dry material is aimed at.

Certainly, the solid-liquid separation can be simultaneously carried out on the two clathrates in the centrifugal machine to form mixed dry materials, when materials are pumped into the centrifugal machine, the formula proportion needs to be paid attention to obtain a clathrate dry material mixture with a satisfactory proportion, and then the mixture is uniformly packaged.

Referring to fig. 2, the auxiliary elevator 313 may lift the packed dry inclusion compound material above the crusher 312, and the crusher 312 breaks the bag body, so that the dry inclusion compound material falls into the stirring tank a, the stirring tank a mixes the dry inclusion compound material with the supernatant fluid of the extract to form the extract inclusion compound in the embodiment, the extract inclusion compound is pumped into the stirring tank G, and the supernatant fluid of the extract for standby in the stirring tank B also enters the stirring tank G to mix the supernatant fluid of the extract with the extract inclusion compound, so as to obtain the extract mixed liquid in the embodiment.

At this time, the extract mixed liquor is a product obtained by sufficiently mixing the extract supernatant with the clathrate dry material according to the formula proportion, and the extract mixed liquor can be pumped into a stirring tank H by a pneumatic diaphragm pump 1002 shown in fig. 3, and a plurality of stirring tanks H can be arranged to receive the extract mixed liquor. The drum H can then be moved to the explosion-proof area of the granulation chamber, weighed on an electronic scale 332, and the target volume of drum H pumped through a diaphragm pump 1001 to a wet granulator 2000 (shown in fig. 1 and 3) to begin the subsequent granulation operation.

From the above processes, by using the extract clathrate mixing system 1000 of this embodiment, in each flow of preparing the extract mixed liquid, the content of manual participation is very little, and multiple clathrates can be processed simultaneously during the automatic production of clathrates, so that compared with the existing manual preparation mode of this section of process, the labor intensity of labor is greatly reduced, and the efficiency is significantly improved. And the flow and the weight related to each flow can be controlled, the randomness of manual weighing is replaced, the proportion of each component of the finally obtained extract mixed liquid meets the formula requirement, the pharmaceutical effective components are reserved to a greater degree by improving the precision, and the effect of improving the quality of the final medicine can be achieved.

To sum up, the cooperation of extract inclusion compound mixing system 1000 of this application through extract processing system 100, inclusion compound processing system 200 and extract inclusion compound mixing measurement system 300 compares in the manual operation of present section technology now, has effectively improved production efficiency, has reduced artifical intensity of labour, and has improved the precision.

The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims (10)

1. An extract clathrate mixing system is characterized by comprising: an extract processing system, an inclusion compound processing system and an extract inclusion compound mixing and metering system;

the mixing and metering system for the extractum inclusion compound comprises an inclusion compound dissolving device, a supernatant temporary storage device, a stirring and mixing device and a metering device;

the extract processing system is used for separating extract supernatant from the extract, supplying the first extract supernatant to the clathrate compound dissolving device, and supplying the second extract supernatant to the supernatant temporary storage device;

the clathrate compound processing system is used for making clathrate compound dry materials and providing the clathrate compound dry materials to the clathrate compound dissolving device;

the clathrate compound dissolving device is used for mixing the first part of extract supernatant with the clathrate compound dry material to form an extract clathrate compound and supplying the extract clathrate compound to the stirring and mixing device, the supernatant temporary storage device is used for supplying the second part of extract supernatant to the stirring and mixing device, the stirring and mixing device is used for mixing the extract clathrate compound with the second part of extract supernatant to form an extract mixed solution and outputting the extract mixed solution to the metering device, and the metering device is used for weighing the target amount of the extract mixed solution.

2. The extractum clathrate mixing system of claim 1, wherein the clathrate compound dissolving device comprises a first agitator tank, a crusher, and an auxiliary hoist, the auxiliary hoist is configured to deliver the clathrate dry material bag provided by the clathrate processing system to the crusher, the crusher is configured to crush the clathrate dry material bag and cause the clathrate dry material in the bag to enter the first agitator tank, and the first agitator tank is configured to mix the clathrate dry material with the first portion of extractum supernatant into extractum clathrate compound.

3. The extractum clathrate mixing system of claim 1, wherein the extractum processing system comprises an extractum feeding device and an extractum processing device, the extractum feeding device is used for conveying extractum to the extractum processing device, the extractum processing device is used for separating extractum into extractum residue and extractum supernatant, the extractum processing device can convey one part of extractum supernatant to the clathrate dissolving device as the first part of extractum supernatant, and convey the other part of extractum supernatant to the supernatant temporary storage device as the second part of extractum supernatant.

4. The extractum clathrate mixing system of claim 1, wherein the stirring and mixing device comprises a second stirring tank and a weighing device, the second stirring tank is used for mixing the extractum clathrate and the second part of extractum supernatant to form an extractum mixed liquid and can output the extractum mixed liquid outwards, and the weighing device is arranged below the second stirring tank to weigh the mass of the second stirring tank and the content.

5. The extractum clathrate mixing system of claim 1, wherein the metering device comprises a third stirring tank and an electronic scale, the third stirring tank is used for storing the extractum mixed liquid, and the electronic scale is used for weighing the third stirring tank and the extractum mixed liquid and weighing out a target amount of extractum mixed liquid.

6. The extractum clathrate mixing system according to claim 1, wherein the clathrate processing system comprises a first inclusion material processing device, a first mixing device and a first inclusion material processing device;

the first inclusion material processing device is used for preparing a first inclusion material liquid and conveying the first inclusion material liquid to the first mixing device, and the first inclusion material processing device is used for finely grinding a first inclusion material and conveying the processed first inclusion material to the first mixing device;

the first mixing device is used for mixing a first inclusion material liquid and a treated first inclusion material and conveying a first inclusion compound formed after mixing to the first inclusion compound treatment device, the first inclusion compound treatment device is used for separating the first inclusion compound into a first waste liquid and a first dry inclusion compound, and the first dry inclusion compound is supplied to the inclusion compound decomposition device.

7. The inclusion compound mixing system of claim 6, wherein the first inclusion material treatment device comprises a feeding device and a refining device;

the refining device is used for processing the first inclusion material supplied by the feeding device to the preset size, and the feeding device is used for controlling the speed of supplying the first inclusion material to the refining device.

8. The inclusion compound mixing system of claim 1, wherein the inclusion compound processing system comprises a second inclusion material processing device, a second included material processing device, a second mixing device, and a second inclusion compound processing device;

the second inclusion material processing device is used for preparing a second inclusion material liquid and conveying the second inclusion material liquid to the second mixing device, and the second inclusion material processing device is used for finely grinding a second inclusion material and conveying the processed second inclusion material to the second mixing device;

the second mixing device is used for mixing a second inclusion material liquid with a second processed inclusion material and conveying a second inclusion compound formed after mixing to the second inclusion compound processing device, the second inclusion compound processing device is used for separating the second inclusion compound into a second waste liquid and a second dry inclusion compound, and the second dry inclusion compound is supplied to the inclusion compound dissolving device.

9. The inclusion compound mixing system of claim 1, wherein the inclusion compound treatment system comprises an inclusion compound treatment device for separating one or more inclusion compounds into a waste liquid and a dry material, and capable of providing the dry material to the inclusion compound dissolution device.

10. The extractum clathrate mixing system of claim 1, wherein the extractum processing system further comprises a first flow meter for metering the outflow of the first portion of extractum supernatant and the second portion of extractum supernatant;

the inclusion compound processing system includes an inclusion material processing device for mixing an inclusion material with a base liquid into an inclusion material liquid, and the inclusion material processing device includes a second flow meter for measuring a doping amount of the base liquid.

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