CN214764831U

CN214764831U - A join in marriage liquid device for production of carfilzomib

Info

Publication number: CN214764831U
Application number: CN202120748141.7U
Authority: CN
Inventors: 赵龙
Original assignee: Wuxi Junhua Engineering Technology Co ltd
Current assignee: Wuxi Junhua Engineering Technology Co ltd
Priority date: 2021-04-13
Filing date: 2021-04-13
Publication date: 2021-11-19
Anticipated expiration: 2031-04-13

Abstract

The utility model discloses a join in marriage liquid device for production of ka feizomi relates to pharmaceutical production technical field. The utility model comprises a stirring tank, wherein a feeding pipe is arranged on one side of the top surface of the stirring tank, a discharging pipe is arranged on one side of the bottom surface of the stirring tank, a first electromagnetic valve is fixedly arranged on the discharging pipe, the stirring device also comprises a first stirring mechanism and a second stirring mechanism, the first stirring mechanism and the second stirring mechanism are movably matched on the stirring tank, and the first stirring mechanism is coaxially arranged on the outer side of the second stirring mechanism; the first stirring mechanism comprises a first stirring shaft and a first stirring blade, and the first stirring shaft is coaxially arranged in the stirring tank. The utility model discloses a setting up of first rabbling mechanism and second rabbling mechanism can realize the stirring and the shearing of raw materials, makes the mixture more even, through the setting of water bath, heating cabinet and refrigeration case, deuterogamies with conveyer pipe and coiled pipe, can realize the quick adjustment of temperature, improves production effect.

Description

A join in marriage liquid device for production of carfilzomib

Technical Field

The utility model belongs to the technical field of pharmaceutical production, especially, relate to a join in marriage liquid device for production of ka feizmi.

Background

Carfilzomib is a proteasome inhibitor and is suitable for treating patients with multiple myeloma, in the preparation process of the carfilzomib, workers can install various raw materials in a certain proportion, sequence and temperature into a liquid preparation device, stir and filter the raw materials to obtain the carfilzomib, and the existing liquid preparation device has the following defects in the liquid preparation process of the carfilzomib:

1. the existing liquid preparation device is used for simply stirring the raw materials through the stirring mechanism after adding various raw materials, so that the whole raw materials are not uniformly mixed, and the production quality of the Carfilzomib is greatly influenced;

2. when the conventional liquid preparation device is used for preparing carfilzomib, the temperature of the liquid preparation device needs to be continuously adjusted to be suitable for mixing different raw materials, but the conventional liquid preparation device is heated mainly by a heating device in a tank wall, so that the heating temperature is inconvenient to control, the heating time is long, and the overall production efficiency is influenced;

therefore, there is a need for improvement of the prior art to solve the above technical problems.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a misce bene, the convenient and high liquid device of joining in marriage that is used for production of non-zumi of card that mixing is thorough, temperature control have solved current liquid device of joining in marriage and have mixed inhomogeneous, the inconvenient control of temperature and the low problem of production efficiency when dispensing to non-zumi of card.

In order to solve the technical problem, the utility model discloses a realize through following technical scheme:

the utility model relates to a liquid preparation device for production of carfilzomib, which comprises an agitator tank, wherein one side of the top surface of the agitator tank is provided with a feeding pipe, one side of the bottom surface of the agitator tank is provided with a discharging pipe, a first electromagnetic valve is fixedly arranged on the discharging pipe, and the liquid preparation device also comprises a first agitating mechanism and a second agitating mechanism, wherein the first agitating mechanism and the second agitating mechanism are movably matched on the agitator tank, and the first agitating mechanism is coaxially arranged outside the second agitating mechanism;

the first stirring mechanism comprises a first stirring shaft and first stirring blades, the first stirring shaft is coaxially arranged in the stirring tank, and a plurality of first stirring blades are arranged on two symmetrical side surfaces of the first stirring shaft in parallel along the vertical direction;

two connecting rods in the second stirring mechanism are symmetrically arranged at two sides of the first stirring shaft, and a plurality of second stirring blades are arranged on one side surface of each connecting rod close to the first stirring shaft in parallel along the vertical direction;

the first stirring blades and the second stirring blades on the same side of the first stirring shaft are arranged alternately.

Further, the both ends of first (mixing) shaft all rotate through antifriction bearing and connect on the agitator tank, and the lower extreme of first (mixing) shaft extends to the below gomphosis of agitator tank in the output of first motor, first motor fixed connection is on the bottom surface of agitator tank.

Furthermore, the upper and lower ends of the two connecting rods are respectively fixedly connected to the same connecting ring, and the top surface of the connecting ring above the connecting rods is fixedly connected with the bottom surface of the sealing ring plate through a plurality of fixing columns uniformly distributed along the circumferential direction;

the top surface of the sealing ring plate is symmetrically connected with linkage columns, and the upper ends of the two linkage columns are respectively and fixedly connected to the bottom surface of the same linkage plate;

the middle part of linkage board is fixed to have cup jointed the second (mixing) shaft, the one end of second (mixing) shaft is rotated and is connected on the top surface of agitator tank, and the other end gomphosis of second (mixing) shaft is in the output of second motor simultaneously, the second motor passes through U-shaped frame fixed connection on the agitator tank top surface in the sealed crown plate outside.

Furthermore, a fixing ring is concentrically arranged on the inner side of the connecting ring, and the fixing ring is connected with the connecting ring through a plurality of fixing rods which are uniformly distributed along the circumferential direction; the fixed ring is sleeved on the first stirring shaft in a sliding manner, and the first stirring shaft above and below the fixed ring is fixedly sleeved with a limiting ring.

Further, the sealing ring plate is in clearance fit with a top plate of the stirring tank, positioning rings are arranged on the inner side wall and the outer side wall of the sealing ring plate, and the positioning rings are in clearance fit with positioning grooves in the top plate of the stirring tank.

Further, still fixed mounting has the controller on the lateral wall of agitator tank, the controller passes through the conducting wire respectively with first solenoid valve, first motor and second motor electric connection.

The water bath box is internally provided with a coiled pipe which is connected in series on a conveying pipe, and two ends of the conveying pipe are respectively communicated with and arranged at the upper end position and the lower end position of the stirring tank; a first water pump is fixedly arranged on the conveying pipe, and a first temperature sensor is fixedly arranged on the inner bottom surface of the water bath box;

a first water delivery pipe is communicated between the lower end of the heating box and the water bath box, and a second water delivery pipe is communicated between the upper end of the heating box and the water bath box; a second water pump is fixedly arranged on the first water delivery pipe, and a second electromagnetic valve is fixedly arranged on the second water delivery pipe;

a third water delivery pipe is communicated between the lower end of the refrigeration box and the water bath box, and a fourth water delivery pipe is communicated between the upper end of the refrigeration box and the water bath box; and a third water pump is fixedly arranged on the third water delivery pipe, and a third electromagnetic valve is fixedly arranged on the fourth water delivery pipe.

Furthermore, an electric heating ring is installed inside the heating box, and a second temperature sensor is fixedly installed on the inner bottom surface of the heating box.

Furthermore, a semiconductor refrigerating sheet is installed inside the refrigerating box, and a third temperature sensor is fixedly installed on the inner bottom surface of the refrigerating box.

Further, the controller is respectively electrically connected with the first water pump, the second water pump, the third water pump, the first temperature sensor, the second electromagnetic valve, the third electromagnetic valve, the electric heating ring, the second temperature sensor, the semiconductor refrigeration piece and the third temperature sensor through conducting wires.

The utility model discloses following beneficial effect has:

1. the utility model discloses when using, first motor and second motor simultaneous working, it rotates to drive first (mixing) shaft and the opposite direction of second stirring axial, under first (mixing) shaft pivoted effect, can drive first stirring leaf and rotate the raw materials stirring in the agitator tank, under second (mixing) shaft pivoted effect, through the linkage board, the linkage post, under the linkage of seal ring board and connecting rod, can realize that second stirring leaf rotates the raw materials stirring in the agitator tank, because first (mixing) shaft and second (mixing) shaft antiport's setting, when stirring the raw materials, can produce a shearing force between the raw materials, thereby make the raw materials mix more evenly, improve the quality of the non-rice with rice production of card.

2. The utility model discloses a setting of conveyer pipe, under the effect of first water pump, can realize the circulation of raw materials in the agitator tank, after the raw materials gets into the coiled pipe, water in the water bath can carry out the heat exchange to the raw materials that flow through, cooperation through between heating cabinet and the water bath can be in advance with temperature heating to preset position, cooperation through between refrigeration case and the water bath can be in advance with temperature reduction to preset position, among the above-mentioned setting, can realize the quick adjustment of temperature to the efficiency that the raw materials mixes has been improved.

Of course, it is not necessary for any particular product to achieve all of the above-described advantages at the same time.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic structural view of the present invention;

FIG. 2 is a right side view of the structure of FIG. 1 in accordance with the present invention;

figure 3 is a vertical cross-sectional view of the structure of figure 1 of the present invention;

fig. 4 is a schematic structural view of a second stirring mechanism in the present invention;

fig. 5 is a bottom view of the structure of fig. 4 according to the present invention;

fig. 6 is a schematic structural view of a first stirring mechanism in the present invention;

fig. 7 is an enlarged view of a portion a in fig. 3 according to the present invention.

In the drawings, the components represented by the respective reference numerals are listed below:

1. a stirring tank; 2. a controller; 3. a delivery pipe; 4. a water bath tank; 5. a second stirring mechanism; 6. a first stirring mechanism; 7. a heating box; 8. a refrigeration case; 101. a feed pipe; 102. a U-shaped frame; 103. a discharge pipe; 104. positioning a groove; 301. a first water pump; 401. a serpentine tube; 402. a first temperature sensor; 501. a second stirring shaft; 502. a connecting rod; 503. a connecting ring; 504. a seal ring plate; 601. a first stirring shaft; 602. a first stirring blade; 603. a limiting ring; 604. a first motor; 701. a second water delivery pipe; 702. a first water delivery pipe; 801. a fourth water delivery pipe; 802. a third water delivery pipe; 1031. a first solenoid valve; 5011. a second motor; 5012. a linkage plate; 5013. a linkage column; 5021. a second stirring blade; 5031. fixing the rod; 5032. a fixing ring; 5041. a positioning ring; 5042. fixing a column; 7011. a second solenoid valve; 7021. a second water pump; 8011. a third electromagnetic valve; 8021. and a third water pump.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

Referring to fig. 1, the utility model relates to a liquid preparation device for production of carfilzomib, which comprises a stirring tank 1, wherein a feeding pipe 101 is arranged on one side of the top surface of the stirring tank 1, a discharging pipe 103 is arranged on one side of the bottom surface of the stirring tank 1, a first electromagnetic valve 1031 is fixedly arranged on the discharging pipe 103, the first electromagnetic valve 1031 is used for controlling the on-off of the discharging pipe 103, the liquid preparation device further comprises a first stirring mechanism 6 and a second stirring mechanism 5, the first stirring mechanism 6 and the second stirring mechanism 5 are movably matched on the stirring tank 1, and the first stirring mechanism 6 is coaxially arranged outside the second stirring mechanism 5;

when the device is used, the feeding pipe 101 is used for feeding raw materials, the discharging pipe 103 is used for discharging finished products from the stirring tank 1, the first stirring mechanism 6 and the second stirring mechanism 5 are matched to realize stirring and shearing of the raw materials, in actual use, the free end of the discharging pipe 103 is also matched with a 0.45-micrometer PVDF filtering device for the process of the finished products, and the finished products after the process are transferred to a liquid storage tank for storage.

As shown in fig. 3 to 7, the first stirring mechanism 6 includes a first stirring shaft 601 and a first stirring blade 602, the first stirring shaft 601 is coaxially disposed inside the stirring tank 1, and a plurality of first stirring blades 602 are disposed on two symmetric sides of the first stirring shaft 601 in parallel along the vertical direction;

the two ends of the first stirring shaft 601 are rotatably connected to the stirring tank 1 through rolling bearings, the lower end of the first stirring shaft 601 extends to the lower part of the stirring tank 1 and is embedded into the output end of the first motor 604, and the first motor 604 is fixedly connected to the bottom surface of the stirring tank 1;

two connecting rods 502 in the second stirring mechanism 5 are symmetrically arranged at two sides of the first stirring shaft 601, and a plurality of second stirring blades 5021 are arranged on one side surface of the connecting rod 502 close to the first stirring shaft 601 in parallel along the vertical direction;

the plurality of first stirring blades 602 and the plurality of second stirring blades 5021 on the same side of the first stirring shaft 601 are arranged alternately, so that the shearing force among the raw materials can be improved, and the stirring and the uniform mixing are more sufficient;

the upper and lower ends of the two connecting rods 502 are respectively fixedly connected to the same connecting ring 503, and the top surface of the connecting ring 503 above the connecting rods 502 is fixedly connected to the bottom surface of the sealing ring plate 504 through a plurality of circumferentially and uniformly distributed fixing columns 5042, and the arrangement can realize the linkage between the sealing ring plate 504 and the connecting ring 503;

the top surface of the sealing ring plate 504 is symmetrically connected with linkage columns 5013, and the upper ends of the two linkage columns 5013 are respectively and fixedly connected to the bottom surface of the same linkage plate 5012;

a second stirring shaft 501 is fixedly sleeved in the middle of the linkage plate 5012, one end of the second stirring shaft 501 is rotatably connected to the top surface of the stirring tank 1, the other end of the second stirring shaft 501 is embedded in the output end of a second motor 5011, and the second motor 5011 is fixedly connected to the top surface of the stirring tank 1 on the outer side of the sealing ring plate 504 through a U-shaped frame 102;

a fixing ring 5032 is concentrically arranged on the inner side of the connecting ring 503, and the fixing ring 5032 is connected with the connecting ring 503 through a plurality of fixing rods 5031 uniformly distributed along the circumferential direction; the fixing ring 5032 is sleeved on the first stirring shaft 601 in a sliding manner, and the first stirring shaft 601 above and below the fixing ring 5032 is fixedly sleeved with the limiting ring 603, so that the fixing ring 5032 can be positioned at the position of the first stirring shaft 601 while the fixing ring 5032 and the first stirring shaft 601 can freely move;

the sealing ring plate 504 is in clearance fit with the top plate of the stirring tank 1, the inner side wall and the outer side wall of the sealing ring plate 504 are respectively provided with a positioning ring 5041, the positioning rings 5041 are in clearance fit with the positioning grooves 104 in the top plate of the stirring tank 1, and the sealing performance of the sealing ring plate 504 and the stirring tank 1 in matching can be realized while the sealing ring plate 504 freely rotates;

when the device is used, the first motor 604 and the second motor 5011 work simultaneously, the first stirring shaft 601 and the second stirring shaft 501 rotate synchronously in opposite directions, the first stirring shaft 601 realizes that the first stirring blade 602 stirs raw materials through linkage, and the second stirring shaft 501 realizes that the second stirring blade 5021 stirs raw materials through linkage.

As shown in fig. 1-2, the stirring device further comprises a water bath tank 4, a heating tank 7 and a refrigerating tank 8, wherein a coiled pipe 401 is arranged in the water bath tank 4, the coiled pipe 401 is connected in series on a conveying pipe 3, and two ends of the conveying pipe 3 are respectively communicated with and arranged at the upper end position and the lower end position of the stirring tank 1; a first water pump 301 is fixedly installed on the delivery pipe 3, a first temperature sensor 402 is fixedly installed on the inner bottom surface of the water bath box 4, and the first temperature sensor 402 is used for detecting the water temperature in the water bath box 4;

a first water delivery pipe 702 is communicated between the lower end of the heating box 7 and the water bath box 4, and a second water delivery pipe 701 is communicated between the upper end of the heating box 7 and the water bath box 4; a second water pump 7021 is fixedly mounted on the first water delivery pipe 702, a second electromagnetic valve 7011 is fixedly mounted on the second water delivery pipe 701, the second electromagnetic valve 7011 is used for controlling the on-off of the second water delivery pipe 701, and the first water delivery pipe 702 and the second water delivery pipe 701 in the arrangement are matched with the second water pump 7021 to realize the circulation between the water bath box 4 and the heating box 7;

a third water delivery pipe 802 is communicated between the lower end of the refrigeration box 8 and the water bath box 4, and a fourth water delivery pipe 801 is communicated between the upper end of the refrigeration box 8 and the water bath box 4; a third water pump 8021 is fixedly installed on the third water delivery pipe 802, a third electromagnetic valve 8011 is fixedly installed on the fourth water delivery pipe 801, the third electromagnetic valve 8011 is used for controlling the on-off of the fourth water delivery pipe 801, and the third water delivery pipe 802 and the fourth water delivery pipe 801 for arrangement are matched with the third water pump 8021 to realize the circulation between the water bath box 4 and the refrigeration box 8;

an electric heating ring is arranged in the heating box 7, and a second temperature sensor is fixedly arranged on the inner bottom surface of the heating box 7 and used for detecting the temperature of water in the heating box 7;

a semiconductor refrigerating sheet is arranged in the refrigerating box 8, and a third temperature sensor is fixedly arranged on the inner bottom surface of the refrigerating box 8 and used for detecting the temperature of water in the refrigerating box 8;

above-mentioned setting is when using, through the setting of first water pump 301, can realize the circulation of agitator tank 1 in conveyer pipe 3, the raw materials of circulation is after getting into coiled pipe 401 in conveyer pipe 3, water in the water bath 4 can and the raw materials between carry out the heat exchange, electric heating coil in the heating cabinet 7 heats water, thereby realize that the temperature of water in the water bath 4 improves fast, the setting of refrigeration case 8 can realize that the semiconductor refrigeration piece refrigerates water, thereby realize the temperature of water in the water bath 4 and reduce fast.

As shown in fig. 1 to 7, a controller 2 is further fixedly mounted on an outer side wall of the stirring tank 1, and the controller 2 is electrically connected to the first electromagnetic valve 1031, the first motor 604, the second motor 5011, the first water pump 301, the second water pump 7021, the third water pump 8021, the first temperature sensor 402, the second electromagnetic valve 7011, the third electromagnetic valve 8011, the electric heating coil, the second temperature sensor, the semiconductor chilling plate, and the third temperature sensor through conducting wires, respectively.

The above is only the preferred embodiment of the present invention, and the present invention is not limited thereto, any technical solutions recorded in the foregoing embodiments are modified, and some technical features thereof are replaced with equivalent ones, and any modification, equivalent replacement, and improvement made thereby all belong to the protection scope of the present invention.

Claims

1. The utility model provides a join in marriage liquid device for production of ka feizomi, includes agitator tank (1), top surface one side of agitator tank (1) is provided with inlet pipe (101), and bottom surface one side of agitator tank (1) is provided with discharging pipe (103) simultaneously, fixed mounting has first solenoid valve (1031), its characterized in that on discharging pipe (103): the stirring device is characterized by further comprising a first stirring mechanism (6) and a second stirring mechanism (5), wherein the first stirring mechanism (6) and the second stirring mechanism (5) are movably matched on the stirring tank (1), and the first stirring mechanism (6) is coaxially arranged on the outer side of the second stirring mechanism (5);

the first stirring mechanism (6) comprises a first stirring shaft (601) and first stirring blades (602), the first stirring shaft (601) is coaxially arranged inside the stirring tank (1), and a plurality of first stirring blades (602) are arranged on two symmetrical side surfaces of the first stirring shaft (601) in parallel along the vertical direction;

two connecting rods (502) in the second stirring mechanism (5) are symmetrically arranged at two sides of the first stirring shaft (601), and a plurality of second stirring blades (5021) are arranged on one side surface of the connecting rods (502) close to the first stirring shaft (601) in parallel along the vertical direction;

the plurality of first stirring blades (602) and the plurality of second stirring blades (5021) on the same side of the first stirring shaft (601) are arranged alternately.

2. The liquid preparation device for producing carfilzomib as claimed in claim 1, wherein both ends of the first stirring shaft (601) are rotatably connected to the stirring tank (1) through rolling bearings, the lower end of the first stirring shaft (601) extends to the lower part of the stirring tank (1) and is embedded in the output end of a first motor (604), and the first motor (604) is fixedly connected to the bottom surface of the stirring tank (1).

3. The liquid distribution device for producing carfilzomib as claimed in claim 1, wherein the upper and lower ends of the two connecting rods (502) are respectively fixedly connected to the same connecting ring (503), and the top surface of the connecting ring (503) above the connecting rods (502) is fixedly connected with the bottom surface of the sealing ring plate (504) through a plurality of circumferentially uniformly distributed fixing columns (5042);

the top surface of the sealing ring plate (504) is symmetrically connected with linkage columns (5013), and the upper ends of the two linkage columns (5013) are respectively and fixedly connected to the bottom surface of the same linkage plate (5012);

the middle part of linkage board (5012) is fixed to be cup jointed second (mixing) shaft (501), the one end of second (mixing) shaft (501) is rotated and is connected on the top surface of agitator tank (1), and the other end gomphosis of second (mixing) shaft (501) is in the output of second motor (5011) simultaneously, second motor (5011) passes through U-shaped frame (102) fixed connection on agitator tank (1) top surface in sealed crown plate (504) outside.

4. The liquid dispensing device for producing carfilzomib as claimed in claim 3, wherein the inner side of the connecting ring (503) is concentrically provided with a fixing ring (5032), and the fixing ring (5032) and the connecting ring (503) are connected through a plurality of fixing rods (5031) uniformly distributed along the circumferential direction; the fixing ring (5032) is sleeved on the first stirring shaft (601) in a sliding manner, and the first stirring shaft (601) above and below the fixing ring (5032) is fixedly sleeved with the limiting ring (603).

5. A liquid dispensing device for carfilzomib production according to claim 3 wherein the sealing ring plate (504) is clearance fitted on the top plate of the agitator tank (1), the inner and outer side walls of the sealing ring plate (504) are each provided with a positioning ring (5041), and the positioning rings (5041) are clearance fitted in positioning grooves (104) in the top plate of the agitator tank (1).

6. The liquid preparation device for producing carfilzomib according to claim 1, wherein a controller (2) is fixedly mounted on the outer side wall of the stirring tank (1), and the controller (2) is electrically connected with the first electromagnetic valve (1031), the first motor (604) and the second motor (5011) through conducting wires respectively.

7. The liquid preparation device for producing carfilzomib as claimed in any one of claims 1-6, further comprising a water bath tank (4), a heating tank (7) and a refrigerating tank (8), wherein a coiled pipe (401) is arranged in the water bath tank (4), the coiled pipe (401) is connected in series on a conveying pipe (3), and two ends of the conveying pipe (3) are respectively communicated and arranged at the upper end position and the lower end position of the stirring tank (1); a first water pump (301) is fixedly installed on the conveying pipe (3), and a first temperature sensor (402) is fixedly installed on the inner bottom surface of the water bath box (4);

a first water delivery pipe (702) is communicated between the lower end of the heating box (7) and the water bath box (4), and a second water delivery pipe (701) is communicated between the upper end of the heating box (7) and the water bath box (4); a second water pump (7021) is fixedly arranged on the first water conveying pipe (702), and a second electromagnetic valve (7011) is fixedly arranged on the second water conveying pipe (701);

a third water delivery pipe (802) is communicated between the lower end of the refrigeration box (8) and the water bath box (4), and a fourth water delivery pipe (801) is communicated between the upper end of the refrigeration box (8) and the water bath box (4); and a third water pump (8021) is fixedly mounted on the third water pipe (802), and a third electromagnetic valve (8011) is fixedly mounted on the fourth water pipe (801).

8. The liquid dispensing device for producing carfilzomib as claimed in claim 7, wherein an electric heating ring is mounted inside the heating box (7), and a second temperature sensor is fixedly mounted on the inner bottom surface of the heating box (7).

9. The liquid preparation device for producing carfilzomib as claimed in claim 7, wherein the interior of the refrigeration box (8) is provided with a semiconductor refrigeration sheet, and a third temperature sensor is fixedly arranged on the inner bottom surface of the refrigeration box (8).

10. The liquid distribution device for carfilzomib production according to claim 7, wherein the controller (2) is electrically connected with the first water pump (301), the second water pump (7021), the third water pump (8021), the first temperature sensor (402), the second electromagnetic valve (7011), the third electromagnetic valve (8011), the electric heating ring, the second temperature sensor, the semiconductor chilling plate and the third temperature sensor through conducting wires.