CN214749753U - CO (carbon monoxide)2Breath isotope detector - Google Patents

Abstract

The utility model discloses a CO₂Breath isotope detector, CO₂The breath isotope detector includes: the infrared laser, the optical cavity and the infrared detector are arranged in sequence; the optical cavity is provided withAn air inlet and an air outlet are arranged; at least one expiration channel communicated with the air inlet, wherein the expiration channel is used for introducing CO into the light cavity₂Expiration; the air outlet channel is communicated with the air outlet; and laser emitted by the infrared laser is transmitted to the infrared detector through the optical cavity. An infrared laser is used as a light source, and CO of different isotopes₂When the difference between the absorption wavelengths is small and an infrared laser is adopted, the wavelength of laser emitted by the infrared laser can be accurately controlled, so that CO of different isotopes can be accurately distinguished₂Thereby improving the accuracy of the analysis.

Description

CO (carbon monoxide)2Breath isotope detector

Technical Field

The utility model relates to an expiration isotope detects technical field, what especially relates to is a CO₂An exhaled isotope detector.

Background

Helicobacter pylori is one of the most common gastric pathogens in the human stomach, and is closely associated with chronic tracheitis and peptic ulcer disease. The microorganism has high urease activity, and can hydrolyze urea in gastric juice to generate carbon dioxide and ammonia gas.

Based on the activity of the urease of the body¹³C Urea breath test (¹³C-UBT) is widely used as a non-invasive diagnostic method, specifically to detect the presence of helicobacter pylori infection in the stomach, and in the prior art,¹³the accuracy of the urea breath test is low.

Accordingly, the prior art is yet to be improved and developed.

SUMMERY OF THE UTILITY MODEL

The to-be-solved technical problem of the present invention is to provide a CO system for overcoming the above drawbacks of the prior art₂An expiratory isotope detector, aiming at solving the problems in the prior art¹³C, the accuracy of the urea breath test is low.

The utility model provides a technical scheme that technical problem adopted as follows:

CO (carbon monoxide)₂A breath isotope detector, comprising:

the infrared laser, the optical cavity and the infrared detector are arranged in sequence; the optical cavity is provided with an air inlet and an air outlet;

at least one expiration channel communicated with the air inlet, wherein the expiration channel is used for introducing CO into the light cavity₂Expiration;

the air outlet channel is communicated with the air outlet;

and laser emitted by the infrared laser is transmitted to the infrared detector through the optical cavity.

Said CO₂The breath isotope detector is characterized in that the infrared laser is a quantum cascade laser.

Said CO₂A breath isotope detector, wherein the wavelength of laser light emitted by the infrared laser comprises: 4874.448cm^-1，4874.086cm^-1And 4874.178cm^-1。

Said CO₂Breath isotope detector wherein said CO₂A breath isotope detector, further comprising:

a zero gas passage communicating with the gas inlet;

an air pump is arranged on the air-free channel.

Said CO₂The breath isotope detector is characterized in that a check valve or a one-way valve is arranged on the zero gas channel.

Said CO₂The breath isotope detector comprises a breath channel, an air outlet channel and a zero air channel, wherein the breath channel, the air outlet channel and the zero air channel all adopt airtight interfaces.

Said CO₂The breath isotope detector is characterized in that the air inlet is positioned at one end of the optical cavity close to the infrared detector;

the air outlet is positioned at one end of the optical cavity close to the infrared laser.

Said CO₂And the expiratory isotope detector is characterized in that a radiator is arranged on one side of the infrared laser, which deviates from the optical cavity.

Said CO₂A breath isotope detector, wherein the infrared laser comprises: the QCL laser, the TEC controller and the LDC controller;

the TEC controller and the LDC controller are connected with the QCL laser.

Said CO₂The breath isotope detector is characterized in that a pretreatment device is arranged on the breath channel.

Has the advantages that: the application adopts an infrared laser as a light source, and CO of different isotopes₂When the difference between the absorption wavelengths is small and an infrared laser is adopted, the wavelength of laser emitted by the infrared laser can be accurately controlled, so that CO of different isotopes can be accurately distinguished₂Thereby improving the accuracy of the analysis.

Drawings

FIG. 1 shows the CO in the present invention₂The structure of the breath isotope detector is shown schematically.

Fig. 2 is a flow chart of an analysis method according to the present invention.

Description of reference numerals:

10. an infrared laser; 11. a QCL laser; 12. a TEC controller; 13. an LDC controller; 15. a heat sink; 20. an optical cavity; 21. an air inlet; 22. an air outlet; 30. an infrared detector; 40. an exhalation passage; 41. a pretreatment device; 50. an air outlet channel; 60. a zero gas channel; 61. an air pump; 62. a check valve; 70. a housing; 80. a display screen; 90. and (5) measuring and analyzing the terminal.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention clearer and clearer, the present invention will be described in further detail below with reference to the accompanying drawings and examples. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

Referring also to figure 1 of the drawings, in which,the utility model provides a CO₂Some embodiments of a radioisotope detector.

As shown in figure 1, the utility model relates to a CO₂A breath isotope detector comprising:

the infrared laser 10, the optical cavity 20 and the infrared detector 30 are arranged in sequence; the light cavity 20 is provided with a gas inlet 21 and a gas outlet 22;

at least one exhale channel 40 in communication with the air inlet 21, the exhale channel 40 for introducing CO into the light chamber 20₂Expiration;

an air outlet channel 50 communicated with the air outlet 22;

wherein, the laser light emitted from the infrared laser 10 propagates through the optical cavity 20 to the infrared detector 30.

It is worth noting that exhalation passageways 40 are used to introduce CO into light chamber 20₂Expiration, expiration channel 40 means the passage of CO₂Passage of exhaled air, CO₂Exhalation refers to the exhalation of the lungs containing CO₂The exhalation of (2). The air outlet channel 50 is a channel through which air in the optical cavity 20 flows out. At the time of analysis, CO is added₂The expired air passes from the expiration channel 40 into the optical cavity 20, and then when the laser light emitted from the infrared laser 10 passes through the optical cavity 20, CO is present in the optical cavity 20₂Expiration, CO₂Absorbs some wavelengths of the laser light, so that the spectrum of the laser light detected by the infrared detector 30 is different from the spectrum of the laser light emitted by the infrared laser 10, and thus can be used for CO₂The breath is analyzed so that CO can be analyzed₂CO in exhaled breath₂The composition of (1).

In particular, CO due to different isotopes in the present application₂The absorption wavelengths of infrared light are different, so that CO of different isotopes can be obtained through the absorbance of different wavelengths₂The larger the absorbance, the larger the amount of the component (b), and the smaller the absorbance, the smaller the amount of the component (b).

It should be noted that the present application uses the infrared laser 10 as the light source, because of CO of different isotopes₂The difference between the absorption wavelengths is small, and red is usedWhen the laser 10 is used, the wavelength of the laser emitted by the infrared laser 10 can be accurately controlled, so that CO of different isotopes can be accurately distinguished₂To analyze CO of different isotopes₂The composition of (1).

The optical cavity 20 includes a tube, a closed lens and a cage-type optical path structure, and the closed lens and the cage-type optical path structure collimate, introduce and extract the laser. The closed lenses are two and are respectively arranged at two ends of the tube body, and the cage type light path structure is positioned between the two closed lenses.

The detection signal generated by the infrared detector 30 sensing the laser is amplified and then sent to the QCLAS analysis system, and the harmonic demodulation is realized, and the high-precision gas concentration signal is obtained through a signal processing algorithm.

A pretreatment device 41 is provided in the exhalation path 40 for CO₂The exhalation is pre-processed and then passed through the exhalation passageways 40 into the optical cavity 20. The pretreatment device 41 may be for CO₂Filtering and drying the breath.

In a preferred implementation manner of the embodiment of the present invention, the wavelength of the laser emitted by the infrared laser 10 includes: 4874.448cm^-1，4874.086cm^-1And 4874.178cm^-1。

In particular, the amount of the solvent to be used,¹²C¹⁶O¹⁶o has an absorption wavelength of 4874.448cm^-1，¹³C¹⁶O¹⁶O has an absorption wavelength of 4874.086cm^-1，¹²C¹⁸O¹⁶O has an absorption wavelength of 4874.178cm^-1. A wavelength of 4874.448cm is obtained by the infrared detector 30^-1，4874.086cm^-1And 4874.178cm^-1Can thereby determine the absorbance of¹²C¹⁶O¹⁶O、¹³C¹⁶O¹⁶O and¹²C¹⁸O¹⁶concentration (or mass) of O, thereby achieving the effect on CO₂Breath was subjected to composition analysis.

In a preferred implementation manner of the embodiment of the present invention, the infrared laser 10 is a quantum cascade laser.

In particular, Quantum Cascade Lasers (QCLs) are novel unipolar semiconductor devices based on the principles of conduction band-to-band transition of electrons in semiconductor quantum wells and phonon-assisted resonant tunneling. The quantum cascade laser has the characteristics that the working wavelength has no direct relation with the band gap of the used material and is only determined by the sub-band spacing of the coupled quantum wells, so that the wavelength can be cut in a large range, and the wavelength of the emitted laser can be conveniently adjusted and controlled.

In a preferred implementation of the embodiment of the present invention, as shown in fig. 1, the CO₂A breath isotope detector, further comprising:

a zero air passage 60 communicating with the air inlet 21;

an air pump 61 is arranged on the air-free passage 60.

Specifically, the zero gas channel 60 is a channel for introducing zero gas into the optical cavity 20, where the zero gas is a gas that does not absorb laser light and enters the optical cavity 20, and therefore, when the zero gas is introduced, the absorbance of the zero gas detected by the infrared detector 30 is 0. Before or after each test, zero gas may be passed from zero gas channel 60 to purge CO from optical cavity 20 through exhalation channel 40 into optical cavity 20₂Breath out to ensure that each test is not disturbed by other gases.

Specifically, the air pump 61 is disposed on the zero air channel 60, and the zero air in the zero air channel 60 is delivered to the optical cavity 20 by the air pump 61, so as to purge the optical cavity 20, and of course, the zero air channel 60 may be further disposed with a check valve 62 or a one-way valve, so as to prevent the air in the optical cavity 20 from flowing back to the zero air channel 60, and prevent CO from flowing back into the zero air channel 60₂The breath leaks, thereby ensuring the cleaning effect of the zero-air channel 60 and improving the accuracy of the analysis result.

The exhalation channel 40, the air outlet channel 50 and the zero air channel 60 all adopt airtight interfaces, and specifically, the exhalation channel 40, the air outlet channel 50 and the zero air channel 60 all adopt airtight interfaces composed of a SWAGELOK 6MM air valve and a stainless steel shell.

In a preferred implementation manner of the embodiment of the present invention, as shown in fig. 1, the air inlet 21 is located at one end of the optical cavity 20 close to the infrared detector 30; the air outlet 22 is located at one end of the optical cavity 20 close to the infrared laser 10.

Specifically, the air inlet 21 is close to the infrared detector 30 and away from the infrared laser 10, and the air outlet 22 is close to the infrared laser 10 and away from the infrared detector 30, so that when CO is present₂The breath entering the optical cavity 20 through the air inlet 21 can sufficiently absorb the light with the corresponding wavelength of the laser light emitted from the infrared laser 10, that is, the laser light emitted from the infrared detector 30 passes through the optical cavity 20, and the CO is absorbed₂The light with corresponding wavelength is gradually absorbed, and when the laser light propagates to the end of the optical cavity 20 close to the laser detector, the laser light and the CO which is not absorbed by the light and enters from the air inlet 21₂Expiratory contact to CO in laser₂Light of the corresponding wavelength is sufficiently absorbed.

In a preferred implementation manner of the embodiment of the present invention, as shown in fig. 1, a heat sink 15 is disposed on one side of the infrared laser 10 away from the optical cavity 20.

Specifically, in order to improve the stability of the laser light emitted by the infrared laser 10, a heat sink 15 is disposed on a side of the infrared laser 10 away from the optical cavity 20 to dissipate heat of the infrared laser 10. The infrared laser 10 includes: QCL laser 11, TEC controller 12 and LDC controller 13 all are connected with QCL laser 11, QCL laser 11 is used for sending laser, TEC controller 12 is used for controlling the temperature, for example, when the temperature rises after TEC controller 12 controls radiator 15 work and reduces the temperature to infrared laser 10, LDC controller 13 controls operating current to the wavelength of the laser that infrared laser 10 sent.

A display screen 80 is arranged on the shell 70 of the detector, and the display screen 80 displays the real-time temperature and the real-time working current of the infrared laser 10 and can also display laser parameters. The detector is connected with a measurement and analysis terminal 90 through a USB interface, and the measurement and analysis terminal 90 can be a computer.

As shown in figure 2, the utility model discloses CO₂The breath isotope detector adopts the following analysis method for analysis, and the analysis method comprises the following steps:

step (ii) ofS100, providing for taking¹³First gas for pre-pulmonary exhalation of C-urea and citric acid and administration¹³C-urea and citric acid followed by a second gas exhaled by the lungs.

In particular, two gas collections are performed in the same lung in order to detect changes in the composition of exhaled breath, which is taken by an individual¹³Collecting first gas exhaled from the lungs of the subject prior to the administration of the C-urea and citric acid to the subject¹³After the C-urea and citric acid, the second gas exhaled from the lungs of the individual is collected. Analyzing the first gas and the second gas to obtain the administration¹³CO produced in lungs after C-Urea and citric acid₂A change in composition. If the subject is infected with helicobacter pylori, the subject is taking¹³The difference between the first gas and the second gas exhaled before and after C-urea and citric acid, respectively, is large because helicobacter pylori-infected individuals decompose urea and, therefore, produce¹³C¹⁶O¹⁶O and¹²C¹⁸O¹⁶o, i.e. in the second gas¹³C¹⁶O¹⁶O and¹²C¹⁸O¹⁶the amount of O is relatively large and,¹²C¹⁶O¹⁶the amount of O is small and the first gas is¹²C¹⁶O¹⁶The amount of O is relatively large and,¹³C¹⁶O¹⁶o and¹²C¹⁸O¹⁶the amount of O is small. If the individual is not infected with H.pylori, the composition of the first gas is not very different from the composition of the second gas. It should be noted that citric acid can promote the decomposition of urea, facilitating the formation¹³C¹⁶O¹⁶O and¹²C¹⁸O¹⁶O。

the exhalation from the lungs of an individual may typically be collected using a gas collection device, which may be a gas collection bag. After the first gas and the second gas are collected, the gas collecting device is connected with the expiration channel, and the first gas in the gas collecting device is introduced into the optical cavity to be analyzed to obtain first detection data.

Specifically, the¹³The mass of C-urea is greater than or equal to50mg, the mass of the citric acid is more than or equal to 4 g. Is taken by an individual¹³When C is urea and citric acid, the reaction solution is prepared,¹³the mass of the C-urea is more than or equal to 50mg, and the mass of the citric acid is more than or equal to 4 g.

Step S200, after the infrared laser is started, the first gas is introduced into the optical cavity from the expiration channel, so that first detection data corresponding to the first gas are obtained through the infrared detector.

It should be noted that the detection order of the first gas and the second gas can be determined as required, that is, the first gas can be detected first, and then the second gas can be detected; alternatively, the second gas may be detected first, followed by the first gas. During detection, the infrared laser is started first, and in order to ensure the stability of laser light emitted by the infrared laser, the infrared laser may be started for a preset time to be preheated, for example, for 30 minutes, so that the infrared laser reaches a stable state. Of course, background calibration may also be performed, and specifically, a background sample is used for testing to obtain background calibration data.

The first gas is then passed from the expiratory channel into the optical cavity, for example, by loading the first gas with a gas collection bag, passing the first gas from the expiratory channel into the optical cavity by pressing the gas collection bag, and contacting the laser in the optical cavity.

In background calibration or one-round test, the CO is used for removing residual gas in the optical cavity₂A breath isotope detector, further comprising:

a zero gas passage communicating with the gas inlet;

an air pump is arranged on the air-free channel.

And introducing zero gas through the zero gas channel, purging the optical cavity, and emptying residual gas in the optical cavity so as to carry out the next round of test.

The step S200 includes:

step S210, starting the air pump to remove the residual air in the optical cavity.

Step S220, the first gas is introduced into the optical cavity from the expiration channel, so that first detection data corresponding to the first gas are obtained through the infrared detector.

Before the first gas is introduced, the gas pump is started to remove the residual gas in the optical cavity. For example, when zero gas is used for background calibration of the infrared laser, if the real-time data detected by the infrared detector is consistent with background calibration data when the optical cavity is purged by introducing the zero gas, it is indicated that residual gas in the optical cavity is completely removed. And then, introducing the first gas into the optical cavity, and detecting first detection data corresponding to the first gas by the infrared detector.

The first detection data includes:¹²C¹⁶O¹⁶the detection data of the optical fiber is O,¹³C¹⁶O¹⁶o probe data and¹²C¹⁸O¹⁶o, detection data. The first detection data may be expressed in terms of a concentration of the first gas, and the first detection data includes:¹²C¹⁶O¹⁶the first concentration of the oxygen is selected to be,¹³C¹⁶O¹⁶the first concentration of the oxygen is selected to be,¹²C¹⁸O¹⁶a first concentration of O.

And S300, introducing the second gas into the optical cavity from the expiration channel so as to obtain second detection data corresponding to the second gas through the infrared detector.

Specifically, the second gas is tested and passed from the exhalation channel into the optical cavity, for example, by loading the second gas with a gas collection bag, passing the second gas from the exhalation channel into the optical cavity by pressing the gas collection bag, and contacting the laser in the optical cavity.

Step S300 specifically includes:

and step S310, starting the air pump, and removing residual air in the optical cavity.

Step S320, introducing the second gas into the optical cavity from the exhalation channel, so as to obtain second detection data corresponding to the second gas through the infrared detector.

Before the second gas is introduced, the gas pump is started to remove the residual gas in the optical cavity. For example, the optical cavity is purged with zero gas to remove residual gas, i.e., the first gas tested before. And then, introducing the second gas into the optical cavity, and detecting second detection data corresponding to the second gas by the infrared detector.

The second detection data includes:¹²C¹⁶O¹⁶the detection data of the optical fiber is O,¹³C¹⁶O¹⁶o probe data and¹²C¹⁸O¹⁶o, detection data. The second detection data may be expressed in terms of a concentration of a second gas, and the second detection data includes:¹²C¹⁶O¹⁶the second concentration of the oxygen is selected from the group consisting of,¹³C¹⁶O¹⁶the second concentration of the oxygen is selected from the group consisting of,¹²C¹⁸O¹⁶a second concentration of O.

Step S400, analyzing the first detection data and the second detection data to obtain an analysis result.

Specifically, after the first detection data and the second detection data are obtained, the first detection data and the second detection data are analyzed to obtain an analysis result.

Specifically, step S400 includes:

step S410, determining according to the first detection data and the second detection data¹³C-DOB value and¹⁸O-DOB value.

Step S420, according to the above¹³C-DOB value and¹⁸and determining the analysis result according to the O-DOB value.

In particular, the amount of the solvent to be used,¹³C-DOB value ═ C-DOB¹³Second abundance of C-¹³A first abundance of C, wherein,¹³second abundance of C ═¹³Second concentration of C/(¹³Second concentration of C +¹²A second concentration of C),¹³first abundance of C ═¹³First concentration of C/(¹³First concentration of C +¹²First concentration of C).¹³Second concentration of C¹³C¹⁶O¹⁶The second concentration of the oxygen is selected from the group consisting of,¹²second concentration of C¹²C¹⁶O¹⁶The second concentration of the oxygen is selected from the group consisting of,¹³the first concentration of C is¹³C¹⁶O¹⁶The first concentration of the oxygen is selected to be,¹²the first concentration of C is¹²C¹⁶O¹⁶A first concentration of O.

¹⁸O-DOB value ═¹⁸Second abundance of O-¹⁸A first abundance of O, wherein,¹⁸second abundance of O ═¹⁸Second concentration of O/(¹⁸Second concentration of O +¹⁶A second concentration of O),¹⁸first abundance of O ═¹⁸First concentration of O/(¹⁸First concentration of O +¹⁶A first concentration of O).¹⁸Second concentration of O¹²C¹⁸O¹⁶The second concentration of the oxygen is selected from the group consisting of,¹⁶second concentration of O¹²C¹⁶O¹⁶The second concentration of the oxygen is selected from the group consisting of,¹⁸the first concentration of O is¹²C¹⁸O¹⁶The first concentration of the oxygen is selected to be,¹⁶the first concentration of O is¹²C¹⁶O¹⁶A first concentration of O.

To obtain¹³C-DOB value and¹⁸after the O-DOB value is according to¹³C-DOB value and¹⁸and determining the analysis result according to the O-DOB value.

Specifically, the analysis result includes: HP positive, HP negative, NUD positive and NUD negative. HP refers to helicobacter pylori, and NUD refers to non-ulcer dyspepsia.

Step S420 specifically includes:

step S421, when the¹³And when the C-DOB value is larger than a preset threshold value, taking HP positive as an analysis result.

Step S422, when the above¹³The C-DOB value is greater than a preset threshold value¹⁸When the O-DOB value is greater than 0, the NUD is positive as the analysis result.

Step S423, when the¹³The C-DOB value is greater than a preset threshold value¹⁸When the O-DOB value is less than or equal to 0, NUD negativity is regarded as the analysis result.

Step S424, when the¹³And when the C-DOB value is less than or equal to a preset threshold value, taking HP negativity as an analysis result.

Specifically, first pass through¹³The size of the C-DOB value judges that the HP is positive or negative,¹³when the C-DOB value is larger than a preset threshold value, the HP is positive,¹³and when the C-DOB value is less than or equal to a preset threshold value, the HP is negative. When HP is positive, the process is continued¹⁸Judging NUD positive or NUD negative according to the O-DOB value,¹⁸if the O-DOB value is more than 0, the NUD is positive,¹⁸an O-DOB value of 0 or less is NUD negative.

For taking only¹³Expiration when C-urea is taken, expiration when citric acid is taken alone, and administration¹³C-urea and citric acid were separately detected by expiration to obtain DOB values, as shown in tables 1, 2 and 3. Is taken orally¹³The change range of the DOB value of the exhaled air is larger during the process of C-urea and citric acid, so that the analysis and the detection are more convenient, and the accuracy is higher.

TABLE 1 administration of drugs alone¹³DOB value of expired air at C-Urea

	09:25AM	09:55AM
			CO2	3.46	3.84
13Abundance of C	10.94	-9.26
			18Abundance of O	35.33	22.09
13C-DOB value		-20.20
			18O-DOB value		-13.24

TABLE 2 DOB values of exhaled breath when only citric acid was administered

TABLE 3 administration of drugs¹³DOB value of expired air at C-Urea and citric acid

It is to be understood that the invention is not limited to the above-described embodiments, and that modifications and variations may be made by those skilled in the art in light of the above teachings, and all such modifications and variations are intended to be included within the scope of the invention as defined in the appended claims.

Claims (10)

1. CO (carbon monoxide)₂A breath isotope detector, comprising:

the infrared laser, the optical cavity and the infrared detector are arranged in sequence; the optical cavity is provided with an air inlet and an air outlet;

at least one exhalation passage in communication with the air inlet, the exhalation passageThe channel is used for introducing CO into the optical cavity₂Expiration;

the air outlet channel is communicated with the air outlet;

and laser emitted by the infrared laser is transmitted to the infrared detector through the optical cavity.

2. CO according to claim 1₂The breath isotope detector is characterized in that the infrared laser is a quantum cascade laser.

3. CO according to claim 1₂The breath isotope detector is characterized in that the wavelength of laser emitted by the infrared laser comprises: 4874.448cm^-1，4874.086cm^-1And 4874.178cm^-1。

4. CO according to claim 1₂An isotope expiration detector, wherein the CO is₂A breath isotope detector, further comprising:

a zero gas passage communicating with the gas inlet;

an air pump is arranged on the air-free channel.

5. CO according to claim 4₂An isotope expiration detector, characterized in that,

and a check valve or a one-way valve is arranged on the zero air passage.

6. CO according to claim 4₂An isotope expiration detector, characterized in that,

the expiration channel, the air outlet channel and the zero air channel all adopt airtight interfaces.

7. CO according to claim 1₂An isotope expiration detector, characterized in that,

the air inlet is positioned at one end of the optical cavity close to the infrared detector;

the air outlet is positioned at one end of the optical cavity close to the infrared laser.

8. CO according to claim 1₂An isotope expiration detector, characterized in that,

and a radiator is arranged on one side of the infrared laser, which deviates from the optical cavity.

9. CO according to claim 8₂An isotope expiration detector, characterized in that,

the infrared laser includes: the QCL laser, the TEC controller and the LDC controller;

the TEC controller and the LDC controller are connected with the QCL laser.

10. CO according to claim 1₂An isotope expiration detector, characterized in that,

and a pretreatment device is arranged on the expiration channel.

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