CN214716531U

CN214716531U - Auxiliary device is loaded to oligonucleotide synthesis post

Info

Publication number: CN214716531U
Application number: CN202120801123.0U
Authority: CN
Inventors: 肖威; 吴朗; 吴铭
Original assignee: Boshang Biotechnology Shanghai Co ltd
Current assignee: Boshang Biotechnology Shanghai Co ltd
Priority date: 2021-04-19
Filing date: 2021-04-19
Publication date: 2021-11-16
Anticipated expiration: 2031-04-19

Abstract

The utility model relates to an auxiliary device is loaded to oligonucleotide synthesis post belongs to oligonucleotide synthesizer technical field. The oligonucleotide synthesis column filling auxiliary device comprises a base, a supporting arm, a synthesis plate and a lower pressing rod. When the oligonucleotide synthetic column filling auxiliary device is used, firstly, a single synthetic column is pre-placed in a synthetic column placing hole arranged in a synthetic plate, the synthetic plate is placed on a clamping seat, then, a movable column pressing module is placed on the synthetic plate, a pressure arm I or a pressure arm II is rotated, and the movable column pressing module is pressed down through a pressure block, a torsion arm and a pressing rod to tightly press the synthetic column in the synthetic plate. This oligonucleotide synthesis post fills auxiliary device presses synthetic post device in batches based on manual lever pressure is supplementary, utilizes mechanical lever to provide corresponding pressure, presses synthetic post to the position of settlement in batches for pressing the intensity of force uniformity, synthetic post leakproofness uniformity, and it is very convenient to operate, can save the manual work in a large number and reduce synthetic failure rate.

Description

Auxiliary device is loaded to oligonucleotide synthesis post

Technical Field

The utility model relates to an auxiliary device is loaded to oligonucleotide synthesis post belongs to oligonucleotide synthesizer technical field.

Background

The conventional operation mode needs to manually press the synthesis column singly or tightly knock the synthesis column by a small hammer. The existing operation mode is slow in speed and uneven in pressing depth, the sealing uniformity of each synthesis column cannot be guaranteed, and the beating process can cause the filter element in the synthesis column to be loosened, so that the synthesis finally fails.

SUMMERY OF THE UTILITY MODEL

In order to overcome the defect that exists among the background art, the utility model provides a technical scheme that its technical problem adopted is: the utility model provides an oligonucleotide synthetic column loads auxiliary device, includes base, support arm, synthetic board and pushing down the depression bar, the one end at the base is fixed to the bottom of support arm, the support arm top is movably provided with the pressure piece through the pivot, be fixed with pressure arm of force one in the pivot, the middle part of base is fixed with the cassette, synthetic board is placed on the cassette, synthetic inboard is equipped with a plurality of synthetic column and places the hole, synthetic board is equipped with the guard edge all around, movable compression bar module has been placed to the top of synthetic board, be fixed with the spacing guide housing of pushing down the depression bar on the support arm, the depression bar passes in the spacing guide housing of pushing down the depression bar, the top of pushing down the depression bar is passed through connecting axle two and torsion arm's bottom swing joint together, the top of torsion arm is passed through connecting axle one and pressure piece's bottom swing joint together.

Preferably, a second pressure arm is fixed on the rotating shaft, and an included angle formed between the first pressure arm and the second pressure arm is 70 degrees.

Preferably, guide clamping grooves are formed in the base and the clamping seat, and guide blocks are arranged at the bottom of the synthetic board corresponding to the guide clamping grooves.

Preferably, the bottom of the movable compression leg module is provided with a protection edge clamping groove corresponding to the protection edge.

The utility model discloses an auxiliary device is loaded to oligonucleotide synthetic post, this auxiliary device is loaded to oligonucleotide synthetic post is in the use, at first place synthetic post that is equipped with in advance at synthetic inboard downthehole placing with single synthetic post, place synthetic board on the cassette, the guide block plays location guide effect at this in-process, place the one end at synthetic board with activity compression leg module after that, turning pressure arm one or pressure arm two, through the pressure piece, torsion arm and lower compression leg push down activity compression leg module, thereby compress tightly the synthetic post of activity compression leg module below in synthetic board, at the removal synthetic board afterwards, compress tightly all synthetic posts in synthetic board. The utility model discloses an auxiliary device is loaded to oligonucleotide synthetic post presses synthetic post device in batches based on manual lever pressure is supplementary, and the synthetic board of synthetic post has been adorned in advance puts into this device cassette, utilizes mechanical lever to provide corresponding pressure, presses synthetic post to the position of settlement in batches for pressing down the pressure degree homogeneous, synthetic post leakproofness homogeneous, and it is very convenient to operate, can save manual work in a large number and reduce synthetic failure rate.

Drawings

The present invention will be further explained with reference to the drawings and examples.

FIG. 1 is a schematic diagram of the structure of an auxiliary device for filling an oligonucleotide synthesis column according to the present invention;

FIG. 2 is a left side view of an oligonucleotide synthesis column packing aid of the present invention;

FIG. 3 is a schematic diagram of the internal structure of an auxiliary device for filling an oligonucleotide synthesis column according to the present invention;

wherein 1, a base; 2. a support arm; 3. a card holder; 4. a guide clamping groove; 5. synthesizing a board; 6. a synthetic column placing hole; 7. a protective edge; 8. a movable compression column module; 9. a protective edge clamping groove; 10. a pressure block; 11. a rotating shaft; 12. a first pressure arm; 13. a second pressure arm; 14. a lower pressure lever; 15. a torsion arm; 16. a guide block; 17. a lower press rod limiting guide cover; 18. a first connecting shaft; 19. and a second connecting shaft.

Detailed Description

The present invention will now be described in further detail with reference to the accompanying drawings. The attached drawings are simplified schematic diagrams, and merely illustrate the basic structure of the present invention in a schematic manner, and thus show only the components related to the present invention.

In a first specific embodiment, please refer to fig. 1-3, an oligonucleotide synthetic column filling auxiliary device comprises a base 1, a supporting arm 2, a synthetic plate 5 and a lower pressing rod 14, wherein the bottom of the supporting arm 2 is fixed at one end of the base 1, the top of the supporting arm 2 is movably provided with a pressure block 10 through a rotating shaft 11, the rotating shaft 11 is fixed with a first pressure arm 12, the middle of the base 1 is fixed with a clamping seat 3, the synthetic plate 5 is placed on the clamping seat 3, the synthetic plate 5 is provided with a plurality of synthetic column placing holes 6, the periphery of the synthetic plate 5 is provided with a protective edge 7, a movable pressing column module 8 is placed above the synthetic plate 5, the supporting arm 2 is fixed with a lower pressing rod limiting guide cover 17, the lower pressing rod 14 passes through the lower pressing rod limiting guide cover 17, the top of the lower pressing rod 14 is movably connected with the bottom of a torque arm 15 through a second connecting shaft 19, the top of the torque arm 15 is movably connected with the bottom of the pressure block 10 through a first connecting shaft 18, a second pressure arm 13 is fixed on the rotating shaft 11, an included angle formed by the first pressure arm 12 and the second pressure arm 13 is 70 degrees, guide clamping grooves 4 are formed in the base 1 and the clamping seat 3, guide blocks 16 are arranged at the bottom of the synthetic plate 5 corresponding to the guide clamping grooves 4, and protective edge clamping grooves 9 are arranged at the bottom of the movable compression leg module 8 corresponding to the protective edges 7.

The utility model discloses an auxiliary device is loaded to oligonucleotide synthetic column, this auxiliary device is loaded to oligonucleotide synthetic column is in the use, at first place synthetic column in advance with single synthetic column in synthetic board 5 be equipped with place in hole 6, place synthetic board 5 on cassette 3, guide block 16 plays the location guide effect at this in-process, after that in the one end of placing synthetic board 5 with activity compression leg module 8, turning pressure arm one 12 or pressure arm two 13, through pressure block 10, torque arm 15 pushes down activity compression leg module 8 with depression bar 14 down, thereby compress tightly synthetic column below activity compression leg module 8 in synthetic board 5, synthetic board 5 is being removed afterwards, compress tightly all synthetic columns in synthetic board 5. The utility model discloses an auxiliary device is loaded to oligonucleotide synthetic post presses synthetic post device in batches based on manual lever pressure is supplementary, and the synthetic board of synthetic post has been adorned in advance puts into this device cassette, utilizes mechanical lever to provide corresponding pressure, presses synthetic post to the position of settlement in batches for pressing down the pressure degree homogeneous, synthetic post leakproofness homogeneous, and it is very convenient to operate, can save manual work in a large number and reduce synthetic failure rate.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications can be made without departing from the scope of the invention.

Claims

1. An oligonucleotide synthesis column packing auxiliary device, comprising a base (1), a supporting arm (2), a synthesis plate (5) and a pressing rod (14), characterized in that: the bottom of the supporting arm (2) is fixed at one end of the base (1), the top of the supporting arm (2) is movably provided with a pressure block (10) through a rotating shaft (11), a pressure arm I (12) is fixed on the rotating shaft (11), a clamping seat (3) is fixed in the middle of the base (1), the synthetic plate (5) is placed on the clamping seat (3), a plurality of synthetic column placing holes (6) are formed in the synthetic plate (5), a protective edge (7) is arranged around the synthetic plate (5), a movable pressure column module (8) is placed above the synthetic plate (5), a lower pressure rod limiting guide cover (17) is fixed on the supporting arm (2), the lower pressure rod (14) penetrates through the lower pressure rod limiting guide cover (17), and the top of the lower pressure rod (14) is movably connected with the bottom of the torsion arm (15) through a connecting shaft II (19), the top of the torsion arm (15) is movably connected with the bottom of the pressure block (10) through a first connecting shaft (18).

2. The oligonucleotide synthesis column packing aid of claim 1, wherein: and a second pressure arm (13) is fixed on the rotating shaft (11), and an included angle formed by the first pressure arm (12) and the second pressure arm (13) is 70 degrees.

3. The oligonucleotide synthesis column packing aid of claim 1, wherein: the base (1) and the clamping seat (3) are provided with guide clamping grooves (4), and the bottom of the synthetic plate (5) is provided with guide blocks (16) corresponding to the guide clamping grooves (4).

4. The oligonucleotide synthesis column packing aid of claim 1, wherein: the bottom of the movable compression column module (8) is provided with a protection edge clamping groove (9) corresponding to the protection edge (7).