CN214714399U - Rotary evaporator device for preparing Raatinib - Google Patents
Rotary evaporator device for preparing Raatinib Download PDFInfo
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- CN214714399U CN214714399U CN202120948293.1U CN202120948293U CN214714399U CN 214714399 U CN214714399 U CN 214714399U CN 202120948293 U CN202120948293 U CN 202120948293U CN 214714399 U CN214714399 U CN 214714399U
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- sleeve pipe
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- flask
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Abstract
The utility model discloses a rotatory evaporimeter device is used in preparation of larotinib, including backup pad, fixed case, motor case and cooling tube, the surface mounting of backup pad has fixed case, install driving motor in the fixed case, it is connected with lifting screw to rotate through fixing bearing in the fixed case, lifting screw passes through shaft coupling and driving motor's output shaft fixed connection, lifting screw's outer wall threaded connection has the connecting rod, the motor case is installed to one side outer wall of connecting rod, and the motor incasement is equipped with sleeve pipe one and sleeve pipe two respectively, rotate through connecting bearing between sleeve pipe one and the sleeve pipe two and connect, the right half of sleeve pipe one is equipped with rotatory flask, the cooling tube is installed to half one on the left side of sleeve pipe two. This rotatory evaporimeter device is used in preparation of larotinib can adjust the height of rotatory flask according to the user demand, makes rotatory flask contact with the surface of water that boils all the time.
Description
Technical Field
The utility model belongs to the technical field of the evaporimeter, concretely relates to rotatory evaporimeter device is used in preparation of larotinib.
Background
The rotary evaporator is also called as a rotary evaporator, is common equipment in a laboratory, consists of a motor, a distillation flask, a heating pot, a condenser pipe and the like, is mainly used for continuously distilling volatile solvents under a reduced pressure condition, is applied to the fields of chemistry, chemical engineering, biological medicine and the like, and is required to be collected by a liquid collecting bottle when waste liquid is collected.
Erlotinib is a potent, oral, selective inhibitor of tropomyosin-receptor-kinase (TRK), a product of genetic abnormalities that occur when the TRK gene is fused to one of the other genes in cancer cells. In the preparation process of the erlotinib, a rotary evaporator is often needed for evaporation operation, but the height of the rotary flask in a water bath heating box cannot be conveniently adjusted by the conventional rotary evaporator, so that the boiling water of the rotary flask and the water bath heating box is separated in the distillation process, and the distillation effect is influenced.
Disclosure of Invention
An object of the utility model is to provide a rotatory evaporimeter device is used in preparation of larotinib to solve the problem that proposes among the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a rotatory evaporimeter device is used in preparation of larotinib, includes backup pad, fixed case, motor case and cooling tube, the surface mounting of backup pad has fixed case, install driving motor in the fixed case, it is connected with the lifting screw to rotate through fixing bearing in the fixed case, the lifting screw passes through shaft coupling and driving motor's output shaft fixed connection, the outer wall threaded connection of lifting screw has the connecting rod, the motor case is installed to one side outer wall of connecting rod, the motor incasement is equipped with sleeve pipe one and sleeve pipe two respectively, rotate through connecting bearing between sleeve pipe one and the sleeve pipe two and connect, the right half of sleeve pipe one is equipped with rotatory flask, the cooling tube is installed to half of left side of sleeve pipe two.
Preferably, the motor incasement is equipped with the mounting panel, and the surface mounting of mounting panel has the rotating electrical machines, the initiative carousel is installed outward to the output shaft of rotating electrical machines, the outer wall of sleeve pipe one is equipped with driven turntable, be equipped with the belt between initiative carousel and the driven turntable.
Preferably, the supporting sleeve is installed on the left half portion of supporting plate surface, sliding connection has the lift post in the supporting sleeve, the surface of lift post is equipped with the fixed plate, and the mounting groove has been seted up on the surface of fixed plate, and the mounting groove internal fixation on fixed plate surface has the receiving flask, the inlet tube of receiving flask extends to in the cooling tube.
Preferably, a condensation pipe is installed in the cooling pipe, and a water inlet and a water outlet of the condensation pipe both extend out of the cooling pipe.
Preferably, the fixed orifices have been seted up to the left side outer wall of cooling tube, install the filling tube in the fixed orifices of cooling tube, the filling tube passes sleeve pipe two and sleeve pipe one to extend to in the rotatory flask.
Preferably, the surface of the supporting plate right below the rotary flask is provided with a water bath heating box, and four corners of the bottom of the supporting plate are provided with anti-slip pads.
Preferably, a moving groove is formed in the outer wall of one side, close to the motor box, of the fixed box, and the connecting rod moves in the moving groove of the fixed box.
The utility model discloses a technological effect and advantage:
according to the rotary evaporator device for preparing the erlotinib, the lifting screw rod is driven to rotate by the driving motor, the height of the motor box can be adjusted, and further the height of the rotary flask can be adjusted, so that the rotary flask is always contacted with boiling water in the water bath heating box, and the distillation effect is ensured; through being connected with the condenser pipe in the cooling tube with outside water installations to can accelerate the heat exchange efficiency in the cooling tube, accelerate distillation efficiency, this rotatory evaporimeter device is used in the preparation of larotinib can adjust the height of rotation flask according to the user demand, makes the rotation flask contact with the surface of water of boiling all the time.
Drawings
Fig. 1 is a schematic structural view of the present invention;
fig. 2 is a cross-sectional view of the fixing box of the present invention;
fig. 3 is a sectional view of the motor case of the present invention;
fig. 4 is a cross-sectional view of the cooling tube of the present invention.
In the figure: the device comprises a supporting plate 1, a fixed box 2, a driving motor 3, a lifting screw rod 4, a connecting rod 5, a motor box 6, a rotating motor 7, a driving turntable 8, a first sleeve, a driven turntable 10, a bearing 11, a second sleeve, a cooling tube 13, a feeding tube 14, a supporting sleeve 15, a lifting column 16, a collecting bottle 17, a water bath heating box 18, a rotating flask 19 and a condenser tube 20.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.
In order to adjust the height of the rotary flask 19 according to the use requirement, as shown in fig. 1 and 2, a fixed box 2 is welded and fixed on the surface of the supporting plate 1, a driving motor 3 is fixed in the fixed box 2 through a bolt, the fixed box 2 is rotatably connected with a lifting screw 4 through a welded fixed bearing, the lifting screw 4 is fixedly connected with an output shaft of a driving motor 3 through a coupler, the outer wall of the lifting screw rod 4 is connected with a connecting rod 5 in a threaded manner, the outer wall of one side of the connecting rod 5 is provided with a motor box 6, the outer wall of one side of the fixed box 2 close to the motor box 6 is provided with a moving groove, the connecting rod 5 moves in the moving groove of the fixed box 2, be equipped with sleeve pipe one 9 and sleeve pipe two 12 in the motor case 6 respectively, the right half one-piece of sleeve pipe one 9 has rotatory flask 19, the left half one-piece of sleeve pipe two 12 bonds and has cooling tube 13.
In order to drive the rotation of rotatory flask 19, guarantee the evaporation effect, as shown in fig. 1 and fig. 3, welded fastening has the mounting panel in the motor case 6, and the surface of mounting panel has rotating electrical machines 7 through the bolt fastening, driving turntable 8 is installed outward to rotating electrical machines 7's output shaft, the outer wall of sleeve pipe one 9 bonds and has driven turntable 10, install the belt between driving turntable 8 and the driven turntable 10, rotate through connecting bearing 11 between sleeve pipe one 9 and the sleeve pipe two 12 and be connected. Furthermore, a rectangular groove is formed in the outer wall of one side of the motor box 6, and a protection plate is fixed in the rectangular groove of the motor box 6 through bolts, so that equipment in the motor box 6 can be maintained conveniently.
In order to accelerate the cooling effect, be convenient for simultaneously reinforced, as shown in fig. 1 and fig. 4, install condenser pipe 20 in the cooling tube 13, condenser pipe 20's water inlet and delivery port all extend to outside the cooling tube 13, the fixed orifices has been seted up to the left side outer wall of cooling tube 13, the fixed orifices of cooling tube 13 internal bonding has filling tube 14, filling tube 14 passes sleeve pipe two 12 and sleeve pipe one 9 to extend to in the rotatory flask 19, the filling tube 14 is located the outside terminal surface of cooling tube 13 and installs the sealing plug.
In order to adjust the height of receiving flask 17, as shown in fig. 1, the left half part on the surface of supporting plate 1 is fixed with supporting sleeve 15 through the bolt, sliding connection has lift post 16 in supporting sleeve 15, threaded hole is seted up to one side outer wall of supporting sleeve 15, supporting sleeve 15's threaded hole internal thread is connected with fixing bolt, the surface of lift post 16 is fixed with the fixed plate through the bolt, and the mounting groove has been seted up on the surface of fixed plate, and the mounting groove internal fixation on fixed plate surface has receiving flask 17, receiving flask 17's inlet tube extends to in the cooling tube 13.
The working principle is as follows: this rotatory evaporimeter device is used in preparation of larotinib, when using, connect external water tank and circulating pump with the water inlet and the delivery port of condenser pipe 20, pour into rotatory flask 19 with solution through filling tube 14, start water bath heating cabinet 18 and heat rotatory flask 19, start rotating electrical machines 7 simultaneously, rotating electrical machines 7 drives initiative carousel 8 and rotates, initiative carousel 8 drives driven turntable 10 through the belt and rotates, and then drive rotatory flask 19 and rotate, the steam that the solution after the heating produced passes through sleeve pipe one 9 and two 12 entering cooling tube 13 of sleeve pipe, cool down to steam through condenser pipe 20, make in the steam liquefaction flows into collecting bottle 17. In-process at the heating of rotation flask 19, when the height of needs rotation flask 19 was adjusted, start driving motor 3, driving motor 3 drives lifting screw 4 and rotates, lifting screw 4 adjusts the height of motor case 6 through connecting rod 5, and then adjusts the height of rotation flask 19, make rotation flask 19 contact with the boiling water in the water bath heating cabinet 18 all the time, adjust the height of lift post 16 in supporting sleeve 15 simultaneously, thereby adjust the height of receiving flask 17.
Claims (7)
1. The utility model provides a preparation of larotinib is with rotatory evaporimeter device, includes backup pad (1), fixed case (2), motor case (6) and cooling tube (13), its characterized in that: the surface mounting of backup pad (1) has fixed case (2), install driving motor (3) in fixed case (2), it is connected with lifting screw (4) to rotate through fixing bearing in fixed case (2), lifting screw (4) are through the output shaft fixed connection of shaft coupling and driving motor (3), the outer wall threaded connection of lifting screw (4) has connecting rod (5), motor case (6) are installed to one side outer wall of connecting rod (5), be equipped with sleeve pipe (9) and sleeve pipe two (12) in motor case (6) respectively, rotate through coupling bearing (11) between sleeve pipe (9) and the sleeve pipe two (12) and connect, the right half of sleeve pipe (9) is equipped with rotatory flask (19), cooling tube (13) are installed to the left half of sleeve pipe two (12).
2. The rotary evaporator device for preparing lapatinib according to claim 1, characterized in that: be equipped with the mounting panel in motor case (6), the surface mounting of mounting panel has rotating electrical machines (7), initiative carousel (8) is installed outward to the output shaft of rotating electrical machines (7), the outer wall of sleeve pipe (9) is equipped with driven turntable (10), be equipped with the belt between initiative carousel (8) and driven turntable (10).
3. The rotary evaporator device for preparing lapatinib according to claim 1, characterized in that: support sleeve (15) are installed to the left half on backup pad (1) surface, sliding connection has lift post (16) in support sleeve (15), the surface of lift post (16) is equipped with the fixed plate, and the mounting groove has been seted up on the surface of fixed plate, and the mounting groove internal fixation on fixed plate surface has receiving flask (17), the inlet tube of receiving flask (17) extends to in cooling tube (13).
4. The rotary evaporator device for preparing lapatinib according to claim 1, characterized in that: install condenser pipe (20) in cooling tube (13), the water inlet and the delivery port of condenser pipe (20) all extend to outside cooling tube (13).
5. The rotary evaporator device for preparing lapatinib according to claim 1, characterized in that: the fixed orifices has been seted up to the left side outer wall of cooling tube (13), install filling tube (14) in the fixed orifices of cooling tube (13), filling tube (14) pass sleeve pipe two (12) and sleeve pipe one (9) to extend to in rotatory flask (19).
6. The rotary evaporator device for preparing lapatinib according to claim 1, characterized in that: the surface mounting of backup pad (1) under rotatory flask (19) has water bath heating cabinet (18), the bottom four corners of backup pad (1) all is equipped with the slipmat.
7. The rotary evaporator device for preparing lapatinib according to claim 1, characterized in that: the outer wall of one side, close to the motor box (6), of the fixed box (2) is provided with a moving groove, and the connecting rod (5) moves in the moving groove of the fixed box (2).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120948293.1U CN214714399U (en) | 2021-05-06 | 2021-05-06 | Rotary evaporator device for preparing Raatinib |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120948293.1U CN214714399U (en) | 2021-05-06 | 2021-05-06 | Rotary evaporator device for preparing Raatinib |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214714399U true CN214714399U (en) | 2021-11-16 |
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ID=78616449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120948293.1U Active CN214714399U (en) | 2021-05-06 | 2021-05-06 | Rotary evaporator device for preparing Raatinib |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214714399U (en) |
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2021
- 2021-05-06 CN CN202120948293.1U patent/CN214714399U/en active Active
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