CN214622667U

CN214622667U - Blood spot groove plate capable of quickly removing blood spot tablets

Info

Publication number: CN214622667U
Application number: CN202120765464.7U
Authority: CN
Inventors: 冯振; 景叶松; 弭兆元
Original assignee: Shandong Ying Sheng Biotechnology Co ltd
Current assignee: Shandong Ying Sheng Biotechnology Co ltd
Priority date: 2021-04-14
Filing date: 2021-04-14
Publication date: 2021-11-05
Anticipated expiration: 2031-04-14

Abstract

The utility model relates to the field of biotechnology, concretely relates to remove blood spot frid of blood spot piece fast. The blood spot plate is provided with through holes distributed in an array manner, the through holes correspond to the notches of the blood spot sheet filtering grooves, and the blood spot sheet filtering grooves are all positioned on one side of the plate body of the blood spot plate and are connected with the plate body through the notches; the blood spot sheet filtering tank prevents the blood spot sheet from passing through, and the reaction liquid can pass through, so that the blood spot sheet is separated. Blood spot piece filter-tank and micropore board hole one-to-one on the blood spot frid, the utility model discloses can ensure the blood spot piece inside the blood spot piece filter-tank, can maintain the normal reaction of reaction liquid and blood spot piece again, improve and hatch efficiency, when getting rid of the blood spot piece, only need will the utility model discloses directly mention with the hand, have simple structure, convenient fast, the characteristics of no cross contamination, excellent in use effect has extensive practicality.

Description

Blood spot groove plate capable of quickly removing blood spot tablets

Technical Field

The utility model relates to the field of biotechnology, concretely relates to remove blood spot frid of blood spot piece fast.

Background

The dried blood spot tablet is obtained by dripping whole blood on a filter paper sheet and drying, and has the advantages of small sample amount, simple preparation method, low storage and transportation cost and the like, so the dried blood spot tablet is widely applied to large-scale disease screening, such as genetic metabolic diseases. The components to be detected are analyzed by analysis methods such as a fluorescence reaction method, a tandem mass spectrometry method and the like, so that the diagnosis result of the patient is reflected.

Generally, in the dry blood spot method analysis operation process, the blood spot piece in the micropore reaction plate is obtained through using the hole puncher, and the diameter is 3mm, gets rid of the blood spot piece from the micropore reaction plate through patting etc. mode after the reaction, and this process is wasted time and energy, and also probably need follow the blood spot piece with the help of tweezers etc. and carry out, even disinfect tweezers, also can increase the risk of sample cross contamination to influence the judgement of testing result.

SUMMERY OF THE UTILITY MODEL

The utility model aims at overcoming the defects in the prior dry blood spot analysis method, providing a blood spot groove plate which has simple structure, is quick and convenient, has no cross contamination and is suitable for a microporous plate for removing blood spot sheets.

In order to achieve the above purpose, the utility model adopts the following technical scheme:

a blood spot slotted plate for quickly removing blood spot sheets is characterized in that through holes distributed in an array mode are formed in the blood spot slotted plate, the through holes correspond to notches of blood spot sheet filtering grooves, and the blood spot sheet filtering grooves are located on one side of a plate body of the blood spot slotted plate and are connected with the plate body through the notches; the blood spot sheet filtering tank prevents the blood spot sheet from passing through, and the reaction liquid can pass through, so that the blood spot sheet is separated.

Advantageous effects

One or more technical schemes that this application provided have following advantage or beneficial effect:

1. the blood spot sheet is ensured to be in the blood spot sheet filter tank, the normal reaction of the reaction liquid and the blood spot sheet can be maintained, the incubation efficiency is improved, and when the blood spot sheet is removed, the blood spot groove plate only needs to be directly lifted by hands. Compared with the prior art, the method has the characteristics of simple structure, rapidness, convenience, no cross contamination, good use effect and wide practicability.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this application, illustrate embodiments of the application and, together with the description, serve to explain the application and are not intended to limit the application.

Fig. 1 is a schematic structural diagram of embodiment 1 of the present invention;

fig. 2 is a schematic structural view of a blood spot sheet filter tank in embodiment 1 of the present invention.

Wherein, the blood spot filter tank comprises 1-a blood spot filter tank, 2-a groove plate, 3-a groove opening, 4-a groove column, 5-a groove hoop and 6-a groove bottom.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

For convenience of description, the words "upper", "lower", "left" and "right" in the present application, if any, merely indicate correspondence with the upper, lower, left and right directions of the drawings themselves, and do not limit the structure, but merely facilitate the description of the present invention and simplify the description, rather than indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the present invention.

As introduced in the background art, the dry blood spot method has the risks of increasing sample cross contamination and influencing the judgment of the detection result in the analysis operation process, and the application provides the blood spot slot plate for quickly removing the blood spot sheet aiming at the problems.

Furthermore, the through holes distributed in the array correspond to the holes of a 96 microporous plate or a 384 microporous plate one by one, and the groove body of the blood spot filter groove can extend into the microporous plate and is matched with the accommodating cavity of the microporous plate. Furthermore, the diameter of the outer side of the notch is slightly smaller than the diameter of the hole of the micropore plate, and the length of the groove body is smaller than the depth of the hole of the micropore plate.

Furthermore, the blood spot groove plate is provided with a supporting part, so that the blood spot groove plate and the fixed blood spot sheet filter tank are supported on the microporous plate. The blood spot groove plate is stable in the incubation process, and the blood spot groove plate cannot fly out or be dislocated due to 96-hole oscillation. And meanwhile, the blood spot groove plate is conveniently taken up when the incubation is finished, and is vertically separated from the 96-hole plate, so that the cross contamination is avoided.

Further, the blood spot piece filter tank includes notch, groove post, groove hoop, tank bottom, and the groove post is along the even array of the vertical direction at notch center, and its one end outside links to each other with the notch inboard, and the other end inboard links to each other with the tank bottom outside, and groove post interlude links to each other with the groove hoop, and it has the round hole to open in the middle of the tank bottom. The blood spot piece filter-tank is kept away from at the horizontal direction and the vertical direction to groove post and tank bottom respectively to prevent that blood spot piece breaks away from at the vertical state in the clearance of groove post, and reaction liquid can make a round trip to flow and fully react with blood spot piece through the clearance of groove post and the hole of tank bottom simultaneously, and furthest increases reaction efficiency, and the incubation liquid flows out from the cell body when simultaneously conveniently hatching the end, reduces the incubation liquid loss that the separation brought.

Furthermore, a round hole with the diameter larger than 2mm and smaller than 3mm is formed in the middle of the bottom of the groove. The flow of liquid when tank bottom round hole had both made things convenient for to hatch improves and hatches efficiency, and when hatching the end simultaneously, the design of round hole diameter was guaranteed and is preventing that the blood spot piece breaks away from the while, and the convenient incubation liquid of as far as flows out from the cell body.

Further, the distance between the groove hoop and the groove bottom is larger than 2mm and smaller than 3 mm. Considering the size of the blood spot sheet, the position of the groove hoop is reasonably designed to ensure that the blood spot sheet is prevented from being separated from the blood spot sheet filtering groove in the vertical state from the gap of the groove column.

Further, the number of the groove columns is 7-9, preferably 8, and the inner side of the end, close to the groove opening, of each groove column is provided with a 45-degree chamfer. The chamfer angle at the inner side of the opening makes the opening more favorable for the entry of blood spot sheets. Too many groove columns are not favorable for full reaction of the reaction liquid, and too few groove columns are difficult to prevent blood spot sheets from being separated from gaps of the columns in the reaction process.

Further, the length of the groove column is 5-9 mm. Different lengths can be reasonably selected, so that the groove body is matched with microporous plates with different hole depths and hole bottom shapes.

Example 1

In a typical embodiment of the present application, as shown in fig. 1, the blood spot filter cells 1 are uniformly arrayed on the cell plate 2, each blood spot filter cell 1 corresponds to a 96-well microporous plate hole one-to-one, as shown in fig. 2, the cell pillars 4 are arrayed with the center circumference of the slot opening 3, the outer sides of the upper ends of the cell pillars 4 are connected with the inner sides of the slot openings 3, the tops of the cell pillars 4 are provided with 45-degree chamfers, the bottoms of the inner sides of the bottom ends of the cell pillars 4 are internally connected with the cell bottoms 6, the middle of the cell bottoms 6 is provided with a round hole, the diameter of the round hole is slightly smaller than 3mm, and the gap between the bottom sides of the cell hoops 5 and the upper sides of the cell bottoms 6 is slightly smaller than 3 mm.

The blood spot groove plate capable of quickly removing the blood spot sheet is placed in a 96-hole microporous plate, the blood spot sheet with the diameter of 3mm is driven into a blood spot sheet filtering groove 1 through a 3mm puncher, the blood spot sheet falls on a groove bottom 6, reaction liquid is added into the 96-hole microporous plate through a pipettor and then placed into an incubation oscillator for incubation, the 96-hole microporous plate is oscillated back and forth in the opposite direction through the incubation oscillator, the groove column 4 and the groove bottom 6 respectively prevent the blood spot sheet from being separated from the blood spot sheet filtering groove 1 in the horizontal direction and the vertical direction, the groove hoop 5 prevents the blood spot sheet from being separated from the blood spot sheet filtering groove 1 in the gap of the groove column 4 in the vertical state, meanwhile, the reaction liquid flows back and forth through the gap of the groove column 4 and the hole of the groove bottom 6 and fully reacts with the blood spot sheet, after the incubation oscillation is finished, the supporting parts at the two sides of the groove plate 2 are directly pinched by hands to lift the blood spot groove plate, and the liquid can flow back into the 96 holes in the gap of the groove bottom 6 and the groove column 4, only the blood spot sheet after the reaction is finished is stored in the blood spot sheet filtering tank 1, so that the purpose of quickly removing the blood spot sheet from the 96-hole microporous plate is realized. Thus, the service cycle of the blood spot plate is completed.

Example 2

In a typical embodiment of the application, the blood spot plate for quickly removing the blood spot sheet is provided, wherein the number of the blood spot sheet filtering grooves is the same as that of a 384-pore plate, and the positions, the pore diameters and the lengths are matched. The rest of the structure is the same as in example 1.

Although the present invention has been described with reference to the accompanying drawings, it is not intended to limit the scope of the present invention, and those skilled in the art should understand that various modifications or variations that can be made by those skilled in the art without inventive work are still within the scope of the present invention.

Claims

1. A blood spot groove plate for quickly removing blood spot sheets is characterized in that through holes distributed in an array mode are formed in the blood spot groove plate and correspond to notches of blood spot sheet filtering grooves, and the blood spot sheet filtering grooves are located on one side of a plate body of the blood spot groove plate and are connected with the plate body through the notches; the blood spot sheet filtering tank prevents the blood spot sheet from passing through, and the reaction liquid can pass through, so that the blood spot sheet is separated.

2. The blood spot plate for rapidly removing blood spot sheets as claimed in claim 1, wherein the through holes distributed in the array correspond to the holes of a 96-microporous plate or a 384-microporous plate one by one, and the groove body of the blood spot sheet filter groove can extend into the microporous plate and is matched with the containing cavity of the microporous plate.

3. The blood spot plate for rapidly removing blood spot sheets according to claim 1, wherein the blood spot plate is provided with a supporting part for supporting the blood spot plate and fixing the blood spot sheet filter tank on the micro-porous plate.

4. The plaque removal plate of claim 1 wherein said plaque filter cells comprise a slot opening, a cell post, a cell hoop, and a cell bottom, wherein the cell post is uniformly arrayed along a vertical direction of the center of the slot opening, one end of the cell post is connected with the inside of the slot opening on the outside, the other end of the cell post is connected with the outside of the cell bottom on the inside, the middle section of the cell post is connected with the cell hoop, and a circular hole is formed in the middle of the cell bottom.

5. The blood spot groove plate for rapidly removing blood spot sheets as claimed in claim 2, wherein the diameter of the outer side of the notch is slightly smaller than the diameter of the hole of the micro-porous plate, and the length of the groove body is smaller than the depth of the hole of the micro-porous plate.

6. The blood spot plate for rapidly removing blood spot tablets as claimed in claim 4, wherein the middle of the bottom of the groove is provided with a round hole with a diameter larger than 2mm and smaller than 3 mm.

7. The blood spot plate for rapidly removing blood spot patch according to claim 4, wherein the distance between the groove hoop and the bottom of the groove is greater than 2mm and less than 3 mm.

8. The blood spot plate for rapidly removing blood spot sheets as claimed in claim 4, wherein the number of the groove columns is 7-9, and the inner side of the end of the groove near the notch is chamfered by 45 degrees.

9. The blood spot plate for rapidly removing blood spot sheets according to claim 4, wherein the number of the groove columns is 8.

10. The blood spot plate for rapidly removing blood spot patch according to claim 4, wherein the length of the groove column is 5-9 mm.