CN214584943U - Dry-type coupled inverted OCT (optical coherence tomography) elastography system - Google Patents
Dry-type coupled inverted OCT (optical coherence tomography) elastography system Download PDFInfo
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Abstract
The utility model provides a dry-type coupled inversion formula OCT elasticity imaging system, is provided with and carries thing module and light path module, carries the thing module and is provided with the OCT imaging window, and the light path module is located OCT imaging window below, and the probe beam that the light path module sent is perpendicular with OCT imaging window place plane. The object carrying module is further provided with an object carrying table and an ultrasonic generator, the object carrying table is arranged around the OCT imaging window in a surrounding mode, the object carrying table is fixedly connected with the OCT imaging window, and the ultrasonic generator is connected with the OCT imaging window. The OCT imaging window is a low-density polyethylene imaging window, a polydimethylsiloxane imaging window or a polyvinyl chloride resin imaging window. The light path module is provided with a lens, a vibrating mirror and an optical fiber collimator, the lens is arranged under the imaging window, the vibrating mirror is arranged under the lens, and the light output end of the optical fiber collimator is right opposite to the vibrating mirror. The dry-coupled inverted OCT elastography system does not need to process the object to be measured, and has the advantages of simple operation steps and high measurement efficiency.
Description
Technical Field
The utility model relates to the technical field of medical equipment, especially, relate to an inversion formula OCT elasticity imaging system of dry-type coupling.
Background
Optical Coherence Tomography (OCT) is an imaging technique rapidly developed in recent years, which uses the basic principle of weak coherent optical interferometers to detect back-reflected or several-time scattered signals of incident weak coherent light at different depth levels of a biological tissue, and obtains a two-dimensional or three-dimensional structural image of the biological tissue by scanning. Biomechanical properties are associated with tissue structure and histopathological changes, and can be used as diagnostic basis. The OCT elastography technology is a technology for clinical diagnosis based on histological pathology, the imaging has high resolution and three-dimensional technical characteristics, can be used for measuring the biological and physical characteristics, and the measurement is performed in vitro and has the characteristic of small wound. The OCT elastic imaging technology excited by ultrasonic waves is an imaging measurement technology which uses an ultrasonic transducer to emit ultrasonic waves to cause sample tissues to vibrate so as to realize tissue elastic parameters, can measure elastic characteristics of a pattern with the resolution of about 10 microns, and has high accuracy and strong availability. However, the propagation of the ultrasonic wave must depend on the propagation medium such as water, so that the existing ultrasonic wave excitation OCT elastography device usually places the measurement sample in agar when working, conducts the ultrasonic wave with water to make the tissue vibrate, and then senses the vibration through the agar to further realize the imaging measurement of the tissue elasticity parameter.
Therefore, it is necessary to provide a dry-coupled inverted OCT elastography system to overcome the deficiencies of the prior art.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to avoid prior art's weak point and provide an inversion formula OCT elasticity imaging system of dry-type coupling, need not to handle the sample in advance, easy and simple to handle and measurement of efficiency is high.
The purpose of the utility model is realized through the following technical measures.
The utility model provides a dry-type coupled inversion formula OCT elasticity imaging system, be provided with and carry thing module and light path module, it is provided with OCT imaging window to carry the thing module, and the light path module is located OCT imaging window below, and the probe beam that the light path module sent is perpendicular with OCT imaging window place plane.
Preferably, the object carrying module is further provided with an object carrying table and an ultrasonic generator, the object carrying table is arranged around the OCT imaging window in a surrounding mode, and the object carrying table is fixedly connected with the OCT imaging window;
the ultrasonic generator is connected with the OCT imaging window.
Preferably, the OCT imaging window is a low density polyethylene imaging window, a polydimethylsiloxane imaging window, or a polyvinyl chloride resin imaging window.
Preferably, the light path module is provided with a lens, a vibrating mirror and an optical fiber collimator, the lens is arranged under the imaging window, the vibrating mirror is arranged under the lens, and the light output end of the optical fiber collimator is right opposite to the vibrating mirror.
Preferably, a focus formed after the light beam passes through the lens is defined as a detection point, and the detection point is superposed with the object to be measured on the OCT imaging window.
Preferably, the system is also provided with an ultrasonic driving module, a galvanometer driving module, an OCT interferometer, an image acquisition and reconstruction module and an imaging control module;
the ultrasonic driving module is connected with an ultrasonic generator, and the galvanometer driving module is connected with a galvanometer;
the OCT interferometer is connected between the optical fiber collimator and the image acquisition and reconstruction module;
the imaging control module is connected with the ultrasonic driving module, the galvanometer driving module and the image acquisition and reconstruction module.
Preferably, the sound wave generating surface of the ultrasonic generator is tightly connected with the OCT imaging window through ultrasonic glue.
Preferably, the ultrasonic generator is a frequency-adjustable ultrasonic generator or a ring-shaped ultrasonic generator;
the frequency-adjustable ultrasonic generator is connected with the OCT imaging window in a bypass shaft mode, and the annular ultrasonic generator is connected with the OCT imaging window in a coaxial mode.
Preferably, the stage is a glass stage or a high density polyethylene stage.
The utility model discloses an inversion formula OCT elasticity imaging system of dry-type coupling is provided with and carries thing module and light path module, it is provided with OCT imaging window to carry the thing module, and the light path module is located OCT imaging window below, and the detecting beam that the light path module sent is perpendicular with OCT imaging window place plane. The OCT imaging window can conduct ultrasonic waves instead of water and agar, so that the system does not need to process the object to be detected during working. In addition, the light path module is positioned below the object carrying module to form an inverted imaging structure, and dry-type coupling inverted imaging can be realized by matching with the OCT imaging window.
Drawings
The present invention will be further described with reference to the accompanying drawings, but the contents in the drawings do not constitute any limitation to the present invention.
Fig. 1 is a schematic structural diagram of embodiment 1 of a dry-coupled inverted OCT elastography system according to the present invention.
Fig. 2 is a schematic top view of the carrier module of embodiment 1 of the dry-coupled inverted OCT elastography system of the present invention.
Fig. 3 is a schematic structural diagram of embodiment 2 of a dry-coupled inverted OCT elastography system according to the present invention.
Fig. 4 is a schematic structural diagram of a carrier module according to embodiment 2 of the present invention.
In fig. 1 to 4, the following are included:
a carrier module 100, an OCT imaging window 110, a carrier 120, an ultrasonic generator 130, a frequency-tunable ultrasonic generator 131, a ring-type ultrasonic generator 132,
An optical path module 200, a lens 210, a galvanometer 220, a fiber collimator 230,
The device comprises an object to be measured 300, an ultrasonic driving module 310, a galvanometer driving module 320, an OCT interferometer 330, an image acquisition and reconstruction module 340 and an imaging control module 350.
Detailed Description
The present invention will be further illustrated with reference to the following examples.
Example 1.
A dry-coupled inverted OCT (optical coherence tomography) elastography system is provided with a carrier module 100 and an optical path module 200, as shown in figure 1, the carrier module 100 is provided with an OCT imaging window 110, the optical path module 200 is positioned below the OCT imaging window 110, and a probe beam emitted by the optical path module 200 is vertical to the plane of the OCT imaging window 110. The optical path module 200 is located below the OCT imaging window 110, and the OCT imaging window can transmit the ultrasonic wave, so that the optical path module 200 and the OCT imaging window 110 can be reversely coupled and imaged in a dry manner, so that the system does not need to perform any processing on the object 300 to be measured during operation, and the imaging steps are simplified.
In this embodiment, the object stage module 100 is further provided with an object stage 120 and an ultrasonic generator 130, the object stage 120 is disposed around the OCT imaging window 110, the object stage 120 is fixedly connected to the OCT imaging window 110, and the ultrasonic generator 130 is connected to the OCT imaging window 110. Note that the shapes of the stage 120 and the OCT imaging window 110 may be a rectangular parallelepiped, a square, a round cake, or the like, and in this embodiment, the OCT imaging window and the stage 120 are specifically rectangular paralleled and the plan view structure is as shown in fig. 2.
In this embodiment, the stage 120 is a glass stage 120 or a high density polyethylene stage 120, and the OCT imaging window 110 is a low density polyethylene imaging window, a polydimethylsiloxane imaging window, or a pvc imaging window. The glass stage 120 or the HDPE stage 120 is transparent and hard, has a carrying function, and is convenient for a user to check the internal structure of the system. The low-density polyethylene imaging window, the polydimethylsiloxane imaging window or the polyvinyl chloride resin imaging window not only can play a loading role, but also can realize the conduction of sound waves. It should be noted that the OCT imaging window 110 is not limited to the low-density polyethylene imaging window, the polydimethylsiloxane imaging window, or the polyvinyl chloride resin imaging window in this embodiment. Other imaging windows made of a material that is transparent to light, flexible, and capable of transmitting ultrasound waves are also possible, and the stage 120 is not limited to the glass stage 120 or the hdpe stage 120 in this embodiment, but may be other.
In this embodiment, the optical path module 200 is provided with a lens 210, a galvanometer 220 and a fiber collimator 230, the lens 210 is disposed under the imaging window, the galvanometer 220 is disposed under the lens 210, and an optical output end of the fiber collimator 230 is opposite to the galvanometer 220. In this embodiment, the galvanometer 220 is specifically a two-dimensional scanning galvanometer, and the galvanometer 220 may rotate freely in space. The fiber collimator 230 emits a light beam, and the position of the detection point can be adjusted by adjusting the angle of the galvanometer 220. The focus formed by the probe beam after passing through the lens 210 is defined as a probe point, and the probe point coincides with the object 300 to be measured on the OCT imaging window 110.
In this embodiment, the optical fiber interferometer is further provided with an ultrasonic driving module 310, a galvanometer driving module 320, an OCT interferometer 330, an image acquisition and reconstruction module 340, and an imaging control module 350, wherein the ultrasonic driving module 310 is connected to the ultrasonic generator 130, the galvanometer driving module 320 is connected to the galvanometer 220, the OCT interferometer 330 is connected between the optical fiber collimator 230 and the image acquisition and reconstruction module 340, and the imaging control module 350 is connected to the ultrasonic driving module 310, the galvanometer driving module 320, and the image acquisition and reconstruction module 340. The ultrasonic driving module 310 is used for controlling the ultrasonic generator 130, and the galvanometer 220 control module is used for controlling the driving galvanometer 220, controlling the frequency and amplitude of the oscillation of the galvanometer 220, realizing the movement of the detection point and further realizing the detection of different positions of the biological tissue. The OCT interferometer 330 detects the reflected or scattered signals of the biological tissue from different depth levels to the laser by analyzing the components of the laser light transmitted back through the OCT optical path probe and the fiber collimator 230, thereby detecting the object 300 or distinguishing the pathological changes of the object 300. The image acquisition and reconstruction module 340 acquires a distribution image of elastic parameters inside the tissue by scanning and analyzing the data of the OCT interferometer 330. The imaging control module 350 controls the ultrasound driver module 310 and the galvanometer driver module 320 based on the results returned by the image acquisition and reconstruction module 340.
In this embodiment, the sound wave generating surface of the ultrasonic generator 130 is tightly connected to the OCT imaging window 110 by ultrasonic adhesive. The ultrasonic generator 130 is a frequency-adjustable ultrasonic generator 131, and the frequency-adjustable ultrasonic generator 131 is coupled to the OCT imaging window 110 by a shaft. The use of ultrasonic glue can ensure that the conduction of ultrasonic waves is not hindered. The adjustable-frequency ultrasonic generator 131 is configured to generate ultrasonic waves of different frequencies, so that the image acquisition and reconstruction module 340 obtains images of the ultrasonic waves of different frequencies. The ultrasonic generator is not limited to the frequency-adjustable ultrasonic generator, and may be a fixed-frequency ultrasonic generator or the like.
The working process of the dry-coupled inverted OCT elastography system of the present embodiment is as follows: the object 300 to be measured is placed on the OCT imaging window 110, the object 300 to be measured is tightly attached to the OCT imaging window 110, the ultrasonic driving module 310 is turned on, the frequency-adjustable ultrasonic generator 131 is driven, ultrasonic waves are generated, and the ultrasonic waves are directly transmitted to the object 300 to be measured through the OCT imaging window 110, so that the object 300 to be measured vibrates. The detection laser passes through the fiber collimator 230 and the optical path module 200, so that the focal point of the beam is vertically irradiated on the object 300 to be measured. The OCT interferometer 330 detects the components of the laser light transmitted back through the fiber collimator 230, detects the reflected or scattered signals of different depth layers of the biological tissue to the laser light, detects the vibration condition of the tissue to be detected, detects the pathological changes of the tissue structure and the interior of the tissue, obtains the distribution image of the elastic parameters in the tissue by the image acquisition and reconstruction module 340, returns the result to the imaging control module 350, and further controls the ultrasonic driving module 310 and the galvanometer driving module 320 by the imaging control module 350.
The dry-coupled inverted OCT elastography system can sense the structure of an object to be measured or distinguish the histopathology change of the object to be measured, and the object to be measured does not need to be processed at any time during sensing, so that the measurement accuracy is ensured, the operation steps of measurement are simplified, and the measurement efficiency is improved.
Example 2.
A dry-coupled inverted OCT elastography system, as shown in fig. 2, with the same other features as in example 1 except that: the ultrasonic generator 130 is a ring-shaped ultrasonic generator 130, and the ring-shaped ultrasonic generator 130 is coaxially connected to the OCT imaging window 110. In this embodiment, the OCT imaging window 110 is a circular cake, and the radius of the circular surface of the OCT imaging window is larger than the radius of the circular surface of the circular ring type ultrasonic generator 130, and the specific structure is shown in fig. 4. The annular ultrasonic generator 130 is provided with a through hole in the middle, laser can penetrate through the through hole to irradiate on tissues to be detected, the generation sound wave surface of the annular ultrasonic generator 130 is tightly connected with the bottom surface of the imaging window cylinder, the annular ultrasonic generator 130 is attached to the imaging window, the contact area is large, ultrasonic waves are more uniformly distributed on the object 300 to be detected, and the final imaging effect is good. The dry-type coupled inverted OCT elastography system is simple in operation steps, high in measurement efficiency and good in imaging effect.
It should be finally noted that the above embodiments are only intended to illustrate the technical solutions of the present invention and not to limit the scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention can be modified or replaced with equivalents without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. A dry-coupled inverted OCT elastography system, characterized by: the OCT imaging system is characterized in that an object carrying module and a light path module are arranged, the object carrying module is provided with an OCT imaging window, the light path module is located below the OCT imaging window, and a detection beam emitted by the light path module penetrates through the OCT imaging window.
2. The dry-coupled inverted OCT elastography system of claim 1, wherein: the object carrying module is also provided with an object carrying table and an ultrasonic generator, the object carrying table is arranged around the OCT imaging window in a surrounding manner, and the object carrying table is fixedly connected with the OCT imaging window;
the ultrasonic generator is connected with the OCT imaging window.
3. The dry-coupled inverted OCT elastography system of claim 2, wherein: the OCT imaging window is a low-density polyethylene imaging window, a polydimethylsiloxane imaging window or a polyvinyl chloride resin imaging window.
4. The dry-coupled inverted OCT elastography system of claim 1, wherein: the optical path module is provided with a lens, a vibrating mirror and an optical fiber collimator, the lens is arranged under the imaging window, the vibrating mirror is arranged under the lens, and the optical output end of the optical fiber collimator is right opposite to the vibrating mirror.
5. The dry-coupled inverted OCT elastography system of claim 1, wherein: and defining a focus formed by the probe beam after passing through the lens as a probe point, wherein the probe point is superposed with the object to be detected on the OCT imaging window.
6. The dry-coupled inverted OCT elastography system of claim 1, wherein: the system is also provided with an ultrasonic driving module, a galvanometer driving module, an OCT interferometer, an image acquisition and reconstruction module and an imaging control module;
the ultrasonic driving module is connected with an ultrasonic generator, and the galvanometer driving module is connected with a galvanometer;
the OCT interferometer is connected between the optical fiber collimator and the image acquisition and reconstruction module;
the imaging control module is connected with the ultrasonic driving module, the galvanometer driving module and the image acquisition and reconstruction module.
7. The dry-coupled inverted OCT elastography system of claim 2, wherein: and the sound wave generating surface of the ultrasonic generator is tightly connected with the OCT imaging window through ultrasonic glue.
8. The dry-coupled inverted OCT elastography system of claim 7, wherein: the ultrasonic generator is a frequency-adjustable ultrasonic generator or a ring-shaped ultrasonic generator;
the frequency-adjustable ultrasonic generator is connected with the OCT imaging window in a paraxial mode, and the annular ultrasonic generator is connected with the OCT imaging window in a coaxial mode.
9. The dry-coupled inverted OCT elastography system of claim 8, wherein: the objective table is a glass objective table or a high-density polyethylene objective table.
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| CN202120537891.XU CN214584943U (en) | 2021-03-16 | 2021-03-16 | Dry-type coupled inverted OCT (optical coherence tomography) elastography system |
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| CN202120537891.XU CN214584943U (en) | 2021-03-16 | 2021-03-16 | Dry-type coupled inverted OCT (optical coherence tomography) elastography system |
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