CN214553533U - Production facility of medetomidine midbody - Google Patents
Production facility of medetomidine midbody Download PDFInfo
- Publication number
- CN214553533U CN214553533U CN202120462835.4U CN202120462835U CN214553533U CN 214553533 U CN214553533 U CN 214553533U CN 202120462835 U CN202120462835 U CN 202120462835U CN 214553533 U CN214553533 U CN 214553533U
- Authority
- CN
- China
- Prior art keywords
- bottle
- medetomidine
- production facility
- reaction
- standing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HRLIOXLXPOHXTA-UHFFFAOYSA-N medetomidine Chemical compound C=1C=CC(C)=C(C)C=1C(C)C1=CN=C[N]1 HRLIOXLXPOHXTA-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 229960002140 medetomidine Drugs 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 20
- 238000006243 chemical reaction Methods 0.000 claims abstract description 31
- 235000013547 stew Nutrition 0.000 claims abstract description 8
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 230000000903 blocking effect Effects 0.000 claims description 8
- 239000002699 waste material Substances 0.000 claims description 7
- 239000011521 glass Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 230000003068 static effect Effects 0.000 abstract description 13
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 230000008878 coupling Effects 0.000 abstract description 2
- 238000010168 coupling process Methods 0.000 abstract description 2
- 238000005859 coupling reaction Methods 0.000 abstract description 2
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 239000010410 layer Substances 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 12
- 238000010521 absorption reaction Methods 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- HRLIOXLXPOHXTA-NSHDSACASA-N dexmedetomidine Chemical compound C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CN=C[N]1 HRLIOXLXPOHXTA-NSHDSACASA-N 0.000 description 3
- 229960004253 dexmedetomidine Drugs 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000012044 organic layer Substances 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- QCZFALDMBXRELM-UHFFFAOYSA-N 1-(1-chloroethyl)-2,3-dimethylbenzene Chemical compound CC(Cl)C1=CC=CC(C)=C1C QCZFALDMBXRELM-UHFFFAOYSA-N 0.000 description 1
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 1
- 229940121947 Alpha 2 adrenoreceptor agonist Drugs 0.000 description 1
- GJSURZIOUXUGAL-UHFFFAOYSA-N Clonidine Chemical compound ClC1=CC=CC(Cl)=C1NC1=NCCN1 GJSURZIOUXUGAL-UHFFFAOYSA-N 0.000 description 1
- YKFRUJSEPGHZFJ-UHFFFAOYSA-N N-trimethylsilylimidazole Chemical compound C[Si](C)(C)N1C=CN=C1 YKFRUJSEPGHZFJ-UHFFFAOYSA-N 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 102000030484 alpha-2 Adrenergic Receptor Human genes 0.000 description 1
- 108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 description 1
- 229960002896 clonidine Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229960002746 dexmedetomidine hydrochloride Drugs 0.000 description 1
- VPNGEIHDPSLNMU-MERQFXBCSA-N dexmedetomidine hydrochloride Chemical group Cl.C1([C@@H](C)C=2C(=C(C)C=CC=2)C)=CNC=N1 VPNGEIHDPSLNMU-MERQFXBCSA-N 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000012074 organic phase Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 230000036280 sedation Effects 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- 238000002627 tracheal intubation Methods 0.000 description 1
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Abstract
The utility model relates to a production facility of medetomidine midbody, including reaction bottle, static bottle, honeycomb duct, row's useless pipe, equipment support, the reaction bottle is located static bottle top, the honeycomb duct is located the reaction bottle, stew between the bottle, equipment support will stew the bottle support and be fixed in on the horizontal plane, it is located static bottle bottom to arrange useless pipe, the static bottle is provided with electronic choke block with reaction bottle, row's useless union coupling department, one deck temperature control layer is being hugged closely to the bottle wall of reaction bottle, the temperature control layer external connection has an automatically controlled display screen, automatically controlled display screen and the bottle of stewing are provided with the dead lever between the bottle, the dead lever is hollow column, the dead lever in-connection have with the communicating pipette of static bottle. The utility model discloses a medetomidine midbody production facility. A plurality of containers are combined to form production equipment, so that normal medetomidine intermediate production and synthesis can be completed, and the complexity of container replacement is reduced.
Description
Technical Field
The utility model relates to a chemical equipment technical field especially relates to a production facility of medetomidine midbody.
Background
Dexmedetomidine (dexmedetomidine) is a potent alpha 2-adrenoreceptor agonist with 8-fold higher affinity for the alpha 2-adrenoreceptor than clonidine and is clinically suitable for sedation in patients who begin intubation and use ventilators during intensive care therapy. Dexmedetomidine is chemically designated (+) -4- (S) - [1- (2, 3-dimethylphenyl) ethyl ] -1H-imidazole, is obtained by resolution of medetomidine, its hydrochloride salt is dexmedetomidine hydrochloride, is commercially available under the tradename PRECEDEXTM, was developed by Orion Pharma, and was first marketed in the United states by Abbott on 23.12.1999.
Most of the existing medetomidine needs to be configured step by step, a large number of containers are needed to be connected, the process is tedious and slow, and the production period is long.
SUMMERY OF THE UTILITY MODEL
In view of the not enough of background art existence, the utility model relates to a production facility of medetomidine midbody according to above-mentioned problem, has designed a medetomidine midbody production facility. A plurality of containers are combined to form production equipment, so that normal medetomidine intermediate production and synthesis can be completed, and the complexity of container replacement is reduced.
The utility model relates to a production facility of medetomidine midbody, including reaction bottle, static bottle, honeycomb duct, row's useless pipe, equipment support, the reaction bottle is located static bottle top, the honeycomb duct is located the reaction bottle, stew between the bottle, equipment support will stew the bottle support and be fixed in on the horizontal plane, it is located static bottle bottom to arrange useless pipe, the static bottle is provided with electronic choke block with reaction bottle, row's useless union coupling department, one deck temperature control layer is being hugged closely to the bottle wall of reaction bottle, the temperature control layer external connection has an automatically controlled display screen, automatically controlled display screen and the bottle of stewing are provided with the dead lever between the bottle, the dead lever is hollow column, the dead lever in-connection have with the communicating pipette of static bottle.
Through adopting above-mentioned scheme, play the simplifying effect to the preparation of medetomidine midbody, need not constantly to change the container, accomplish efficiently, convenient operation.
Further, the liquid level height of the solvent in the standing bottle is smaller than the connecting position of the standing bottle and the pipette.
By adopting the scheme, the solution is prevented from overflowing.
Further, the reaction bottle is funnel-shaped.
By adopting the scheme, the filling is convenient.
Furthermore, the reaction bottle, the standing bottle, the flow guide pipe and the waste discharge pipe are made of glass.
By adopting the scheme, the observation is convenient, and the chemical reaction is not participated.
Furthermore, the electric control display screen controls the temperature regulation of the temperature control layer and the on-off control of the electric blocking block.
By adopting the scheme, the control and the regulation are convenient.
Further, a reagent adding funnel is further arranged above the side of the standing bottle, and the joint of the reagent adding funnel and the standing bottle and the joint of the standing bottle and the pipette are located on the same horizontal plane.
By adopting the scheme, the reaction solution is convenient to add.
Furthermore, the joint of the equipment support and the standing bottle is provided with a fixing ring, and an anti-skid pad is arranged inside the fixing ring.
By adopting the scheme, the overall stability is improved.
Drawings
The present invention will be further explained with reference to the drawings and examples.
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
Reference numeral, 1, a reaction flask; 2. standing the bottle; 3. a flow guide pipe; 4. a waste discharge pipe; 5. an equipment support; 6. an electric blocking block; 7. an electronic control display screen; 8. fixing the rod; 9. a pipette; 10. a reagent addition funnel; 11. and (4) fixing the ring.
Detailed Description
The technical solution in the embodiments of the present invention will be clearly and completely described and discussed below with reference to the accompanying drawings of the present invention, and it is obvious that only some examples, not all examples, of the present invention are described herein, and all other embodiments obtained by a person of ordinary skill in the art without creative work belong to the protection scope of the present invention based on the embodiments of the present invention.
For the convenience of understanding the embodiments of the present invention, the following detailed description will be given by way of example with reference to the accompanying drawings, and the embodiments are not limited to the embodiments of the present invention.
The embodiment 1 of the utility model discloses an as to refer to fig. 1 and show, leak hopper-shaped reaction bottle 1 including the curved surface, be located 1 below the reaction bottle honeycomb duct 3, with honeycomb duct connection 3's static bottle 2, with the row's of being connected waste pipe 4 of bottle 2 bottoms of stewing, static bottle 2 is provided with equipment support 5, can be fixed with the equipment body, equipment support 5 and the bottle 2 of stewing are provided with solid fixed ring 11 between, gu fixed ring 11 inner wall is provided with the slipmat, adopt rubber material and play anti-skidding stabilizing effect with the contact of static bottle 2.
Both ends all are provided with electronic chock 6 about the quiet bottle 2 for liquid inflow reservation in the quiet bottle 2 of control, a layer temperature control layer is pasted outward to reaction flask 1, the temperature control layer is provided with an automatically controlled display screen 7 outward, the controllable temperature control layer temperature of automatically controlled display screen 7 rises or descends, can realize the rapid cooling effect of 1 solution of reaction flask. And the electric control display screen 7 is electrically connected with the temperature control layer and the electric blocking block 6 and controls the temperature control layer and the electric blocking block 6 to work.
The automatic liquid absorption device is characterized in that a hollow columnar fixing rod 8 is further arranged between the electronic control display screen 7 and the standing bottle 2, a liquid absorption tube 9 is arranged in the fixing rod 8, the liquid absorption tube 9 is communicated with the inside of the standing bottle 2, the liquid absorption tube 9 can penetrate into the standing bottle 2 to perform liquid absorption operation, an inlet is further formed in the same horizontal plane of the joint of the fixing rod 8 and the standing bottle 2, and is connected with a reagent adding funnel 10 to facilitate adding of reaction reagents. The liquid level of the solution in the standing bottle 2 is lower than the plane of the joint of the fixed rod 8 and the standing bottle 2. Preventing the reagent from overflowing.
The utility model discloses a theory of operation and step are as follows:
putting titanium tetrachloride into a reaction bottle 1 containing dichloromethane, dropwise adding N-trimethylsilyl imidazole dissolved in dichloromethane under ice bath, controlling a temperature control layer through an electronic control display screen 7 in the dropwise adding process to enable the temperature in the reaction bottle 1 to be lower than 10 ℃, keeping the temperature and stirring for 30min after the dropwise adding is finished, then dropwise adding 1- (1-chloroethyl) -2, 3-dimethylbenzene, heating to reflux reaction for 3h after the dropwise adding is finished, slowly dropwise adding water to stop the reaction, controlling the temperature in the dropwise adding process to be lower than 20 ℃, then opening an electric blocking block 6 in a flow guide pipe 3 to enable the solution to enter a standing bottle 2, closing the electric blocking block 6 and standing for 15 min, and dividing the solution into three layers. Opening an electric blocking block 6 at the bottom of the standing bottle 2, discarding a bottom water layer, closing, separating a medetomidine intermediate layer, adding 15mL of water from a reagent adding funnel 10 to extract an upper organic layer, collecting a water layer, adding water to the water layer, combining the medetomidine intermediate layer and the upper organic layer, shaking up and down for 10 minutes, separating, and absorbing an upper strong acid water layer by using a pipette 9; extracting the material layer with water, collecting water phase, washing residual organic impurities in the water layer with dichloromethane twice, adding dichloromethane into the water phase, adjusting the organic phase to be strongly alkaline (pH is more than or equal to 10) with 30% NaOH solution, separating the water layer, washing the organic layer twice with water, washing with saturated sodium chloride solution until the solution is clear, concentrating to obtain oily matter, and preparing the product.
In the description of the present invention, it should be noted that the terms "first", "second" and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present invention, and are not intended to limit the technical solution of the present invention, and the protection scope of the present invention is not limited thereto, although the present invention is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: those skilled in the art can still modify or easily conceive of changes in the technical solutions described in the foregoing embodiments or make equivalent substitutions for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not substantially depart from the spirit and scope of the embodiments of the present invention, and are intended to be included within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (7)
1. A production facility of medetomidine midbody which is characterized in that: including reaction bottle, stationary bottle, honeycomb duct, waste discharge pipe, equipment support, the reaction bottle is located stationary bottle top, the honeycomb duct is located the reaction bottle, stews between the bottle, equipment support will stew the bottle support and be fixed in on the horizontal plane, waste discharge pipe is located stationary bottle bottom, stationary bottle and reaction bottle, waste discharge pipe junction are provided with electronic stopper piece, the one deck temperature control layer is hugged closely to the bottle wall of reaction bottle, the temperature control layer external connection has an automatically controlled display screen, automatically controlled display screen and stew and be provided with the dead lever between the bottle, the dead lever is hollow column, the dead lever in-connection has and the communicating pipette of stationary bottle.
2. A medetomidine intermediate production facility as in claim 1, characterized by: the liquid level height of the solvent in the standing bottle is smaller than the joint of the standing bottle and the pipette.
3. A medetomidine intermediate production facility as claimed in claim 2, characterized in that: the reaction bottle is funnel-shaped.
4. A medetomidine intermediate production facility as claimed in claim 3, characterized in that: the reaction bottle, the standing bottle, the flow guide pipe and the waste discharge pipe are made of glass.
5. A medetomidine intermediate production facility as in claim 4, characterized by: the electric control display screen controls the temperature regulation of the temperature control layer and the on-off control of the electric blocking block.
6. A medetomidine intermediate production facility as in claim 5, characterized by: and a reagent adding funnel is further arranged above the side of the standing bottle, and the joint of the reagent adding funnel and the standing bottle and the joint of the standing bottle and the pipette are positioned on the same horizontal plane.
7. A medetomidine intermediate production facility as in claim 6, characterized by: the equipment support is provided with solid fixed ring with the bottle junction that stews, gu fixed ring inside is provided with the slipmat.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120462835.4U CN214553533U (en) | 2021-03-03 | 2021-03-03 | Production facility of medetomidine midbody |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120462835.4U CN214553533U (en) | 2021-03-03 | 2021-03-03 | Production facility of medetomidine midbody |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214553533U true CN214553533U (en) | 2021-11-02 |
Family
ID=78352693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120462835.4U Expired - Fee Related CN214553533U (en) | 2021-03-03 | 2021-03-03 | Production facility of medetomidine midbody |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214553533U (en) |
-
2021
- 2021-03-03 CN CN202120462835.4U patent/CN214553533U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211102 |