CN214553397U - Pesticide microsphere generating device - Google Patents
Pesticide microsphere generating device Download PDFInfo
- Publication number
- CN214553397U CN214553397U CN202120375410.XU CN202120375410U CN214553397U CN 214553397 U CN214553397 U CN 214553397U CN 202120375410 U CN202120375410 U CN 202120375410U CN 214553397 U CN214553397 U CN 214553397U
- Authority
- CN
- China
- Prior art keywords
- micro
- emulsification
- mixer
- extraction
- oil phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Abstract
The utility model is suitable for a pesticide chemical industry equipment technical field provides a generating device of pesticide microballon, including emulsification mechanism, extraction micromixing mechanism and solidification micro-reactor. The utility model provides a generating device of pesticide microballon through setting up extraction micro-mixer and solidification micro-reactor, improves the solvent evaporation method, makes the emulsion and carries out the extraction with mixing in the extraction micro-mixer in the second oil phase component to solidify at solidification micro-reactor and obtain solid microsphere structure; the problems of evaporation and excessive volatilization of volatile solvents caused by extraction and solidification of emulsion by using a reaction kettle in the prior art are avoided.
Description
Technical Field
The utility model belongs to the technical field of pesticide chemical industry equipment, more specifically say, relate to a generating device of pesticide microballon.
Background
At present, the preparation of pesticide sustained release preparations from biodegradable materials such as polylactic acid, polylactic acid-glycolic acid copolymer, polypropylene carbonate and the like is gradually becoming a hot point of domestic and foreign research, and the preparation method thereof is mainly a solvent evaporation method. The method needs to use a volatile organic solvent, and the volatile organic solvent slowly volatilizes into the air from a water phase in the reaction process so as to form a slow-release microsphere structure. Specifically, in the method, the oil phase and the water phase are emulsified to obtain an emulsion, and the emulsion is stirred or kept still in a reaction kettle to slowly volatilize the volatile solvent into the air (to realize extraction and solidification) so as to form the microspheres. However, in the conventional process for preparing the microsphere structure, the volatile solvent has the problems of evaporation and volatilization, which easily causes a safety problem.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a generating device of pesticide microballon aims at solving current microballon structure and makes the in-process have volatile solvent to evaporate, volatile technical problem.
In order to achieve the above object, the utility model adopts the technical scheme that a pesticide microsphere generating device is provided, include:
an emulsification mechanism for emulsifying the water phase component and the first oil phase component to obtain an emulsion;
the extraction micro-mixing mechanism comprises a second oil phase raw material tank and an extraction micro-mixer, wherein the second oil phase raw material tank is used for placing a second oil phase component and is provided with a second oil phase raw material tank discharge port; the extraction micro-mixer is provided with a first extraction feed inlet for receiving emulsion, a second extraction feed inlet communicated with the discharge port of the second oil-phase raw material tank and a discharge port of the extraction micro-mixer, and is used for realizing the extraction operation of second oil-phase components and the emulsion; and
and the curing microreactor is provided with a curing microreactor feeding port and a curing microreactor discharging port which are communicated with the extracting micromixer discharging port and used for curing to obtain microspheres.
Further, the extraction micro-mixer is a Y-type micro-reactor structure.
Further, the curing microreactor is of a capillary microreactor structure.
Further, the curing microreactor is coiled.
Further, the emulsification mechanism comprises an aqueous phase raw material tank for placing an aqueous phase component, a first oil phase raw material tank for placing a first oil phase component, an emulsification micro-mixer and an emulsification micro-reactor;
the water phase raw material tank is provided with a discharge hole of the water phase raw material tank, and the first oil phase raw material tank is provided with a discharge hole of the first oil phase raw material tank;
the emulsification micro-mixer is provided with a first emulsification micro-mixer feeding port communicated with the water phase raw material tank discharging port, a second emulsification micro-mixer feeding port communicated with the first oil phase raw material tank discharging port and an emulsification micro-mixer discharging port, and is used for realizing preliminary emulsification mixing of a water phase component and a first oil phase component;
the emulsification micro-reactor is provided with an emulsification micro-reactor feeding hole communicated with the emulsification micro-mixer discharging hole and an emulsification micro-reactor discharging hole communicated with the first extraction feeding hole; for effecting re-emulsified mixing of the aqueous phase component and the first oil phase component.
Further, the emulsification micro-mixer is of a T-shaped micro-reactor structure.
Further, the emulsifying micro mixer is provided with a first feeding channel communicated with a feeding port of the first emulsifying micro mixer, a second feeding channel communicated with a feeding port of the second emulsifying micro mixer and a discharging channel communicated with a discharging port of the emulsifying micro mixer, the central axis of the discharging channel and the central axis of the first feeding channel are arranged in a collinear way, and the discharging channel is communicated with the first feeding channel; the central axis of the second feeding channel is perpendicular to the central axis of the first feeding channel, and the second feeding channel is communicated with the first feeding channel.
Further, the emulsification micro-reactor is in a capillary micro-reactor structure.
Further, the emulsification microreactor is coiled.
Compared with the prior art, the pesticide microsphere generating device improves the solvent evaporation method by arranging the extraction micro-mixer and the curing micro-reactor, so that emulsion and a second oil phase component are mixed and extracted in the extraction micro-mixer and are cured in the curing micro-reactor to obtain a solid microsphere structure; the problems of evaporation and excessive volatilization of volatile solvents caused by extraction and solidification of emulsion by using a reaction kettle in the prior art are avoided.
Drawings
Fig. 1 is a schematic diagram of a device for generating pesticide microspheres according to an embodiment of the present application.
In the figure: 1. a water phase feed tank; 2. a first oil phase feed tank; 3. a second oil phase feed tank; 4. a first feed pump; 5. a second feed pump; 6. a third feed pump; 7. an emulsification micro-mixer; 8. an emulsification microreactor; 9. an extraction micro-mixer; 10. and curing the microreactor.
Detailed Description
In order to make the technical problem, technical solution and advantageous effects to be solved by the present invention more clearly understood, the following description is given in conjunction with the accompanying drawings and embodiments to illustrate the present invention in further detail. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
It should be noted that the terms "length," "width," "height," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "head," "tail," and the like, are used in the orientation or positional relationship indicated in the drawings for convenience in describing the invention and for simplicity in description, and do not indicate or imply that the device or element so referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore should not be construed as limiting the invention.
It is also noted that, unless expressly stated or limited otherwise, the terms "mounted," "connected," "secured," "disposed," and the like are intended to be inclusive and mean, for example, that they may be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. Further, "plurality" or "a plurality" means two or more unless specifically limited otherwise.
Referring to fig. 1, an embodiment of the device for generating pesticide microspheres according to the present invention will now be described. The pesticide microsphere generating device comprises an emulsifying mechanism, an extraction micro-mixing mechanism and a curing micro-reactor 10, wherein the emulsifying mechanism, the extraction micro-mixing mechanism and the curing micro-reactor 10 are connected according to the process steps. Specifically, the pesticide active ingredient and the biodegradable polymer are dissolved in a volatile solvent to form a first oil phase; mixing and dissolving an emulsifier and water to form a water phase; the emulsifying mechanism is used for emulsifying the water phase component and the first oil phase component so as to obtain the oil-in-water type emulsion.
The extraction micro-mixing mechanism includes a second oil phase raw material tank 3 for placing a second oil phase component and an extraction micro-mixer 9. Second oil phase head tank 3 has a second oil phase head tank discharge port. The extraction micro-mixer 9 is provided with a first extraction feed inlet for receiving the emulsion, a second extraction feed inlet communicated with a discharge outlet of the second oil phase raw material tank, and a discharge outlet of the extraction micro-mixer, and the extraction micro-mixer 9 is used for mixing and extracting the second oil phase component and the emulsion.
The curing microreactor 10 is provided with a curing microreactor feeding port and a curing microreactor discharging port which are communicated with a discharging port of the extraction micromixer, and the pesticide microsphere structure is finally obtained by curing in the curing microreactor 10. Specifically, a water-soluble solvent which has low solubility with the pesticide active ingredient and can be mutually dissolved with a selected volatile solvent is used as a second oil phase, the second oil phase is mixed with the oil-in-water emulsion through an extraction micro-mixer 9, the volatile solvent in the first oil phase is quickly extracted by the water-soluble solvent in the external water phase in a curing micro-reactor 10, the biodegradable polymer is quickly separated out due to the reduction of the solubility to form a solid microsphere structure, and the pesticide active ingredient is wrapped in the solid microsphere structure. And finally, discharging the microsphere solution from an outlet, and performing centrifugal drying to obtain pesticide microsphere solid powder.
Thus, in this embodiment, the emulsion and the second oil phase component are not stirred or left to stand in the reaction kettle as in the prior art, but are sequentially mixed and extracted in the extraction micro-mixer 9 and solidified in the solidification micro-reactor 10 to obtain the solid microsphere structure, so that the process of evaporating and removing the volatile solvent in the prior art is eliminated, and the volatile solvent is less volatilized and less wasted.
Compared with the prior art, the pesticide microsphere generating device provided by the embodiment of the utility model improves the solvent evaporation method by arranging the extraction micro-mixer and the curing micro-reactor, so that the emulsion and the second oil phase component are mixed and extracted in the extraction micro-mixer, and are cured in the curing micro-reactor to obtain a solid microsphere structure; the problems of evaporation and excessive volatilization of volatile solvents caused by extraction and solidification of emulsion by using a reaction kettle in the prior art are avoided, and the safety is improved.
Referring to fig. 1, as a specific embodiment of the apparatus for generating pesticide microspheres according to the present invention, the solidification microreactor 10 is a capillary-type microreactor structure. The capillary micro-reactor structure can fully mix the emulsion and the second oil phase in the capillary micro-reactor structure, and accelerate the reaction, and the curing time of the microspheres is shortened to several minutes from 4-5 hours in the prior art.
Referring to fig. 1, as a specific embodiment of the apparatus for generating pesticide microspheres according to the present invention, a curing micro-reactor 10 (capillary micro-reactor structure) is coiled to reduce the occupied space.
Referring to fig. 1, as a specific embodiment of the device for generating pesticide microspheres provided by the present invention, the emulsifying mechanism includes an aqueous phase raw material tank 1 for placing an aqueous phase component, a first oil phase raw material tank 2 for placing a first oil phase component, an emulsifying micro mixer 7, and an emulsifying micro reactor 8. Aqueous phase head tank 1 has an aqueous phase head tank discharge gate, and first oil phase head tank 2 has a first oil phase head tank discharge gate.
The emulsification micro-mixer 7 is provided with a first emulsification micro-mixer feeding port communicated with the water phase raw material tank discharging port, a second emulsification micro-mixer feeding port communicated with the first oil phase raw material tank discharging port and an emulsification micro-mixer discharging port, and the emulsification micro-mixer 7 is used for realizing preliminary emulsification mixing of the water phase component and the first oil phase component.
The emulsification micro-reactor 8 has an emulsification micro-reactor feed port in communication with the emulsification micro-mixer discharge port and an emulsification micro-reactor discharge port in communication with the first extraction feed port. The emulsification microreactor 8 is used to achieve re-emulsification mixing of the aqueous phase component and the first oil phase component. The emulsified components flow into the extraction micro-mixer 9 through the discharge port of the emulsification micro-reactor.
The water phase component and the first oil phase component are emulsified and mixed twice by the emulsification micro-mixer 7 and the emulsification micro-reactor 8 to obtain the oil-in-water emulsion, the whole emulsification process time is short, the equipment is simple, and the emulsification cost is low.
For convenience of understanding, the following examples illustrate the use process of the device for generating pesticide microspheres provided in the embodiments of the present invention, and it should be understood that the following examples are only provided to help readers to understand the structure and use process of the embodiments, and should not limit the application scope of the present application or the embodiments.
Firstly, fully dissolving polyvinyl alcohol and water, uniformly mixing the polyvinyl alcohol and the water to serve as water phase components, and placing the water phase components in a water phase raw material tank 1; fully dissolving and uniformly mixing polylactic acid, pesticide active ingredients and ethyl acetate to serve as a first oil phase component, and placing the first oil phase component in a first oil phase raw material tank 2; absolute ethyl alcohol as a second oil phase component is placed in a second oil phase raw material tank 3.
Secondly, emulsification operation, namely simultaneously inputting the water phase component and the first oil phase component into an emulsification micro-mixer 7, preliminarily emulsifying and mixing the water phase component and the first oil phase component through the emulsification micro-mixer 7 to form oil-in-water type emulsion, and then entering an emulsification micro-reactor 8 for re-emulsification.
Then, the extraction operation is performed, the emulsion enters an extraction micro-mixer 9, and simultaneously the second oil phase component enters the extraction micro-mixer 9, is mixed with the emulsion, and after mixing, the absolute ethyl alcohol is dissolved in the water phase and enters a curing micro-reactor 10.
Then, a curing operation is carried out, in the curing microreactor 10, ethyl acetate in the oil phase is rapidly diffused into the water phase, so that polylactic acid is rapidly separated out due to the reduction of solubility, and the pesticide active ingredients are wrapped in the polylactic acid to form solid drug-carrying microspheres. Naturally, after the microsphere solution is discharged from the discharge port of the curing microreactor, centrifugal drying is also needed to finally obtain the polylactic acid pesticide microspheres (the centrifugal drying in the prior art is not described herein again).
Use the embodiment of the utility model provides an in the preparation process of pesticide microballon, avoid prior art to utilize reation kettle to mix solidification emulsion and cause volatile solvent to evaporate and excessively volatile problem at second oil phase component, the particle diameter and the distribution of the pesticide microballon that finally the preparation obtained moreover can realize accurate control than prior art.
Referring to fig. 1, as a specific embodiment of the apparatus for generating pesticide microspheres according to the present invention, the emulsification microreactor 8 is a capillary-type microreactor structure. The capillary micro-reactor structure can ensure that the preliminarily emulsified water phase component and the first oil phase component are fully mixed in the capillary micro-reactor structure, and the reaction is accelerated.
Referring to fig. 1, as a specific embodiment of the device for generating pesticide microspheres according to the present invention, an emulsification microreactor 8 (capillary microreactor structure) is coiled to reduce the occupied space.
Referring to fig. 1, as a specific embodiment of the apparatus for generating pesticide microspheres of the present invention, the extraction micro-mixer 9 is a Y-type micro-reactor structure. The Y-type micro-reactor structure can be used for fully mixing the emulsified liquid and the second oil phase component to achieve a better extraction effect.
Referring to fig. 1, as a specific embodiment of the device for generating pesticide microspheres according to the present invention, the emulsification micro-mixer 7 is a T-type micro-reactor structure, and the T-type micro-reactor structure can obtain a better emulsification effect.
Referring to fig. 1, as a specific embodiment of the device for generating pesticide microspheres provided by the present invention, an emulsification micro mixer 7 (T-type micro reactor structure) has a first feeding channel communicated with a feeding port of the first emulsification micro mixer, a second feeding channel communicated with a feeding port of the second emulsification micro mixer, and a discharging channel communicated with a discharging port of the emulsification micro mixer.
The central axis of the discharging channel is collinear with the central axis of the first feeding channel, and the discharging channel is communicated with the first feeding channel. The central axis of the second feeding channel is perpendicular to the central axis of the first feeding channel, and the second feeding channel is communicated with the first feeding channel. That is, the first feed channel and the discharge channel can be considered as a straight channel, and the discharge channel is divided after the first feed channel and the second feed channel are vertically merged. The water phase component is conveyed in the first feeding channel, the first oil phase component is conveyed in the second feeding channel, and then after the first feeding channel and the second feeding channel are combined, the water phase component and the first oil phase component start to be emulsified and mixed in the discharging channel.
Referring to fig. 1, as a specific implementation manner of the device for generating pesticide microspheres provided by the present invention, the device for generating pesticide microspheres provided by the embodiment of the present invention further includes a first feeding pump 4, a second feeding pump 5, and a third feeding pump 6. The first feeding pump 4 is connected in series on a connecting pipeline between the water phase raw material tank 1 and the emulsification micro-mixer 7, and the first feeding pump 4 is used for providing power for the process of conveying the water phase components into the emulsification micro-mixer 7. The second feeding pump 5 is connected in series on the connecting pipeline between the first oil phase raw material tank 2 and the emulsification micro-mixer 7, and the second feeding pump 5 is used for providing power for the process of conveying the first oil phase components into the emulsification micro-mixer 7. The third feeding pump 6 is connected in series with a connecting pipeline between the second oil phase raw material tank 3 and the extraction micro-mixer 9, and the third feeding pump 6 is used for providing power for the process of conveying the second oil phase components into the extraction micro-mixer 9.
The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (9)
1. The generating device of pesticide microballon, its characterized in that includes:
an emulsification mechanism for emulsifying the water phase component and the first oil phase component to obtain an emulsion;
the extraction micro-mixing mechanism comprises a second oil phase raw material tank and an extraction micro-mixer, wherein the second oil phase raw material tank is used for placing a second oil phase component and is provided with a second oil phase raw material tank discharge port; the extraction micro-mixer is provided with a first extraction feed inlet for receiving emulsion, a second extraction feed inlet communicated with the discharge port of the second oil-phase raw material tank and a discharge port of the extraction micro-mixer, and is used for realizing the extraction operation of second oil-phase components and the emulsion; and
and the curing microreactor is provided with a curing microreactor feeding port and a curing microreactor discharging port which are communicated with the extracting micromixer discharging port and used for curing to obtain microspheres.
2. The apparatus for generating pesticide microspheres as claimed in claim 1, wherein the extraction micromixer is a Y-type micro-reactor structure.
3. The apparatus for generating pesticide microspheres as claimed in claim 1, wherein the curing microreactor is a capillary microreactor structure.
4. The apparatus for generating pesticide microspheres as claimed in claim 3, wherein the curing microreactor is coiled.
5. The apparatus for generating agricultural chemical microspheres according to any one of claims 1 to 4, wherein the emulsification mechanism comprises an aqueous phase raw material tank for holding an aqueous phase component, a first oil phase raw material tank for holding a first oil phase component, an emulsification micromixer, and an emulsification microreactor;
the water phase raw material tank is provided with a discharge hole of the water phase raw material tank, and the first oil phase raw material tank is provided with a discharge hole of the first oil phase raw material tank;
the emulsification micro-mixer is provided with a first emulsification micro-mixer feeding port communicated with the water phase raw material tank discharging port, a second emulsification micro-mixer feeding port communicated with the first oil phase raw material tank discharging port and an emulsification micro-mixer discharging port, and is used for realizing preliminary emulsification mixing of a water phase component and a first oil phase component;
the emulsification micro-reactor is provided with an emulsification micro-reactor feeding hole communicated with the emulsification micro-mixer discharging hole and an emulsification micro-reactor discharging hole communicated with the first extraction feeding hole; for effecting re-emulsified mixing of the aqueous phase component and the first oil phase component.
6. The apparatus for generating pesticide microspheres as claimed in claim 5, wherein the emulsifying micro mixer is a T-type micro reactor structure.
7. The apparatus for generating pesticide microspheres as claimed in claim 5, wherein the emulsification micro mixer has a first feeding channel communicated with the feeding port of the first emulsification micro mixer, a second feeding channel communicated with the feeding port of the second emulsification micro mixer, and a discharging channel communicated with the discharging port of the emulsification micro mixer, the central axis of the discharging channel is arranged in line with the central axis of the first feeding channel, and the discharging channel is communicated with the first feeding channel; the central axis of the second feeding channel is perpendicular to the central axis of the first feeding channel, and the second feeding channel is communicated with the first feeding channel.
8. The apparatus for generating pesticide microspheres as claimed in claim 5, wherein the emulsification microreactor is a capillary microreactor structure.
9. The apparatus for generating pesticide microspheres as claimed in claim 8, wherein the emulsification microreactor is coiled.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120375410.XU CN214553397U (en) | 2021-02-18 | 2021-02-18 | Pesticide microsphere generating device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120375410.XU CN214553397U (en) | 2021-02-18 | 2021-02-18 | Pesticide microsphere generating device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214553397U true CN214553397U (en) | 2021-11-02 |
Family
ID=78351012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120375410.XU Active CN214553397U (en) | 2021-02-18 | 2021-02-18 | Pesticide microsphere generating device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214553397U (en) |
-
2021
- 2021-02-18 CN CN202120375410.XU patent/CN214553397U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101543507B1 (en) | A continuous process for preparing microspheres and microspheres prepared thereby | |
| CN100534597C (en) | Device and method for making particles | |
| US6291013B1 (en) | Emulsion-based processes for making microparticles | |
| Watanabe et al. | Continuous fabrication of monodisperse polylactide microspheres by droplet-to-particle technology using microfluidic emulsification and emulsion–solvent diffusion | |
| CN105688767B (en) | A kind of preparation method of vanillic aldehyde microcapsules | |
| JP2021527561A (en) | Equipment, systems, and methods for the continuous production of nanomaterials and high-purity chemicals | |
| Teo et al. | Continuous fabrication of core-shell aerogel microparticles using microfluidic flows | |
| CN214553397U (en) | Pesticide microsphere generating device | |
| DE60017461T2 (en) | APPARATUS AND METHOD FOR THE MANUFACTURE OF MICROPARTICLES BASED ON IN-LINE SOLVENT EXTRACTION | |
| Li et al. | Solvent evaporation self-motivated continual synthesis of versatile porous polymer microspheres via foaming-transfer | |
| CN103111208B (en) | A kind of solid suspension list distribution emulsion and emulsification method thereof | |
| CN102389756B (en) | Method for preparing micro spheres by multiple emulsion process | |
| CN112494456B (en) | Ethyl cellulose hollow microcapsule | |
| WO2010112379A1 (en) | Method and apparatus for the manufacture of a colloidal dispersion using controlled micro-channel flow | |
| CN104032129B (en) | A kind of microcapsules for enrichment rare earth ion and preparation method thereof | |
| EP3755307B1 (en) | A spray drying process with continuous preparation of spray solution | |
| CN106139943A (en) | A kind of membrane emulsifier and emulsion preparation method | |
| EP1728814A1 (en) | Process for the preparation of nanoparticles making use of porous membranes | |
| CN204799187U (en) | Emulsification device is assisted to throttle formula emulsification cauldron | |
| US20080260852A1 (en) | Supercritical fluid extraction produced by in-line homogenization | |
| CN212139212U (en) | Preparation facilities of nicotinamide mononucleotide and herbal extract microcapsule | |
| CN216321700U (en) | Homogenizer inlet device | |
| CN215233829U (en) | Emulsification equipment of levorotatory polylactic acid microballon | |
| US6204308B1 (en) | Organic compounds | |
| CN112430335B (en) | Structure-controllable anisotropic polymer microsphere and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |