CN215233829U

CN215233829U - Emulsification equipment of levorotatory polylactic acid microballon

Info

Publication number: CN215233829U
Application number: CN202120832732.2U
Authority: CN
Inventors: 赵楠; 金夏菲; 杨锐; 孙淋暂
Original assignee: Puliyan Nanjing Medical Technology Co ltd
Current assignee: Puliyan Nanjing Medical Technology Co ltd
Priority date: 2021-04-22
Filing date: 2021-04-22
Publication date: 2021-12-21
Anticipated expiration: 2031-04-22

Abstract

The utility model discloses an emulsification device of levogyration polylactic acid microballon relates to the emulsified technical field of microballon, aims at solving among the prior art because unable stirring laminating inner wall material leads to the insufficient problem of emulsification. Its technical scheme main points are that the reaction bin is including the communicating upper bin body and the lower bin body, the upper bin body and the internal vertical direction of following respectively of lower bin are provided with first (mixing) shaft and second (mixing) shaft, be provided with on the first (mixing) shaft and be square stirring frame, the cover is equipped with the first gasbag with the laminating of upper bin inside wall on the lateral wall that the stirring frame kept away from first (mixing) shaft, second (mixing) shaft bottom is provided with the installation pole along the horizontal direction, the tip that the second (mixing) shaft was kept away from to the installation pole upwards is provided with the down tube-stand along the incline direction of lower bin inside wall, the cover is equipped with the second gasbag with the laminating of lower bin inside wall on the down tube-stand. The utility model discloses reached and scraped the adhesion under the material of reaction storehouse inside wall, ensured the purpose of emulsification effect.

Description

Emulsification equipment of levorotatory polylactic acid microballon

Technical Field

The utility model belongs to the technical field of the emulsified technique of microballon and specifically relates to an emulsification equipment of levorotatory polylactic acid microballon is related to.

Background

The levorotatory polylactic acid microspheres exist in a microsphere form, and the microsphere carrier can overcome some defects of the existing medicinal preparation and has the advantages of controlling the release speed of the medicament to achieve long-acting slow release, increasing medicament targeting, reducing toxic and side effects, improving curative effect and the like. The current definition of microspheres in pharmaceutics refers to micro-spherical entities, spherical or sphere-like, formed by dissolving or dispersing drugs in high molecular materials, which are generally prepared into suspensions for injection or oral administration. The particle size range of the microspheres is generally 1-500 um, the small particle can be several nanometers, the large particle can reach 800um, the particle size is smaller than 500nm, the microspheres are also commonly called nanospheres or nanoparticles, and the microspheres belong to the category of colloids. The micronized preparation of the medicine can be prepared by an emulsion solution volatilization method.

The method is that two phases which are not miscible are made into emulsion by mechanical stirring or ultrasonic emulsification, the inner phase solvent is volatilized and removed, the balling material is separated out and solidified into microspheres. The solvent of the inner dispersed phase must have some solubility and volatility in the outer continuous phase. Under slow stirring, the inner dispersed phase solvent continuously diffuses to the outer phase, transports to the liquid surface and volatilizes into the air. The extraction-volatilization-extraction process is repeated, so that the carrier material in the inner dispersed phase is separated out to form a capsule membrane, and the drug is wrapped in the capsule membrane until the microspheres are completely solidified. The emulsifying equipment mainly makes the materials move at high speed in narrow gaps between the reactor and the stirring blades, and the materials are sheared by stronger hydraulic force, thereby achieving the effects of emulsification and crushing.

The prior Chinese patent with the application number of CN201921939308.7 discloses a polylactic acid microsphere emulsifying machine with uniform dispersion degree, which mainly relates to the field of microsphere emulsifying machines. The shell comprises an upper shell and a lower shell which are arranged up and down, wherein the upper shell is a cylindrical shell, and the lower shell is an inverted conical shell; a coaxial high-speed rotating shaft is arranged in the upper shell, and the rotating speed of the high-speed rotating shaft is 600-1200 r/min; the lower shell is internally provided with a coaxial uniform-speed rotating shaft, and the rotating speed of the uniform-speed rotating shaft is 400-800 r/min. The bottom of the uniform-speed rotating shaft is provided with a stirring rod, the stirring rod extends horizontally, the number of the stirring rods is 2-4, the stirring rods surround the uniform-speed rotating shaft annular array, the upper portion of each stirring rod is provided with vertically extending upper comb teeth, and the lower portion of each stirring rod is provided with 2-4 rows of lower comb teeth.

The above prior art solutions have the following drawbacks: in the stirring process, the material of adhesion on the casing inside wall is difficult to by the intensive mixing, influences whole emulsification effect, and this problem remains to be solved.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing an emulsification device of levorotatory polylactic acid microballon, it has the effect of processing.

The above utility model discloses an above-mentioned utility model purpose can realize through following technical scheme:

an emulsification device of levorotatory polylactic acid microspheres comprises a reaction bin, wherein the reaction bin comprises an upper bin body and a lower bin body which are communicated, the lower bin body is funnel-shaped, the upper bin body is wide at the upper part, the lower bin body is narrow at the lower part, a first stirring shaft and a second stirring shaft are respectively arranged in the upper bin body and the lower bin body along the vertical direction, and the first stirring shaft and the second stirring shaft are respectively driven by a first rotating motor and a second rotating motor; be provided with on the first (mixing) shaft and be square stirring frame, the cover is equipped with the first gasbag with the laminating of upper bin body inside wall on the lateral wall that stirring frame kept away from first (mixing) shaft, second (mixing) shaft bottom is provided with the installation pole along the horizontal direction, the tip that the second (mixing) shaft was kept away from to the installation pole upwards is provided with the down tube along the incline direction of lower bin body inside wall, the cover is equipped with the second gasbag with the laminating of lower bin body inside wall on the down tube.

Through adopting above-mentioned technical scheme, first gasbag and second gasbag can dismantle with stirring frame and down tube respectively and be connected.

Through adopting above-mentioned technical scheme, first gasbag and second gasbag all are provided with the magic subsides including primary and secondary face, second gasbag and second gasbag are fixed around stirring frame and down tube and by the magic subsides respectively.

By adopting the technical scheme, the first stirring support rods extending horizontally are uniformly distributed on the circumferential side wall of the first stirring shaft along the axial direction of the first stirring shaft.

By adopting the technical scheme, the inclined stirring plate is obliquely arranged at the bottom of the first stirring shaft.

Through adopting above-mentioned technical scheme, the top of second (mixing) shaft is connected with the horizontal pole along the horizontal direction, the horizontal pole is along the axial equipartition second stirring branch of arranging vertical extension.

By adopting the technical scheme, the first air bag and the second air bag are both flexible rubber air bags.

To sum up, the utility model discloses a beneficial technological effect does:

1. through the arrangement of the stirring frame, the first air bag, the diagonal rod and the second air bag, the first air bag and the second air bag are fully attached to the inner wall of the reaction bin in the stirring process, and the wall-hung materials are scraped along with the rotation of the stirring frame and the diagonal rod, so that the emulsification is more sufficient;

2. the detachable connection of the first air bag and the stirring frame and the detachable connection of the second air bag and the diagonal rod are realized through the arrangement of the magic tapes, so that the first air bag and the second air bag are convenient to replace;

3. through the setting of first stirring branch and second stirring branch for the material stirs in turn at last storehouse body and lower storehouse body, further improves emulsification sufficiency.

Drawings

Fig. 1 is a schematic view of the overall structure of the embodiment of the present invention.

In the figure, 1, a reaction bin; 2. a first stirring shaft; 21. a stirring frame; 22. a first stirring strut; 23. a first air bag; 24. an oblique stirring plate; 25. a first rotating electrical machine; 3. a second stirring shaft;

31. a cross bar; 32. a second stirring strut; 33. mounting a rod; 34. a second air bag; 35. a diagonal bar; 36. a second rotating electrical machine.

Detailed Description

The present invention will be described in further detail with reference to the accompanying drawings.

Referring to fig. 1, for the utility model discloses an emulsification equipment of levorotatory polylactic acid microballon, including reaction storehouse 1, reaction storehouse 1 is including communicating upper bin body and lower storehouse body, and the upper bin body is cylindrical, and the lower storehouse body is wide infundibulate down narrowly. The upper bin body and the lower bin body are internally provided with a first stirring shaft 2 and a second stirring shaft 3 respectively along the vertical direction, the first stirring shaft 2 and the second stirring shaft 3 are respectively driven by a first rotating motor 25 and a second rotating motor 36, wherein the first stirring motor is positioned at the top of the upper bin body, and the second stirring motor is positioned at the bottom of the lower bin body.

Be provided with on the circumference lateral wall of first (mixing) shaft 2 that the longitudinal section is square stirring frame 21, first (mixing) shaft 2 runs through the central point that stirs frame 21 and puts, and the cover is equipped with the first gasbag 23 with the laminating of last storehouse body inside wall on the lateral wall that stirring frame 21 kept away from first (mixing) shaft 2. The bottom of the second stirring shaft 3 is provided with an installation rod 33 along the horizontal direction, the end part of the installation rod 33 far away from the second stirring shaft 3 is upwards provided with an inclined rod 35 along the inclined direction of the lower bin body side wall, and the inclined rod 35 is sleeved with a second air bag 34 attached to the lower bin body inner side wall. The first air bag 23 and the second air bag 34 are both flexible rubber air bags.

The first air bag 23 and the second air bag 34 are respectively detachably connected with the stirring frame 21 and the inclined rod 35. First gasbag 23 and second gasbag 34 all are provided with the magic subsides including primary and secondary face, and both can encircle a week around stirring frame 21 and down tube 35 respectively, then are fixed by the primary and secondary face of magic subsides on the gasbag. In this embodiment, due to the square structure of the agitator frame 21, after the first airbag 23 is wound on the vertical rod on one side of the agitator frame 21, the top and the bottom of the first airbag 23 are respectively abutted against the top and the bottom of the agitator frame 21, so as to prevent the first airbag 23 from sliding in the vertical direction, and realize the fixed installation of the first airbag 23. Because there is the flex point in the junction of the lower storehouse body and the upper storehouse body, the second gasbag 34 top and the upper storehouse body and the flex point butt of the lower storehouse body that the cover is established on the down tube 35 to prevent that second gasbag 34 from breaking away from the down tube 35, realize the fixed mounting of second gasbag 34. When the first air bag 23 and the second air bag 34 need to be replaced, the air bags are attached to the inner wall of the reaction chamber 1, and the air pressure in the air bags is adjusted within a reasonable range. Due to the deformation characteristics of the first air bag 23 and the second air bag 34, the reaction chamber can adapt to the shape change of the inner wall of the reaction chamber 1, and the wall-mounted materials can be cleaned in time, so that the emulsification effect is guaranteed.

First stirring struts 22 extending horizontally are uniformly arranged on the circumferential side wall of the first stirring shaft 2 along the axial direction thereof. The top end of the second stirring shaft 3 is connected with a cross rod 31 along the horizontal direction, and second stirring support rods 32 which extend vertically are uniformly distributed on the cross rod 31 along the axial direction. The first stirring strut 22 and the second stirring strut 32 can make the materials to be subjected to comprehensive actions of centrifugal extrusion, high-speed cutting, impact, grinding and the like, thereby achieving the effects of emulsification and crushing.

The bottom of the first stirring shaft 2 is obliquely provided with an oblique stirring plate 24, and the oblique stirring plate 24 and the horizontal direction and the vertical direction are both at an angle smaller than 90 degrees. The slant stirring plate 24 makes the material flow in turn between the upper bin body and the lower bin body, easily forms the wadding flow and obtains different shearing forces, makes the liquid drop more exquisite, and particle size distribution is narrower, therefore the mixed liquid stability that generates is better. In this embodiment, the stirring structure of the upper bin body and the lower bin body can be used jointly or independently, and the rotating speed can be adjusted, so that the device is suitable for different processes.

The embodiment of this specific implementation mode is the preferred embodiment of the present invention, not limit according to this the utility model discloses a protection scope, so: all equivalent changes made according to the structure, shape and principle of the utility model are covered within the protection scope of the utility model.

Claims

1. The utility model provides an emulsification equipment of levorotatory polylactic acid microballon, includes reaction bin (1), its characterized in that: the reaction bin (1) comprises an upper bin body and a lower bin body which are communicated, the lower bin body is funnel-shaped, the upper bin body is wide at the upper part and the lower bin body is narrow at the lower part, a first stirring shaft (2) and a second stirring shaft (3) are respectively arranged in the upper bin body and the lower bin body along the vertical direction, and the first stirring shaft (2) and the second stirring shaft (3) are respectively driven by a first rotating motor (25) and a second rotating motor (36); be provided with on first (mixing) shaft (2) and be square stirring frame (21), the cover is equipped with first gasbag (23) with the laminating of last storehouse body inside wall on the lateral wall that first (mixing) shaft (2) was kept away from in stirring frame (21), second (mixing) shaft (3) bottom is provided with installation pole (33) along the horizontal direction, the tip that second (mixing) shaft (3) were kept away from in installation pole (33) upwards is provided with down sloping direction of storehouse body side wall, the cover is equipped with second gasbag (34) with the laminating of lower storehouse body inside wall on sloping pole (35).

2. The emulsification equipment of levorotatory polylactic acid microballon of claim 1, characterized in that: the first air bag (23) and the second air bag (34) are respectively detachably connected with the stirring frame (21) and the diagonal rod (35).

3. The emulsification equipment of levorotatory polylactic acid microballon of claim 2, characterized in that: first gasbag (23) and second gasbag (34) all are provided with the magic subsides including the primary and secondary face, second gasbag (34) and second gasbag (34) are respectively around stirring frame (21) and down tube (35) and fixed by the magic subsides.

4. The emulsification equipment of levorotatory polylactic acid microballon of claim 3, characterized in that: and horizontally extending first stirring support rods (22) are uniformly distributed on the circumferential side wall of the first stirring shaft (2) along the axial direction.

5. The emulsification equipment of levorotatory polylactic acid microballon of claim 4, characterized in that: an inclined stirring plate (24) is obliquely arranged at the bottom of the first stirring shaft (2).

6. The emulsification equipment of levorotatory polylactic acid microballon of claim 5, characterized in that: the top of second (mixing) shaft (3) is connected with horizontal pole (31) along the horizontal direction, second stirring branch (32) of vertical extension are arranged along axial equipartition in horizontal pole (31).

7. The emulsification equipment of levorotatory polylactic acid microballon of claim 6, characterized in that: the first air bag (23) and the second air bag (34) are both flexible rubber air bags.