CN214539539U

CN214539539U - Flow cell method dissolution instrument automatic flow adjustment plunger pump and dissolution instrument thereof

Info

Publication number: CN214539539U
Application number: CN202120689287.9U
Authority: CN
Inventors: 祝锦敏
Original assignee: Shenzhen Wahyong Analytical Instrument Co ltd
Current assignee: Shenzhen Wahyong Analytical Instrument Co ltd
Priority date: 2021-04-02
Filing date: 2021-04-02
Publication date: 2021-10-29
Anticipated expiration: 2031-04-02

Abstract

The utility model discloses a flow cell method degree of dissolution appearance automatically regulated flow plunger pump and degree of dissolution appearance thereof, plunger pump can measure external temperature through temperature sensor including dissolving out passageway, temperature sensor, heater, drive assembly and controller, and when the temperature was less than when predetermineeing the temperature, the controller can control the heater is right the piston heats, so that the temperature of piston risees, makes the piston is in non-shrinkage temperature range to the inner wall that makes piston and cylinder can the in close contact with all the time, and then guarantees the leakproofness of syringe, and the better syringe of leakproofness can make the difficult weeping of cylinder at the in-process that the piston rod promoted the piston to remove, thereby guarantees the accuracy of sample volume.

Description

Flow cell method dissolution instrument automatic flow adjustment plunger pump and dissolution instrument thereof

Technical Field

The utility model relates to a medicine detects technical field, in particular to flow pool method degree of dissolution appearance automatically regulated flow plunger pump and degree of dissolution appearance thereof.

Background

The dissolution instrument is a commonly used test instrument in the field of drug production test, and can simulate the dissolution time and dissolution characteristics of a drug in a human body so as to predict the release concentration of the drug in the human body.

The dissolution instrument generally comprises a solvent storage, a constant flow pump, a flow cell, a filter and a sampler, wherein the constant flow pump on the market at present generally adopts an injector to extract a sample in a solvent tank. In prior art, the syringe includes the cylinder and sets up piston and piston rod in the cylinder, the one end and the piston connection of piston rod, the afterbody of cylinder are exposed to the other end, can promote the piston through the piston rod and come and go the operation along the inner wall of cylinder, because the piston receives external environment's influence easily, under microthermal environment, the easy shrinkage of piston, the unable in close contact with of the inner wall of the piston of shrinkage and cylinder, lead to the leakproofness of syringe to be relatively poor, the syringe that the leakproofness is relatively poor is at the in-process cylinder easy weeping of piston rod promotion piston removal, thereby influence the accuracy of sample volume.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a flow cell method degree of dissolution appearance automatically regulated flow plunger pump and degree of dissolution appearance thereof aims at solving the piston among the prior art and receives external environment's influence easily, and under microthermal weather, the easy shrinkage of piston, the unable in close contact with of the piston of shrinkage and the inner wall of cylinder leads to the relatively poor technical problem of leakproofness of cylinder.

In order to solve the technical problem, the utility model provides a technical scheme does:

a plunger pump capable of automatically adjusting flow of a dissolution instrument by a flow cell method is characterized by comprising:

the dissolving channel comprises an injector, the injector comprises a needle cylinder, a piston and a piston rod, the piston and the piston rod are arranged in the needle cylinder, one end of the piston rod is connected with the piston, and the other end of the piston rod is exposed out of the tail part of the needle cylinder;

a temperature sensor for measuring an outside temperature;

a heater for heating the piston;

the driving assembly is used for driving the piston rod to move;

a controller for controlling the heater to heat the piston according to the temperature measured by the temperature sensor so as to increase the temperature of the piston, thereby enabling the piston to be in a non-cold-contraction temperature range; the controller is also used for controlling the driving component to drive the piston rod to move so that the piston rod drives the piston to reciprocate along the inner wall of the needle cylinder, and therefore the head of the needle cylinder extracts a sample or discharges the sample.

Preferably, the syringe and/or the piston rod are made of heat conducting material, and the heater is used for heating the syringe and/or the piston rod to transfer the heat of the syringe and/or the piston rod to the piston, so that the temperature of the piston is increased, and the piston is in a non-cold-contraction temperature range.

Preferably, drive assembly includes motor, lead screw and nut component, the motor with the one end of lead screw is connected, the nut component cover is established on the lead screw, the other end of piston rod with the nut component is connected, the controller is still used for control motor drive the lead screw rotates, the lead screw drives the nut component motion, so that the nut component drives the piston rod motion, make the piston rod drive the piston is followed the inner wall of cylinder is moved back and forth, thereby makes the head extraction sample of cylinder or will the sample is discharged.

Preferably, the driving assembly further comprises a stopper for limiting a range of movement of the nut element along the lead screw to prevent the nut element from coming off from the other end of the lead screw.

Preferably, the plunger pump further comprises a guide assembly for guiding the nut element to move in a predetermined direction.

Preferably, the nut element includes the nut and connects respectively the first slider and the second slider of nut, the direction subassembly includes first guide post and second guide post, be equipped with first through-hole on the first slider, be equipped with the second through-hole on the second slider, first slider passes through first through-hole cover is established on the first guide post, the second slider passes through the second through-hole cover is established on the second guide post, the lead screw drives the nut motion, so that the nut drives respectively first slider with the second slider is along corresponding ground first guide post with the motion of second guide post.

Preferably, the dissolution channel further comprises a first three-way pipe, a second three-way pipe, a first three-way valve and a second three-way valve, the number of the injectors is two, the first injector and the second injector are respectively provided, an A port of the first three-way pipe is communicated with an A port of the first three-way valve, a B port is communicated with a solvent input end, a C port is communicated with an A port of the second three-way valve, a B port of the first three-way valve is communicated with the head of the first injector needle cylinder, a C port is communicated with an A port of the second three-way pipe, a B port of the second three-way pipe is communicated with a solvent output end, a B port of the second three-way valve is communicated with the head of the second injector needle cylinder, and a C port is communicated with a C port of the second three-way pipe.

Preferably, the head of the first syringe needle cylinder is detachably communicated with the port B of the first three-way valve, and the other end of the first syringe piston rod is detachably connected with the driving assembly; the head of the second syringe needle cylinder is detachably communicated with the port B of the second three-way valve, and the other end of the second syringe piston rod is detachably connected with the driving assembly.

Preferably, the plunger pump further comprises a weighing component, the weighing component is used for weighing the weight of the sample discharged by the syringe, and the controller is further used for controlling the distance for driving the piston rod to move in the syringe by the driving component according to the weight weighed by the weighing component.

The utility model provides another technical scheme does:

a dissolution instrument comprises the plunger pump.

Compared with the prior art, the utility model discloses following beneficial effect has:

this application can measure external temperature through temperature sensor, when the temperature is less than preset the temperature, the controller can control the heater is right the piston heats, so that the temperature of piston risees, makes the piston is in non-shrinkage temperature range to the inner wall that makes piston and cylinder can the in close contact with all the time, and then guarantees the leakproofness of syringe, and the syringe that the leakproofness is better can make the difficult weeping of cylinder at the in-process that the piston rod promoted the piston and removed, thereby guarantees the accuracy of sample volume.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.

Fig. 1 is a perspective view of a flow cell-based dissolution meter self-regulating flow plunger pump according to one embodiment of the present invention;

fig. 2 is a side view of a flow cell method dissolution meter self-regulating flow plunger pump according to one embodiment of the present invention;

fig. 3 is a schematic view of a dissolution channel according to one embodiment of the invention.

100. A flow cell method dissolution instrument automatically adjusts a flow plunger pump; 1. a dissolution channel; 11. an injector; 111. a needle cylinder; 112. a piston; 113. a piston rod; 12. a first three-way pipe; 13. a second three-way pipe; 14. a first three-way valve; 15. a second three-way valve; 16. a first syringe; 17. a second syringe; 2. a temperature sensor; 3. a heater; 4. a drive assembly; 41. a motor; 42. a screw rod; 43. a nut member; 431. a nut; 432. a first slider; 433. a second slider; 44. a limiting member; 45. a first motor; 46. a second motor; 5. a controller; 6. a pull rod; 7. a guide assembly; 71. a first guide post; 72. a second guide post; 8. a weighing assembly; 9. a support; 91. a first chute; 92. a second chute; 10. a base plate; 20. test tubes.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

It should be noted that all the directional indicators (such as upper, lower, left, right, front and rear … …) in the embodiment of the present invention are only used to explain the relative position relationship between the components, the motion situation, etc. in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indicator is changed accordingly.

In addition, the descriptions related to "first", "second", etc. in the present invention are for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicit ly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, "and/or" in the whole text includes three schemes, taking a and/or B as an example, including a technical scheme, and a technical scheme that a and B meet simultaneously; in addition, the technical solutions in the embodiments may be combined with each other, but it must be based on the realization of those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should not be considered to exist, and is not within the protection scope of the present invention.

1-3, in one embodiment, a flow cell dissolution apparatus autoregulating flow plunger pump 100 is provided, the plunger pump 100 including a dissolution channel 1, a temperature sensor 2, a heater 3, a drive assembly 4, and a controller 5. The dissolution channel 1 comprises an injector 11, the injector 11 comprises a cylinder 111, and a piston 112 and a piston rod 113 which are arranged in the cylinder 111, one end of the piston rod 113 is connected with the piston 112, and the other end is exposed out of the tail part of the cylinder 111; the temperature sensor 2 is used for measuring the outside temperature; the heater 3 is used for heating the piston 112; the driving assembly 4 is used for driving the piston rod 113 to move; the controller 5 is used for controlling the heater 3 to heat the piston 112 according to the temperature measured by the temperature sensor 2, so that the temperature of the piston 112 is increased, and the piston 112 is in a non-cold-contraction temperature range; the controller 5 is further configured to control the driving assembly 4 to drive the piston rod 113 to move, so that the piston rod 113 drives the piston 112 to reciprocate along the inner wall of the syringe 111, thereby enabling the head of the syringe 111 to draw a sample or discharge the sample.

This embodiment can measure external temperature through temperature sensor 2, and when the temperature was less than preset the temperature, controller 5 can control heater 3 was right piston 112 heats, so that piston 112's temperature risees, makes piston 112 is in non-shrinkage temperature within range to make the inner wall of piston 112 and cylinder 111 can be in close contact with all the time, and then guarantee syringe 11's leakproofness, syringe 11 that the leakproofness is better can make the difficult weeping of cylinder 111 at the in-process that piston rod 113 promoted piston 112 and removed, thereby guarantee the accuracy of sample volume.

Specifically, the cylinder 111 and/or the piston rod 113 are made of a heat conductive material, and the heater 3 is configured to heat the cylinder 111 and/or the piston rod 113 so that heat of the cylinder 111 and/or the piston rod 113 is transferred to the piston 112, so that the temperature of the piston 112 is increased, and the piston 112 is in a non-cold-shrink temperature range.

In this embodiment, the piston rod 113 is made of a metal material, and the heater 3 is configured to heat the other end of the piston rod 113 to increase the temperature of the other end of the piston rod 113, and due to a heat conduction effect, the temperature is transmitted from the other end of the piston rod 113 to the one end of the piston rod 113, and then is transmitted from the one end of the piston rod 113 to the piston 112, so that the temperature of the piston 112 is increased; the cylinder 111 is made of a glass material, and the piston 112 is made of a rubber material.

The plunger pump 100 further comprises a pull rod 6, and the other end of the piston rod 113 is connected with the driving assembly 4 through the pull rod 6.

In the present embodiment, the temperature sensor 2 and the heater 3 are respectively provided on the tie bar 6.

The drive assembly 4 comprises a motor 41, a screw rod 42 and a nut element 43, the motor 41 is connected with one end of the screw rod 42, the nut element 43 is sleeved on the screw rod 42, the other end of the piston rod 113 is connected with the nut element 43, the controller 5 is further used for controlling the motor 41 to drive the screw rod 42 to rotate, the screw rod 42 drives the nut element 43 to move, so that the nut element 43 drives the piston rod 113 to move, the piston rod 113 drives the piston 112 to move back and forth along the inner wall of the needle cylinder 111, and the sample is extracted from the head of the needle cylinder 111 or the sample is discharged.

In particular, the other end of the piston rod 113 and the nut element 43 are connected by means of a tie rod 6.

The driving assembly 4 further includes a limiting member 44, and the limiting member 44 is used for limiting the moving range of the nut element 43 along the lead screw 42 so as to prevent the nut element 43 from being disengaged from the other end of the lead screw 42.

The plunger pump 100 further comprises a guide assembly 7, the guide assembly 7 being adapted to guide the movement of the nut element 43 in a predetermined direction.

The nut element 43 comprises a nut 431 and a first slider 432 and a second slider 433 which are respectively connected with the nut 431, the guide assembly 7 comprises a first guide column 71 and a second guide column 72, a first through hole is formed in the first slider 432, a second through hole is formed in the second slider 433, the first slider 432 is sleeved on the first guide column 71 through the first through hole, the second slider 433 is sleeved on the second guide column 72 through the second through hole, and the screw rod 42 drives the nut 431 to move, so that the nut 431 respectively drives the first slider 432 and the second slider 433 to move along the first guide column 71 and the second guide column 72 correspondingly.

Specifically, the stoppers 44 are respectively connected to the tops of the first guide posts 71 and the second guide posts 72.

Specifically, the nut element 43 further includes a first connecting rod and a second connecting rod, the other end of the piston rod 113 is connected to the pull rod 6, one end of the first connecting rod and one end of the second connecting rod are respectively connected to the pull rod 6, the other end of the first connecting rod is connected to the first slider 432, and the other end of the second connecting rod is connected to the second slider 433.

As shown in fig. 3, the dissolution channel 1 further includes a first three-way pipe 12, a second three-way pipe 13, a first three-way valve 14 and a second three-way valve 15, the number of the injectors 11 is two, and the injectors are respectively a first injector 16 and a second injector 17, a port a of the first three-way pipe 12 is communicated with a port a of the first three-way valve 14, a port B is communicated with a solvent input end, a port C is communicated with a port a of the second three-way valve 15, a port B of the first three-way valve 14 is communicated with a head of the first injector 16, a port C is communicated with a port a of the second three-way pipe 13, a port B of the second three-way pipe 13 is communicated with a solvent output end, a port B of the second three-way valve 15 is communicated with a head of the second injector 17, and a port C is communicated with a port C of the second three-way pipe 13.

In this embodiment, the number of the dissolution channels 1 is seven, the seven dissolution channels 1 are divided into two groups, the first group of dissolution channels is composed of four dissolution channels 1, and the second group of dissolution channels is composed of three dissolution channels 1. The number of the driving assemblies 4 is four, the four driving assemblies 4 are grouped into two groups and divided into a first group of driving assemblies and a second group of driving assemblies, the number of the pull rods 6 is four, the four pull rods 6 are grouped into two groups and divided into a first group of pull rods and a second group of pull rods, one driving assembly 4 in the first group of driving assemblies drives one pull rod 6 in the first group of pull rods to move, so that one pull rod 6 drives the piston rods 113 in the four injectors 11 in the first group of dissolution channels to move respectively. The other drive assembly 4 in the first group drives the other pull rod 6 in the first group to move, so that the other pull rod 6 drives the piston rods 113 in the other four injectors 11 in the first group of dissolution channels to move respectively. The second set of dissolution channels may be referenced to the first set of dissolution channels and will not be described in detail herein. The flow cell dissolution experiment can be synchronously performed through the two dissolution channels, so that the working efficiency of the plunger pump 100 is improved.

The head of the syringe of the first injector 16 is detachably communicated with the port B of the first three-way valve 14, and the other end of the piston rod of the first injector 16 is detachably connected with the drive assembly 4; the head of the syringe of the second injector 17 is detachably communicated with the port B of the second three-way valve 15, and the other end of the piston rod of the second injector 17 is detachably connected with the drive assembly 4. When the piston 112 and the cylinder 111 are damaged during a long-term use, a new syringe 11 can be simply and rapidly replaced without affecting the operation schedule of the plunger pump 100.

Specifically, the other end of the piston rod of the first injector 16 is detachably connected with one of the pull rods 6, and the other end of the piston rod of the second injector 17 is detachably connected with the other pull rod 6.

As shown in fig. 3, the plunger pump 100 further includes a weighing component 8, the weighing component 8 is used for weighing the sample discharged from the syringe 11, and the controller 5 is further used for adjusting the distance that the piston 112 moves in the syringe 111 according to the weight weighed by the weighing component 8. The controller 5 can adjust the moving distance of the piston 112 in the cylinder 111 to realize the automatic correction of the flow rate of the injector 11, thereby improving the accuracy of the experiment.

Specifically, the controller 5 controls the driving assembly 4 to drive the piston rod 113 to move by a range, so that the piston rod 113 drives the piston 112 to move by a distance in the cylinder 111, thereby adjusting the movement distance of the piston 112 in the cylinder 111.

As shown in fig. 1, the sampler further comprises a support 9 and a bottom plate 10, and the support 9, the driving assembly 4 and the guiding assembly 7 are respectively arranged on the bottom plate 10.

As shown in fig. 2, a first sliding groove 91 and a second sliding groove 92 are formed in the support 9, the injector 11 and the pull rod 6 are disposed on one side of the support 9, the driving component 4 and the guiding component 7 are disposed on the other side of the support 9, the first connecting rod is connected to the pull rod 6 and the first sliding block on both sides, and the second connecting rod is connected to the pull rod 6 and the second sliding block on both sides.

Specifically, the motor 41 is disposed on the base plate 10, and the bottom of the first guide post 71 and the bottom of the second guide post 72 are disposed on the base plate 10.

Operation of the drive assembly 4, the guide assembly 7 and the injector 11:

the motor 41 drives the screw rod 42 to rotate, the screw rod 42 drives the nut 431 to move, the nut 431 drives the first slider 432 and the second slider 433 to move along the first guide column 71 and the second guide column 72 correspondingly, the first slider 432 and the second slider 433 drive the corresponding first connecting rod and the second connecting rod to operate, the first connecting rod and the second connecting rod drive the pull rod 6 to move respectively, the pull rod 6 drives the piston rod 113 to move, so that the piston rod 113 drives the piston 112 to move back and forth along the inner wall of the needle cylinder 111, and thus the head of the needle cylinder 111 extracts a sample or discharges the sample.

The work flow of the dissolution channel 1:

step one, the port C of the first three-way valve 14 is closed, the port a and the port B are opened, the port a of the second three-way valve 15 is closed, and the first motor 45 drives the first syringe 16 to draw a sample.

Step two, the end a of the first three-way valve 14 is closed, the port B and the port C are opened, the end C of the second three-way valve 15 is closed, and the first motor 45 drives the first syringe 16 to discharge the sample into the test tube 20. Meanwhile, the port C of the second three-way valve 15 is closed, the ports a and B are opened, the port a of the first three-way valve 14 is closed, and the second syringe 17 is driven by the second motor 46 to draw a sample.

And step three, closing the end A of the second three-way valve 15, opening the port B and the port C, closing the end C of the first three-way valve 14, and driving the second injector 17 by the second motor 46 to discharge the sample into the container. And simultaneously, repeating the step one. The first syringe 16 and the second syringe 17 can be alternately discharged with the sample. The two injectors are controlled by the two motors 41 and the two three-way valves to alternately and complementarily output pulse or constant-flow solvents, so that the solvent outflow precision of the plunger pump 100 is improved.

The above only be the preferred embodiment of the utility model discloses a not consequently restriction the utility model discloses a patent range, all are in the utility model discloses a conceive, utilize the equivalent structure transform of what the content was done in the description and the attached drawing, or direct/indirect application all is included in other relevant technical field the utility model discloses a patent protection within range.

Claims

1. A plunger pump capable of automatically adjusting flow of a dissolution instrument by a flow cell method is characterized by comprising:

a temperature sensor for measuring an outside temperature;

a heater for heating the piston;

the driving assembly is used for driving the piston rod to move;

2. The plunger pump of claim 1, wherein the barrel and/or the piston rod are made of a thermally conductive material, and the heater is configured to heat the barrel and/or the piston rod to transfer heat from the barrel and/or the piston rod to the piston to raise the temperature of the piston to bring the piston within a non-cold-shrink temperature range.

3. The plunger pump according to claim 1, wherein the driving assembly comprises a motor, a screw rod and a nut element, the motor is connected with one end of the screw rod, the nut element is sleeved on the screw rod, the other end of the piston rod is connected with the nut element, the controller is further configured to control the motor to drive the screw rod to rotate, the screw rod drives the nut element to move, so that the nut element drives the piston rod to move, the piston rod drives the piston to move back and forth along the inner wall of the needle cylinder, and the head of the needle cylinder draws a sample or discharges the sample.

4. The plunger pump of claim 3, wherein the drive assembly further comprises a stop for limiting the range of movement of the nut element along the lead screw to prevent the nut element from coming off the other end of the lead screw.

5. The plunger pump of claim 3, further comprising a guide assembly for guiding the nut member in a predetermined direction.

6. The plunger pump according to claim 5, wherein the nut element comprises a nut and a first slider and a second slider respectively connected to the nut, the guiding assembly comprises a first guiding post and a second guiding post, the first slider is provided with a first through hole, the second slider is provided with a second through hole, the first slider is sleeved on the first guiding post through the first through hole, the second slider is sleeved on the second guiding post through the second through hole, and the screw rod drives the nut to move, so that the nut drives the first slider and the second slider to move along the first guiding post and the second guiding post correspondingly.

7. The plunger pump of claim 1, wherein the dissolution channel further comprises a first three-way pipe, a second three-way pipe, a first three-way valve and a second three-way valve, the number of the injectors is two, the first injector and the second injector are respectively, the port A of the first three-way pipe is communicated with the port A of the first three-way valve, the port B is communicated with the solvent input end, the port C is communicated with the port A of the second three-way valve, the port B of the first three-way valve is communicated with the head of the first injector syringe, the port C is communicated with the port A of the second three-way pipe, the port B of the second three-way pipe is communicated with the solvent output end, the port B of the second three-way valve is communicated with the head of the second injector syringe, and the port C is communicated with the port C of the second three-way valve.

8. The plunger pump of claim 7, wherein the head of the first syringe barrel is in removable communication with the B port of the first three-way valve, the other end of the first syringe piston rod being removably connected to the drive assembly; the head of the second syringe needle cylinder is detachably communicated with the port B of the second three-way valve, and the other end of the second syringe piston rod is detachably connected with the driving assembly.

9. The plunger pump of claim 1, further comprising a weighing assembly configured to weigh the sample discharged from the syringe, wherein the controller is further configured to control a distance that the drive assembly drives the piston rod to move within the syringe according to the weight weighed by the weighing assembly.

10. A dissolution apparatus comprising a plunger pump as claimed in any one of claims 1 to 9.