CN214514581U - Reation kettle is used in preparation of high purity 4-fluorobenzoyl acetonitrile - Google Patents
Reation kettle is used in preparation of high purity 4-fluorobenzoyl acetonitrile Download PDFInfo
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- CN214514581U CN214514581U CN202120606193.0U CN202120606193U CN214514581U CN 214514581 U CN214514581 U CN 214514581U CN 202120606193 U CN202120606193 U CN 202120606193U CN 214514581 U CN214514581 U CN 214514581U
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Abstract
The utility model provides a reation kettle is used in preparation of high-purity 4-fluorobenzoyl acetonitrile, the reactor comprises a kettle body, cauldron body top is provided with the kettle cover, kettle cover top center department installs the motor through the positioning seat, the motor side is provided with batch hopper, batch hopper side is provided with the valve, the internal (mixing) shaft that passes through coupling joint with the motor output shaft that is provided with of cauldron, the (mixing) shaft side-mounting has the stirring rake, the stirring rake side is equipped with the connecting rod, connecting rod one end and (mixing) shaft fixed connection, connecting rod other end fixedly connected with scraper blade, the both sides of the cauldron body are provided with inlet pipe and intake pipe respectively, the (mixing) shaft downside is provided with the baffle, the baffle bottom is connected with the funnel. The utility model has the advantages of being scientific and reasonable in structural design, easy operation is convenient, and the processing stability is good, can make the material react under nitrogen protection, has guaranteed reaction quality.
Description
Technical Field
The utility model belongs to the technical field of the preparation of medical intermediate, especially indicate a reation kettle is used in preparation of high-purity 4-fluorobenzoyl acetonitrile.
Background
4-fluorobenzoylacetonitrile is an important intermediate for the synthesis of Blonanserin (Blonanserin), a new drug for the treatment of schizophrenia, and is widely used industrially due to the special properties of its own functional groups. The present applicant has proposed a process for preparing high purity 4-fluorobenzoylacetonitrile (chinese patent application No. 201410525652.7), which comprises reacting acetonitrile with 4-methyl fluorobenzoate to synthesize 4-fluorobenzoylacetonitrile, using alkali metal as base and acetonitrile as solvent. The solvent may be a mixture of acetonitrile and anhydrous ether. The preparation method can avoid the generation of impurities 4-methoxybenzoyl acetonitrile and benzoylacetonitrile which are extremely similar to the product in properties, and has the advantages of simple purification mode, yield of over 93 percent and product purity of over 99 percent. However, the existing reaction kettle is not suitable for the method, the main reasons are that the existing intermediate preparation device is complex in structure and difficult to operate, materials are easy to adhere to the inner wall of a container during reaction, material waste is caused, manual treatment is needed, the working efficiency is reduced, and in addition, the general preparation device is poor in heat insulation performance, and the processing effect cannot be guaranteed.
SUMMERY OF THE UTILITY MODEL
In order to solve the defects of the prior art, the utility model provides a reaction kettle for preparing high-purity 4-fluorobenzoyl acetonitrile.
The technical scheme of the utility model is realized like this:
a reaction kettle for preparing high-purity 4-fluorobenzoyl acetonitrile comprises a kettle body, wherein a kettle cover is arranged at the top of the kettle body, a motor is installed at the center of the top of the kettle cover through a positioning seat, a feeding hopper is arranged on the side face of the motor, a valve is arranged on the side face of the feeding hopper, a stirring shaft connected with an output shaft of the motor through a coupling is arranged in the kettle body, a stirring paddle is installed on the side face of the stirring shaft, a connecting rod is arranged on the side face of the stirring paddle, one end of the connecting rod is fixedly connected with the stirring shaft, a scraping plate is fixedly connected to the other end of the connecting rod, a feeding pipe and an air inlet pipe are respectively arranged on two sides of the kettle body, a baffle is arranged on the lower side of the stirring shaft, a funnel is connected to the bottom of the baffle, an electromagnetic valve is arranged on the side face of the funnel, a separation pipe is connected to the outer side of the kettle body, a control switch is arranged on the lower side of the separation pipe, install thermodetector on the inner wall of the cauldron body, cauldron body bottom is provided with the collecting box that communicates with it, be provided with the concentration board in the collecting box, the electrical heating board is installed to the concentration board upside, the collecting box side is provided with the chamber door.
Preferably, the bottom of the kettle body is provided with a support column, and the bottom of the support column is provided with a base.
Preferably, a sealing ring is arranged between the top of the kettle body and the kettle cover.
Preferably, the outer side of the kettle body is provided with a jacket, and both sides of the jacket are respectively provided with a liquid inlet pipe and a liquid outlet pipe.
Compared with the prior art, the utility model continuously stirs the mixed solution by the rotation of the motor-driven stirring shaft and the stirring paddle, so that the material liquid can be fully mixed, the mixed material adhered on the inner wall of the kettle body is scraped by the scraper blade in the stirring process, and the material waste caused by the material remaining in the kettle body is avoided; the kettle body and the kettle cover are designed separately, so that a user can open and close the kettle quickly, the interior of the kettle body can be cleaned conveniently, and the workload of the user is reduced; the sealing performance of the whole device is ensured by arranging the sealing ring, the internal environment of the kettle can be effectively insulated by arranging the jacket, and the overheating or overcooling of the inner cavity of the kettle is avoided, so that the inner cavity of the kettle is always in a proper temperature range; through setting up the collecting box, can heat the concentrated processing that steps up through inside electric heating board to the solution after the preparation, be convenient for obtain 4-fluorobenzoyl acetonitrile crude, improve the result of use of device.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is an enlarged view of a structure at a in fig. 1.
Fig. 3 is a schematic structural view of the collecting box in fig. 1.
In the figure: 1 kettle body, 11 support columns, 12 kettle covers, 13 sealing rings, 14 positioning seats, 15 motors, 16 feeding hoppers, 17 stirring shafts, 18 stirring paddles, 19 connecting rods, 2 scraping plates, 21 clamping sleeves, 22 feeding pipes, 23 air inlet pipes, 24 baffle plates, 25 funnels, 26 separating pipes, 27 control switches, 28 temperature detectors, 29 collecting boxes, 3 concentration plates, 31 electric heating plates and 32 box doors
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
As shown in fig. 1-3: a reaction kettle for preparing high-purity 4-fluorobenzoyl acetonitrile comprises a kettle body 1, wherein a support column 11 is arranged at the bottom of the kettle body 1, a base is arranged at the bottom of the support column 11, a kettle cover 12 is arranged at the top of the kettle body 1, a sealing ring 13 is arranged between the top of the kettle body 1 and the kettle cover 12, and the kettle body 1 and the kettle cover 12 are designed to be separated, so that a user can rapidly open and close the kettle body 1 to clean the interior of the kettle body 1, the sealing performance of the whole device is ensured by arranging the sealing ring 13, a motor 15 is arranged at the center of the top of the kettle cover 12 through a positioning seat 14, the motor 15 is connected with a power supply and a control switch 27 through a lead, a feeding hopper 16 is arranged on the side surface of the motor 15, a valve is arranged on the side surface of the feeding hopper 16, a stirring shaft 17 connected with an output shaft of the motor 15 through a coupler is arranged in the kettle body 1, a stirring paddle 18 is arranged on the side surface of the stirring shaft 17, and a connecting rod 19 is arranged on the side surface of the stirring paddle 18, 19 one ends of connecting rod and (mixing) shaft 17 fixed connection, 19 other end fixedly connected with scraper blade 2 of connecting rod, rotate through motor 15 drive (mixing) shaft 17 and stirring rake 18 and continuously stir mixed solution for the feed liquid can the intensive mixing, strike off the misce bene of adhesion on the internal wall of cauldron 1 through scraper blade 2 at the stirring in-process, avoid the material to remain and cause the material extravagant in the internal portion of cauldron 1, on the other hand has alleviateed user's work burden.
The outer side of the kettle body 1 is provided with a jacket 21, the two sides of the jacket 21 are respectively provided with a liquid inlet pipe and a liquid outlet pipe, the jacket 21 is arranged to effectively preserve heat of the environment in the kettle body 1 and avoid overheating or overcooling of the inner cavity of the kettle body 1, so that the inner cavity of the kettle body 1 is always in a proper temperature range, the two sides of the kettle body 1 are respectively provided with a material inlet pipe 22 and a gas inlet pipe 23, the lower side of the stirring shaft 17 is provided with a baffle 24, the bottom of the baffle 24 is connected with a funnel 25, the side surface of the funnel 25 is provided with an electromagnetic valve, the outer side of the kettle body 1 is connected with a separation pipe 26, the lower side of the separation pipe 26 is provided with a control switch 27, the inner wall of the kettle body 1 is provided with a temperature detector 28, the bottom of the kettle body 1 is provided with a collecting box 29 communicated with the baffle, the collecting box 29 is internally provided with a concentration plate 3, the upper side of the concentration plate 3 is provided with an electric heating plate 31, the side surface of the collecting box 29 is provided with a box door 32, and by arranging the collecting box 29, the prepared solution can be heated, pressurized and concentrated through the internal electric heating plate 31, so that a 4-fluorobenzoyl acetonitrile crude product can be conveniently obtained, and the using effect of the device is improved.
When the reaction kettle for preparing the high-purity 4-fluorobenzoyl acetonitrile is used, a solvent is placed in the kettle body 1 in advance, and solid alkali metal is put into the kettle body 1 from a feeding hopper 16; the gas inlet pipe 23 is connected with nitrogen generation equipment, nitrogen enters the kettle body 1, under the protection of nitrogen, a heat preservation medium is injected into a liquid inlet pipe and a liquid outlet pipe of the jacket 21 to keep the temperature below minus 30 ℃, liquid materials are added into the kettle body 1 through the feed pipe 22, and the adding sequence and the requirements are as described in Chinese patent application No. 201410525652.7 and a preparation method named as high-purity 4-fluorobenzoylacetonitrile. After the reaction is finished, the electromagnetic valve on the side surface of the funnel 25 is opened, the mixed liquid automatically enters the inner cavity at the lower part of the kettle body 1, the valve at the lower side of the kettle body 1 is opened after the reaction is confirmed to be finished, so that the mixed liquid enters the collecting box 29, and the electric heating plate 31 is opened to carry out heating treatment on the mixed liquid, so that a concentrated finished product is obtained.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (4)
1. A reation kettle is used in preparation of high purity 4-fluorobenzoylacetonitrile which characterized in that: comprises a kettle body (1), wherein a kettle cover (12) is arranged at the top of the kettle body (1), a motor (15) is arranged at the center of the top of the kettle cover (12) through a positioning seat (14), a feeding hopper (16) is arranged on the side of the motor (15), a valve is arranged on the side of the feeding hopper (16), a stirring shaft (17) which is connected with an output shaft of the motor (15) through a coupling is arranged in the kettle body (1), a stirring paddle (18) is arranged on the side of the stirring shaft (17), a connecting rod (19) is arranged on the side of the stirring paddle (18), one end of the connecting rod (19) is fixedly connected with the stirring shaft (17), a scraper (2) is fixedly connected with the other end of the connecting rod (19), an inlet pipe (22) and an inlet pipe (23) are respectively arranged on the two sides of the kettle body (1), a baffle plate (24) is arranged on the lower side of the stirring shaft (17), baffle (24) bottom is connected with funnel (25), funnel (25) side is provided with the solenoid valve, the cauldron body (1) outside is connected with separator tube (26), separator tube (26) downside is provided with control switch (27), install thermodetector (28) on the inner wall of the cauldron body (1), cauldron body (1) bottom is provided with collecting box (29) that communicate with it, be provided with concentrated board (3) in collecting box (29), electric heating board (31) are installed to concentrated board (3) upside, collecting box (29) side is provided with chamber door (32).
2. The reaction kettle for preparing high-purity 4-fluorobenzoylacetonitrile according to claim 1, wherein: the cauldron body (1) bottom is provided with support column (11), support column (11) bottom is provided with the base.
3. The reaction kettle for preparing high-purity 4-fluorobenzoylacetonitrile according to claim 1, wherein: and a sealing ring (13) is arranged between the top of the kettle body (1) and the kettle cover (12).
4. The reaction kettle for preparing high-purity 4-fluorobenzoylacetonitrile according to claim 1, wherein: the kettle is characterized in that a jacket (21) is installed on the outer side of the kettle body (1), and a liquid inlet pipe and a liquid outlet pipe are respectively arranged on two sides of the jacket (21).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120606193.0U CN214514581U (en) | 2021-03-25 | 2021-03-25 | Reation kettle is used in preparation of high purity 4-fluorobenzoyl acetonitrile |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120606193.0U CN214514581U (en) | 2021-03-25 | 2021-03-25 | Reation kettle is used in preparation of high purity 4-fluorobenzoyl acetonitrile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214514581U true CN214514581U (en) | 2021-10-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120606193.0U Active CN214514581U (en) | 2021-03-25 | 2021-03-25 | Reation kettle is used in preparation of high purity 4-fluorobenzoyl acetonitrile |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214514581U (en) |
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2021
- 2021-03-25 CN CN202120606193.0U patent/CN214514581U/en active Active
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