CN214513809U - Sulfobutyl betacyclodextrin sodium production system - Google Patents
Sulfobutyl betacyclodextrin sodium production system Download PDFInfo
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- CN214513809U CN214513809U CN202120500737.5U CN202120500737U CN214513809U CN 214513809 U CN214513809 U CN 214513809U CN 202120500737 U CN202120500737 U CN 202120500737U CN 214513809 U CN214513809 U CN 214513809U
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Abstract
The utility model relates to a sulfobutyl betacyclodextrin sodium production system. The device comprises a betacyclodextrin dissolution kettle, wherein an outlet of the betacyclodextrin dissolution kettle is connected with an inlet end of an ultrafiltration membrane with the MWCO of 2000, an outlet end of the ultrafiltration membrane with the MWCO of 2000 is connected with an inlet of a reaction kettle, an inlet of the reaction kettle is also connected with an outlet of a sulbutrolactone storage tank, an outlet of the reaction kettle is connected with an inlet end of an ultrafiltration membrane with the MWCO of 3000, an outlet end of the ultrafiltration membrane with the MWCO of 3000 is connected with an inlet of a first material liquid storage tank, an outlet of the first material liquid storage tank is connected with an inlet end of an ultrafiltration membrane with the MWCO of 1500, an outlet end of the ultrafiltration membrane with the MWCO of 1500 is connected with an inlet of a second material liquid storage tank, an outlet of the second material liquid storage tank is connected with an inlet end of a microbial filter, and an outlet end of the microbial filter is connected with a dryer. The utility model discloses can get rid of the impurity and the microorganism of reaction process.
Description
Technical Field
The utility model belongs to the technical field of the medicine, concretely relates to sulfobutyl betacyclodextrin sodium production system.
Background
The sulfobutyl betacyclodextrin sodium serving as a novel pharmaceutic adjuvant has high water solubility, low nephrotoxicity, no hemolysis and good safety, and is mainly used as an injection solubilization adjuvant. The sulfobutyl betacyclodextrin sodium is prepared by adopting a chemical synthesis method, the betacyclodextrin reacts with the sulfobutyrolactone under the alkaline condition, and then the sulfobutyl betacyclodextrin sodium is obtained by refining and drying. The sulfobutyl betacyclodextrin sodium is used as an injection auxiliary material, has high quality requirement, and particularly has strict requirements on bacterial endotoxin and microorganisms in a finished product.
Therefore, there is a need to develop a sulfobutyl-betacyclodextrin sodium production system capable of removing impurities and microorganisms of the reaction process.
SUMMERY OF THE UTILITY MODEL
The be not enough to prior art, the utility model aims at providing a sulfobutyl betacyclodextrin sodium production system gets rid of reaction process's impurity and microorganism through the combination of the membrane of different grade type, guarantees the production of high quality sulfobutyl betacyclodextrin sodium.
In order to realize the above purpose, the technical scheme of the utility model is as follows:
the production system of sulfobutyl beta-cyclodextrin sodium comprises a beta-cyclodextrin dissolving kettle, wherein an outlet of the beta-cyclodextrin dissolving kettle is connected with an inlet end of an ultrafiltration membrane with the molecular weight cutoff of 2000, an outlet end of the ultrafiltration membrane with the molecular weight cutoff of 2000 is connected with an inlet of a reaction kettle, an inlet of the reaction kettle is also connected with an outlet of a sulfobutyrolactone storage tank, an outlet of the reaction kettle is connected with an inlet end of an ultrafiltration membrane with the molecular weight cutoff of 3000, an outlet end of the ultrafiltration membrane with the molecular weight cutoff of 3000 is connected with an inlet of a first material liquid storage tank, an outlet of the first material liquid storage tank is connected with an inlet end of an ultrafiltration membrane with the molecular weight cutoff of 1500, an outlet end of the ultrafiltration membrane with the molecular weight cutoff of 1500 is connected with an inlet of a second material liquid storage tank, an outlet of the second material liquid storage tank is connected with an inlet end of a microbial filter, and an outlet of the microbial filter is connected with an inlet of a dryer.
Wherein:
preferably, the pore size of the microbial filter is 0.22 μm.
Preferably, the dryer is a spray drying tower.
The working principle and the process are as follows:
during work, betacyclodextrin and aqueous alkali are mixed in a betacyclodextrin dissolving kettle, and then starch residues in the betacyclodextrin are removed through an ultrafiltration membrane with the cut-off molecular weight of 2000 and then enter a reaction kettle. The sulfobutyrolactone enters the reaction kettle from the sulfobutyrolactone storage tank to react with the alkaline solution of beta-cyclodextrin to obtain the sulfobutyl beta-cyclodextrin sodium solution.
The sulfobutyl-beta-cyclodextrin sodium solution firstly passes through an ultrafiltration membrane with the molecular weight cutoff of 3000, macromolecular by-products in the reaction process are removed, and the solution enters a first material liquid storage tank for storage.
Then, the beta-cyclodextrin and micromolecular saccharides in the reaction process are removed by an ultrafiltration membrane with the molecular weight cutoff of 1500, and the beta-cyclodextrin and the micromolecular saccharides enter a second material liquid storage tank for storage.
Finally, the microorganisms are removed through a microorganism filter with the pore diameter of 0.22 μm.
And (4) drying the solution after the microorganisms are removed in a dryer to obtain the product.
Compared with the prior art, the beneficial effects of the utility model are as follows:
the utility model discloses simple structure, reasonable in design through the combination of the membrane of different grade type, gets rid of reaction process's impurity and microorganism, guarantees the production of high quality sulfobutyl beta cyclodextrin sodium.
Drawings
Fig. 1 is a schematic structural diagram of the present invention;
in the figure: 1. betacyclodextrin dissolution kettle; 2. ultrafiltration membrane with molecular weight cut-off of 2000; 3. a sulbutrolactone storage tank; 4. a reaction kettle; 5. ultrafiltration membrane with molecular weight cutoff of 3000; 6. a first feed liquid storage tank; 7. ultrafiltration membrane with cut-off molecular weight of 1500; 8. a second feed liquid storage tank; 9. a microbial filter; 10. and (7) a dryer.
Detailed Description
The present invention will be further described with reference to the following detailed description.
Example 1
As shown in figure 1, the sulfobutyl betacyclodextrin sodium production system comprises a betacyclodextrin dissolving kettle 1, wherein an outlet of the betacyclodextrin dissolving kettle 1 is connected with an inlet end of an ultrafiltration membrane 2 with the molecular weight cutoff of 2000, an outlet end of the ultrafiltration membrane 2 with the molecular weight cutoff of 2000 is connected with an inlet of a reaction kettle 4, an inlet of the reaction kettle 4 is also connected with an outlet of a sulfobutyrolactone storage tank 3, an outlet of the reaction kettle 4 is connected with an inlet end of an ultrafiltration membrane 5 with the molecular weight cutoff of 3000, an outlet end of the ultrafiltration membrane 5 with the molecular weight cutoff of 3000 is connected with an inlet of a first material liquid storage tank 6, an outlet of the first material liquid storage tank 6 is connected with an inlet end of an ultrafiltration membrane 7 with the molecular weight cutoff of 1500, an outlet end of the ultrafiltration membrane 7 with the molecular weight cutoff of 1500 is connected with an inlet of a second material liquid storage tank 8, an outlet of the second material liquid storage tank 8 is connected with an inlet end of a microbial filter 9, the outlet end of the microbial filter 9 is connected to the inlet of a dryer 10.
The pore size of the microbial filter 9 is 0.22 μm.
The dryer 10 is a spray drying tower.
During work, betacyclodextrin and aqueous alkali are mixed in a betacyclodextrin dissolving kettle 1, and then starch residues in the betacyclodextrin are removed through an ultrafiltration membrane 2 with the cut-off molecular weight of 2000 and then enter a reaction kettle 4. The sulfobutyrolactone enters a reaction kettle 4 from a sulfobutyrolactone storage tank 3 to react with the aqueous alkali of beta-cyclodextrin to obtain a sulfobutyl beta-cyclodextrin sodium solution.
The sulfobutyl betacyclodextrin sodium solution firstly passes through an ultrafiltration membrane 5 with the molecular weight cutoff of 3000, macromolecular by-products in the reaction process are removed, and the solution enters a first material liquid storage tank 6 for storage.
Then, the beta-cyclodextrin and the micromolecule saccharides in the reaction process are removed through an ultrafiltration membrane 7 with the cut-off molecular weight of 1500, and the beta-cyclodextrin and the micromolecule saccharides enter a second material liquid storage tank 8 for storage.
Finally, the microorganisms are removed through a microorganism filter 9 with a pore size of 0.22 μm.
The solution after the microorganism removal enters a dryer 10 for drying to obtain the product.
It is understood that the above description is only a preferred embodiment of the present invention, and is not intended to limit the present invention in any way, and that any person skilled in the art may make modifications or changes to the equivalent embodiment using the above disclosure. However, any simple modification, equivalent change and modification made to the above embodiments according to the technical substance of the present invention still belong to the protection scope of the technical solution of the present invention.
Claims (3)
1. A sulfobutyl betacyclodextrin sodium production system is characterized in that: comprises a betacyclodextrin dissolving kettle (1), wherein an outlet of the betacyclodextrin dissolving kettle (1) is connected with an inlet end of an ultrafiltration membrane (2) with the molecular weight cutoff of 2000, an outlet end of the ultrafiltration membrane (2) with the molecular weight cutoff of 2000 is connected with an inlet of a reaction kettle (4), an inlet of the reaction kettle (4) is also connected with an outlet of a sulfobutyrolactone storage tank (3), an outlet of the reaction kettle (4) is connected with an inlet end of an ultrafiltration membrane (5) with the molecular weight cutoff of 3000, an outlet end of the ultrafiltration membrane (5) with the molecular weight cutoff of 3000 is connected with an inlet of a first material liquid storage tank (6), an outlet of the first material liquid storage tank (6) is connected with an inlet end of an ultrafiltration membrane (7) with the molecular weight cutoff of 1500, an outlet end of the ultrafiltration membrane (7) with the molecular weight cutoff of 1500 is connected with an inlet of a second material liquid storage tank (8), an outlet of the second material liquid storage tank (8) is connected with an inlet end of a microbial filter (9), the outlet end of the microorganism filter (9) is connected with the inlet of the dryer (10).
2. The sulfobutyl-betaxocyclodextrin sodium production system of claim 1, wherein: the pore diameter of the microbial filter (9) is 0.22 μm.
3. The sulfobutyl-betaxocyclodextrin sodium production system of claim 1, wherein: the dryer (10) is a spray drying tower.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120500737.5U CN214513809U (en) | 2021-03-09 | 2021-03-09 | Sulfobutyl betacyclodextrin sodium production system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120500737.5U CN214513809U (en) | 2021-03-09 | 2021-03-09 | Sulfobutyl betacyclodextrin sodium production system |
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| Publication Number | Publication Date |
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| CN214513809U true CN214513809U (en) | 2021-10-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120500737.5U Active CN214513809U (en) | 2021-03-09 | 2021-03-09 | Sulfobutyl betacyclodextrin sodium production system |
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| CN (1) | CN214513809U (en) |
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2021
- 2021-03-09 CN CN202120500737.5U patent/CN214513809U/en active Active
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