CN214472807U

CN214472807U - Disc incubation and optical detection device with centrifugal function

Info

Publication number: CN214472807U
Application number: CN202022997576.3U
Authority: CN
Inventors: 何大永; 王弼陡; 刘亮; 江浩; 谢立国
Original assignee: Suzhou Institute of Biomedical Engineering and Technology of CAS
Current assignee: Suzhou Institute of Biomedical Engineering and Technology of CAS
Priority date: 2020-12-14
Filing date: 2020-12-14
Publication date: 2021-10-22
Anticipated expiration: 2030-12-14

Abstract

The utility model discloses a disc incubation and optical detection device with centrifugation function, it includes: a first platform; the clamping cover assembly is movably arranged on the first platform; the centrifugal heating assembly comprises a first motor fixedly mounted on the first platform for providing centrifugal force, a disk fixed on an output shaft of the first motor for placing a reagent, and a heating rod positioned below the disk for heating; an optical assembly located on the first platform at a position aligned with the reagent for optical detection; the clamping cover assembly moves to a clamping state of being clamped above the disk or an opening state of being far away from the disk along a vertical plane in a two-dimensional mode. The utility model provides a problem that equipment function singleness, many equipment switch work efficiency are low has advantages such as function integrated level height, effectively utilize space, convenient operation, raise the efficiency.

Description

Disc incubation and optical detection device with centrifugal function

Technical Field

The utility model relates to the field of biotechnology, more specifically say, the utility model relates to a disc incubation and optical detection device with centrifugal function.

Background

In the field of biotechnology, disc biochips are often subjected to incubation, centrifugation, optical detection, and the like. Because the function of the equipment is single, the equipment with different functions needs to be switched when the equipment is used for finishing the functions of incubation, centrifugation, optical detection and the like, and the equipment needs to be assisted by manpower or other machines, so that the working time is prolonged, the working efficiency is reduced, and the large-batch automatic supply in a short time is difficult to realize.

SUMMERY OF THE UTILITY MODEL

To the weak point that exists in the above-mentioned technique, the utility model provides a disc incubation and optical detection device with centrifugation function solves the problem that equipment function singleness, multiple unit switch work efficiency are low, has advantages such as function integrated level height, effectively utilize space, convenient operation, raise the efficiency.

In order to achieve these objects and other advantages in accordance with the present invention, the present invention provides a method for manufacturing a semiconductor device, comprising:

the embodiment of the utility model provides a disc incubation and optical detection device with centrifugation function, it includes:

a first platform;

the clamping cover assembly is movably arranged on the first platform;

a centrifugal heating assembly including a first motor fixedly mounted on the first platform to provide centrifugal force, a disk fixed to an output shaft of the first motor for placing a reagent, and a heating rod positioned below the disk for heating; and the number of the first and second groups,

an optical assembly located on the first platform at a position aligned with the reagent for optical detection;

and the clamping cover assembly moves to a clamping state of clamping the upper part of the disk or an opening state of being far away from the disk along a vertical plane in a two-dimensional mode.

Preferably, the centrifugal heating assembly further comprises:

a second platform fixedly mounted to an outer side of the first motor; a first groove which radially extends out and is used for placing the heating rod is formed in the side surface of the second platform; and the number of the first and second groups,

the centrifugal disc is arranged at the axis position of the second platform, and the axis of the centrifugal disc is fixedly arranged on an output shaft of the first motor;

the centrifugal disc comprises a centrifugal disc body, wherein a first positioning block is arranged on the axis of the centrifugal disc body, a first positioning hole is formed in the axis of the disc body, the first positioning block is matched and clamped with the first positioning hole, and the disc body is fixedly installed on the centrifugal disc body.

Preferably, the centrifugal heating assembly further comprises:

the second positioning blocks comprise a plurality of second positioning blocks which are arranged along the edge of the centrifugal disc in the radial direction and form a circle;

the second positioning holes comprise a plurality of second positioning holes which are arranged along the radial direction of the edge of the disk and form a circle;

and the second positioning block is matched and clamped with the second positioning hole.

Preferably, the optical assembly is further provided with a laser lamp for optical detection, the second platform is provided with a first through hole, and the disk is provided with a second groove for placing a reagent; the first through hole is communicated with the second groove, and laser emitted by the laser lamp sequentially penetrates through the first through hole and the second groove to reach the reagent on the disk.

Preferably, the card cover assembly includes:

the two-dimensional part comprises a second motor and a first guide rail which are fixedly connected, a first sliding table fixedly connected to an output shaft of the second motor, a connecting block fixedly connected to the first sliding table, a third motor and a second guide rail fixedly connected to the connecting block, and a second sliding table fixedly connected to an output shaft of the third motor; and the number of the first and second groups,

the side edge of the third platform is fixedly connected to the second sliding platform, and the third platform is provided with a third groove with a downward opening;

the second motor drives the first sliding table to horizontally slide along the first guide rail in a rotating mode, the third motor drives the second sliding table to vertically slide along the second guide rail in a rotating mode, and the third sliding table is driven to move horizontally or vertically respectively until the third sliding table reaches the position above the disk, so that the third groove is matched with the disk to be clamped or separated from the disk to be opened.

Preferably, the third groove side is further provided with a second through hole for accommodating the heating rod in a clamping state.

Preferably, the card cover assembly further comprises:

the refrigerating sheet is embedded in the position, corresponding to the heating position of the disc in the clamping state, on the third platform;

the cooling fin is arranged above the refrigerating fin and used for cooling; and the number of the first and second groups,

and a cover plate which is provided to the third stage to cover the heat sink.

Preferably, the card cover component further comprises a fan, which is arranged between the heat sink and the cover plate; and the side edge of the cover plate is also provided with a third through hole for heat dissipation.

The utility model discloses at least, include following beneficial effect:

(1) the utility model provides a disc incubation and optical detection device with centrifugation function, through centrifugation and heating of centrifugation heating element, optical detection of optical element and the removal block of card lid subassembly or open, realize accomplishing function experiments such as centrifugation, incubation and optical detection on an experiment platform, the function integrated level is high, can effectively utilize the experiment platform space, and the operation is convenient, improves work efficiency;

(2) the first motor rotates to drive the centrifugal disc fixedly connected with the output shaft of the first motor to do centrifugal motion, the centrifugal disc and the disc are fixedly installed in a matched mode through the first positioning hole and the first positioning block, and the disc also does centrifugal motion

(3) The second positioning holes in the shape of a circle are matched and clamped with the second positioning blocks, so that the disk is further limited in the circumferential direction, the disk is prevented from being thrown away during centrifugation, and the stability of the disk is improved;

(4) a second through hole for accommodating the heating rod in a clamping state is further formed in the side edge of the third groove, so that the heating rod can be exposed when the third groove is clamped with the second platform;

(5) the clamping cover assembly further comprises a refrigerating piece, a radiating piece and a cover piece, wherein the refrigerating piece is embedded in a position, corresponding to the heating position of the disc piece in the clamping state, on the third platform and used for refrigerating and cooling; the cooling fin is arranged above the refrigerating fin and used for further cooling; a cover plate is provided to the third stage to cover the heat sink for protecting the device.

Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

FIG. 1 is a schematic view of the overall structure of a disk incubation and optical detection device with centrifugation according to the present invention;

FIG. 2 is a schematic view of the structure of the present invention showing the opening of the cover plate of the disk incubation and optical detection device with centrifugation function;

FIG. 3-1 is a front view of a centrifugal heating assembly according to the present invention;

FIG. 3-2 is a cross-sectional view taken along the direction M-M in FIG. 3-1;

description of reference numerals:

1. a first platform; 21. a first motor; 22. a disk; 221. a first positioning hole; 222. a second positioning hole; 223. a second groove; 23. a heating rod; 24. a second platform; 241. a first groove; 242. a first through hole; 25. a centrifugal pan; 251. a first positioning block; 26. a heat insulation plate; 3. an optical component; 31. a laser light; 41. a third platform; 411. a second through hole; 421. a second motor; 422. a first guide rail; 423. a first sliding table; 424. connecting blocks; 425. a third motor; 426. a second guide rail; 427. a second sliding table; 43. a refrigeration plate; 44. a heat sink; 45. a cover sheet; 451. a third through hole; 46. a fan.

Detailed Description

The technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings, and it is to be understood that the described embodiments are only some embodiments, but not all embodiments, of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the embodiments of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed in a specific orientation, and be operated, and thus are not to be construed as limiting the present invention, and furthermore, the terms "first", "second", and "third" are used for descriptive purposes only and are not intended to indicate or imply relative importance.

In the description of the embodiments of the present invention, it should be noted that unless explicitly stated or limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; the connection may be direct, indirect or communication between two elements, wireless or wired. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

Furthermore, terms such as "having," "including," and "comprising," used in various embodiments of the present invention described below, do not preclude the presence or addition of one or more other elements or combinations thereof; the technical features involved can be combined with each other as long as they do not conflict with each other.

< example 1>

As shown in fig. 1-2, an embodiment of the present invention provides a disk incubation and optical detection device with centrifugation function, which includes: a first platform 1, a card cover component, a centrifugal heating component and an optical component 3.

Wherein the centrifugal heating assembly comprises a first motor 21 fixedly mounted to the first platform 1, a disc 22 fixed to an output shaft of the first motor 21, and a heating rod 23 positioned below the disc 22. The biological reagent is put on the disc 22, the rotation of the first single machine drives the disc 22 fixedly connected with the output shaft to rotate, and the first motor 21 provides centrifugal force for the disc 22. The heating rod 23 heats the reagent on the disk 22. The optical assembly 3 is located on the first platform 1 at a position aligned with the reagent and can be used for optical detection by laser irradiation. The card cover assembly is movably arranged on the first platform 1, and specifically, the card cover assembly moves along a vertical plane in two dimensions to a clamping state of being clamped above the disk 22 or an opening state of being far away from the disk 22. When centrifugation or incubation is needed, the cover assembly moves downwards along the vertical plane after moving above the disk 22 in two dimensions and is installed on the disk 22 in a matched mode to achieve clamping, the disk 22 is prevented from being thrown out during centrifugation, and a relative space is provided for incubation. When the experiment is finished and needs to be opened, the card cover assembly moves vertically upwards and then moves horizontally out, and the opening state is finished, so that the reagent on the disc 22 can be conveniently taken and placed.

The utility model provides an above-mentioned embodiment, through centrifugation heating element's centrifugation and heating, optical component 3's optical detection and the removal block of card lid subassembly or open, realize accomplishing function experiments such as centrifugation, incubation and optical detection on an experiment platform, the function integrated level is high, can effectively utilize the experiment platform space, and the operation is convenient, improves work efficiency.

< example 2>

On the basis of the embodiment 1, as shown in fig. 1, 2, 3-1 and 3-2, the embodiment of the invention provides a preferable implementation mode of the centrifugal heating assembly.

In a first aspect, the centrifugal heating assembly further comprises a second platform 24 and a centrifugal disc 25. The second platform 24 is fixedly installed outside the first motor 21, and a first groove 241 for placing the heating rod 23 is formed at a side surface of the second platform 24 to extend in a radial direction. The centrifugal disc 25 is arranged at the axis position of the second platform 24, and the axis of the centrifugal disc 25 is fixedly arranged on the output shaft of the first motor 21. The centrifugal disc 25 is provided with a first positioning block 251 at the axis, the disc 22 is provided with a first positioning hole 221 at the axis, the first positioning block 251 is matched and clamped with the first positioning hole 221, and the disc 22 is fixedly installed on the centrifugal disc 25. In this embodiment, the first motor 21 rotates to drive the centrifugal disc 25 fixedly connected to the output shaft thereof to perform centrifugal motion, and the centrifugal disc 25 and the disk 22 are fixedly mounted in a matching manner through the first positioning hole 221 and the first positioning block 251, so that the disk 22 also performs centrifugal motion. The first groove 241, which radially extends from the side of the second platform 24, facilitates the taking and placing of the heating rod 23.

In the second aspect, to further limit and fix the disk 22 to the centrifugal disk 25, the centrifugal heating assembly further includes a second positioning block (not specifically shown) and a second positioning hole 222. The second positioning blocks comprise a plurality of second positioning blocks which are arranged along the edge of the centrifugal disc 25 in the radial direction and form a circle; the second positioning holes 222 include a plurality of holes arranged radially along the edge of the disk 22 to form a circle; the second positioning block is matched and clamped with the second positioning hole 222. In this embodiment, the circular second positioning holes 222 are matched and clamped with the second positioning blocks, so as to further limit the disk 22 in the circumferential direction, thereby ensuring that the disk 22 is not thrown away during centrifugation, and improving the stability of the disk 22. As to the number of the second positioning holes 222 and the second positioning blocks matching with each other, the present invention is preferably in the shape of two circles with different radii.

In a third aspect, in order to ensure an incubation temperature environment, the centrifugal heating assembly further comprises a heat shield 26, the heat shield 26 being fixedly mounted between the first motor 21 and the second platform 24. Because the heating rod 23 is placed in the first groove 241 radially extending from the side of the second platform 24, the heat insulation plate 26 is fixedly installed between the first motor 21 and the second platform 24 for preventing the heat of the heating rod 23 from being transmitted downwards, so that the energy of the heating rod 23 is upwards as much as possible to provide the incubation for the reagent on the disk 22, and the incubation efficiency is improved.

< example 3>

On the basis of embodiments 1 and 2, as shown in fig. 1, 2, 3-1, 3-2, the embodiments of the present invention provide a preferred embodiment of an optical component 3.

Specifically, the optical assembly 3 is provided with a laser lamp 31, the second platform 24 is provided with a first through hole 242, the disk 22 is provided with a second groove 223 for placing a reagent, the first through hole 242 is communicated with the second groove 223, and the laser emitted by the laser lamp 31 sequentially passes through the first through hole 242 and the second groove 223 to reach the reagent on the disk 22 for optical detection. As to the shape and position of the first through hole 242 and the second groove 223, the present invention preferably provides the second groove 223 with its opening facing upward on the disk 22, and the first through hole 242 with its opening facing outward is disposed along the second platform 24 in radial direction, so as to facilitate the laser alignment of the reagent after the disk 22 is centrifuged.

< example 4>

On the basis of embodiments 1-3, as shown in fig. 1, 2, 3-1 and 3-2, the embodiment of the present invention provides a preferred embodiment of the card cover assembly.

In a first aspect, the card cover assembly includes a two-dimensional member and a third platform 41. The two-dimensional member includes a second motor 421 and a first guide rail 422 fixedly connected, a first slide table 423 fixedly connected to an output shaft of the second motor 421, a connecting block 424 fixedly connected to the first slide table 423, a third motor 425 and a second guide rail 426 fixedly connected to the connecting block 424, and a second slide table 427 fixedly connected to an output shaft of the third motor 425. The third platform 41 is fixedly connected to the second sliding platform 427 at its side edge, and the third platform 41 is provided with a third groove (not specifically shown in the figure) with a downward opening. In this embodiment, the second motor 421 rotates to drive the first sliding table 423 to slide horizontally along the first guide rail 422, and the third motor 425 rotates to drive the second sliding table 427 to slide vertically along the second guide rail 426. Specifically, the horizontal sliding of the first sliding table 423 drives the third platform 41 to move horizontally, and the vertical sliding of the second sliding table 427 drives the third platform 41 to move vertically, so that the third platform 41 can move horizontally or vertically on a vertical plane, for example, when an experiment needs to be performed, the third platform 41 moves vertically downward to the third groove to be clamped with the disk 22 after moving horizontally from an initial position to above the disk 22, and after the experiment is finished, the third platform 41 moves vertically upward and then moves horizontally to the initial position to realize opening and homing.

It should supplement the explanation, the connection piece is exactly the effect of connecting first slip table 423 with third motor 425 and second guide rail 426, the utility model discloses preferably be the connection piece of L type to a side of the connection piece of further preferred L type passes through nut fixed mounting to first slip table 423, and another side also passes through nut fixed mounting to third motor 425 and second guide rail 426 on, both satisfied two-dimensional motion, simple structure, installation convenience again.

In the second aspect, the third groove side is further provided with a second through hole 411 for accommodating the heating rod 23 in the engagement state. In this embodiment, since the third groove of the third platform 41 needs to be clamped to the outer side of the second platform 24 during the clamping process, the extendable heating rod 23 is placed in the first groove 241 of the second platform 24, and therefore, the second through hole 411 can be disposed to meet the requirement of exposing the heating rod 23 when the third groove is clamped to the second platform 24.

In a third aspect, the card cover assembly further comprises a cooling plate 43, a heat sink 44 and a cover plate 45. The cooling plate 43 is embedded in the third platform 41 at a position corresponding to the position where the disk 22 is heated when in the engaged state, and is used for cooling. A heat sink 44 is provided above the cooling fins 43 for further heat dissipation. A cover sheet 45 is provided on the third stage 41 to cover the heat sink 44 for protecting the device. As for the number of the radiation fins 44, the present invention is not particularly limited.

In the fourth aspect, for further heat dissipation, the card cover assembly further includes a fan 46, and the fan 46 is disposed between the heat sink 44 and the cover plate 45 for further heat dissipation. The side of the cover plate 45 is further provided with a third through hole 451 for further heat dissipation. As for the size and the number of the third through holes 451, the present invention is not particularly limited.

It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious changes and modifications can be made without departing from the scope of the invention.

Claims

1. A disk incubation and optical detection device with centrifugation, comprising:

a first platform (1);

the clamping cover assembly is movably arranged on the first platform (1);

a centrifugal heating assembly comprising a first motor (21) fixedly mounted on the first platform (1) to provide centrifugal force, a disk (22) fixed to an output shaft of the first motor (21) for placing a reagent thereon, and a heating rod (23) located below the disk (22) for heating; and the number of the first and second groups,

an optical assembly (3) located on the first platform (1) in a position aligned with the reagent for optical detection;

the clamping cover assembly moves to a clamping state of being clamped above the disk (22) or an opening state of being far away from the disk (22) along a vertical plane in a two-dimensional mode.

2. The apparatus for incubation and optical detection of a disk with centrifugation according to claim 1, wherein the centrifugation heating unit further comprises:

a second platform (24) fixedly mounted to the outside of the first motor (21); a first groove (241) which radially extends out and is used for placing the heating rod (23) is formed in the side surface of the second platform (24); and the number of the first and second groups,

the centrifugal disc (25) is arranged at the axis position of the second platform (24), and the axis of the centrifugal disc (25) is fixedly arranged on an output shaft of the first motor (21);

the centrifugal disc (25) is characterized in that a first positioning block (251) is arranged at the axis of the centrifugal disc (25), a first positioning hole (221) is formed in the axis of the disc (22), the first positioning block (251) is matched and clamped with the first positioning hole (221), and the disc (22) is fixedly installed on the centrifugal disc (25).

3. The apparatus for incubation and optical detection of a disk with centrifugation according to claim 2, wherein the centrifugation heating unit further comprises:

the second positioning blocks comprise a plurality of second positioning blocks which are arranged along the edge of the centrifugal disc (25) in the radial direction and form a circle;

the second positioning holes (222) comprise a plurality of circles which are arranged along the radial direction of the edge of the disk (22);

the second positioning block is matched and clamped with the second positioning hole (222).

4. The apparatus for incubation and optical detection of a disk with centrifugation according to claim 2, wherein the optical assembly (3) is further provided with a laser lamp (31) for optical detection, the second platform (24) is provided with a first through hole (242), and the disk (22) is provided with a second groove (223) for placing a reagent; the first through hole (242) is communicated with the second groove (223), and laser emitted by the laser lamp (31) sequentially penetrates through the first through hole (242) and the second groove (223) to reach the reagent of the disc (22).

5. The apparatus for incubation and optical detection of a centrifuged disc according to claim 2, wherein the cartridge cover assembly comprises:

the two-dimensional part comprises a second motor (421) and a first guide rail (422) which are fixedly connected, a first sliding table (423) fixedly connected to an output shaft of the second motor (421), a connecting block (424) fixedly connected to the first sliding table (423), a third motor (425) and a second guide rail (426) fixedly connected to the connecting block (424), and a second sliding table (427) fixedly connected to an output shaft of the third motor (425); and the number of the first and second groups,

a third platform (41) with a side fixedly connected to the second sliding table (427), wherein the third platform (41) is provided with a third groove with a downward opening;

the second motor (421) drives the first sliding table (423) to horizontally slide along the first guide rail (422) in a rotating mode, the third motor (425) drives the second sliding table (427) to vertically slide along the second guide rail (426) in a rotating mode, and the third platform (41) is driven to move horizontally or vertically until the third platform reaches the position above the disk (22) to enable the third groove to be matched with the disk (22) in a clamping mode or the third groove to be separated from the disk (22) to be opened.

6. The apparatus for incubation and optical detection of disks with centrifugation according to claim 5, wherein the third well side is further provided with a second through hole (411) for receiving the heating rod (23) in the engaged state.

7. The apparatus for incubation and optical detection of a centrifuged disc according to claim 5, wherein the cartridge cover assembly further comprises:

a refrigerating sheet (43) embedded in the third platform (41) at a position corresponding to the heating position of the disk (22) in the clamping state;

a heat sink (44) disposed above the cooling fins (43) for dissipating heat; and the number of the first and second groups,

a cover sheet (45) which is provided to the third stage (41) so as to cover the heat sink (44).

8. The optical disk incubation and detection apparatus with centrifugation function according to claim 7, wherein said card cover assembly further comprises a fan (46) disposed between said heat sink (44) and said cover plate (45); the side edge of the cover plate (45) is also provided with a third through hole (451) for heat dissipation.