CN214426520U - Heat exchange device for bioreactor - Google Patents
Heat exchange device for bioreactor Download PDFInfo
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- CN214426520U CN214426520U CN202120556984.7U CN202120556984U CN214426520U CN 214426520 U CN214426520 U CN 214426520U CN 202120556984 U CN202120556984 U CN 202120556984U CN 214426520 U CN214426520 U CN 214426520U
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- pipe
- cavity
- heat exchange
- bioreactor
- inlet tube
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Abstract
The utility model discloses a heat transfer device for bioreactor, including two piece at least cavity risers, inlet tube and wet return, be connected with the cavity ring pipe between the cavity riser, cavity ring pipe and cavity riser communicate each other, and inlet tube and wet return are connected respectively in the cavity riser upper end of difference, and inlet tube and wet return upper end connect through connecing the subassembly soon and fix on bioreactor's stainless steel end cover board. The utility model discloses a set the baffle inserts that the reactor is used for the choked flow to pass oxygen to hollow structure to configuration water inlet and return water mouth, this baffle inserts can play the choked flow and pass the effect of oxygen, can also play reactor temperature control's effect. The device organically combines the baffle and the heat exchange device into a whole, and has the following advantages compared with a small reactor with jacket type heat exchange: the structure is simple and beautiful; the occupied space is small; the weight is light; the off-line sterilization is convenient, and the transportation and the operation are convenient.
Description
Technical Field
The utility model relates to a heat transfer device especially relates to a heat transfer device for bioreactor.
Background
The fermentation tank is one of the bioreactors, and can provide a proper reaction environment for living cells or enzyme growth and metabolism and perform cell proliferation or production. The control process of the biological reaction process comprises a plurality of control conditions such as temperature control, aeration control, stirring control and the like, wherein the temperature control is an extremely important factor, and different cells or enzymes are greatly influenced by temperature in the process of culture metabolism, so that the growth of the cells and the yield of products are directly influenced. However, the temperature control method of the conventional small-sized stirring bioreactor is realized by an external jacket, and the specific operation method is to regulate and control the temperature in the reactor by conveying a heat exchange medium to the jacket. The jacket type heat exchange mode has the defects that the occupied space of the small reactor is increased, the tank body is heavy, a certain amount of softened water needs to be added into the jacket to ensure the sterilization effect during off-line sterilization, and the operation is complicated. Therefore, it is an urgent problem for those skilled in the art to develop a heat exchange device for a bioreactor.
Disclosure of Invention
The utility model provides a heat exchange device for a bioreactor, which aims to solve the defects.
The above object of the present invention is achieved by the following technical solutions: the utility model provides a heat transfer device for bioreactor, includes two piece at least cavity risers, inlet tube and wet return, is connected with the cavity ring pipe between the cavity riser, and cavity ring pipe and cavity riser communicate each other (the medium can flow wantonly), inlet tube and wet return are connected respectively in the cavity riser upper end of difference, inlet tube and wet return upper end connect through connecing the subassembly soon and fix on bioreactor's stainless steel end cover board.
Further, connect the subassembly soon and include fast interface, adapter and sealing washer, the fast interface passes through the adapter and is connected with inlet tube, wet return, the sealing washer sets up at the adapter outer wall.
Further, the number of the hollow stand pipes is four.
Further, the number of the hollow circular ring pipes is at least one.
Further, the cross sections of the hollow vertical pipe and the hollow circular ring pipe are rectangular pipes or circular.
Furthermore, the quick-connection assembly, the hollow vertical pipe, the hollow circular pipe, the water inlet pipe and the water return pipe are all made of stainless steel.
During installation, the hollow vertical pipe, the hollow circular ring pipe, the water inlet pipe and the water return pipe are all arranged in the bioreactor tank body, and the quick connector is connected with the hollow vertical pipe through the adapter and the sealing ring and is fixed on the outer side of the stainless steel end cover plate.
When the reactor is in operation, the utility model discloses a device both can play the choked effect of baffle, can play the effect to reactor temperature regulation control again. When the heat exchanger works, a heat exchange medium enters from the water inlet pipe and flows into the hollow vertical pipe and the hollow circular ring pipe, the hollow vertical pipe and the hollow circular ring pipe can be quickly distributed under the pushing of the heat exchange medium pump, and the heat exchange medium finally flows out through the water return pipe. The culture material in the reactor passes through under the continuous stirring action of agitator and the utility model discloses the outer surface contact of device, temperature regulation and control operation is accomplished in quick heat transfer.
The utility model is applied to small stirring glass bioreactors of 3L, 5L, 7L, 10L and the like. The method specifically comprises the following steps: the reaction system is compared with a jacketed heat exchange bioreactor on a 5L bioreactor. Tap water is used as a cooling medium, the temperature is reduced from 37 ℃ to 15 ℃ for 23.7min (the scheme) and 24.6min (the jacket type), and the temperature difference is very stable within the range of +/-0.2 ℃. And in the off-line sterilization process, the weight of the bioreactor of the utility model is about 5kg lighter than that of a jacketed heat exchange bioreactor, and the bioreactor is more flexible and convenient to move.
The utility model discloses with prior art's advantage be: the utility model discloses a set the baffle inserts that the reactor is used for the choked flow to pass oxygen to hollow structure to configuration water inlet and return water mouth, this baffle inserts can play the choked flow and pass the effect of oxygen, can also play reactor temperature control's effect. The device organically combines the baffle and the heat exchange device into a whole, and has the following advantages compared with a small reactor with jacket type heat exchange: the structure is simple and beautiful; the occupied space is small; the weight is light; the off-line sterilization is convenient, and the transportation and the operation are convenient.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic diagram of the practical application of the present invention.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings.
As shown in fig. 1 and 2, a heat exchange device for a bioreactor comprises at least two hollow vertical pipes 1, a water inlet pipe 2 and a water return pipe 3, wherein a hollow circular pipe 4 is connected between the hollow vertical pipes 1, the hollow circular pipe 4 and the hollow vertical pipes 1 are communicated with each other (the medium can flow freely), the water inlet pipe 2 and the water return pipe 3 are respectively connected to the upper ends of the different hollow vertical pipes 1, and the upper ends of the water inlet pipe 2 and the water return pipe 3 are connected and fixed on a stainless steel end cover plate of a bioreactor 6 through a quick connection component 5.
Further, the quick-connection assembly 5 comprises a quick connector 501, an adapter 502 and a sealing ring 503, wherein the quick connector 501 is connected with the water inlet pipe 2 and the water return pipe 3 through the adapter 502, and the sealing ring 503 is arranged on the outer wall of the adapter 502.
Further, the number of the hollow risers 1 is four.
Further, the number of the hollow circular ring tubes 4 is at least one.
Further, the cross sections of the hollow vertical pipe 1 and the hollow circular ring pipe 4 are rectangular pipes or circular.
Further, the quick-connection assembly 5, the hollow vertical pipe 1, the hollow circular pipe 4, the water inlet pipe 2 and the water return pipe 3 are all made of stainless steel.
During installation, the hollow vertical pipe 1, the hollow circular ring pipe 4, the water inlet pipe 2 and the water return pipe 3 are all arranged in the tank body of the bioreactor 6, and the quick connector 501 is connected with the hollow vertical pipe 1 through the adapter 502 and the sealing ring 503 and is fixed on the outer side of the stainless steel end cover plate 7.
When the reactor is in operation, the utility model discloses a device both can play the choked effect of baffle, can play the effect to reactor temperature regulation control again. During operation, heat transfer medium gets into from inlet tube 2, flows into in cavity riser 1 and the hollow ring pipe 4, can distribute fast cavity riser 1 and hollow ring pipe 4 under the promotion of heat transfer medium pump income pressure, and heat transfer medium flows out through wet return 3 at last. The culture material in the reactor passes through under the continuous stirring action of agitator and the utility model discloses the outer surface contact of device, temperature regulation and control operation is accomplished in quick heat transfer.
The utility model is applied to small stirring glass bioreactors 6 such as 3L, 5L, 7L, 10L, etc. The method specifically comprises the following steps: a comparison was made with jacketed heat exchange bioreactor 6 on a 5L bioreactor 6. Tap water is used as a cooling medium, the temperature is reduced from 37 ℃ to 15 ℃ for 23.7min (the scheme) and 24.6min (the jacket type), and the temperature difference is very stable within the range of +/-0.2 ℃. And in the off-line sterilization process, the weight of the bioreactor 6 of the utility model is about 5kg lighter than that of the bioreactor 6 with jacket type heat exchange, and the carrying is more flexible and convenient.
The above only is the embodiment of the present invention, not limiting the patent scope of the present invention, all the equivalent structures or equivalent processes that are used in the specification and the attached drawings or directly or indirectly applied to other related technical fields are included in the patent protection scope of the present invention.
Claims (6)
1. A heat exchange device for a bioreactor, characterized in that: including two piece at least cavity risers, inlet tube and wet return, be connected with the cavity ring pipe between the cavity riser, cavity ring pipe and cavity riser communicate each other, inlet tube and wet return are connected respectively in the cavity riser upper end of difference, inlet tube and wet return upper end connect through the fast subassembly and fix on bioreactor's stainless steel end cap board.
2. A heat exchange apparatus for a bioreactor according to claim 1, wherein: the quick-connection assembly comprises a quick connector, an adapter and a sealing ring, the quick connector is connected with a water inlet pipe and a water return pipe through the adapter, and the sealing ring is arranged on the outer wall of the adapter.
3. A heat exchange apparatus for a bioreactor according to claim 1, wherein: the number of the hollow vertical pipes is four.
4. A heat exchange apparatus for a bioreactor according to claim 1, wherein: at least one hollow circular ring tube is arranged.
5. A heat exchange apparatus for a bioreactor according to claim 1, wherein: the cross sections of the hollow vertical pipe and the hollow circular ring pipe are rectangular pipes or circular.
6. A heat exchange apparatus for a bioreactor according to claim 1, wherein: the quick connection component, the hollow vertical pipe, the hollow annular pipe, the water inlet pipe and the water return pipe are all made of stainless steel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120556984.7U CN214426520U (en) | 2021-03-18 | 2021-03-18 | Heat exchange device for bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120556984.7U CN214426520U (en) | 2021-03-18 | 2021-03-18 | Heat exchange device for bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214426520U true CN214426520U (en) | 2021-10-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120556984.7U Active CN214426520U (en) | 2021-03-18 | 2021-03-18 | Heat exchange device for bioreactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214426520U (en) |
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2021
- 2021-03-18 CN CN202120556984.7U patent/CN214426520U/en active Active
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