CN214334967U - Nucleic acid reaction control device and detection equipment - Google Patents
Nucleic acid reaction control device and detection equipment Download PDFInfo
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- CN214334967U CN214334967U CN202120257839.9U CN202120257839U CN214334967U CN 214334967 U CN214334967 U CN 214334967U CN 202120257839 U CN202120257839 U CN 202120257839U CN 214334967 U CN214334967 U CN 214334967U
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- nucleic acid
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Abstract
The utility model discloses a nucleic acid reaction controlling means, including heat conduction base, heating member and temperature sensor, be equipped with on the heat conduction base along axially extended mounting groove, heating member and temperature sensor all install in the mounting groove, still are equipped with the bleeder vent that is linked together with the mounting groove on the heat conduction base. The utility model also discloses a check out test set of having above-mentioned nucleic acid reaction controlling means. The utility model discloses a set up heating member and temperature sensor, realize the accurate control of micro-fluidic chip at the testing process temperature.
Description
Technical Field
The utility model belongs to the technical field of nucleic acid testing technique and specifically relates to a nucleic acid reaction controlling means is related to.
Background
In vitro diagnosis refers to taking samples (blood, body fluid, tissue, etc.) from a human body and performing detection analysis to diagnose diseases, and corresponding instruments and reagents are needed in the detection process. The microfluidic chip is also called a lab-on-a-chip, and generally refers to that basic operations such as sample preparation, reaction, separation, detection and the like in the processes of biological, chemical and medical analysis are concentrated on a chip with a micro-channel in a micron scale to complete a system function. The micro-fluidic chip is a chip integrating a plurality of experimental steps, micro-size flow channels and chambers which are arranged in a certain rule are generally arranged on the micro-fluidic chip, different reagents are released according to a certain sequence and flow into a specified chamber through different flow channels to complete specified biochemical reaction so as to realize the purposes of sample preparation, detection and the like, and the micro-fluidic chip has the characteristics of high density, large scale, high flux, multiple functions and the like, and plays an important role in the fields of chemistry, biology and the like. Compared with a macroscopic scale experimental device, the technology obviously reduces the consumption of samples and improves the reaction efficiency. Meanwhile, the pollution of waste generated in experiments to the environment is reduced, and the parallel advantage of the operation of the microfluidic chip can realize high-throughput and automatic control; and can be precisely controlled by a micro-structure such as a micro-valve micro-pump. When the micro-fluidic chip is detected, some steps need to be heated to realize better reaction, so a heating device needs to be provided to realize heating and temperature measurement when the steps need to be heated.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to overcome prior art's defect, provide a nucleic acid reaction controlling means to realize that micro-fluidic chip heats and temperature detection at the in-process of reaction.
In order to achieve the above object, the utility model provides a following technical scheme: the utility model provides a nucleic acid reaction controlling means, nucleic acid reaction controlling means includes heat conduction base, heating member and temperature sensor, be equipped with the mounting groove along axial extension on the heat conduction base, heating member and temperature sensor all install in the mounting groove, still be equipped with on the heat conduction base with the bleeder vent that the mounting groove is linked together.
Preferably, the heat conduction base comprises a heating part and a mounting part which are connected, and a limiting convex ring is formed at the intersection of the heating part and the mounting part.
Preferably, the mounting portion includes a first body portion and a second body portion connected to each other, and a step structure is formed at an intersection of the first body portion and the second body portion.
Preferably, the mounting grooves include a first mounting groove for mounting the heating member and a second mounting groove for mounting the temperature sensor, the first mounting groove being communicated with the second mounting groove.
Preferably, the first mounting groove includes a first receiving groove provided on the heating portion and a second receiving groove provided on the mounting portion, and the second mounting groove includes a third receiving groove provided on the heating portion and a fourth receiving groove provided on the mounting portion.
Preferably, the part of the heating element in the mounting groove is provided with a limiting part for limiting.
Preferably, the limiting part is hemispherical.
Preferably, the ventilation hole is formed on the heating part.
The utility model also discloses a check out test set of having above-mentioned nucleic acid reaction controlling means.
The utility model has the advantages that:
the utility model discloses a nucleic acid reaction controlling means through setting up heating member and temperature sensor, has realized heating and temperature measurement to the reaction in-process, has further realized the accurate control of reaction in-process temperature among the micro-fluidic chip.
Drawings
FIG. 1 is a schematic view of a nucleic acid reaction control apparatus according to the present invention;
FIG. 2 is a schematic diagram of a nucleic acid reaction control device of the present invention mounted on a microfluidic chip;
FIG. 3 is an exploded view of a nucleic acid reaction control apparatus according to the present invention.
Reference numerals: 10. the heat conduction base comprises a heat conduction base body 11, a heating element 12, a temperature sensor 13, a heating part 14, an installation part 15, air holes 16, a limiting convex ring 17, a first installation groove 18, a second installation groove 19, a first body part 20, a second body part 21, an end face 22, a first end 23, a second end 24, a limiting part 25 and a microfluidic chip.
Detailed Description
The technical solution of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings of the present invention.
Referring to fig. 1-3, the present invention discloses a nucleic acid reaction control device, which comprises a heat conducting base 10, a heating element 11 and a temperature sensor 12, for heating and detecting the temperature during the nucleic acid reaction, thereby ensuring the normal operation of the reaction process. Heat conduction base 10 includes heating portion 13 and installation department 14, heating portion 13 adopts the aluminum product material, and is equipped with bleeder vent 15, bleeder vent 15 is used for breathing freely, has avoided the hindrance of air when inserting heat conduction base 10 of heating member 11 and temperature sensor 12 to lead to heating member 11 and temperature sensor 12 to insert not to end, influence the heating and the temperature measurement of device. Further, a limiting convex ring 16 is formed at the intersection of the heating portion 13 and the mounting portion 14, so that the heat conducting base 10 can be stably mounted and fixed.
Be equipped with on the heat conduction base 10 along the mounting groove that circumference extended to, heating member 11 and temperature sensor 12 all install in the mounting groove, the mounting groove is linked together with bleeder vent 15. The installation grooves include a first installation groove 17 and a second installation groove 18, the first installation groove 17 is used for assembling the heating element 11, the second installation groove 18 is used for assembling the temperature sensor 12, and the first installation groove 17 and the second installation groove 18 are communicated. The first mounting groove 17 comprises a first accommodating groove formed in the heating portion 13 and a second accommodating groove formed in the mounting portion 14, and the first accommodating groove is communicated with the second accommodating groove; the second mounting groove 18 includes a third receiving groove provided on the heating portion 13 and a fourth receiving groove provided on the mounting portion 14, and the third receiving groove and the fourth receiving groove are communicated with each other. In this embodiment, the first mounting groove 17 and the second mounting groove 18 are preferably communicated, but in other embodiments, the first mounting groove 17 and the second mounting groove 18 may be selectively not communicated according to actual requirements, that is, the first mounting groove 17 and the second mounting groove 18 are separately disposed.
Referring to fig. 1 to 3, the mounting portion 14 includes a first body portion 19 and a second body portion 20, and a step structure is formed at an intersection of the first body portion 19 and the second body portion 20, and the step structure can prevent the heat conduction base 10 from being moved by an external force after being mounted in place, so as to affect a heating effect. The second body portion 20 has an end face 21, the temperature sensor 12 has a first end 22 and a second end 23 opposite to each other, and the second end 23 extends out of the second body portion 17 along with the end face 21.
As shown in fig. 3, the heating member 11 is provided with a limiting portion 24 for limiting, the limiting portion 24 is hemispherical and is disposed in the mounting groove, so that the heating member 11 is prevented from moving after being mounted in place, and the heating member 11 is more stably mounted.
Referring to fig. 2 and 3, the nucleic acid reaction control device is mounted on a microfluidic chip 25, and the heat conducting base 10 is disposed on the microfluidic chip 25, so as to heat and measure the temperature of the microfluidic chip 25 during the processes of cracking, nucleic acid reaction, and the like, and thus, the normal operation of the whole device is realized. In this embodiment, the upper end of the microfluidic chip is provided with one nucleic acid reaction control device, the lower end of the microfluidic chip is provided with three nucleic acid reaction control devices, and the positions of the nucleic acid reaction control devices are set according to the positions of the flow channels of the microfluidic chip, so that heating and temperature measurement can be performed in corresponding steps.
The utility model also discloses a check out test set, including nucleic acid reaction controlling means for heating and temperature detection under the different environment.
The present invention is to be improved and the technical content and features of the present invention are disclosed as above, however, those skilled in the art may still make various substitutions and modifications based on the teaching and disclosure of the present invention without departing from the spirit of the present invention, therefore, the protection scope of the present invention should not be limited to the contents disclosed in the embodiments, but should include various substitutions and modifications without departing from the present invention and be covered by the claims of the present patent application.
Claims (9)
1. The utility model provides a nucleic acid reaction controlling means, its characterized in that, nucleic acid reaction controlling means includes heat conduction base, heating member and temperature sensor, be equipped with on the heat conduction base along axially extended mounting groove, heating member and temperature sensor all install in the mounting groove, still be equipped with on the heat conduction base with the bleeder vent that the mounting groove is linked together.
2. The apparatus according to claim 1, wherein the heat-conducting base includes a heating portion and a mounting portion connected to each other, and a stopper projection is formed at a junction of the heating portion and the mounting portion.
3. The nucleic acid reaction control device according to claim 2, wherein the mounting portion includes a first body portion and a second body portion connected to each other, and a step structure is formed at a junction of the first body portion and the second body portion.
4. The nucleic acid reaction control device according to claim 2, wherein the mounting groove includes a first mounting groove for mounting the heating member and a second mounting groove for mounting the temperature sensor, the first mounting groove communicating with the second mounting groove.
5. The nucleic acid reaction control device according to claim 4, wherein the first mounting groove includes a first receiving groove provided in the heating portion and a second receiving groove provided in the mounting portion, and the second mounting groove includes a third receiving groove provided in the heating portion and a fourth receiving groove provided in the mounting portion.
6. The nucleic acid reaction control device according to claim 1, wherein a portion of the heating member located in the mounting groove is provided with a stopper for limiting.
7. The nucleic acid reaction control device according to claim 6, wherein the stopper has a hemispherical shape.
8. The nucleic acid reaction control apparatus according to claim 2, wherein the vent hole is provided in the heating portion.
9. A detection apparatus comprising the nucleic acid reaction control device according to any one of claims 1 to 8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120257839.9U CN214334967U (en) | 2021-01-29 | 2021-01-29 | Nucleic acid reaction control device and detection equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120257839.9U CN214334967U (en) | 2021-01-29 | 2021-01-29 | Nucleic acid reaction control device and detection equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214334967U true CN214334967U (en) | 2021-10-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202120257839.9U Active CN214334967U (en) | 2021-01-29 | 2021-01-29 | Nucleic acid reaction control device and detection equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214334967U (en) |
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2021
- 2021-01-29 CN CN202120257839.9U patent/CN214334967U/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Tian Yongtao Inventor after: Zhu Qilang Inventor after: Larry Leia Inventor before: Tian Yongtao Inventor before: Zhu Qilang Inventor before: Larry Leia |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230508 Address after: Room A, 7th Floor, Building 65, No. 421 Hongcao Road, Xuhui District, Shanghai, 200000 Patentee after: Serun (Shanghai) Medical Technology Co.,Ltd. Address before: 510700 unit 601, 6th floor, No.8 helix 3 Road, Guangzhou International Biological Island, Huangpu District, Guangzhou City, Guangdong Province Patentee before: Green leaf diagnostic product technology (Guangdong) Co.,Ltd. |