CN214242146U

CN214242146U - Rapid obesity-related gene detection kit

Info

Publication number: CN214242146U
Application number: CN202120002528.8U
Authority: CN
Inventors: 罗亚品; 刘淑莉; 赵瑞瑞; 童京京; 张辉
Original assignee: Zhengzhou Huazhiyuan Medical Laboratory Co ltd
Current assignee: Zhengzhou Huazhiyuan Medical Laboratory Co ltd
Priority date: 2021-01-04
Filing date: 2021-01-04
Publication date: 2021-09-21
Anticipated expiration: 2031-01-04

Abstract

The utility model discloses a quick obesity relevant gene detect reagent box relates to gene detect reagent box technical field, including box body, lid, be equipped with the sample support in the box body, lid pass through threaded connection, box body, lid are the metal material, the inside of box body, lid is equipped with the vacuum intermediate layer, be equipped with the metallic tank in the box body, the metallic tank is used for storing the dry ice, the shell of metallic tank is made by the stainless steel, the upper end of metallic tank is equipped with the opening, the opening part is equipped with the aluminum alloy sheet, the aluminum alloy sheet is used for sealing the metallic tank, the utility model is used for the low temperature of saliva sample is preserved, can produce low temperature environment in the reagent box, prolongs the save time of sample, prevents that the sample from inefficacy at the mailing in-process.

Description

Rapid obesity-related gene detection kit

Technical Field

The utility model relates to a gene detection kit technical field specifically is a quick obesity related gene detect reagent box.

Background

With the continuous development of economy in China, the living standard of people is continuously improved, people are advancing towards the goal of comprehensively entering a well-being society, the diet of people is continuously rich, and the obesity problem is brought along with the diet, at present, in urban and rural residents in China, the overweight rate and the obesity rate of residents aged 18 and above are respectively 34.3 percent and 16.4 percent, the overweight rate and the obesity rate of teenagers aged 6-17 are respectively 11.1 percent and 7.9 percent, the overweight rate and the obesity rate of children aged 6 and below are respectively 6.8 percent and 3.6 percent, the heat of various social websites and forums is high on the topic of how to lose weight, and some people even adopt the more drastic means of diet conservation, fat extraction operation and the like to lose weight, so that the negative influence on the self health is more than that the obesity occurs.

In 2009, Nature Genetics published research reports, and 6 newly discovered genes, namely TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 were analyzed, the 6 newly discovered genes control obesity by affecting the nerve center, and then researchers discovered more genes affecting obesity, which not only caused by diet control, but also affected the absorption and utilization of fat and sugar by human body, and affected the increase of body weight from the metabolic level, so that the human body suffered from rapid obesity under the condition that the energy intake level exceeds the demand, therefore, the self obesity genes are known from the gene level, and the weight loss is facilitated scientifically, efficiently and healthily.

With the development of gene detection technology, the obesity gene detection can be realized by a saliva sample, but because saliva contains a large amount of microorganisms such as bacteria, oral epithelial cells in the saliva can rapidly die and are decomposed by the microorganisms, so that gene information in the sample is lost, and a kit containing the sample needs a long time to reach a detection laboratory by mail.

SUMMERY OF THE UTILITY MODEL

The utility model aims to provide a: the rapid obesity related gene detection kit can prolong the storage time of a sample and prevent the sample from losing efficacy in the mailing process.

The utility model adopts the technical scheme as follows:

the utility model provides a quick obesity related gene detect reagent box, includes box body, lid, be equipped with the sample pipe holder in the box body, lid pass through threaded connection, box body, lid are the metal material, the inside of box body, lid is equipped with the vacuum intermediate layer, be equipped with the metallic tank in the box body, the metallic tank is used for storing the dry ice, the shell of metallic tank is made by the stainless steel, the upper end of metallic tank is equipped with the opening, the opening part is equipped with the aluminum alloy sheet metal, the aluminum alloy sheet metal is used for sealing the metallic tank.

Preferably, an exhaust device is arranged on the box cover and comprises an exhaust pipe and a guide rod, a groove is formed in the exhaust pipe, the guide rod moves up and down in the groove, and when the guide rod moves to the top of the groove, the exhaust pipe communicates the inner side and the outer side of the box cover.

Preferably, the outer sides of the box body and the box cover are provided with foam plastic gaskets.

Preferably, the groove is T-shaped, an L-shaped pipeline is arranged on the side face of the exhaust pipe, the L-shaped pipeline is communicated with the groove, a T-shaped pipeline is arranged inside the guide rod, the lower end of the T-shaped pipeline is provided with openings on two sides of the guide rod, the upper end of the T-shaped pipeline is provided with an opening on the upper surface of the guide rod, and the guide rod moves to the top of the groove and is communicated with the T-shaped pipeline.

Preferably, the exhaust pipe extends out of the upper surface of the box cover, and a rubber cap is arranged at an opening at the upper end of the exhaust pipe.

Preferably, a convex block is arranged on the inner side of the rubber cap, and the shape of the convex block is matched with the shape of the opening at the upper end of the exhaust pipe.

To sum up, owing to adopted above-mentioned technical scheme, the beneficial effects of the utility model are that:

(1) the kit is internally provided with a metal tank storing dry ice, after a sample tube storing a saliva sample is placed into the kit, a thin needle is used for puncturing an aluminum alloy thin plate at the opening of the metal tank, the dry ice in the metal tank is sublimated rapidly and absorbs a large amount of heat, so that the temperature in the kit is rapidly reduced to below 0 ℃, most of microorganisms in the saliva are killed rapidly in a low-temperature environment, or the saliva is in a dormant state due to low temperature, oral epithelial cells in the saliva cannot be decomposed, the oral epithelial cells in the saliva are well preserved in the rapid cooling process, and CO generated by sublimation of the dry ice₂The specific gravity is high, the air in the reagent box is discharged out of the reagent box from the exhaust pipe under the pressure action, so that the reagent box is filled with low-temperature CO₂Gas, and keep kit internal pressure a little higher than external pressure all the time, prevent that outside air from getting into and leading to the temperature to rise fast, thereby keep the low temperature state in making the reagent box for a long time, in addition, because be equipped with the vacuum intermediate layer in box body, the lid, can effectively avoid.

(2) The foam plastic gaskets are arranged on the outer sides of the box body and the box cover, so that the detection personnel can be prevented from being frostbitten when taking and placing the kit in a low-temperature state, and the collision of the kit in the transportation process is reduced.

Drawings

Fig. 1 is a front view structure diagram of the present invention.

Fig. 2 is a front view of the present invention.

Fig. 3 is a front view structural view of the metal can.

Fig. 4 is an enlarged view of a portion a in fig. 1.

The labels in the figure are: 1-box body, 2-box cover, 3-sample tube holder, 4-vacuum interlayer, 5-metal can, 6-aluminum alloy sheet, 7-exhaust pipe, 8-guide rod, 9-groove, 10-foam plastic gasket, 11-L-shaped pipeline, 12-T-shaped pipeline, 13-rubber cap, and 14-lug.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more clearly understood, the following detailed description of the present invention is made with reference to the accompanying drawings and examples, and it should be understood that the specific examples described herein are only for the purpose of explaining the present invention and are not intended to limit the present invention.

Example 1

A rapid obesity related gene detection kit comprises a box body 1 and a box cover 2, wherein a sample tube holder 3 is arranged in the box body 1, the sample tube holder 3 is made of foam plastic and used for placing a sample tube, the box body 1 and the box cover 2 are connected through threads, the box body 1 and the box cover 2 are made of metal materials, a vacuum interlayer 4 is arranged in the box body 1 to improve the heat insulation performance of the kit, a metal tank 5 is arranged in the box body 1, the metal tank 5 is fixed at the bottom of the inner side of the box body 1, the shell of the metal tank 5 is made of stainless steel with the thickness of 1mm, the volume of the metal tank is 8mL, dry ice is arranged in the metal tank, an opening is formed in the upper end of the metal tank 5, an aluminum alloy thin plate 6 is arranged at the opening, the aluminum alloy thin plate 6 is welded on the metal tank 5 and seals the metal tank 5, an exhaust device is arranged on the box cover 2 and comprises an exhaust pipe 7 and a guide rod 8, a groove 9 is formed in the exhaust pipe 7, the guide rod 8 and the longitudinal section of the groove 9 is in a T shape, the cross section is square, and guide arm 8, the cross section size of recess 9 is the same, guide arm 8 can reciprocate in

recess

9, 7 sides of blast pipe are equipped with 2L-shaped pipelines 11, L-shaped pipeline 11 and recess 9 intercommunication, the inside T-shaped pipeline 12 that is equipped with of guide arm 8, the lower extreme of T-shaped pipeline 12 is equipped with the opening in the both sides of guide arm 8, the upper end of T-shaped pipeline 12 is equipped with the opening at the upper surface of guide arm 8, when guide arm 8 moved the recess 9 top, L-shaped pipeline 11 and T-shaped pipeline 12 intercommunication, make the inside and outside both sides of lid 2 communicate.

The upper surface of lid 2 is stretched out to blast pipe 7, and the upper end opening part of blast pipe 7 is equipped with rubber cap 13, and the inboard of rubber cap 13 is equipped with lug 14, and lug 14's shape and the upper end opening shape looks adaptation of blast pipe 7 use rubber cap 13 to seal blast pipe 7 when the kit is not used, prevent that blast pipe 7 from receiving the pollution jam, pull out rubber cap 13 after putting into the sample, the blast pipe of being convenient for exhausts.

The outer sides of the box body 1 and the box cover 2 are provided with foam plastic gaskets 10 which can prevent the reagent box from being frostbitten when the reagent box in a low temperature state is taken and placed.

The working principle is as follows: when the device is used, a sample tube filled with a saliva sample is placed into the sample tube holder 3, then a thin needle is used for puncturing the aluminum alloy thin plate 6 at the opening of the metal can 5, so that dry ice begins to volatilize, the box cover 2 is arranged on the box body 1 and screwed tightly, the kit is sent back to a detection laboratory, the dry ice is continuously sublimated into carbon dioxide gas in the transportation process, and simultaneously a large amount of heat is absorbed, so that a low-temperature environment is rapidly generated in the kit, most of microorganisms are killed, the internal pressure of the kit is gradually increased when the dry ice volatilizes, the guide rod 8 is pushed to move to the top of the groove 9, so that the inner side and the outer side of the box cover 2 are communicated, redundant gas in the kit is discharged, the specific gravity of the carbon dioxide is far greater than that of air outside can be prevented from entering the kit, the heat exchange between the inner side and the outer side of the kit is reduced, meanwhile, the heat insulation capability of the kit can be further improved due to the arrangement of the vacuum interlayer 4, and the duration time of the low-temperature state is prolonged, ensure that the reagent box is in a low-temperature state during transportation.

The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.

Claims

1. The utility model provides a quick obesity related gene detect reagent box, includes box body (1), lid (2), be equipped with sample pipe holder (3) in box body (1), lid (2) pass through threaded connection, its characterized in that, box body (1), lid (2) are the metal material, the inside of box body (1), lid (2) is equipped with vacuum interlayer (4), be equipped with metallic tank (5) in box body (1), metallic tank (5) are used for storing the dry ice, the shell of metallic tank (5) is made by the stainless steel, the upper end of metallic tank (5) is equipped with the opening, the opening part is equipped with aluminum alloy sheet (6), aluminum alloy sheet (6) are used for sealing metallic tank (5).

2. The rapid obesity-related gene detection kit according to claim 1, wherein an exhaust device is arranged on the box cover (2), the exhaust device comprises an exhaust pipe (7) and a guide rod (8), a groove (9) is formed in the exhaust pipe (7), the guide rod (8) moves up and down in the groove (9), and when the guide rod (8) moves to the top of the groove (9), the exhaust pipe (7) communicates the inner side and the outer side of the box cover (2).

3. The rapid obesity-related gene detection kit according to claim 1, wherein the outer sides of the box body (1) and the box cover (2) are provided with foam plastic gaskets (10).

4. The rapid obesity-related gene detection kit according to claim 2, wherein the groove (9) is T-shaped, the side of the exhaust pipe (7) is provided with an L-shaped pipeline (11), the L-shaped pipeline (11) is communicated with the groove (9), a T-shaped pipeline (12) is arranged inside the guide rod (8), the lower end of the T-shaped pipeline (12) is provided with openings at two sides of the guide rod (8), the upper end of the T-shaped pipeline (12) is provided with an opening at the upper surface of the guide rod (8), and when the guide rod (8) moves to the top of the groove (9), the L-shaped pipeline (11) is communicated with the T-shaped pipeline (12).

5. The rapid obesity-related gene detection kit according to claim 2, wherein the exhaust pipe (7) extends out of the upper surface of the box cover (2), and a rubber cap (13) is arranged at the upper end opening of the exhaust pipe (7).

6. The rapid obesity-related gene detection kit according to claim 5, wherein the inner side of the rubber cap (13) is provided with a bump (14), and the shape of the bump (14) is matched with the shape of the upper end opening of the exhaust pipe (7).