CN214130397U

CN214130397U - PRP extraction and separation needle cylinder and extraction and separation set comprising same

Info

Publication number: CN214130397U
Application number: CN202022591690.6U
Authority: CN
Inventors: 鄂青
Original assignee: Felderson Jiangsu Biotechnology Co ltd
Current assignee: Felderson Jiangsu Biotechnology Co ltd
Priority date: 2020-11-10
Filing date: 2020-11-10
Publication date: 2021-09-07
Anticipated expiration: 2030-11-10

Abstract

The utility model relates to a PRP extraction and separation needle cylinder and an extraction and separation suit containing the needle cylinder, wherein the PRP extraction and separation suit comprises a PRP extraction and separation needle cylinder and a collecting device, and the PRP extraction and separation needle cylinder comprises a main needle cylinder, a secondary needle cylinder and an injector needle cylinder; one end of the main needle cylinder is provided with a main needle cylinder interface, a capillary tube is arranged in the main needle cylinder and communicated with the interior of the main needle cylinder, and an internal thread is arranged in the main needle cylinder interface; a matched plugging part is arranged outside the main syringe interface; the secondary needle cylinder is arranged in the main needle cylinder, a fixing part is arranged at the part of the lower part close to the interface of the main needle cylinder, and external threads are arranged at the outer side of the fixing part; the upper part of the secondary needle cylinder is provided with a secondary needle cylinder flank, and the outer side of the cylinder body of the secondary needle cylinder is provided with a sealing ring; the syringe needle cylinder is arranged inside the secondary needle cylinder, the lower part of the syringe needle cylinder is provided with a clamping part, and the clamping part is detachably connected with the fixed part; the syringe has push rod inside the syringe cylinder, and the push rod includes piston, push rod shaft and boosting head. The utility model has the advantages of, PRP draws separation suit convenient operation, and the PRP concentration of drawing is high, and the pollution risk is low.

Description

PRP extraction and separation needle cylinder and extraction and separation set comprising same

Technical Field

The utility model relates to an immiscible liquid separation device field, especially a PRP draws and separates cylinder and contain the extraction and separation suit of this cylinder.

Background

PRP (Platelet Rich Plasma) is a Platelet Rich Plasma obtained by extracting certain venous blood, and centrifuging and separating in vitro; the PRP mainly comprises platelets, leukocytes and fibronectin, wherein the platelets can release a large amount of growth factors and cytokines after being activated, the leukocytes have an anti-infection function, and the fibronectin can provide a cell scaffold. At present, PRP is widely applied to clinic, including orthopedics, ophthalmology, plastic cosmetology department and the like, and with further research on PRP, the PRP can be widely applied to clinic.

Most of the existing PRP extracting and separating tools adopt a syringe type structure, PRP preparation is basically carried out by manual repeated centrifugation, and certain improvement is carried out on the extracting and separating tools in some researches, such as Chinese invention patents: a structure disclosed by a platelet-rich plasma extraction kit (application publication number: CN105214343A) comprises a first needle cylinder, a second needle cylinder, a push rod and a protective cap, wherein a blood sampling hole is formed in the front end part of the first needle cylinder, the protective cap is detachably sleeved on the front end part of the first needle cylinder, the second needle cylinder can be inserted on the rear end part of the first needle cylinder in a sliding manner along the front-back direction, a first piston is sleeved on the front end part of the second needle cylinder, the first piston and the inner wall of the first needle cylinder are arranged in a sealing manner, the push rod is inserted on the rear end part of the second needle cylinder and can slide along the inner wall of the second needle cylinder in a sealing manner, and the extraction kit further comprises a hose penetrating through the axial surface of the first piston and used for communicating the inner cavities of the first needle cylinder and the second needle cylinder; after the blood extracted by the extracting set with the structure is centrifuged to be blood layered, the extracting set vertically pushes the second needle cylinder downwards slightly to drive the first piston to move downwards, red blood cells positioned at the lower layer in the first needle cylinder are extruded out and discarded, middle platelets and upper plasma are left, the red blood cells are extruded out by centrifugation again, then the push rod needs to be pulled directly and slightly to drive the third piston to move upwards, the platelets positioned at the lower layer in the first needle cylinder are sucked into the second needle cylinder through the hose penetrating through the axial surface of the first piston to obtain the required platelet-rich plasma, and the plasma left in the first needle cylinder is pushed out by slightly pushing the second needle cylinder; in the using process, when the first piston moves downwards to extrude red blood cells on the lower layer of the first syringe, the centrifugally layered blood plasma is easily mixed again under pressure, and the red blood cells are difficult to remove; when the platelets in the lower layer in the first syringe are sucked through the hose, the plasma on the upper parts of the platelets after layering is easily sucked, platelet-rich plasma with sufficient concentration is difficult to obtain, and the using effect is not ideal.

Still there is a structure of drawing the separation instrument like chinese utility model patent: the extraction and separation tool for platelet-rich plasma (No. CN209464641U) comprises an outer needle cylinder and an inner needle cylinder which slides up and down in the outer needle cylinder, wherein the top of the outer needle cylinder is provided with a plug, the top end of the inner needle cylinder is provided with a through hole, the periphery of the top of the inner needle cylinder is sleeved with an inner cylinder piston, the inner cylinder piston is used as a sealing element and is in airtight contact with the inner wall of the outer needle cylinder, the inner cylinder piston slides up and down on the inner wall of the outer needle cylinder along with the inner needle cylinder, the inner needle cylinder is internally provided with an injector assembly, the injector assembly comprises an injection sleeve and a push rod which moves up and down in the injection sleeve, the periphery of the top of the push rod is sleeved with a push rod piston, the push rod piston is used as a sealing element and is in airtight contact with the inner wall of the injection sleeve, and a needle hole of the outer needle cylinder, the through hole and a needle hole of the injection sleeve form a fluid communication channel together; however, in the structure, the inner needle cylinder is connected with the outer needle cylinder, the injector assembly is arranged in the inner needle cylinder, when the blood drawing operation is carried out, the injection sleeve needs to be pulled so as to drive the inner needle cylinder to move, a certain pressure difference exists between the inner needle cylinder and the outer needle cylinder, and the threaded connection or the buckle connection between the injection sleeve and the inner needle cylinder is easily damaged when the injection sleeve and the outer needle cylinder are pulled upwards; in addition, when the injection sleeve is taken down from the inner needle cylinder, the inner needle cylinder is arranged inside the injection needle cylinder, so that the treatment is difficult in case of being blocked; the embedded structure of the inner needle cylinder makes the whole extraction and separation tool more difficult to produce, maintain, replace and the like.

Therefore, further improvement of the tool for extraction and separation of PRP is required.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a PRP draws separation cylinder and contains the separation suit that draws of this cylinder, can provide one kind and use convenient, draw effectual PRP and draw the instrument.

In order to achieve the above object, one aspect of the present invention is to provide a PRP extraction separation syringe, which comprises a main syringe, a sub-syringe and an injector syringe;

the main needle cylinder is of a hollow cylindrical structure, one end of the main needle cylinder is provided with a main needle cylinder interface, a capillary tube is arranged inside the main needle cylinder interface and communicated with the inside of the main needle cylinder, and an internal thread is arranged inside the main needle cylinder interface; a matched plugging part is arranged outside the main needle cylinder interface, and a main needle cylinder side wing is arranged at the upper part of the main needle cylinder;

the secondary needle cylinder is arranged in the main needle cylinder and is of a hollow cylindrical structure, the outer diameter of the secondary needle cylinder is smaller than the inner diameter of the main needle cylinder, the length of the secondary needle cylinder is larger than that of the main needle cylinder, a fixing part is arranged on the part, close to the interface of the main needle cylinder, of the lower part of the secondary needle cylinder, the fixing part protrudes towards the interior of the secondary needle cylinder, and external threads are arranged on the outer side of the fixing part; the upper part of the secondary needle cylinder is provided with a secondary needle cylinder side wing, and the outer side of the cylinder body of the secondary needle cylinder is provided with a sealing ring;

the syringe needle cylinder is arranged inside the secondary needle cylinder, has a hollow cylindrical structure, and has an outer diameter smaller than the inner diameter of the secondary needle cylinder and a length larger than the length of the secondary needle cylinder; the lower part of the syringe needle cylinder is provided with a clamping part which is detachably connected with the fixed part; the upper part of the syringe is provided with a syringe flank;

a push rod is arranged in the syringe needle cylinder and comprises a piston, a push rod shaft and a boosting head, the outer diameter of the piston is matched with the inner diameter of the syringe needle cylinder, the push rod shaft is a long and thin cylinder and is arranged at the center of the piston, and the length of the push rod shaft is greater than that of the syringe needle cylinder; the boosting head is arranged at the end part of the push rod shaft.

Furthermore, the structure and the size of the main needle cylinder interface are the same as those of the clamping part.

Furthermore, an external thread matched with the interface of the main syringe is arranged in the plugging part.

Furthermore, a convex part is arranged in the plugging part and extends into the capillary of the interface of the main syringe.

Furthermore, the plugging part is made of elastic materials and is sleeved outside the main syringe interface.

Furthermore, the clamping part and the fixing part are connected through threads or clamped.

Furthermore, the tail end of the syringe needle cylinder is provided with a detachable mistake-proofing pull end cover.

Another aspect of the utility model provides a PRP extraction and separation suit, including above PRP extraction and separation cylinder, still include with the collection device of connection can be dismantled to the syringe cylinder, the collection device bottom is equipped with the bleeder vent.

Further, collection device is the cylindrical bottle column structure of both ends open-ended, wherein bottleneck end be provided with joint portion outside connection structure assorted external screw thread, bottle bottom end is fixed with waterproof ventilated membrane, the waterproof ventilated membrane outside is fixed with the foraminiferous end cover of detachable.

Furthermore, the collecting device is a conical flask with a hole at the bottom, and an external thread matched with the connecting structure outside the clamping part is arranged at the bottle mouth end.

The utility model relates to a PRP draws separation cylinder and contains the draw separation suit of this cylinder and compare with prior art and have following advantage:

(1) the operation is convenient, the PRP extraction and separation effect is good, the concentration of the prepared PRP is high, the environment for transferring the PRP in the needle cylinder is relatively closed, and the risk of external pollution is reduced;

(2) the production and the manufacture are convenient, the connection among all parts is tight, the drawing and the pushing are convenient, the detachable structure between the syringe needle cylinder and the secondary needle cylinder is flexible, and the maintenance is convenient.

Drawings

Fig. 1 is a front view of a PRP extraction separation cartridge of the present invention;

FIG. 2 is a top view of a PRP extraction separation cartridge of the present invention;

FIG. 3 is a sectional view of the PRP extraction separation cylinder of the present invention along the A-A direction;

FIG. 4 is a schematic view of the usage status of the PRP extracting, separating, assembling and collecting device of the present invention;

fig. 5 is a sectional view of the use state of the PRP extraction separation set collecting device of the present invention.

Detailed Description

The present invention will be further described with reference to the accompanying drawings and specific embodiments.

Example 1

As shown in fig. 1-3, the PRP extraction and separation syringe of the present invention comprises a main syringe 1, a sub-syringe 2 and an injector syringe 3;

the main needle cylinder 1 is of a hollow cylindrical structure, one end of the main needle cylinder is provided with a main needle cylinder interface 11, a capillary tube 12 is arranged inside the main needle cylinder interface 11 and communicated with the inside of the main needle cylinder 1, and connecting parts such as internal threads and the like are arranged in the main needle cylinder interface 11 and used for connecting parts such as external needles and the like; the main syringe interface 11 is provided with a matched plugging part 4, generally, the plugging part 4 can be made of hard material, the inside of the plugging part is provided with an external thread matched with the internal thread of the main syringe interface for connection, and the plugging part can also be made of elastic material and is sleeved outside the main syringe interface in an interference fit manner; the outer diameter of the blocking part 4 is preferably the same as that of the main needle cylinder 1; the upper part of the main needle cylinder 1 is provided with a main needle cylinder side wing 13 which can be held in an auxiliary way when blood is extracted;

the secondary needle cylinder 2 is arranged inside the main needle cylinder 1 and is also of a hollow cylindrical structure, the outer diameter of the secondary needle cylinder is smaller than the inner diameter of the main needle cylinder 1, the length of the secondary needle cylinder is larger than that of the main needle cylinder 1, a fixing part 21 is arranged on the part, close to the interface of the main needle cylinder 1, of the lower part of the secondary needle cylinder 2, the fixing part 21 protrudes towards the inside of the secondary needle cylinder 2, and the outer side of the fixing part is provided with external threads; the upper part of the secondary needle cylinder 2 is provided with secondary needle cylinder side wings 22 on which fingers can be fixed, so that the secondary needle cylinder 2 can be conveniently pushed and pulled; the outer side of the cylinder body of the secondary needle cylinder 2 is provided with a sealing ring 23, when the secondary needle cylinder 2 moves up and down in the main needle cylinder 1, the sealing ring 23 can play a role in sealing and blocking, and blood plasma and the like in the main needle cylinder 1 are prevented from leaking to the outer part of the cylinder body of the secondary needle cylinder 2;

the syringe needle cylinder 3 is arranged inside the secondary needle cylinder 2, has a hollow cylindrical structure, the outer diameter of the syringe needle cylinder is smaller than the inner diameter of the secondary needle cylinder 2, and the length of the syringe needle cylinder is larger than that of the secondary needle cylinder 2; the lower part of the syringe needle cylinder 3 is provided with a clamping part 31, the clamping part 31 is detachably connected with the fixing part 21, the structure of the clamping part 31 is similar to that of the main syringe interface 11, a secondary capillary tube for communicating the secondary needle cylinder 2 with the syringe needle cylinder 3 is arranged in the clamping part 31, and the clamping part 31 is internally provided with a connecting structure such as internal threads matched with the fixing part 21; when the blood plasma is extracted from the human body, the syringe needle cylinder 3 and the secondary needle cylinder 2 are fixed together without generating relative displacement; the upper part of the syringe cylinder 3 is provided with a syringe cylinder side wing 32 which is also convenient for push-pull operation;

a push rod 5 is arranged in the syringe needle cylinder 3, the push rod 5 comprises a piston 51, a push rod shaft 52 and a boosting head 53, the outer diameter of the piston 51 is matched with the inner diameter of the syringe needle cylinder 3, soft materials are generally adopted, interference fit is adopted, sufficient pressure is ensured to be generated during pulling and pushing, the push rod shaft 52 can be a slender cylinder and is arranged at the center of the piston 51, and the length of the push rod shaft is greater than that of the syringe needle cylinder 3; the boosting head 53 is generally in a disc shape, is arranged at the end part of the push rod shaft 52 and is convenient for fingers to apply pressure when injection is performed;

the structure and the size of the main syringe interface 11 and the clamping part 31 can be the same, and the main syringe interface and the clamping part are provided with internal threads with the same size, and the structure and the size of the capillary are the same.

The blood sampling or injection can adopt a conventional needle head, the blood sampling needle head is arranged at the outer side of the interface of the main syringe, and the injection needle head is arranged on the clamping part 31 of the syringe of the injector.

More preferably, the PRP extraction and separation cartridge has a structure similar to that described above, and a boss 41 or a protruding part such as a rubber pad is further provided at a position corresponding to the capillary 12 in the center of the stopper 4, and the protruding part protrudes into the capillary 12 to seal the capillary 12, thereby preventing leakage of blood plasma and the like during centrifugation.

The tail end of the syringe needle cylinder 3 is also provided with an anti-error pull end cover 7, and when plasma is extracted, the syringe needle side wing 32 on the syringe needle cylinder 3 and the boosting head 53 can be fixed together due to the fact that the number of the syringe needles is large and the anti-error pull end cover 7 is arranged for preventing error pulling; the mistake proofing end cover 7 is detachable.

Example 2

As shown in fig. 4 and 5, a PRP extraction and separation kit, including the PRP extraction and separation cylinder of embodiment 1, still include collection device 6, collection device 6 one end opening, the opening part is equipped with 31 outside connection structure assorted external screw threads of joint portion etc., collection device 6 preferably adopts the bottle column structure, for example can adopt the cylindrical bottle column structure of both ends open-ended, wherein the bottleneck end is provided with 31 outside connection structure assorted external screw threads of joint portion, the bottle bottom has TPU or the waterproof ventilated membrane of PUW through ultrasonic bonding, the waterproof ventilated membrane outside is fixed with the foraminiferous end cover of detachable.

The collecting device 6 can also be a conical bottle, the bottom of the bottle is provided with a vent hole 61 to keep the air pressure inside and outside the bottle body consistent, and the liquid and the like in the collecting device 6 can be smoothly injected or pumped out.

The utility model relates to a PRP extraction separation cylinder and contain extraction separation suit of this cylinder when using, at first will prevent mistake and draw end cover 7 to screw up, take off shutoff portion 4, install the blood sampling syringe needle on main cylinder interface 11, hold main cylinder 1, draw secondary cylinder 2 backward, secondary cylinder 2 moves upward together with syringe cylinder 3 in it, with blood suction to main cylinder 1; taking down the blood sampling needle, installing the plugging part 4 on the interface of the main needle cylinder, wherein the plugging part 4 is positioned below, centrifuging the main needle cylinder 1, layering red blood cells and low-concentration PRP after the centrifugation is finished, and the red blood cell layer is close to the plugging part 4 and positioned below the low-concentration PRP; pulling the push rod 5 of the syringe needle cylinder 3 backwards, pumping the low-concentration PRP into the syringe needle cylinder 3, unscrewing the clamping part 31 at the lower part of the syringe needle cylinder 3, and detaching the syringe needle cylinder 3 from the secondary needle cylinder 2;

if the extracted low-concentration PRP concentration meets the use requirement, the clamping part 31 of the syringe cylinder 3 is provided with the syringe needle for use;

if the PRP concentration does not meet the use requirement, the syringe 3 with the low-concentration PRP can be further centrifuged to obtain the PRP meeting the requirement for use;

in the case of embodiment 2, the syringe barrel 3 with the low-concentration PRP extracted can be taken down, the collecting device 6 is fixed on the clamping portion 31 below the syringe barrel 3, the low-concentration PRP in the syringe barrel 3 is pushed into the collecting device 6, then the anti-mistake pulling end cover 7 is reset and fixed, the syringe barrel side wing 32 and the pushing-assisting head 53 are fixed, so that the piston 51 is fixed at the position of the syringe barrel 3 close to the collecting device 6, and the low-concentration PRP in the collecting device 6 is sealed;

6 bottom centrifugation once more up of collection device, the Platelet layer gathering is at the opening part that is close to collection device 6 after the centrifugation, and the upper strata is PPP (Platelet Poor Plasma), and in all taking out the syringe cylinder 3 with the Platelet layer, can take off collection device 6 after drawing sufficient PPP again, obtain the PRP of suitable concentration after with Platelet and PPP mixing in syringe cylinder 3, it can to inject to load on the syringe needle.

In the description of the present specification, it is to be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc., indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience of describing the technical solutions of the present patent and for simplification of the description, but do not indicate or imply that the referred devices or elements must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be interpreted as limiting the present patent application.

Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of this patent application, "plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.

In this specification, unless expressly stated or limited otherwise, the terms "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integral to one another; can be mechanically or electrically connected; they may be directly connected or indirectly connected through intervening media, or they may be connected internally or in any other suitable relationship, unless expressly stated otherwise. The specific meanings of the above terms in the present specification can be understood by those of ordinary skill in the art as appropriate.

In this specification, unless explicitly stated or limited otherwise, a first feature may be "on" or "under" a second feature such that the first and second features are in direct contact, or the first and second features are in indirect contact via an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.

Although embodiments of the present invention have been shown and described, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art without departing from the scope of the present invention.

Claims

1. A PRP extraction and separation needle cylinder is characterized by comprising a main needle cylinder, a secondary needle cylinder and an injector needle cylinder;

2. The PRP extraction separation syringe of claim 1, wherein the primary syringe interface is the same in configuration and size as the snap-fit portion.

3. A PRP extraction separation cartridge as claimed in claim 1, wherein said blocking portion is internally provided with an external thread matching said primary cartridge interface.

4. A PRP extraction separation cartridge according to claim 3, wherein said blocking portion is provided with a protrusion therein, said protrusion extending into a capillary of said primary cartridge port.

5. The PRP extraction separation syringe of claim 1, wherein the stopper is made of an elastic material and is fitted to the outside of the main syringe port.

6. The PRP extraction separation syringe of claim 1, wherein the engaging portion is engaged with the fixing portion by a screw or a snap.

7. The PRP extraction separation cartridge of claim 1, wherein the distal end of said syringe cartridge is provided with a removable error-proof cap.

8. A PRP extraction and separation kit comprising the PRP extraction and separation cartridge of any one of claims 1-7, further comprising a collection device removably connected to the syringe cartridge, wherein the bottom of the collection device is provided with air vents.

9. The PRP extraction and separation kit of claim 8, wherein the collection device is a cylindrical bottle-shaped structure with two open ends, wherein the bottle mouth end is provided with an external thread matching with the external connection structure of the clamping portion, a waterproof breathable membrane is fixed at the bottom end of the bottle, and a detachable end cap with holes is fixed at the outer side of the waterproof breathable membrane.

10. The PRP extraction and separation kit according to claim 8, wherein the collection device is a conical flask with an opening at the bottom, and the mouth end of the flask is provided with an external thread matching with the connecting structure outside the clamping portion.