CN214071420U - Freezing tube for stem cell transfer - Google Patents
Freezing tube for stem cell transfer Download PDFInfo
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- CN214071420U CN214071420U CN202023196791.XU CN202023196791U CN214071420U CN 214071420 U CN214071420 U CN 214071420U CN 202023196791 U CN202023196791 U CN 202023196791U CN 214071420 U CN214071420 U CN 214071420U
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Abstract
The utility model discloses a stem cell shifts uses cryovial, include base, freezing body, fixed knot structure, drive structure, seal structure, first sealing plug, press board, fixed box, piston, spring, intake pipe, gasbag, check valve and exhaust structure. The utility model has the advantages that: through there being fixed knot to construct at base internal connection, it is connected with the drive structure to rotate in base inside, be equipped with seal structure at freezing body top, make freezing body can be fixed by drive structure driven fixed knot structure in the transfer process, make freezing body be difficult to take place to empty, drive piston extrusion spring through pressing down the pressing plate and slide in fixed box inner wall, make gaseous pass through the intake pipe earlier inside the check valve is impressed the gasbag through again, the realization is to aerifing of gasbag, the first sealing plug of expanded gasbag extrusion and freezing body, the leakproofness of freezing body has been strengthened, thereby can prevent effectively that outside impurity from getting into inside the freezing body and causing the pollution to the stem cell.
Description
Technical Field
The utility model relates to a cryovial specifically is a cryovial is used in stem cell transfer belongs to stem cell transfer technical field.
Background
The stem cell is a pluripotent cell with self-renewal ability, can be differentiated into a plurality of APSC pluripotent cells under certain conditions, is a primitive cell with self-replication and multidirectional differentiation potential, namely the stem cell maintains the unoriented differentiation state and has the proliferation ability, can be differentiated into a plurality of functional cells or tissues and organs under proper conditions or given proper signals, the stem cell is derived from embryo, fetal tissue and adult tissue, the embryonic stem cell from the embryo and fetal tissue has the pluripotent differentiation property, can be differentiated into almost more than 200 mature cell types in a mature individual, and adult stem cells from the tissues of the adult individual comprise hematopoietic stem cells, neural stem cells, pancreatic stem cells and the like, and can be separated and cultured from different human tissues, then be detected and identified, and then be frozen at the deep low temperature of-196 ℃, so that the stem cells can be revived to be used for reinfusion to a patient when in clinical need, and the purpose of treating diseases is achieved.
The freezing pipe is needed for transferring and storing stem cells, however, the traditional freezing pipe has single function, and the stem cells are easy to topple over during transferring and the stem cells extracted from the freezing pipe are easy to be polluted by the external environment due to no good fixing performance and sealing performance, so that the medical value of the stem cells is reduced.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a cryovial is used in stem cell transfer in order to solve above-mentioned problem, both possessed good fixity ability, also improved the sealing performance of cryovial.
The utility model realizes the above purpose by the following technical proposal, a cryovial for stem cell transfer, which comprises a base and a cryovial body, wherein the top of the cryovial body is connected with a sealing structure, the sealing structure comprises a first sealing plug, a pressing plate, a fixing box, a piston, a spring, an air inlet pipe, an air bag and a one-way valve, the top of the cryovial body is in threaded connection with the first sealing plug, the inner wall of the first sealing plug is fixedly connected with the fixing box, the piston is in sliding connection with the inner wall of the fixing box, the interior of the piston is fixedly connected with one end of the pressing plate, the pressing plate penetrates through and is in sliding connection with the inner wall of the fixing box, the inner wall of the fixing box is fixedly connected with one end of the spring, the other end of the spring is fixedly connected with the piston, the inner wall of the fixing box is fixedly connected with two air inlet pipes, the air bag is fixedly connected to the inner wall of the first sealing plug, the one-way valve is fixedly mounted inside the air bag, the air inlet pipe is communicated with the one-way valve, the base is connected with a fixing structure, the base is rotatably connected with a driving structure inside, and the first sealing plug is connected with an exhaust structure.
Preferably, in order to facilitate the driving the fixing structure, the driving structure comprises a knob and a rotating shaft, the knob is rotatably connected to the outer wall of the base, one end of the rotating shaft is rotatably connected to the inner wall of the base, and the other end of the rotating shaft penetrates through the inner wall of the base and is fixedly connected to the inside of the knob.
Preferably, in order to change the transmission direction of the force, the driving structure further includes a first bevel gear, a second bevel gear and a screw rod, the side wall of the rotating shaft is fixedly connected with the first bevel gear, the first bevel gear is meshed with the second bevel gear, the second bevel gear is fixedly connected to one end of the screw rod, the other end of the screw rod is rotatably connected to the inner wall of the base, and the rotation directions of the threads at the two ends of the screw rod are opposite.
Preferably, have good fixed effect in order to guarantee fixed knot to construct, fixed knot constructs including splint, rubber pad and fixed disk, the lateral wall threaded connection of lead screw has two splint, splint sliding connection in the inner wall of base, the lateral wall fixedly connected with of splint the rubber pad, fixed disk fixed connection in the inner wall of base.
Preferably, in order to facilitate the discharge of the gas in the airbag, the exhaust structure includes an exhaust pipe and a second sealing plug, the exhaust pipe is fixedly connected to the inner wall of the first sealing plug and communicated with the airbag, and the second sealing plug is in threaded connection with one end of the exhaust pipe, which is away from the airbag.
Preferably, in order to facilitate the rotation of the knob and the fixation of the freezing pipe body, the cross section of the knob is of a convex structure, and the cross section of the rubber pad is of an arc structure.
The utility model has the advantages that: through there being fixed knot to construct at base internal connection, it is connected with the drive structure to rotate in base inside, be equipped with seal structure at freezing body top, make freezing body can be fixed by drive structure driven fixed knot structure in the transfer process, make freezing body be difficult to take place to empty, drive piston extrusion spring through pressing down the board and slide in fixed box inner wall, make gaseous pass through the intake pipe earlier inside the check valve is impressed the gasbag through the process, the realization is to aerifing of gasbag, the piston resets under the effect of spring, can realize pressing once more, the first sealing plug of expanded gasbag extrusion and freezing body, the leakproofness of freezing body has been strengthened, thereby can prevent effectively that outside impurity from getting into inside the freezing body and causing the pollution to the stem cell.
Drawings
Fig. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the connection structure of the freezing tube body and the sealing structure shown in FIG. 1;
FIG. 3 is a schematic view of a connection structure between the driving structure and the fixing structure shown in FIG. 1;
fig. 4 is an enlarged view of the portion a shown in fig. 2.
In the figure: 1. the refrigerator comprises a base, 2, a refrigerating pipe body, 3, a fixing structure, 31, a clamping plate, 32, a rubber pad, 33, a fixed disc, 4, a driving structure, 41, a knob, 42, a rotating shaft, 43, a first bevel gear, 44, a second bevel gear, 45, a screw rod, 5, a sealing structure, 51, a first sealing plug, 52, a pressing plate, 53, a fixing box, 54, a piston, 55, a spring, 56, an air inlet pipe, 57, an air bag, 58, a one-way valve, 6, an exhaust structure, 61, an exhaust pipe, 62 and a second sealing plug.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1-4, a freezing tube for stem cell transfer includes a base 1 and a freezing tube body 2, the top of the freezing tube body 2 is connected with a sealing structure 5, the sealing structure 5 includes a first sealing plug 51, a pressing plate 52, a fixing box 53, a piston 54, a spring 55, an air inlet tube 56, an air bag 57 and a one-way valve 58, the top of the freezing tube body 2 is connected with the first sealing plug 51 by screw threads, the inner wall of the first sealing plug 51 is fixedly connected with the fixing box 53, the piston 54 is slidably connected with the inner wall of the fixing box 53, one end of the pressing plate 52 is fixedly connected inside the piston 54, the pressing plate 52 penetrates and is slidably connected with the inner wall of the fixing box 53, one end of the spring 55 is fixedly connected to the inner wall of the fixing box 53, the other end of the spring 55 is fixedly connected to the piston 54, the inner wall of the fixing box 53 is fixedly connected with two air inlet tubes 56, the air bag 57 is fixedly connected to the inner wall of the first sealing plug 51, the one-way valve 58 is fixedly installed inside the air bag 57, the air inlet pipe 56 is communicated with the one-way valve 58, the base 1 is connected with the fixing structure 3, the base 1 is rotatably connected with the driving structure 4, and the first sealing plug 51 is connected with the exhaust structure 6.
As a technical optimization scheme of the utility model, drive structure 4 includes knob 41 and pivot 42, knob 41 rotate connect in the outer wall of base 1, the one end of pivot 42 rotate connect in the inner wall of base 1, just the other end of pivot 42 runs through inner wall and the fixed connection of base 1 in inside knob 41.
As a technical optimization scheme of the utility model, drive structure 4 still includes first bevel gear 43, second bevel gear 44 and lead screw 45, the lateral wall fixedly connected with of pivot 42 first bevel gear 43, first bevel gear 43 mesh in second bevel gear 44, second bevel gear 44 fixed connection in the one end of lead screw 45, the other end of lead screw 45 rotate connect in the inner wall of base 1, just the screw rotation opposite direction at lead screw 45 both ends.
As a technical optimization scheme of the utility model, fixed knot constructs 3 including splint 31, rubber pad 32 and fixed disk 33, the lateral wall threaded connection of lead screw 45 has two splint 31, splint 31 sliding connection in the inner wall of base 1, splint 31's lateral wall fixedly connected with rubber pad 32, fixed disk 33 fixed connection in the inner wall of base 1.
As a technical optimization scheme of the utility model, exhaust structure 6 includes blast pipe 61 and second sealing plug 62, blast pipe 61 fixed connection in the inner wall of first sealing plug 51 and communicate in gasbag 57, second sealing plug 62 threaded connection in blast pipe 61 deviates from gasbag 57's one end.
As a technical optimization scheme of the utility model, the cross-section of knob 41 is "protruding" shape structure, the cross-section of rubber pad 32 is the arc structure.
When the utility model is used, the freezing tube body 2 is placed on the fixed disk 33 and the knob 41 is rotated by fingers, thereby driving the rotating shaft 42 fixedly connected with the knob 41 to rotate on the inner wall of the base 1, because the first bevel gear 43 is fixedly connected with the side wall of the rotating shaft 42 and the second bevel gear 44 is fixedly connected with the side wall of the screw rod 45, the rotation of the rotating shaft 42 drives the first bevel gear 43 to be meshed with the second bevel gear 44, thereby further driving the screw rod 45 to rotate on the inner wall of the base 1, the thread directions at the two ends of the screw rod 45 are opposite, so the two clamping plates 31 are close to each other when the screw rod 45 rotates, thereby two rubber pads 32 fixedly connected with the side walls of the two clamping plates 31 extrude the freezing tube body 2, thereby realizing the clamping and fixing of the freezing tube body 2, which is not easy to topple, because the first sealing plug 51 is connected with the top end of the freezing tube body 2 by pressing the pressing plate 52, thereby the piston 54 that the extrusion is fixed with it slides in the inner wall of fixed box 53 and extrudes spring 55, thereby gas is discharged into intake pipe 56 and passes through check valve 58 and gets into the inside of gasbag 57 through intake pipe 56, under the spring action of spring 55, realize the reset of piston 54, make according to board 52 can be pressed repeatedly until the inside gas of gasbag 57 fills up gasbag 57, gasbag 57 extrudees first sealing plug 51 and freezing body 2 this moment, thereby the leakproofness of freezing body 2 has been strengthened, when needs take the stem cell, through rotatory second sealing plug 62 thereby communicate blast pipe and external environment, thereby release gasbag 57 inside gas.
It is obvious to a person skilled in the art that the invention is not restricted to details of the above-described exemplary embodiments, but that it can be implemented in other specific forms without departing from the spirit or essential characteristics of the invention. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (6)
1. The utility model provides a stem cell shifts uses cryovial, includes base (1) and freezing body (2), its characterized in that: the top of the freezing pipe body (2) is connected with a sealing structure (5), the sealing structure (5) comprises a first sealing plug (51), a pressing plate (52), a fixing box (53), a piston (54), a spring (55), an air inlet pipe (56), an air bag (57) and a one-way valve (58), the top of the freezing pipe body (2) is in threaded connection with the first sealing plug (51), the inner wall of the first sealing plug (51) is fixedly connected with the fixing box (53), the piston (54) is in sliding connection with the inner wall of the fixing box (53), one end of the pressing plate (52) is fixedly connected inside the piston (54), the pressing plate (52) penetrates through and is in sliding connection with the inner wall of the fixing box (53), the inner wall of the fixing box (53) is fixedly connected with one end of the spring (55), and the other end of the spring (55) is fixedly connected with the piston (54), the inner wall fixedly connected with of fixed box (53) is two intake pipe (56), gasbag (57) fixed connection in the inner wall of first sealing plug (51), check valve (58) fixed mounting in the inside of gasbag (57), intake pipe (56) communicate in check valve (58), base (1) is connected with fixed knot constructs (3), base (1) internal rotation is connected with drive structure (4), first sealing plug (51) are connected with exhaust structure (6).
2. The cryostraw for stem cell transfer according to claim 1, wherein: drive structure (4) include knob (41) and pivot (42), knob (41) rotate connect in the outer wall of base (1), the one end of pivot (42) rotate connect in the inner wall of base (1), just the other end of pivot (42) runs through the inner wall and the fixed connection of base (1) are in inside knob (41).
3. The cryostraw for stem cell transfer according to claim 2, wherein: the driving structure (4) further comprises a first bevel gear (43), a second bevel gear (44) and a screw rod (45), the side wall of the rotating shaft (42) is fixedly connected with the first bevel gear (43), the first bevel gear (43) is meshed with the second bevel gear (44), the second bevel gear (44) is fixedly connected to one end of the screw rod (45), the other end of the screw rod (45) is rotatably connected to the inner wall of the base (1), and the rotating directions of threads at two ends of the screw rod (45) are opposite.
4. The cryostraw for stem cell transfer according to claim 3, wherein: fixed knot constructs (3) including splint (31), rubber pad (32) and fixed disk (33), the lateral wall threaded connection of lead screw (45) has two splint (31), splint (31) sliding connection in the inner wall of base (1), the lateral wall fixedly connected with of splint (31) rubber pad (32), fixed disk (33) fixed connection in the inner wall of base (1).
5. The cryostraw for stem cell transfer according to claim 1, wherein: the exhaust structure (6) comprises an exhaust pipe (61) and a second sealing plug (62), the exhaust pipe (61) is fixedly connected to the inner wall of the first sealing plug (51) and communicated with the air bag (57), and the second sealing plug (62) is in threaded connection with one end, deviating from the air bag (57), of the exhaust pipe (61).
6. The cryostraw for stem cell transfer according to claim 4, wherein: the section of the knob (41) is of a convex structure, and the section of the rubber pad (32) is of an arc structure.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023196791.XU CN214071420U (en) | 2020-12-25 | 2020-12-25 | Freezing tube for stem cell transfer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202023196791.XU CN214071420U (en) | 2020-12-25 | 2020-12-25 | Freezing tube for stem cell transfer |
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| Publication Number | Publication Date |
|---|---|
| CN214071420U true CN214071420U (en) | 2021-08-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202023196791.XU Active CN214071420U (en) | 2020-12-25 | 2020-12-25 | Freezing tube for stem cell transfer |
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| CN (1) | CN214071420U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114703137A (en) * | 2021-12-31 | 2022-07-05 | 浙江金时代生物技术有限公司 | Method for differentiating umbilical cord mesenchymal stem cells into neural stem cells by utilizing cryopreserved umbilical cord mesenchymal stem cells |
-
2020
- 2020-12-25 CN CN202023196791.XU patent/CN214071420U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114703137A (en) * | 2021-12-31 | 2022-07-05 | 浙江金时代生物技术有限公司 | Method for differentiating umbilical cord mesenchymal stem cells into neural stem cells by utilizing cryopreserved umbilical cord mesenchymal stem cells |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A freezing tube for stem cell transfer Effective date of registration: 20220713 Granted publication date: 20210831 Pledgee: Rizhao Donggang Rural Commercial Bank Co.,Ltd. Pledgor: Shandong Xinchao Biotechnology Co.,Ltd. Registration number: Y2022980010363 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230614 Granted publication date: 20210831 Pledgee: Rizhao Donggang Rural Commercial Bank Co.,Ltd. Pledgor: Shandong Xinchao Biotechnology Co.,Ltd. Registration number: Y2022980010363 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: A cryotube for stem cell transfer Effective date of registration: 20230615 Granted publication date: 20210831 Pledgee: Rizhao Donggang Rural Commercial Bank Co.,Ltd. Pledgor: Shandong Xinchao Biotechnology Co.,Ltd. Registration number: Y2023980044210 |