CN213951209U - Fermentation device is used in production of staurosporine - Google Patents
Fermentation device is used in production of staurosporine Download PDFInfo
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- CN213951209U CN213951209U CN202022652961.4U CN202022652961U CN213951209U CN 213951209 U CN213951209 U CN 213951209U CN 202022652961 U CN202022652961 U CN 202022652961U CN 213951209 U CN213951209 U CN 213951209U
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Abstract
The utility model relates to a fermentation device for producing staurosporine, which comprises supporting legs, a base, a tank body, a sealing cover, a stirring device and a heating plate, wherein the base is arranged at the upper end of the supporting legs, the tank body is arranged on the base, and the heating plate is arranged in the base and is used for heating the tank body; the sealing cover is buckled and hermetically connected on the tank body, a feed pipe and a liquid inlet pipe are arranged on the side wall of the tank body, and a discharge pipe is arranged at the lower end of the tank body; the stirring device is arranged in the tank body and is used for stirring materials in the tank body; an annular pipe body is fixed at the upper end part of the inner side surface of the tank body, a plurality of water spraying ports are formed in the annular pipe body, the spraying directions of the water spraying ports are aligned to the inner side surface of the tank body, and the annular pipe body is connected with a high-pressure water source through a connecting pipe; the high-pressure water source sprays high-pressure water to the inner side surface of the tank body through the connecting pipe and the annular pipe body, and the high-pressure water flows away downwards along the inner side surface of the tank body to take away part of materials adhered to the inner surface of the fermentation tank; the inner surface of the fermentation tank after fermentation is cleaned.
Description
Technical Field
The utility model belongs to the technical field of microbial fermentation, concretely relates to fermenting installation is used in production of staurosporine.
Background
Staurosporine is a broad-spectrum non-specific protein kinase C inhibitor that potently inhibits protein kinase C and most other kinases including tyrosine protein kinases. Can be used for resisting various infectious diseases caused by yeast and fungi, inhibiting cell proliferation to induce apoptosis, abolishing cell cycle check point, and inhibiting angiogenesis. Staurosporine is mainly extracted from actinomycete fermentation liquor; wherein the fermentation tank is an important device for the fermentation of important actinomycetes.
The utility model discloses an authorization notice number is CN 207544282U's china utility model discloses an "organic ferment fermentation cylinder", this fermentation cylinder includes base, the fermentation tank body and sealed lid, be provided with the bracket on the base, be provided with the mounting groove on the bracket, mounting groove and bracket joint are passed through to the bottom of the fermentation tank body, the bracket corresponds the fermentation tank body and is provided with the hot plate to bottom contact setting through hot plate and the fermentation tank body, the side of the fermentation tank body is provided with driving motor, the inside output that corresponds driving motor of the fermentation tank body is connected with the stirring shaft, the bottom that corresponds the fermentation tank body on the stirring shaft is provided with the stirring blade, the top fixed connection of sealed lid and the fermentation tank body, sealed covering is provided with the pipe of excreting, it is provided with one-way pressure relief valve in the pipe to excrete. After the fermentation tank body completes fermentation, part of materials are adhered to the inner surface of the fermentation tank and cannot be cleaned in time.
SUMMERY OF THE UTILITY MODEL
In order to clean part of materials adhered to the inner surface of a fermentation tank in time after fermentation, the utility model provides a fermentation device for producing staurosporine; in order to achieve the above object, the utility model discloses a technical scheme specifically as follows:
a fermentation device for producing staurosporine comprises supporting legs, a base, a tank body, a sealing cover, a stirring device and a heating plate, wherein the base is arranged at the upper ends of the supporting legs, the tank body is arranged on the base, and the heating plate is arranged in the base and used for heating the tank body; the sealing cover is buckled and hermetically connected to the tank body, a feeding pipe and a liquid inlet pipe are arranged on the side wall of the tank body, and a discharging pipe is arranged at the lower end of the tank body; the stirring device is arranged in the tank body and is used for stirring materials in the tank body; the upper end part of the inner side surface of the tank body is fixed with an annular pipe body, the annular pipe body is provided with a plurality of water spraying ports, the spraying directions of the water spraying ports are aligned to the inner side surface of the tank body, and the annular pipe body is connected with a high-pressure water source through a connecting pipe.
The utility model discloses a fermentation device for staurosporine production's beneficial effect: materials and liquid enter the tank body through the feed pipe and the liquid inlet pipe respectively, and the tank body is maintained within a certain temperature range under the action of the heating plate, so that the fermentation of the materials in the tank body is completed; discharging from a discharging pipe after fermentation is completed; the high-pressure water source sprays high-pressure water to the inner side surface of the tank body through the connecting pipe and the annular pipe body, and flows away downwards along the inner side surface of the tank body under the action of the weight of the water, so that partial materials adhered to the inner surface of the fermentation tank are taken away; thereby realizing timely cleaning of partial materials adhered to the inner surface of the fermentation tank after fermentation.
Further, the base is close to one side of the jar body is provided with the cavity, the hot plate sets up in the base, fill in the cavity and carry hot water, the hot plate through carrying hot water to jar body heating.
Has the advantages that: through set up the cavity of filling with heat transfer water near the jar body at the base, the hot plate heats heat transfer water, and heat transfer water convection is favorable to the even heating to the jar body.
Further, the outer surfaces of the tank body and the sealing cover are provided with heat insulation layers, the heat insulation layers are specifically foam layers, and the outer surfaces of the foam layers are provided with protective layers.
Has the advantages that: the heat dissipation in the tank body is reduced by arranging the heat-insulating layer, so that the temperature in the tank body is kept constant within a certain range; the energy consumption is reduced.
Further, the stirring device comprises a motor, a stirring shaft and stirring blades, the motor is arranged on one side of the tank body, the stirring shaft horizontally rotates in the tank body, and one end of the stirring shaft is fixedly butted with an output shaft of the motor; one end of the stirring blade is fixed on the circumferential side surface of the stirring shaft.
Has the advantages that: the stirring device is set into the motor, the stirring shaft and the stirring blades, and the stirring shaft is horizontally arranged, so that the stirring device has a simple structure and is beneficial to fully stirring materials.
Further, the fermentation device for producing staurosporine further comprises a processor and a temperature sensor, wherein the temperature sensor is arranged at the lower end part of the inner side surface of the tank body, the processor is arranged on the outer side surface of the tank body, and the temperature sensor, the heating plate and the motor are respectively in electric signal connection with the processor.
Has the advantages that: the temperature sensor detects the temperature of the materials in the tank body, generates an electric signal and transmits the electric signal to the processor, after the electric signal is analyzed and processed by the processor, when the temperature is too high, the processor sends an instruction to the motor, the motor is started, the materials are stirred, and the heat dissipation of the materials is enhanced; when the temperature is too low, the processor sends an instruction to the heating plate, the power of the heating plate is increased, and the heating of the tank body is enhanced.
Further, fermentation device is used in staurosporine production still includes level gauge and alarm, the level gauge sets up the adaptation position of the medial surface of the jar body, the alarm sets up on the lateral surface of the jar body, level gauge and alarm respectively with treater signal of telecommunication is connected.
Has the advantages that: when liquid is added into the tank body through the liquid inlet pipe, the liquid level meter is immersed in the liquid, generates an electric signal and transmits the electric signal to the processor, the processor sends an instruction to the alarm, the alarm sounds to finish the addition of the liquid, and the liquid is prevented from being added too little.
Further, the fermentation device for producing staurosporine also comprises an air pressure balance valve, and the air pressure balance valve is arranged on the sealing cover.
Has the advantages that: through setting up the atmospheric pressure balanced valve, make the internal atmospheric pressure of jar keep balance, prevent that the internal atmospheric pressure of jar is too high, be favorable to going on smoothly of fermentation process.
Drawings
FIG. 1 is a schematic perspective view of an embodiment of a fermentation apparatus for producing staurosporine according to the present invention;
FIG. 2 is a front view of FIG. 1;
FIG. 3 is a top view of FIG. 1;
FIG. 4 is a cross-sectional view taken at A-A of FIG. 3;
FIG. 5 is a schematic diagram of an embodiment of a fermentation apparatus for producing staurosporine according to the present invention.
Reference numbers in the figures: 1-supporting legs, 2-base, 3-tank body, 4-sealing cover, 5-stirring device, 51-motor, 52-stirring shaft, 53-stirring blade, 6-heating plate, 7-feeding pipe, 8-liquid inlet pipe, 9-discharging pipe, 10-annular pipe body, 11-water spray nozzle, 12-connecting pipe, 13-gas outlet pipe, 14-air pressure balance valve, 15-cavity chamber, 16-heat insulation layer, 17-iron sheet, 18-processor, 19-temperature sensor, 20-liquid level meter and 21-alarm.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments:
the specific structure of the embodiment of the fermentation device for producing staurosporine of the utility model is shown in figures 1-4, and comprises a supporting leg 1, a base 2, a tank body 3, a sealing cover 4, a stirring device 5 and a heating plate 6. The base 2 is arranged at the upper end of the supporting leg 1, the tank body 3 is arranged on the base 2, and the heating plate 6 is arranged in the base 2 and used for heating the tank body 3; the 4 lock sealing connections of sealed lid are provided with inlet pipe 7 and feed liquor pipe 8 on jar body 3's lateral wall on jar body 3, are provided with discharging pipe 9 on jar body 3's lower extreme. An annular pipe body 10 is fixed at the upper end part of the inner side surface of the tank body 3, and the annular pipe body 10 is fixed on the inner side surface of the tank body 3 through a connecting rod; the annular pipe body 10 is provided with a plurality of water spraying ports 11, the spraying directions of the water spraying ports 11 are aligned to the inner side surface of the tank body 3, and the annular pipe body 10 is connected with a high-pressure water source through a connecting pipe 12. In this embodiment, the fermentation device for producing staurosporine further comprises an air pressure balance valve 14, wherein the air pressure balance valve 14 is arranged on the sealing cover 4, specifically, the air outlet pipe 13 is arranged on the sealing cover 4, and the air pressure balance valve 14 is arranged on the air outlet pipe 13; by arranging the air pressure balance valve 14, the air pressure in the tank body 3 is kept balanced, the air pressure in the tank body 3 is prevented from being too high, and the fermentation process is favorably and smoothly carried out.
In the embodiment, a chamber 15 is arranged on one side of the base 2 close to the tank body 3, the heating plate 6 is arranged in the base 2, heat transfer water is filled in the chamber 15, and the heating plate 6 heats the tank body 3 through the heat transfer water; through setting up the cavity 15 of filling with heat transfer water near jar body 3 at base 2, heat transfer water heating, heat transfer water convection is favorable to the even heating to jar body 3 to heat 6 hot water convection. The outer surfaces of the tank body 3 and the sealing cover 4 are provided with an insulating layer 16, the insulating layer 16 is specifically a foam layer, and the outer surface of the foam layer is provided with a protective layer; the protective layer is specifically an iron sheet 17, is fixed on the outer surface of the foam layer through screws, and is provided with a heat insulation layer 16, so that the heat loss in the tank body 3 is reduced, and the temperature in the tank body 3 is kept constant within a certain range; the energy consumption is reduced. In other embodiments, the base is not provided with a chamber, the heating plate is tightly attached to the outer surface of the tank body, and the heating plate directly heats the tank body.
The stirring device 5 is arranged in the tank body 3 and is used for stirring materials in the tank body 3; in the embodiment, the stirring device 5 comprises a motor 51, a stirring shaft 52 and a stirring blade 53, wherein the motor 51 is arranged at one side of the tank body 3, the stirring shaft 52 horizontally rotates in the tank body 3, and one end of the stirring shaft is fixedly butted with an output shaft of the motor 51; one end of the stirring blade 53 is fixed on the circumferential side surface of the stirring shaft 52; the stirring device 5 is provided with the motor 51, the stirring shaft 52 and the stirring blades 53, and the stirring shaft 52 is horizontally arranged, so that the stirring device has a simple structure and is beneficial to fully stirring materials. In other embodiments, the stirring device comprises a motor, a stirring shaft and stirring blades, wherein the stirring shaft is vertically and rotatably assembled in the tank body instead of horizontally rotating.
In this embodiment, as shown in fig. 5, the fermentation device for producing staurosporine further comprises a processor 18, a temperature sensor 19, a liquid level meter 20 and an alarm 21, wherein the temperature sensor 19 is arranged at the lower end part of the inner side surface of the tank body 3, the processor 18 is arranged on the outer side surface of the tank body 3, the liquid level meter 20 is arranged at a matching position of the inner side surface of the tank body 3, the alarm 21 is arranged on the outer side surface of the tank body 3, and the temperature sensor 19, the heating plate 6, the motor 51, the liquid level meter 20 and the alarm 21 are respectively in electric signal connection with the processor 18. The temperature sensor 19 detects the temperature of the material in the tank 3, generates an electric signal and transmits the electric signal to the processor 18, after the electric signal is analyzed and processed by the processor 18, when the temperature is too high, the processor 18 sends an instruction to the motor 51, the motor 51 is started, the material is stirred, and the heat dissipation of the material is enhanced; when the temperature is too low, the processor 18 sends a command to the heating plate 6, the power of the heating plate 6 is increased, and the heating of the tank body 3 is enhanced. When liquid is added into the tank body 3 through the liquid inlet pipe 8, when the liquid submerges the liquid level meter 20, the liquid level meter 20 generates an electric signal and transmits the electric signal to the processor 18, the processor 18 sends an instruction to the alarm 21, the alarm 21 sounds, the liquid addition is completed, and the liquid addition is prevented from being too little. The processor 18 is specifically a programmable 51 single chip microcomputer, the type of the temperature sensor 19 is an RTD temperature sensor 19, the liquid level meter 20 is a common liquid level sensor, and the alarm 21 is specifically an alarm bell.
When the fermentation tank is used, materials and liquid enter the tank body 3 through the feeding pipe 7 and the liquid inlet pipe 8 respectively, the materials are uniformly mixed and maintained at a certain temperature and pressure under the combined action of the temperature sensor 19, the processor 18, the air pressure balance valve 14, the heating plate 6 and the stirring device 5, the materials are uniformly fermented, the fermented materials are discharged from the discharging pipe 9, a high-pressure water source sprays high-pressure water to the inner side surface of the tank body 3 through the connecting pipe 12 and the annular pipe body 10, and the high-pressure water flows away downwards along the inner side surface of the tank body 3 under the weight action of the water, so that part of the materials adhered to the inner surface of the fermentation tank are taken away; thereby realizing timely cleaning of partial materials adhered to the inner surface of the fermentation tank after fermentation.
In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood according to specific situations by those skilled in the art.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and replacements can be made without departing from the technical principle of the present invention, and these modifications and replacements should also be regarded as the protection scope of the present invention.
Claims (7)
1. A fermentation device for producing staurosporine comprises supporting legs, a base, a tank body, a sealing cover, a stirring device and a heating plate, wherein the base is arranged at the upper ends of the supporting legs, the tank body is arranged on the base, and the heating plate is arranged in the base and used for heating the tank body; the sealing cover is buckled and hermetically connected to the tank body, a feeding pipe and a liquid inlet pipe are arranged on the side wall of the tank body, and a discharging pipe is arranged at the lower end of the tank body; the stirring device is arranged in the tank body and is used for stirring materials in the tank body; the water tank is characterized in that an annular pipe body is fixed at the upper end of the inner side surface of the tank body, a plurality of water spraying ports are formed in the annular pipe body, the spraying directions of the water spraying ports are aligned to the inner side surface of the tank body, and the annular pipe body is connected with a high-pressure water source through a connecting pipe.
2. The fermentation device for producing staurosporine according to claim 1, wherein a chamber is provided at one side of the base adjacent to the tank, the heating plate is provided in the base, the chamber is filled with heat transfer water, and the heating plate heats the tank through the heat transfer water.
3. The fermentation device for producing staurosporine according to claim 2, wherein an insulating layer is arranged on the outer surfaces of the tank body and the sealing cover, the insulating layer is specifically a foam layer, and a protective layer is arranged on the outer surface of the foam layer.
4. The fermentation device for producing staurosporine according to claim 2 or 3, wherein the stirring device comprises a motor, a stirring shaft and a stirring blade, the motor is arranged at one side of the tank body, the stirring shaft horizontally rotates in the tank body, and one end of the stirring shaft is fixedly butted with an output shaft of the motor; one end of the stirring blade is fixed on the circumferential side surface of the stirring shaft.
5. The fermentation device for producing staurosporine according to claim 4, further comprising a processor and a temperature sensor, wherein the temperature sensor is arranged at the lower end of the inner side of the tank body, the processor is arranged on the outer side of the tank body, and the temperature sensor, the heating plate and the motor are respectively in electrical signal connection with the processor.
6. The fermentation device for producing staurosporine according to claim 5, further comprising a liquid level meter and an alarm, wherein the liquid level meter is arranged at a position adapted to the inner side surface of the tank body, the alarm is arranged on the outer side surface of the tank body, and the liquid level meter and the alarm are respectively in electrical signal connection with the processor.
7. The staurosporine-producing fermentation device of claim 1, further comprising a pneumatic pressure balancing valve disposed on the sealing cap.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022652961.4U CN213951209U (en) | 2020-11-17 | 2020-11-17 | Fermentation device is used in production of staurosporine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022652961.4U CN213951209U (en) | 2020-11-17 | 2020-11-17 | Fermentation device is used in production of staurosporine |
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| Publication Number | Publication Date |
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| CN213951209U true CN213951209U (en) | 2021-08-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202022652961.4U Active CN213951209U (en) | 2020-11-17 | 2020-11-17 | Fermentation device is used in production of staurosporine |
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| Country | Link |
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| CN (1) | CN213951209U (en) |
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- 2020-11-17 CN CN202022652961.4U patent/CN213951209U/en active Active
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