CN213943552U - High-speed centrifuge for preparing targeted chondrocyte exosomes - Google Patents
High-speed centrifuge for preparing targeted chondrocyte exosomes Download PDFInfo
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- CN213943552U CN213943552U CN202022883184.4U CN202022883184U CN213943552U CN 213943552 U CN213943552 U CN 213943552U CN 202022883184 U CN202022883184 U CN 202022883184U CN 213943552 U CN213943552 U CN 213943552U
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- speed centrifuge
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Abstract
The utility model discloses a relate to centrifuge technical field, specifically be a high-speed centrifuge for preparing targeted chondrocyte exosome, including the high-speed centrifuge casing, the high-speed centrifuge casing is the cylindric box structure of no upper surface. The middle centrifugal liner of the utility model is clamped on the clamping plate in the high-speed centrifuge shell through the clamping sleeve, and the upper end of the middle centrifugal liner is sealed by the rubber sealing cover compressed by the elastic spring, so that the middle centrifugal liner is convenient to disassemble and assemble and is convenient to clean, the original integral centrifuge structure is replaced, and the practicability is strong; the utility model discloses well centrifugal inner bag right side lower extreme is provided with the discharge pipe, is provided with manual valve on the discharge pipe, filters lower floor's centrifugation material when making things convenient for the discharge pipe to open, and the follow-up taking out of supernatant facilitates the use, and the structure sets up rationally.
Description
Technical Field
The utility model relates to a centrifuge technical field specifically is a high-speed centrifuge for preparing target chondrocyte exosome.
Background
In the process of preparing the targeted chondrocyte exosomes, a high-speed centrifugation method is needed to obtain exosomes, and a high-speed centrifuge is often used in the high-speed centrifugation method, but the following defects still exist in the actual use process of the high-speed centrifuge:
1. in the prior art, a high-degree centrifuge is not easy to clean after being used, exosomes are adhered to the inner wall of the high-degree centrifuge or other substances are not completely cleaned, so that the next use is influenced, and the preparation of exosomes is influenced;
2. in the prior art, the high-degree centrifuge is often inconvenient to disassemble and assemble in the using process, so that exosomes are difficult to put in and take out in the preparation process, and the use has a qualitative defect.
To this end, we propose a high-speed centrifuge for the preparation of targeted chondrocyte exosomes to well address the above drawbacks.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a high-speed centrifuge for preparing targeted chondrocyte exosome to solve the problem that provides in the above-mentioned background art.
In order to achieve the above object, the utility model provides a following technical scheme: a high-speed centrifuge for preparing targeted chondrocyte exosomes comprises a high-speed centrifuge shell, wherein the high-speed centrifuge shell is of a cylindrical box structure without an upper surface, a centrifugal inner container is arranged inside the high-speed centrifuge shell, a cutting sleeve is fixedly welded at the middle position of the bottom surface of the centrifugal inner container and is clamped on a clamping plate in a matching manner, the clamping plate is fixedly welded at the outer ring of the upper end of a motor rotating shaft, the lower end of the motor rotating shaft movably penetrates through the bottom surface of the high-speed centrifuge shell, a motor shell is installed at the bottom of the high-speed centrifuge shell through screws, a motor is fixedly welded at the middle position of the motor shell, the upper end of the motor is in transmission connection with the lower end of the motor rotating shaft, a power supply box is arranged on the left side of the motor, the power supply box is fixedly welded at the inner bottom surface of the motor shell, an upper sealing cover is sealed above the high-speed centrifuge shell, and a fixed ring groove is arranged on the bottom surface of the outer ring of the upper sealing cover, the magnetic ring is fixedly embedded in the fixed ring groove and is fixedly adsorbed on the upper surface of the shell of the high-speed centrifuge.
Preferably, the right lower end of the centrifugal inner container is communicated with the outside and is provided with a discharge pipe, and the discharge pipe is provided with a manual valve.
Preferably, the clamping groove is formed in the middle of the clamping sleeve, the clamping groove and the clamping plate are matched, the clamping plate is of a cross structure, four groups of mounting holes are distributed in the clamping sleeve in a circular array mode, the magnetic columns are fixedly embedded in the mounting holes, and the magnetic columns and the clamping plate are fixedly adsorbed.
Preferably, a rubber ring is arranged at a position where the motor rotating shaft movably penetrates through the high-speed centrifuge shell, and the rubber ring is fixedly arranged on the high-speed centrifuge shell in a circular ring shape.
Preferably, the lower surface intermediate position of going up the closing cap is provided with flexible groove, is provided with the rubber seal lid in the flexible groove, and the rubber seal lid matches the setting with the upper end opening part of centrifugal inner bag, and the fixed surface of rubber seal lid is equipped with multiunit elastic spring, and the fixed welding in upper end inner wall in flexible groove in multiunit elastic spring's upper end.
Preferably, the inside of high-speed centrifuge casing is provided with removes the wheel, it is equipped with the multiunit to remove the wheel, and the multiunit removes the wheel and is the outer lane department of circular array form activity laminating at centrifugal inner bag, removes the rotation axis connection that runs through from top to bottom activity on taking turns to and removes the tip of taking turns the bracing piece, the both ends of axis of rotation all are connected with stop nut through screw-thread fit, remove the wheel bracing piece and keep away from the fixed welding of one end of removing the wheel on the inner wall of high-speed centrifuge casing.
Compared with the prior art, the beneficial effects of the utility model are that:
1. the middle centrifugal liner of the utility model is clamped on the clamping plate in the high-speed centrifuge shell through the clamping sleeve, and the upper end of the middle centrifugal liner is sealed by the rubber sealing cover compressed by the elastic spring, so that the middle centrifugal liner is convenient to disassemble and assemble and is convenient to clean, the original integral centrifuge structure is replaced, and the practicability is strong;
2. the utility model discloses well centrifugal inner bag right side lower extreme is provided with the discharge pipe, is provided with manual valve on the discharge pipe, filters lower floor's centrifugation material when making things convenient for the discharge pipe to open, and the follow-up taking out of supernatant facilitates the use, and the structure sets up rationally.
Drawings
FIG. 1 is a schematic structural view of the present invention;
fig. 2 is the structure schematic diagram of the utility model when the card sleeve is connected with the card board.
In the figure: the high-speed centrifugal machine comprises a high-speed centrifugal machine shell 1, a centrifugal inner container 2, a motor shell 3, an upper sealing cover 4, a fixed ring groove 5, a magnetic ring 6, a telescopic groove 7, a rubber sealing cover 8, an elastic spring 9, a movable wheel supporting rod 10, a rotating shaft 11, a limiting nut 12, a movable wheel 13, a manual valve 14, a discharge pipe 15, a clamping sleeve 16, a clamping plate 17, a motor rotating shaft 18, a rubber ring 19, a motor 20, a power supply box 21, a mounting hole 22, a magnetic column 23 and a clamping groove 24.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
Referring to fig. 1 to 2, the present invention provides a technical solution: a high-speed centrifuge for preparing targeted chondrocyte exosomes comprises a high-speed centrifuge shell 1, wherein a centrifugal inner container 2 is arranged inside the high-speed centrifuge shell 1, the right lower end of the centrifugal inner container 2 is communicated with the outside and is provided with a discharge pipe 15, a manual valve 14 is arranged on the discharge pipe 15, the manual valve 14 is opened, and a base solution is discharged firstly, so that the effect of separating a supernatant and the base solution is achieved;
a plurality of groups of moving wheels 13 are movably attached to the outer ring of the centrifugal liner 2, the moving wheels 13 are connected to the end parts of moving wheel support rods 10 through rotating shafts 11 which are movably penetrated up and down, two ends of each rotating shaft 11 are connected with limit nuts 12 through thread matching, one ends, far away from the moving wheels 13, of the moving wheel support rods 10 are fixedly welded on the inner wall of the high-speed centrifuge shell 1, so that the moving wheels 13 can play a stabilizing and guiding role on the outer ring of the centrifugal liner 2, the centrifugal liner 2 is not prone to shaking and shifting during high-speed rotation centrifugation, the structure is stable, and normal centrifugal work is guaranteed;
the middle position of the bottom surface of the centrifugal inner container 2 is fixedly welded with a clamping sleeve 16, the clamping sleeve 16 is clamped on a clamping plate 17 in a matching way, the clamping plate 17 is fixedly welded at the outer ring of the upper end of the motor rotating shaft 18, the middle position of the clamping sleeve 16 is provided with a clamping groove 24, the clamping groove 24 and the clamping plate 17 are arranged in a matching way, the purpose that the centrifugal inner container 2 is arranged on the motor rotating shaft 18 in a sitting way is realized, the clamping plate 17 is of a cross structure, the clamping plate 17 and the clamping sleeve 16 cannot rotate relatively when fixed in the clamping sleeve, the clamping sleeve 16 and the centrifugal inner container 2 can be driven to rotate synchronously when the motor rotating shaft 18 rotates, the high rotation and centrifugation of the centrifugal inner container 2 are realized, four groups of mounting holes 22 are distributed on the clamping sleeve 16 in a circular array, magnetic columns 23 are fixedly embedded in the mounting holes 22, the magnetic columns 23 and the clamping plate 17 are fixedly adsorbed, the fixing stability between the clamping sleeve 16 and the clamping plate 17 is further enhanced, and the clamping plate 17 is made of stainless steel plates;
there is motor casing 3 bottom of high-speed centrifuge casing 1 through the screw mounting, and the fixed welding of intermediate position of motor casing 3 has motor 20, and motor 20's upper end is connected with the lower extreme transmission of motor shaft 18, and motor 20's left side is provided with power supply box 21, has placed direct current battery in the power supply box 21, and the motor 20 model is: d110BLD2000-48A-30S, the direct current battery is a 48V direct current battery, the direct current battery is electrically connected with the motor 20 and used in a matched mode, power supply of the motor 20 is guaranteed, the direct current battery is arranged, an original mode of using an alternating current power supply is replaced, and the use and the movement are convenient;
an upper sealing cover 4 is sealed above the high-speed centrifuge shell 1, a fixing ring groove 5 is arranged on the bottom surface of the outer ring of the upper sealing cover 4, a magnetic ring 6 is fixedly embedded in the fixing ring groove 5, and the magnetic ring 6 is fixedly adsorbed on the upper surface of the high-speed centrifuge shell 1.
The bottom surface that the lower extreme activity of motor shaft 18 passed high-speed centrifuge casing 1 sets up, and the position that motor shaft 18 activity passed high-speed centrifuge casing 1 is provided with rubber circle 19, and rubber circle 19 is the fixed setting of ring form on high-speed centrifuge casing 1, and rubber circle 19 has guaranteed that motor shaft 18 passes the leakproofness of high centrifuge casing 1 position, and motor shaft 18 can normally rotate.
Go up the lower surface intermediate position of closing cap 4 and be provided with flexible groove 7, be provided with rubber seal lid 8 in flexible groove 7, rubber seal lid 8 matches the setting with the upper end opening part of centrifugal inner bag 2, the fixed surface of rubber seal lid 8 is equipped with multiunit elastic spring 9, the fixed welding in upper end of multiunit elastic spring 9 is on the upper end inner wall of flexible groove 7, fig. 1 is elastic spring 9's compression state, can compress tightly rubber seal lid 8 in real time, the sealing of centrifugal inner bag 2 upper end has been guaranteed, inside liquid is difficult for spilling when centrifugal inner bag 2 rotates the centrifugation, and centrifugal inner bag 2 can normally rotate.
The working principle is as follows:
when the centrifugal container is used, substances needing centrifugation are placed into the centrifugal container 2, the centrifugal container 2 is directly clamped on a clamping plate 17 at the upper end of a motor rotating shaft 18 through a clamping sleeve 16 at the bottom to realize installation, then the upper sealing cover 4 is covered, the upper sealing cover 4 is fixedly adsorbed on the upper end surface of the high-speed centrifuge shell 1 through a magnetic ring 6, a rubber sealing cover 8 in the middle of the upper sealing cover 4 is sealed at an opening at the upper end of the centrifugal container 2 through the elastic pressing action of an elastic spring 9 to realize sealing, and the centrifugal container 2 can rotate without influencing the centrifugal work;
when the centrifugal machine works, the motor 20 drives the clamping sleeve 16 to synchronously rotate through the motor rotating shaft 18, the clamping sleeve 16 is fixedly welded at the bottom of the centrifugal inner container 2, the centrifugal inner container 2 also synchronously rotates at a high speed to generate a centrifugal effect, after the centrifugation is finished, the centrifugal inner container 2 is taken out after the standing is finished, the manual valve 14 is opened, the base liquid is firstly discharged, the effect of separating the supernatant and the base liquid is achieved, and the centrifugal inner container 2 is convenient to take out and clean and is convenient to use next time.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. A high speed centrifuge for the preparation of targeted chondrocyte exosomes, comprising a high speed centrifuge housing (1), characterized by: the high-speed centrifuge shell (1) is of a cylindrical box structure without an upper surface, a centrifugal inner container (2) is arranged inside the high-speed centrifuge shell (1), a clamping sleeve (16) is fixedly welded in the middle of the bottom surface of the centrifugal inner container (2), the clamping sleeve (16) is clamped on a clamping plate (17) in a matching mode, the clamping plate (17) is fixedly welded at the outer ring of the upper end of a motor rotating shaft (18), the lower end of the motor rotating shaft (18) movably penetrates through the bottom surface of the high-speed centrifuge shell (1), a motor shell (3) is installed at the bottom of the high-speed centrifuge shell (1) through screws, a motor (20) is fixedly welded in the middle of the motor shell (3), the upper end of the motor (20) is in transmission connection with the lower end of the motor rotating shaft (18), a power box (21) is arranged on the left side of the motor (20), and the power box (21) is fixedly welded on the inner bottom surface of the motor shell (3), an upper sealing cover (4) is sealed above the high-speed centrifuge shell (1), a fixing ring groove (5) is arranged on the bottom surface of the outer ring of the upper sealing cover (4), a magnetic ring (6) is fixedly embedded in the fixing ring groove (5), and the magnetic ring (6) is fixedly adsorbed on the upper surface of the high-speed centrifuge shell (1).
2. A high speed centrifuge for the preparation of targeted chondrocyte exosomes according to claim 1, characterized in that: the right lower end of the centrifugal inner container (2) is communicated with the outside and is provided with a discharge pipe (15), and the discharge pipe (15) is provided with a manual valve (14).
3. A high speed centrifuge for the preparation of targeted chondrocyte exosomes according to claim 1, characterized in that: clamping grooves (24) are formed in the middle of the clamping sleeve (16), the clamping grooves (24) and the clamping plates (17) are matched, the clamping plates (17) are of a cross structure, four groups of mounting holes (22) are distributed on the clamping sleeve (16) in a circular array mode, magnetic columns (23) are fixedly embedded in the mounting holes (22), and the magnetic columns (23) and the clamping plates (17) are fixedly adsorbed.
4. A high speed centrifuge for the preparation of targeted chondrocyte exosomes according to claim 1, characterized in that: the rubber ring (19) is arranged at the position where the motor rotating shaft (18) movably penetrates through the high-speed centrifugal machine shell (1), and the rubber ring (19) is fixedly arranged on the high-speed centrifugal machine shell (1) in a circular ring shape.
5. A high speed centrifuge for the preparation of targeted chondrocyte exosomes according to claim 1, characterized in that: the lower surface intermediate position of going up closing cap (4) is provided with flexible groove (7), is provided with rubber seal lid (8) in flexible groove (7), and rubber seal lid (8) matches the setting with the upper end opening part of centrifugal inner bag (2), and the fixed surface of rubber seal lid (8) is equipped with multiunit elastic spring (9), and the upper end fixed welding of multiunit elastic spring (9) is on the upper end inner wall of flexible groove (7).
6. A high speed centrifuge for the preparation of targeted chondrocyte exosomes according to claim 1, characterized in that: the inside of high-speed centrifuge casing (1) is provided with removes wheel (13), it is equipped with the multiunit to remove wheel (13), and the multiunit is removed wheel (13) and is the outer lane department of circular array form activity laminating at centrifugal inner bag (2), removes axis of rotation (11) that runs through from top to bottom activity on wheel (13) and connects the tip at removal wheel bracing piece (10), the both ends of axis of rotation (11) all are connected with stop nut (12) through screw-thread fit, the one end fixed welding that removes wheel (13) was kept away from in removal wheel bracing piece (10) is on the inner wall of high-speed centrifuge casing (1).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022883184.4U CN213943552U (en) | 2020-12-04 | 2020-12-04 | High-speed centrifuge for preparing targeted chondrocyte exosomes |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202022883184.4U CN213943552U (en) | 2020-12-04 | 2020-12-04 | High-speed centrifuge for preparing targeted chondrocyte exosomes |
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| CN213943552U true CN213943552U (en) | 2021-08-13 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117720993A (en) * | 2024-02-07 | 2024-03-19 | 山东善缘生物科技有限公司 | Stem cell exosome extractor |
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2020
- 2020-12-04 CN CN202022883184.4U patent/CN213943552U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117720993A (en) * | 2024-02-07 | 2024-03-19 | 山东善缘生物科技有限公司 | Stem cell exosome extractor |
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