CN213903561U - Detection and analysis system based on micro-fluidic chip - Google Patents
Detection and analysis system based on micro-fluidic chip Download PDFInfo
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- CN213903561U CN213903561U CN202120026758.8U CN202120026758U CN213903561U CN 213903561 U CN213903561 U CN 213903561U CN 202120026758 U CN202120026758 U CN 202120026758U CN 213903561 U CN213903561 U CN 213903561U
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Abstract
The utility model discloses a detection and analysis system based on micro-fluidic chip, it relates to micro-fluidic technical field. The technical scheme is characterized by comprising a micro-fluidic chip, wherein a liquid inlet, a liquid outlet and an oil inlet are formed in the micro-fluidic chip; the chip cover plate is respectively provided with an oil inlet channel communicated with the oil inlet, a sample liquid inlet tank communicated with the liquid inlet, a liquid storage tank communicated with the liquid outlet and an overflow tank communicated with an opening at the top end of the liquid storage tank; the liquid in the liquid storage tank flows into the liquid collecting pipe after passing through the overflow groove; and the liquid level sensor is used for detecting the emulsion liquid level in the liquid receiving pipe, and the detection position of the liquid level sensor is close to the bottom end of the liquid receiving pipe. The utility model discloses can make all the collection of the produced emulsion of all sample liquids all, avoid sample liquid extravagant to can judge the complete time point of the whole collection completions of emulsion automatically accurately, realize the effective utilization of bio-oil, reduce bio-oil's waste.
Description
Technical Field
The utility model relates to a micro-fluidic technology field, more specifically say, it relates to a detection and analysis system based on micro-fluidic chip.
Background
The micro-fluidic chip technology integrates basic operation units of sample preparation, reaction, separation, detection and the like in the biological, chemical and medical analysis process into a micron-scale chip to automatically complete the whole analysis process, and has been developed into a brand-new research field crossing the disciplines of biology, chemistry, medicine, fluid, electronics, materials, machinery and the like due to the huge potential of the micro-fluidic chip in the fields of biology, chemistry, medicine and the like.
At present, when a microfluidic chip is used for detecting and analyzing sample liquid, some problems to be solved urgently exist. Firstly, for sample liquids with different volumes, how to ensure the complete collection of the emulsion when the generated emulsion is collected; secondly, how to effectively utilize the biological oil in the process of collecting the emulsion to avoid the waste of the biological oil; and finally, automatically and accurately judging the finishing time point of the complete collection of the emulsion.
SUMMERY OF THE UTILITY MODEL
Not enough to prior art exists, the utility model aims to provide a detection and analysis system based on micro-fluidic chip, it can make all the produced emulsion of sample liquid all collect, avoids sample liquid extravagant to can judge the complete time point of the whole collection completions of emulsion automatically accurately, realize the effective utilization of bio-oil, reduce bio-oil's waste.
In order to achieve the above purpose, the utility model provides a following technical scheme:
a microfluidic chip-based detection and analysis system, comprising:
the micro-fluidic chip is provided with a liquid inlet, a liquid outlet and an oil inlet;
the chip cover plate is respectively provided with an oil inlet channel communicated with the oil inlet, a sample liquid inlet groove communicated with the liquid inlet, a liquid storage groove communicated with the liquid outlet and an overflow groove communicated with an opening at the top end of the liquid storage groove;
the liquid in the liquid storage tank flows into the liquid collecting pipe after passing through the overflow tank; and the number of the first and second groups,
and the liquid level sensor is used for detecting the emulsion liquid level in the liquid receiving pipe, and the detection position of the liquid level sensor is close to the bottom end of the liquid receiving pipe.
Further, a downward inclined overflow channel and a vertically arranged discharge channel are arranged in the overflow groove; the high point of the overflow channel is communicated with the top opening of the liquid storage tank, and the low point of the overflow channel is communicated with the top opening of the discharge channel.
Further, the inner wall of the discharge passage is provided with a flow guide inclined plane.
Further, the bottom of sample feed liquor groove is the binding off setting.
Furthermore, the liquid level sensor is U-shaped, and a detection port used for the bottom end of the liquid receiving pipe to stretch into is arranged at the top end of the liquid level sensor.
Furthermore, a sealing part in contact with the microfluidic chip is arranged in the chip cover plate, and the oil inlet channel is arranged in the sealing part.
To sum up, the utility model discloses following beneficial effect has:
1. the utility model can collect all the emulsions generated by all the sample liquids, avoid the waste of the sample liquids, automatically and accurately judge the finishing time point of the complete collection of the emulsions, realize the effective utilization of the bio-oil and reduce the waste of the bio-oil;
2. in the detection and analysis process of sample liquids with different volumes, the ending time point can be automatically judged, the biological oil is fully utilized, and the waste of the biological oil is reduced.
Drawings
FIG. 1 is a schematic structural diagram of a detection and analysis system based on a microfluidic chip in an embodiment;
FIG. 2 is a schematic structural diagram of a microfluidic chip in an embodiment;
FIG. 3 is a sectional view of a cover plate of a chip in an embodiment;
FIG. 4 is a schematic structural diagram of a liquid collecting tube and a liquid level sensor in an embodiment;
FIG. 5 is a schematic diagram showing a state change of the liquid level sensor in the embodiment.
In the figure: 1. a microfluidic chip; 11. a liquid inlet; 12. a liquid outlet; 13. an oil inlet; 2. a chip cover plate; 21. a sealing part; 211. an oil inlet channel; 22. a sample liquid inlet tank; 23. a liquid storage tank; 24. an overflow trough; 3. a liquid collecting pipe; 4. a liquid level sensor; 41. a probe port.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications to the present embodiment without inventive contribution as required after reading the present specification, but all of them are protected by patent laws within the scope of the claims of the present invention.
Example (b):
a detection and analysis system based on a microfluidic chip, referring to fig. 1 to 5, comprising:
the micro-fluidic chip 1 is provided with a liquid inlet 11, a liquid outlet 12 and an oil inlet 13, and a micro-fluidic channel (not shown in the drawing) is arranged in the micro-fluidic chip 1;
the chip cover plate 2 is covered on the microfluidic chip 1, and the chip cover plate 2 is respectively provided with an oil inlet channel 211 communicated with the oil inlet 13, a sample liquid inlet groove 22 communicated with the liquid inlet 11, a liquid storage groove 23 communicated with the liquid outlet 12 and an overflow groove 24 communicated with an opening at the top end of the liquid storage groove 23;
the liquid collecting pipe 3 is placed below the overflow groove 24, and the liquid in the liquid storage groove 23 flows into the liquid collecting pipe 3 after passing through the overflow groove 24; and the number of the first and second groups,
and the liquid level sensor 4 is used for detecting the liquid level of the emulsion in the liquid receiving pipe 3, and the detection position of the liquid level sensor 4 is close to the bottom end of the liquid receiving pipe 3.
Referring to fig. 1 to 4, a liquid inlet 11, a liquid outlet 12 and a liquid inlet 13 form a group of detection ports, and in this embodiment, the microfluidic chip 1 is provided with eight groups of detection ports, so the number of the liquid receiving tubes 3 is eight, and the eight liquid receiving tubes 3 are connected in sequence to form eight connecting tubes; meanwhile, in the embodiment, eight liquid level sensors 4 are adopted to form an array to detect the eight liquid receiving tubes 3 respectively; specifically, the main body of the liquid level sensor 4 is U-shaped, and the top end of the liquid level sensor is provided with a detection port 41 for the bottom end of the liquid receiving tube 3 to extend into; the detection position of level sensor 4 in this embodiment is close to the bottom of receiving liquid pipe 3, drips into and surveys again after emulsion formation certain liquid level in the receiving liquid pipe 3, can improve and detect the precision, and the oil mass in final receiving liquid pipe 3 is few moreover, can realize the make full use of to bio-oil, reduces bio-oil's waste.
Referring to fig. 1 and 3, a downwardly inclined overflow channel is provided in the overflow tank 24, and a vertically arranged discharge channel; the high point of the overflow channel is communicated with the top opening of the liquid storage tank 23, and the low point of the overflow channel is communicated with the top opening of the discharge channel; the density of the oil is greater than that of the emulsion, and the liquid storage tank 23 plays a role in temporarily storing the emulsion and the oil in the emulsion generation process; when the liquid storage tank 23 is filled with the emulsion and the oil, the emulsion can preferentially flow through the overflow tank 24 from the top end opening of the liquid storage tank 23 and drop into the liquid receiving pipe 3, so that the separation of the emulsion and the oil is realized.
Referring to fig. 3, in this embodiment, the top end of the liquid storage tank 23 is arranged in a closed manner, so that the separation of the emulsion and the oil is facilitated, the complete collection of the emulsion is realized, and the waste of the bio-oil is reduced; the bottom end of the sample liquid inlet groove 22 is in a closed-up arrangement, so that the sample liquid can flow out conveniently, and the waste of the sample liquid is avoided; the inner wall of the discharge channel is provided with a flow guide inclined plane, so that liquid residue is avoided through the flow guide inclined plane, further, the emulsion is completely collected, and the waste of the biological oil is reduced; the chip cover plate 2 is internally provided with a sealing part 21 which is in contact with the microfluidic chip 1, the oil inlet channel 211 is arranged in the sealing part 21, the sealing part 21 is used for improving the sealing property and avoiding the leakage of biological oil, and the material of the sealing part is preferably rubber.
Claims (6)
1. A detection analysis system based on a microfluidic chip is characterized by comprising:
the micro-fluidic chip is provided with a liquid inlet, a liquid outlet and an oil inlet;
the chip cover plate is respectively provided with an oil inlet channel communicated with the oil inlet, a sample liquid inlet groove communicated with the liquid inlet, a liquid storage groove communicated with the liquid outlet and an overflow groove communicated with an opening at the top end of the liquid storage groove;
the liquid in the liquid storage tank flows into the liquid collecting pipe after passing through the overflow tank; and the number of the first and second groups,
and the liquid level sensor is used for detecting the emulsion liquid level in the liquid receiving pipe, and the detection position of the liquid level sensor is close to the bottom end of the liquid receiving pipe.
2. The microfluidic chip-based detection and analysis system according to claim 1, wherein: an overflow channel which is inclined downwards and a discharge channel which is vertically arranged are arranged in the overflow groove; the high point of the overflow channel is communicated with the top opening of the liquid storage tank, and the low point of the overflow channel is communicated with the top opening of the discharge channel.
3. The microfluidic chip-based detection and analysis system according to claim 2, wherein: and a flow guide inclined plane is arranged on the inner wall of the discharge channel.
4. The microfluidic chip-based detection and analysis system according to claim 1, wherein: the bottom of sample feed liquor groove is the close up setting.
5. The microfluidic chip-based detection and analysis system according to claim 1, wherein: the liquid level sensor is U-shaped, and its top is provided with and is used for the survey mouth that receipts liquid pipe bottom stretched into.
6. The microfluidic chip-based detection and analysis system according to claim 1, wherein: the chip cover plate is internally provided with a sealing part which is in contact with the microfluidic chip, and the oil inlet channel is arranged in the sealing part.
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| CN202120026758.8U CN213903561U (en) | 2021-01-06 | 2021-01-06 | Detection and analysis system based on micro-fluidic chip |
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| CN202120026758.8U CN213903561U (en) | 2021-01-06 | 2021-01-06 | Detection and analysis system based on micro-fluidic chip |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112857504A (en) * | 2021-01-06 | 2021-05-28 | 苏州索真生物技术有限公司 | Detection analysis system and method based on micro-fluidic chip |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112857504A (en) * | 2021-01-06 | 2021-05-28 | 苏州索真生物技术有限公司 | Detection analysis system and method based on micro-fluidic chip |
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