CN213903545U

CN213903545U - Detect camera bellows device and chemiluminescence immunoassay appearance

Info

Publication number: CN213903545U
Application number: CN202022409816.3U
Authority: CN
Inventors: 隋一鸣; 徐炯宽; 蒋文格; 陈�胜; 张明弟
Original assignee: Suzhou Lihe Biomedical Engineering Co ltd
Current assignee: Suzhou Lihe Biomedical Engineering Co ltd
Priority date: 2020-10-27
Filing date: 2020-10-27
Publication date: 2021-08-06
Anticipated expiration: 2030-10-27

Abstract

The application relates to a detect camera bellows includes: the camera bellows assembly, the detection assembly and the upper door assembly; the detection assembly is provided with a shutter assembly, and the shutter assembly is used for opening and closing a channel between the photomultiplier and the dark room; the light filtering component is used in the camera bellows component and divides the camera bellows into a camera bellows A and a camera bellows B which are sealed and not communicated with each other; the shutter assembly is adopted, so that the response speed can be obviously improved; and secondly, the light filtering component is adopted, and the sealed window is additionally arranged, so that the sealed shading effect on the darkroom is improved. In addition, through set up piezoelectric sensor in darkroom box cavity, can prevent effectively that the determine module from being filled, lead to detecting instrument contaminated, corruption.

Description

Detect camera bellows device and chemiluminescence immunoassay appearance

Technical Field

The application belongs to the technical field of medical equipment, and particularly relates to a detection camera bellows device for a chemiluminescence immunoassay analyzer.

Background

The chemiluminescence immunoassay is a means for detecting mainly by utilizing the specific reaction of an antigen and an antibody, and because the detection signal can be amplified and displayed by utilizing an isotope, an enzyme, a chemiluminescence substance and the like, when in experiment, the antigen or the antibody is connected with certain enzyme to form an enzyme-labeled antigen or antibody, the enzyme-labeled antigen or antibody not only retains the immunocompetence thereof, but also retains the activity of the enzyme, then a luminescence substrate is added after washing, in a laboratory, the detection liquid is usually detected in a reaction cup, after the luminescence substrate is added, the reaction cup is sent into a detection dark box for detection, and the luminescence amount of the substance in the reaction cup in the detection dark box is detected, so that the luminescence immunoassay of the detection liquid is realized.

In the existing design, whether the reaction cup is placed at the detection position cannot be detected in the measurement dark box, so that liquid can still be added if the reaction cup is not normally placed at the detection position in the cavity of the dark box body in the operation process, and the measurement chamber is filled, so that instruments are polluted and corroded. In addition, the existing chemiluminescence immunoassay analyzer detection dark box generally adopts an inlet and outlet baffle plate for sealing and shading, and the problem of low operation efficiency exists.

Disclosure of Invention

The invention provides a detection camera bellows device for a chemiluminescence immunoassay analyzer, which aims to solve the problems that whether a reaction cup is placed at a detection position cannot be detected in a measurement camera bellows in the prior art, a measurement chamber is often filled, instruments are polluted and corroded, and the operation efficiency is low due to the fact that an inlet baffle and an outlet baffle are adopted for shading.

The technical scheme adopted by the invention for solving the technical problems is as follows: a detection camera bellows device, comprising: the camera bellows assembly, the detection assembly and the upper door assembly; the upper door assembly can open and close the darkroom and is used for placing the reaction cup into or taking the reaction cup out of the darkroom, and the detection assembly is used for detecting the light emission quantity of liquid in the reaction cup in the darkroom;

the detection assembly comprises a photomultiplier and a shutter assembly; the shutter assembly is used for opening and closing the passage of the photomultiplier and the dark room, and the shutter assembly is controlled to open and close through an electric signal.

Furthermore, the camera bellows assembly also comprises a filtering assembly, wherein the filtering assembly comprises a filter, a filter pressing plate and a filter sealing ring; the light filtering component is positioned in a space formed by the darkroom box body and the detection component, the light filter is disc-shaped, a light filter boss for supporting the light filter is arranged in the darkroom box body, the light filter pressing plate is annular and is connected in the darkroom box body through a screw, the light filter pressing plate is used for pressing the light filter on the light filter boss in the darkroom box body, the joint of the light filter and the darkroom box body is sealed through a light filter sealing ring, and the darkroom is divided into a darkroom A and a darkroom B which are sealed and not communicated with each other by the light filtering component.

During operation, the reaction cup is in darkroom B, the operation such as filling substrate liquid is also carried out in darkroom B, even because of the maloperation, because of darkroom A and darkroom B are sealed each other, liquid medium can not get into darkroom A, can not pollute detection device such as photomultiplier, and can avoid darkroom A to be filled by liquid, avoid detection device to be disturbed by steam, the luminescence of liquid in the reaction cup can get into darkroom A by darkroom B through the light filter, can normally carry out the detection of luminous quantity.

Furthermore, the camera bellows subassembly still includes the sensor that is used for detecting whether the reaction cup is put into the camera bellows, and the sensor is piezoelectric sensor, installs in the camera bellows box for whether preset position in the camera bellows is put into to the detection reaction cup bottom, through using the sensor, ensures just to carry out the operation of filling substrate liquid after the preset position has been put into to the reaction cup, avoids leading to the camera bellows to be filled because of the maloperation.

Further, the door assembly comprises: the device comprises a screw motor, a motor fixing plate, a screw nut, an upper door connecting plate and an upper door pressing plate; the upper door is positioned at the upper part of the darkroom box body, the upper door is matched with the structure of the inlet and the outlet at the upper part of the darkroom box body, the upper door pressing plate is fixedly arranged at the upper part of the darkroom box body, and the upper door can reciprocate in a groove formed by the upper door pressing plate and the darkroom box body and is used for opening and closing the inlet and the outlet at the upper part of the darkroom box body; the motor fixing plate is fixedly connected with the darkroom box body, the screw motor is fixedly installed on the motor fixing plate, the screw nut is matched with the screw motor, the upper door connecting plate is used for fixedly connecting the upper door and the screw nut together, and the screw motor can drive the screw nut to reciprocate and further drive the upper door to reciprocate.

Further preferably, the upper door assembly further comprises: a slide block and a guide rail; the guide rail and the lead screw motor are axially parallel and fixedly mounted on the darkroom box body, the sliding block is matched with the guide rail and can reciprocate along the guide rail, the sliding block is fixedly connected with the upper door connecting plate, the upper door connecting plate drives the sliding block to reciprocate on the guide rail, and the guide rail and the sliding block are used for enabling the reciprocating motion of the upper door to be more stable.

Further preferably, the upper door assembly further comprises: a photoelectric sensor and an upper door separation blade; the upper door separation blade is fixedly installed on the upper door connecting plate, the photoelectric sensor is fixedly installed on the darkroom box body, the photoelectric sensor and the upper door separation blade are matched for use and used for detecting that the upper door is in an open or closed state, and preferably 2 photoelectric sensors are used.

Further, the aforementioned detection assembly further includes: a shutter sealing ring and a multiplier tube connecting plate; the device comprises a camera, a camera box, a camera connecting plate, a shutter assembly, a photomultiplier, a shutter sealing ring, a camera connecting plate, a camera box body, a camera, a photoelectric multiplier and a camera, wherein the camera connecting plate is fixedly connected with the camera box body to form a partial space of the camera, the shutter assembly is fixedly installed on one side, close to the camera, of the camera connecting plate, the photomultiplier is fixedly installed on the other side of the camera connecting plate, and the joint of the shutter assembly and the camera connecting plate is sealed through the shutter sealing ring.

Furthermore, the detection camera bellows device is also provided with a waste liquid pipeline which is fixedly connected with the camera bellows body and used for discharging redundant liquid of the perfusion needle.

The second aspect of the present application also provides a chemiluminescent immunoassay analyzer comprising the detection dark box device described herein.

The invention has the beneficial effects that:

1. according to the technical scheme, the piezoelectric sensor is arranged in the cavity of the dark room box body, when the reaction cup reaches the detection position, the piezoelectric sensor senses whether the reaction cup is in a state or not, when the reaction cup is in a state, the substrate liquid is added into the reaction cup through the substrate filling connector, and when the reaction cup is not in a state, the substrate liquid cannot be continuously added, so that the problem that the measuring chamber is filled to cause corrosion and pollution to an instrument is solved.

2. In the detection dark box device, the shutter assembly is adopted, so that the response speed can be obviously improved; and secondly, a light filtering component is adopted, and a sealed window is additionally arranged, so that the detection component is prevented from being filled, and a detection instrument is prevented from being polluted and corroded.

3. The application provides a detect camera bellows device for chemiluminescence immunoassay appearance, detection accuracy is high.

Drawings

The technical solution of the present application is further explained below with reference to the drawings and the embodiments.

FIG. 1 is a front view of the inspection camera of the present application;

FIG. 2 is a cross-sectional view of the inspection camera box assembly of the present application;

FIG. 3 is a side view of the inspection camera of the present application;

FIG. 4 is a top view of the detection camera bellows apparatus of the present application;

FIG. 5 is a schematic perspective view of the inspection camera bellows apparatus of the present application;

FIG. 6 is an enlarged detail view of the filter assembly;

FIG. 7 is a schematic view of the installed position of the filter assembly;

FIG. 8 is a schematic view of an upper door assembly;

FIG. 9 is a schematic view of a detection assembly;

the reference numbers in the figures are:

101: darkroom box

1011: darkroom A

1012: darkroom B

1013: optical filter boss

102: light filtering assembly

1021: optical filter

1022: optical filter pressing plate

1023: optical filter sealing ring

201: photomultiplier tube

202: shutter assembly

203: shutter sealing ring

204: multiplier tube connecting plate

301: lead screw motor

302: motor fixing plate

303: screw nut

304: upper door

305: upper door connecting plate

306: upper door pressure plate

307: sliding block

308: guide rail

3091: photoelectric sensor A

3092: photoelectric sensor B

310: upper door stop sheet

311: reaction cup guide bracket

312: liquid injection needle assembly

4: piezoelectric sensor

5: reaction cup

6: waste liquid pipeline

Detailed Description

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict.

In the description of the present application, it is to be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the present application and for simplicity in description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated in a particular manner, and are not to be considered limiting of the scope of the present application. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the invention, the meaning of "a plurality" is two or more unless otherwise specified.

In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art through specific situations.

Examples

The present embodiment provides a dark box detection device, as shown in fig. 1 to 5, including: the camera bellows assembly, the detection assembly and the upper door assembly; the camera bellows assembly comprises a camera bellows body 101, an inner space for accommodating the reaction cup 5 is arranged in the camera bellows body 101, the inner space for accommodating the reaction cup 5 is sealed to form a camera bellows after the upper door assembly, the camera bellows assembly and the detection assembly are connected, the upper door assembly can open and close the camera bellows and is used for placing the reaction cup 5 into or taking the reaction cup out of the camera bellows, and the detection assembly is used for detecting the light emission quantity of liquid in the reaction cup 5 in the camera bellows;

as shown in fig. 9, the detection unit of the present embodiment includes a photomultiplier tube 201, a shutter unit 202; the shutter assembly 202 is used for opening and closing the passage of the photomultiplier tube 201 and the dark room, and the shutter assembly 202 is controlled to open and close by an electric signal.

As shown in fig. 2 and 9, the detecting assembly of the present embodiment further includes: a shutter seal ring 203, a multiplier tube connecting plate 204; the photomultiplier tube connecting plate 204 is fixedly connected with the darkroom box 101 to form a partial space of the darkroom, the shutter assembly 202 is fixedly installed on one side, close to the darkroom, of the photomultiplier tube connecting plate 204, the photomultiplier tube 201 is fixedly installed on the other side of the photomultiplier tube connecting plate 204, and the joint of the shutter assembly 202 and the photomultiplier tube connecting plate 204 is sealed through a shutter sealing ring 203.

As shown in fig. 6 and 7, the black box assembly of the present embodiment further includes a filter assembly 102, wherein the filter assembly 102 includes a filter 1021, a filter pressing plate 1022, and a filter gasket 1023; the optical filter assembly 102 is located in a space formed by the darkroom box body 101 and the detection assembly, the optical filter 1021 is in a disc shape, an optical filter boss 1013 supporting the optical filter 1021 is arranged in the darkroom box body 101, the optical filter pressing plate 1022 is in a ring shape, the optical filter pressing plate 1022 is connected in the darkroom box body 101 through screws, the optical filter pressing plate 1022 is used for pressing the optical filter 1021 on the optical filter boss 1013 in the darkroom box body 101, the connection part of the optical filter 1021 and the darkroom box body 101 is not sealed through an optical filter sealing ring 1023, and the darkroom is divided into a darkroom A1011 and a darkroom B1012 which are sealed and communicated with each other by the optical filter assembly 102.

When the reaction cup 5 works, the reaction cup is arranged in the darkroom B1012, the operations of filling substrate liquid and the like are also carried out in the darkroom B1012, even if the operation is wrong, because the darkroom A1011 and the darkroom B1012 are sealed mutually, liquid media cannot enter the darkroom A1011, detection devices such as the photomultiplier 201 and the like cannot be polluted, the darkroom A1011 can be prevented from being filled with liquid, the detection devices are prevented from being interfered by water vapor, the luminescence of the liquid in the reaction cup 5 can enter the darkroom A1011 from the darkroom B1012 through the optical filter 1021, and the detection of the luminescence quantity can be normally carried out.

As shown in FIGS. 2 and 6, the camera bellows assembly of this embodiment further comprises a piezoelectric sensor 4 for detecting whether the cuvette 5 is placed in the camera bellows, and the piezoelectric sensor is mounted in the camera bellows 101 for detecting whether the bottom of the cuvette 5 is placed at a predetermined position in the camera bellows.

As shown in fig. 5 and 8, the upper door assembly of the present embodiment includes: a screw motor 301, a motor fixing plate 302, a screw nut 303, an upper door 304, an upper door connecting plate 305 and an upper door pressing plate 306; the upper door 304 is positioned at the upper part of the darkroom box body 101, the upper door 304 is matched with the structure of the upper inlet and outlet of the darkroom box body 101, the upper door pressing plate 306 is fixedly arranged at the upper part of the darkroom box body 101, and the upper door 304 can reciprocate in a groove formed by the upper door pressing plate 306 and the darkroom box body 101 and is used for opening and closing the upper inlet and outlet of the darkroom box body 101; the motor fixing plate 302 is fixedly connected with the darkroom box 101, the lead screw motor 301 is fixedly installed on the motor fixing plate 302, the lead screw nut 303 is matched with the lead screw motor 301, the upper door connecting plate 305 is used for fixedly connecting the upper door 304 and the lead screw nut 303 together, and the lead screw motor 301 can drive the lead screw nut 303 to reciprocate so as to drive the upper door 304 to reciprocate.

As shown in fig. 8, the upper door assembly of the present embodiment further includes: a slider 307 and a guide 308; the guide rail 308 and the lead screw motor 301 are fixedly mounted on the darkroom box 101 in an axially parallel manner, the slider 307 is matched with the guide rail 308 and can reciprocate along the guide rail 308, the slider 307 is fixedly connected with the upper door connecting plate 305, the upper door connecting plate 305 can drive the slider 307 to reciprocate on the guide rail 308, and the guide rail 308 and the slider 307 are used for enabling the reciprocating motion of the upper door 304 to be more stable.

As shown in fig. 5 and 8, the upper door assembly of the present embodiment further includes: a photoelectric sensor A3091, a photoelectric sensor B3092 and an upper door baffle plate 310; the upper door stop sheet 310 is fixedly mounted on the upper door connecting plate 305, the photoelectric sensor A3091 and the photoelectric sensor B3092 are fixedly mounted on the darkroom box body, and the photoelectric sensor A3091, the photoelectric sensor B3092 and the upper door stop sheet 310 are matched for use and used for detecting that the upper door 304 is in an open or closed state.

As shown in FIG. 8, the detection dark box of this embodiment is further provided with a reaction cup guide holder 311 and a liquid injection needle assembly 312, wherein the reaction cup guide holder 311 is used for guiding the reaction cup to enter the dark chamber at a correct position, and the liquid injection needle assembly 312 is used for adding the substrate liquid into the reaction cup.

As shown in FIG. 1, the detection chamber of this embodiment is further provided with a waste liquid pipe 6, and the waste liquid pipe 6 is fixedly connected to the chamber housing 101 for draining the excess substrate liquid in the liquid injection needle assembly 312.

The working process of the embodiment is as follows: firstly, a lead screw motor 301 drives a lead screw nut 303 to move rightwards, further drives an upper door 304 to move rightwards, an upper inlet and an upper outlet of a darkroom box body 101 are opened, a manipulator drives a reaction cup 5 filled with a reagent to be tested to place the reaction cup 5 into a darkroom B1012 along a reaction cup guide support 311, when a piezoelectric sensor 4 senses that the cup bottom of the reaction cup 5 is located at a preset position, the system sends an electric signal to the manipulator, the manipulator releases the reaction cup 5, then the lead screw motor 301 drives the lead screw nut 303 to move leftwards, further drives the upper door 304 to move leftwards, the upper inlet and the upper outlet of the darkroom box body 101 are closed, a darkroom is formed inside the darkroom box body 101, then the system adds substrate liquid into the reaction cup 5 through a liquid injection needle assembly 312, redundant substrate liquid is discharged through a waste liquid pipeline 6, after the reaction is finished, the system sends an electric signal, and a shutter assembly 202 opens a channel between a photomultiplier 201 and the darkroom, the light emitted by the reaction in the reaction cup 5 enters the darkroom A1011 from the darkroom B1012 through the filter assembly 102 and is further detected by the photomultiplier 201, after the detection, the shutter assembly 202 closes the channel between the photomultiplier 201 and the darkroom, then the lead screw motor 301 drives the lead screw nut 303 to move rightwards, further drives the upper door 304 to move rightwards, opens the upper inlet and outlet of the darkroom box 101, the manipulator takes the tested reaction cup 5 out of the darkroom, the upper door 304 closes the upper inlet and outlet of the darkroom box 101 again, and the photomultiplier 201 transmits the detection result to the system. The next cycle of operation can then proceed.

In light of the foregoing description of the preferred embodiments according to the present application, it is to be understood that various changes and modifications may be made without departing from the spirit and scope of the invention. The technical scope of the present application is not limited to the contents of the specification, and must be determined according to the scope of the claims.

Claims

1. A detection camera bellows device, characterized by comprising: the camera bellows assembly, the detection assembly and the upper door assembly;

the upper door assembly can open and close the darkroom and is used for placing the reaction cup into or taking the reaction cup out of the darkroom, and the detection assembly is used for detecting the light emission quantity of liquid in the reaction cup in the darkroom;

the detection assembly comprises a photomultiplier and a shutter assembly; the shutter assembly is used for opening and closing the passage of the photomultiplier tube and the dark room.

2. The apparatus of claim 1, wherein the camera bellows assembly further comprises a filter assembly comprising a filter, a filter platen, a filter gasket;

the light filtering component is positioned in a space formed by the darkroom box body and the detection component, the light filter is disc-shaped, a light filter boss for supporting the light filter is arranged in the darkroom box body, the light filter pressing plate is annular and is connected in the darkroom box body through a screw, the light filter pressing plate is used for pressing the light filter on the light filter boss in the darkroom box body, the joint of the light filter and the darkroom box body is sealed through a light filter sealing ring, and the darkroom is divided into a darkroom A and a darkroom B which are sealed and not communicated with each other by the light filtering component.

3. The apparatus of claim 1, wherein the chamber assembly further comprises a sensor for detecting whether the cuvette is placed in the chamber, the sensor being mounted in the chamber body.

4. The apparatus as claimed in claim 3, wherein the sensor is a piezoelectric sensor for detecting whether the bottom of the reaction cup is placed at a predetermined position in the dark room.

5. The apparatus of any one of claims 1 to 3, wherein the upper door assembly comprises: the device comprises a screw motor, a motor fixing plate, a screw nut, an upper door connecting plate and an upper door pressing plate;

the upper door is positioned at the upper part of the darkroom box body, the upper door is matched with the structure of the inlet and the outlet at the upper part of the darkroom box body, the upper door pressing plate is fixedly arranged at the upper part of the darkroom box body, and the upper door can reciprocate in a groove formed by the upper door pressing plate and the darkroom box body and is used for opening and closing the inlet and the outlet at the upper part of the darkroom box body; the motor fixing plate is fixedly connected with the darkroom box body, the screw motor is fixedly installed on the motor fixing plate, the screw nut is matched with the screw motor, the upper door connecting plate is used for fixedly connecting the upper door and the screw nut together, and the screw motor can drive the screw nut to reciprocate and further drive the upper door to reciprocate.

6. The apparatus of claim 5, wherein the upper door assembly further comprises: a slide block and a guide rail;

the guide rail and the lead screw motor are axially parallel and fixedly mounted on the darkroom box body, the sliding block is matched with the guide rail and can reciprocate along the guide rail, the sliding block is fixedly connected with the upper door connecting plate, and the upper door connecting plate drives the sliding block to reciprocate on the guide rail.

7. The apparatus of claim 5, wherein the upper door assembly further comprises: a photoelectric sensor and an upper door separation blade;

the upper door separation blade is fixedly installed on the upper door connecting plate, the photoelectric sensor is fixedly installed on the darkroom box body, and the photoelectric sensor and the upper door separation blade are matched for use and used for detecting that the upper door is in an open or closed state.

8. The detection camera device according to any one of claims 1 to 3, wherein the detection assembly further comprises: a shutter sealing ring and a multiplier tube connecting plate;

the device comprises a camera, a camera box, a camera connecting plate, a shutter assembly, a photomultiplier, a shutter sealing ring, a camera connecting plate, a camera box body, a camera, a photoelectric multiplier and a camera, wherein the camera connecting plate is fixedly connected with the camera box body to form a partial space of the camera, the shutter assembly is fixedly installed on one side, close to the camera, of the camera connecting plate, the photomultiplier is fixedly installed on the other side of the camera connecting plate, and the joint of the shutter assembly and the camera connecting plate is sealed through the shutter sealing ring.

9. The apparatus according to any one of claims 1 to 3, wherein the detection chamber further comprises a waste liquid pipe fixedly connected to the chamber body for draining excess liquid from the filling needle.

10. A chemiluminescent immunoassay analyzer comprising the detection chamber device of any one of claims 1 to 9.