CN213813625U

CN213813625U - Immunomagnetic bead detection kit

Info

Publication number: CN213813625U
Application number: CN202022577055.2U
Authority: CN
Inventors: 彭俊; 黄燕华; 崔娇娇; 苗凤杰; 秦蕾; 汪中厅; 吴德; 黄牧一; 朱雄伟
Original assignee: Wuhan Jiayuan Biomedical Engineering Co ltd
Current assignee: Wuhan Jiayuan Biomedical Engineering Co ltd
Priority date: 2020-11-10
Filing date: 2020-11-10
Publication date: 2021-07-27
Anticipated expiration: 2030-11-10

Abstract

The utility model discloses an immunomagnetic bead detection kit, which comprises a movable top cover, a reagent tube is arranged below the movable top cover, a bottom box is arranged below the reagent tube, a chute is arranged inside the movable top cover, a fixing plate is arranged below the chute, a first through hole is arranged in the fixed plate, a rotating plate is arranged below the fixed plate and can be meshed with other gears in the bottom box through the arranged gears, thereby driving a plurality of bottom boxes to rotate when the motor is started, thereby improving the working efficiency, the strong magnetic plate can make a plurality of bottom boxes mutually adsorbed, avoid the mutual separation of the two bottom boxes during rotation, through the first through-hole and the second through-hole that set up, can make things convenient for the entering of magnetic bead, make the commentaries on classics board rotate through promoting the regulating plate to make the second through-hole keep away from first through-hole and realize the inside sealed of reagent pipe.

Description

Immunomagnetic bead detection kit

Technical Field

The utility model relates to a medical science inspection technical field specifically is an immunomagnetic bead detect reagent box.

Background

The immunomagnetic beads are a new immunological technology developed in recent years, combine the special advantages of immobilized reagents with high specificity of immunological reaction, and permeate into various fields of pathology, physiology, pharmacology, microorganism, biochemistry, molecular genetics and the like on the basis of immunology, so that the immunomagnetic beads are more and more widely applied to the aspects of immunoassay, cell separation, biomacromolecule purification, molecular biology and the like.

The reagent of immunomagnetic bead and cell suspension all produce the sediment when stewing easily, and current agitating unit stirs by the manual work more, and the bacterium is bred easily in reagent pipe and the excessive contact of air, and the manual stirring once can only carry out the stirring of a reagent pipe, and the not high and frequent stirring operation of efficiency causes the waste of manpower easily.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide an immunomagnetic bead detect reagent box to solve the problem that proposes in the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme: an immunomagnetic bead detection kit comprises a movable top cover, a reagent tube is arranged below the movable top cover, a bottom box is arranged below the reagent tube, a chute is arranged inside the movable top cover, a fixed plate is arranged below the chute, a first through hole is formed inside the fixed plate, a rotating plate is arranged below the fixed plate, a second through hole is formed in the rotating plate, the rotating plate is positioned inside the movable top cover and rotatably connected with the movable top cover, a box body is sleeved outside the reagent tube, the bottom of the box body is connected with the top of the bottom box, a bottom bin is arranged at the bottom of the reagent tube, a magnetic disk is arranged inside the bottom bin, four limiting holes are formed in the side wall of the magnetic disk, a first limiting plate is connected inside the limiting holes in an inserting and combining manner, the first limiting plate is fixedly connected with the side wall of the bottom bin, a rotating rod is fixedly connected with the bottom of the magnetic disk, the bottom of bull stick and the output fixed connection of motor, the motor is located the inside of end box, the motor runs through the roof of end box, just the inside of end box is provided with the gear, gear and bull stick fixed connection, one side of gear runs through the curb plate and another of end box the inside gear engagement of end box is connected.

As a further aspect of the present invention: the movable top cover, the chute and the fixed plate are of an integral structure, the first through hole and the second through hole are far away from the central positions of the fixed plate and the rotating plate, the rotating plate rotates by an angle to enable the first through hole to be communicated with the second through hole, and the size of the second through hole is equal to that of the first through hole.

The advantages of adopting the further scheme are as follows: through the first through-hole and the second through-hole that set up, can make things convenient for the entering of magnetic bead.

As a further aspect of the present invention: the adjustable cover is characterized in that an adjusting ring is arranged on the outer side of the movable top cover, an adjusting plate is slidably connected to the inner portion of the adjusting ring, and the adjusting plate is fixedly connected with the rotating plate.

The advantages of adopting the further scheme are as follows: the adjusting plate is pushed to enable the rotating plate to rotate to enable the second through hole to be far away from the first through hole, and sealing of the inside of the reagent tube can be achieved.

As a further aspect of the present invention: the gear at the position of the motor is a driving wheel, the gear in the other bottom box is a driven wheel, and the side walls, which are tightly attached to each other, of the two adjacent bottom boxes are provided with meshing ports for the two adjacent gears to be in contact and meshed.

The advantages of adopting the further scheme are as follows: through the gear that sets up, can with other the inside gear engagement of end box to can drive a plurality of end boxes when starter motor and rotate, thereby improve work efficiency.

As a further aspect of the present invention: the inside lateral wall fixedly connected with of reagent pipe assists the stirring board, one side of end box and the both sides of another end box all are provided with strong magnetic plate, mutual actuation is connected between the strong magnetic plate.

The advantages of adopting the further scheme are as follows: through the strong magnetic plate that sets up, can make and adsorb each other between a plurality of end boxes, break away from each other between two end boxes when avoiding rotating.

As a further aspect of the present invention: the outside fixedly connected with second limiting plate of bull stick, the second limiting plate rotates to be connected in the top of end box, bull stick fixed connection puts in the central point of gear, the bottom fixedly connected with lantern ring of activity top cap, the inside of the lantern ring is provided with the sealing ring.

The advantages of adopting the further scheme are as follows: through the lantern ring and the sealing ring that set up, can seal the mouth of pipe of reagent pipe, prevent that the bacterium from getting into.

Compared with the prior art, the beneficial effects of the utility model are that:

1. the bottom boxes can be meshed with other gears in the bottom boxes through the arranged gears, so that the bottom boxes can be driven to rotate while the motor is started, the working efficiency is improved, the bottom boxes can be adsorbed mutually through the arranged strong magnetic plate, the two bottom boxes are prevented from being separated from each other during rotation, magnetic beads can conveniently enter through the arranged first through hole and the second through hole, the rotating plate is rotated through pushing the adjusting plate, and the second through hole is far away from the first through hole to seal the inside of the reagent tube;

2. through the lantern ring and the sealing ring that set up, can seal the mouth of pipe of reagent pipe, prevent that the bacterium from getting into, through spacing hole and the first limiting plate that sets up, can fix the inside at the end storehouse with the disk to drive reagent pipe wholly when rotating the bull stick and rotate, through the supplementary stirring board that sets up, can make the suspension to the inside of reagent pipe carry out certain passive stirring at reagent pipe round trip to rotate.

Drawings

FIG. 1 is a schematic diagram of a front view of an immunomagnetic bead detection kit;

FIG. 2 is a schematic view of the internal structure of the immunomagnetic bead assay kit in a front view;

FIG. 3 is a schematic diagram of a top view of an immunomagnetic bead assay kit;

FIG. 4 is a schematic view of the bottom connection structure of the bottom case in the immunomagnetic bead detection kit;

FIG. 5 is an enlarged schematic view of the structure A in the immunomagnetic bead detection kit;

in the figure: 1. a movable top cover; 2. a reagent tube; 3. a bottom case; 4. a chute; 5. a fixing plate; 6. a first through hole; 7. rotating the plate; 8. a second through hole; 9. an auxiliary stirring plate; 10. a collar; 11. a seal ring; 12. a bottom bin; 13. a first limit plate; 14. a limiting hole; 15. a magnetic disk; 16. a rotating rod; 17. a second limiting plate; 18. a motor; 19. a gear; 20. an engagement port; 21. a ferromagnetic plate; 22. an adjusting ring; 23. an adjusting plate; 24. and (5) a box body.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Referring to fig. 1-5, in an embodiment of the present invention, an immunomagnetic bead detection kit includes a movable top cap 1, a reagent tube 2 is disposed below the movable top cap 1, a bottom case 3 is disposed below the reagent tube 2, a chute 4 is disposed inside the movable top cap 1, a fixing plate 5 is disposed below the chute 4, a first through hole 6 is disposed inside the fixing plate 5, a rotating plate 7 is disposed below the fixing plate 5, a second through hole 8 is disposed on the rotating plate 7, the rotating plate 7 is rotatably connected to the inside of the movable top cap 1, a case body 24 is sleeved outside the reagent tube 2, the bottom of the case body 24 is connected to the top of the bottom case 3, a bottom case 12 is disposed at the bottom of the reagent tube 2, a magnetic disk 15 is disposed inside the bottom case 12, four limiting holes 14 are disposed on a side wall of the magnetic disk 15, a first limiting plate 13 is inserted into the limiting holes 14, the magnetic disk 15 can be fixed inside the bottom case, thereby it is whole rotatory to drive reagent pipe 2 when rotating bull stick 16, the lateral wall fixed connection of first limiting plate 13 and end storehouse 12, the bottom fixedly connected with bull stick 16 of magnetic disc 15, the bottom of bull stick 16 and the output fixed connection of motor 18, motor 18 is located the inside of end box 3, motor 18 runs through the roof of end box 3, and the inside of end box 3 is provided with gear 19, gear 19 and bull stick 16 fixed connection, the curb plate that one side of gear 19 runs through end box 3 is connected with the inside gear 19 meshing of another end box 3, can mesh with the inside gear 19 of other end box 3, thereby can drive a plurality of end boxes 3 and rotate when starting motor 18, thereby improve work efficiency.

Preferably, activity top cap 1, chute 4 and fixed plate 5 structure as an organic whole, first through-hole 6 and second through-hole 8 all keep away from fixed plate 5 and change the central point of board 7 and put and change and can make first through-hole 6 and second through-hole 8 intercommunication after board 7 rotates an angle, and second through-hole 8 equals with the size of first through-hole 6, can make things convenient for the entering of magnetic bead.

Preferably, adjustable ring 22 has been seted up in the outside of activity top cap 1, and adjustable ring 22's inside sliding connection has regulating plate 23, and regulating plate 23 and commentaries on classics board 7 fixed connection promote regulating plate 23 and make commentaries on classics board 7 rotate to make second through-hole 8 keep away from first through-hole 6 and realize the inside sealed of reagent pipe 2.

Preferably, the gear 19 at the position of the motor 18 is a driving gear, the gear 19 inside the other bottom case 3 is a driven gear, and the side wall of the two adjacent bottom cases 3 which are close to each other is provided with an engagement opening 20 for the two adjacent gears 19 to contact and engage.

Preferably, the supplementary stirring board 9 of inside lateral wall fixedly connected with of reagent pipe 2, one side of end box 3 and the both sides of another end box 3 all are provided with strong magnetic plate 21, and mutual actuation is connected between strong magnetic plate 21, can make and adsorb each other between a plurality of end boxes 3, breaks away from each other between two end boxes 3 when avoiding rotating.

Preferably, the outside fixedly connected with second limiting plate 17 of bull stick 16, second limiting plate 17 rotate to be connected in the top of end box 3, and bull stick 16 fixed connection puts in gear 19's central point, and the bottom fixedly connected with lantern ring 10 of activity top cap 1, the inside of lantern ring 10 are provided with sealing ring 11, can seal the mouth of pipe of reagent pipe 2, prevent that the bacterium from getting into.

The utility model discloses a theory of operation is: when the device is used, cell suspension is poured into the reagent tube 2, the movable top cover 1 is covered subsequently, the lantern ring 10 and the sealing ring 11 at the bottom of the movable top cover 1 can wrap the tube opening, so that the tube opening of the reagent tube 2 is sealed, bacteria are prevented from entering the reagent tube, the first limiting plate 13 inside the bottom bin 12 is inserted into the limiting hole 14 on the surface of the bottom bin 12, the rotating rod 16 is rotated through the starting motor 18, so that the reagent tube 2 is positioned in the box body 24 to rotate, the rotating rod 16 can drive the gears 19 meshed with each other to rotate when rotating, the strong magnetic plates 21 at two sides of the bottom bin 3 can enable the bottom bins 3 to be mutually adsorbed, the rotating plate 7 can be rotated through rotating the adjusting plate 23, the rotating plate 7 can enable the first through hole 6 to be communicated with the second through hole 8, so that the through holes communicated with the first through hole 6 and the second through hole 8 can be poured into magnetic beads to continue stirring, thereby the magnetic beads are fully contacted with the suspension and the magnetic field formed by the magnetic disc 15 can adsorb the magnetic beads to the bottom.

Although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.

Claims

1. The utility model provides an immunomagnetic bead detect reagent box, includes activity top cap (1), its characterized in that: a reagent tube (2) is arranged below the movable top cover (1), a bottom box (3) is arranged below the reagent tube (2), a chute (4) is arranged inside the movable top cover (1), a fixing plate (5) is arranged below the chute (4), a first through hole (6) is formed inside the fixing plate (5), a rotating plate (7) is arranged below the fixing plate (5), a second through hole (8) is formed in the rotating plate (7), the rotating plate (7) is positioned inside the movable top cover (1) and is rotatably connected with the movable top cover, a box body (24) is sleeved outside the reagent tube (2), the bottom of the box body (24) is connected with the top of the bottom box (3), a bottom bin (12) is arranged at the bottom of the reagent tube (2), a magnetic disk (15) is arranged inside the bottom bin (12), and four limit holes (14) are formed in the side wall of the magnetic disk (15), the inside of spacing hole (14) is inserted and is closed and be connected with first limiting plate (13), the lateral wall fixed connection of first limiting plate (13) and end storehouse (12), bottom fixedly connected with bull stick (16) of disk (15), the bottom of bull stick (16) and the output fixed connection of motor (18), motor (18) are located the inside of end box (3), motor (18) run through the roof of end box (3), just the inside of end box (3) is provided with gear (19), gear (19) and bull stick (16) fixed connection, one side of gear (19) is run through the curb plate and another of end box (3) the inside gear (19) meshing of end box (3) is connected.

2. The immunomagnetic bead detection kit of claim 1, wherein: the movable top cover (1), the chute (4) and the fixed plate (5) are of an integral structure, the first through hole (6) and the second through hole (8) are far away from the center positions of the fixed plate (5) and the rotating plate (7), the rotating plate (7) rotates by an angle, then the first through hole (6) is communicated with the second through hole (8), and the second through hole (8) is equal to the first through hole (6) in size.

3. The immunomagnetic bead detection kit of claim 1, wherein: adjusting ring (22) have been seted up in the outside of activity top cap (1), the inside sliding connection of adjusting ring (22) has regulating plate (23), regulating plate (23) and commentaries on classics board (7) fixed connection.

4. The immunomagnetic bead detection kit of claim 1, wherein: the gear (19) at the position of the motor (18) is a driving wheel, the gear (19) in the other bottom box (3) is a driven wheel, and the side walls of the two adjacent bottom boxes (3) which are tightly attached to each other are provided with meshing openings (20) for the two adjacent gears (19) to be in contact and meshed.

5. The immunomagnetic bead detection kit of claim 1, wherein: the inside lateral wall fixedly connected with of reagent pipe (2) assists stirring board (9), one side of end box (3) and the both sides of another end box (3) all are provided with strong magnetic plate (21), mutual actuation is connected between strong magnetic plate (21).

6. The immunomagnetic bead detection kit of claim 1, wherein: the outside fixedly connected with second limiting plate (17) of bull stick (16), second limiting plate (17) rotate to be connected in the top of end box (3), bull stick (16) fixed connection puts in the central point of gear (19), the bottom fixedly connected with lantern ring (10) of activity top cap (1), the inside of lantern ring (10) is provided with sealing ring (11).