CN213491226U - Exosome storage bottle and atomizer of NK cell secretion - Google Patents
Exosome storage bottle and atomizer of NK cell secretion Download PDFInfo
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- CN213491226U CN213491226U CN202021206706.0U CN202021206706U CN213491226U CN 213491226 U CN213491226 U CN 213491226U CN 202021206706 U CN202021206706 U CN 202021206706U CN 213491226 U CN213491226 U CN 213491226U
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Abstract
An exosome storage bottle and an atomizer secreted by NK cells relate to the technical field of exosome atomization. The utility model provides a current atomizer have operating procedure many when carrying out the secretion body dilution of NK cell secretion and move the liquid, cause the waste of medical supplies such as secretion body storage bottle easily to and cause secondary pollution's problem. The utility model discloses a spraying bottleneck is seted up on NK cell secreted exosome atomizer body upper portion, the atomising head sets up spraying bottleneck department on the atomizer body, the spraying bottleneck is seted up down to atomizer body lower part, the internal diameter of atomizer body equals with the external diameter of exosome storage body, circle in the atomizer body lower part is equipped with the second internal thread with the first screw-thread fit of exosome storage body, atomizer body and exosome storage body threaded connection, the external diameter of atomizer body equals with the bellied external diameter of first annular of exosome storage body. The utility model is used for the storage and the spraying of the secreted exosome of NK cell.
Description
Technical Field
The utility model relates to an exosome spraying technical field, concretely relates to exosome storage bottle and atomizer of NK cell secretion.
Background
Exosomes (Exosomes) are membrane vesicles freely secreted by most cells, about 30-200nm in diameter, with a buoyant density in sucrose gradients between 1.10-1.21g/ml, predominantly of phospholipid bilayer structure. Exosomes occur naturally in body fluids, including blood, saliva, urine, cerebrospinal fluid, and breast milk, among others. Exosomes have important functions in different disease pathogenesis. In recent years, exosomes have been the focus of research, and related literature and declaration projects have exploded and promoted the clinical transformation of the technology. It is best to extract the exosomes with higher bioactivity. However, since the technology and environment for exosome separation and purification are strict, the practical operation is difficult to achieve, and in order to improve the working efficiency, exosome freeze-dried powder or exosome suspension (containing cell factors) is generally stored at low temperature, for example, short-term storage at 4 ℃ or long-term storage at-80 ℃. The exosome secreted by NK cells can be directly sprayed to throat, tonsil, vocal cord and the like of a patient for diagnosis and treatment through a sprayer after being uniformly mixed with interferon, and has better clinical effect. The existing sprayers are generally of two types, one sprayer comprises a spraying head and a spraying bottle body, and the spraying medicine solution can be sprayed into a nozzle by pressing a manual button on the spraying head. However, this kind of sprayer needs to dilute the exosome lyophilized powder or exosome suspension (including cytokine) through the syringe and then fill in the sprayer in the form of solution, and it is easy to cause secondary pollution in the exosome lyophilized powder or exosome suspension (including cytokine) dilution and filling process, and the syringe and exosome storage bottle that are used can not be used again, easily causes waste. Another sprayer is a spray bottle with medicine mixing function, and the spray bottle has the advantages of no secondary pollution. But the defects are that the spray head and the spray bottle body are disposable and need to be treated as medical garbage after being used, which is easy to cause waste.
In summary, the conventional nebulizer has many operation steps when diluting and pipetting exosomes secreted by NK cells, and is prone to waste of medical materials such as exosome storage bottles and cause secondary pollution.
SUMMERY OF THE UTILITY MODEL
The utility model aims at solving current atomizer and having operating procedure many when carrying out the secretion body dilution of NK cell secretion and move the liquid, cause the waste of medical supplies such as secretion body storage bottle easily to and cause secondary pollution's problem, and then provide a secretion body storage bottle and atomizer of NK cell secretion.
The technical scheme of the utility model is that:
an NK cell secreted exosome storage bottle comprises an exosome storage bottle body 11 and an exosome storage bottle cap 12, the exosome storage bottle body 11 is of a hollow cylindrical structure, a storage bottle opening 111 is formed in the upper portion of the exosome storage bottle body 11, a first external thread 112 is arranged on the outer circle of the upper portion of the exosome storage bottle body 11, a first annular bulge is radially and outwards extended from the lower portion of the outer cylindrical surface of the exosome storage bottle body 11, the exosome storage bottle cap 12 is of a hollow cylindrical structure, a storage cap opening 121 is formed in the lower portion of the exosome storage bottle cap 12, the inner diameter of the exosome storage bottle cap 12 is equal to the outer diameter of the exosome storage bottle body 11, a first internal thread 122 matched with the first external thread 112 of the exosome storage bottle body 11 is formed in the lower portion of the exosome storage bottle cap 12, the exosome storage bottle cap 12 is in threaded connection with the exosome storage bottle body 11, the outer diameter of the exosome storing bottle cap 12 is equal to the outer diameter of the first annular bulge of the exosome storing bottle body 11.
Further, the secretion body storage bottle of NK cell secretion still includes first O type sealing washer 13, and the upper cover plate lower surface that the secretion body stored bottle lid 12 is equipped with the first ring channel 123 that corresponds with the storage bottleneck 111 of secretion body storage body 11, and first O type sealing washer 13 is installed in first ring channel 123, and secretion body storage bottle lid 12 is through first O type sealing washer 13 and the sealed cooperation of secretion body storage body 11.
An NK cell secretion exosome sprayer comprises a sprayer body 21, spray head 22 and exosome storage body 11, atomizer body 21 is hollow cylindrical structure, atomizer body 21 upper portion is seted up and is gone up spraying bottleneck 211, atomizer body 21 upper portion excircle be equipped with spray head 22 complex second external screw thread 212, spray head 22 sets up the last spraying bottleneck 211 department at atomizer body 21, spray head 22 and atomizer body 21 threaded connection, atomizer body 21 lower part is opened and is established spraying bottleneck 213 down, the internal diameter of atomizer body 21 equals with exosome storage body 11's external diameter, be equipped with the second internal thread 214 with exosome storage body 11's first external screw thread 112 complex in atomizer body 21 lower part, atomizer body 21 and exosome storage body 11 threaded connection, the external diameter of atomizer body 21 equals with exosome storage body 11's the bellied external diameter of first annular.
Further, the exosome nebulizer secreted by NK cells further comprises a second O-ring seal 23, a second annular protrusion 215 radially extends inwards from the lower portion of the inner cylindrical surface of the nebulizer body 21, a second annular groove 216 corresponding to the storage bottle opening 111 of the exosome storage body 11 is formed in the lower surface of the second annular protrusion 215, the second O-ring seal 23 is installed in the second annular groove 216, and the nebulizer body 21 is in sealing fit with the exosome storage body 11 through the second O-ring seal 23.
Further, the spray head 22 comprises an exosome spray bottle cap 221, a spray pump device 222, a pressing head 223, a lengthening nozzle 224, a nozzle sleeve 225 and a liquid guiding pipe 226, the exosome spray bottle cap 221 is of a hollow cylindrical structure, a spray cap opening 2211 is formed in the lower portion of the exosome spray bottle cap 221, a third internal thread 2212 matched with the second external thread 212 of the nebulizer bottle body 21 is arranged on the inner circle of the lower portion of the exosome spray bottle cap 221, the exosome spray bottle cap 221 is spirally installed on the upper spray bottle opening 211 of the nebulizer bottle body 21, an upper cover plate of the exosome spray bottle cap 221 axially extends upwards to form a cylindrical pump chamber upper cavity 2213, a circular hole is formed in a top plate of the pump chamber upper cavity 2213, an internal thread is arranged on the inner circle lower portion of the pump chamber upper cavity 2213, the spray pump device 222 is spirally installed on the pump chamber upper cavity 2213, a pressing sliding sleeve 2214 is coaxially sleeved outside the pump chamber upper cavity 2213, the pressing head 223, the press head 223 is internally provided with a liquid inlet channel 2231, the liquid outlet end of the spray pump device 222 is communicated with the liquid inlet channel 2231 of the press head 223, the liquid inlet end of the spray pump device 222 is connected with the upper end of the liquid guide pipe 226, the press head 223 is provided with a lengthening nozzle 224, the end part of the lengthening nozzle 224 is provided with a liquid spray opening 2241, the lengthening nozzle 224 is internally provided with a liquid spray channel 2242 communicated with the liquid spray opening 2241 and the liquid inlet channel 2231, and the end part of the lengthening nozzle 224 is sleeved with a nozzle sleeve 225.
Further, the spray pump device 222 includes a cylindrical pump chamber lower cavity 2221, an upper pump rod 2222, an upper compression spring 2223, a suction plug 2224, a lower pump rod 2225, a lower compression spring 2226 and a pump ball 2227, wherein the upper portion of the outer cylindrical surface of the cylindrical pump chamber lower cavity 2221 is provided with a pump chamber external thread matched with the pump chamber internal thread, the cylindrical pump chamber lower cavity 2221 is connected with the pump chamber upper cavity 2213 by a screw thread to form a pump chamber, the lower end of the cylindrical pump chamber lower cavity 2221 extends downwards along the axial direction to form a hollow cylindrical protrusion, an annular step is arranged inside the hollow cylindrical protrusion, the aperture of the annular step is smaller than the diameter of the pump ball 2227, the pump ball 2227 is arranged inside the hollow cylindrical protrusion, the lower compression spring 2226 is vertically arranged inside the hollow cylindrical protrusion, the upper end of the upper pump rod 2222 is inserted into a circular hole in the top plate of the pump chamber upper cavity 2213 and is arranged at the lower end of the liquid inlet channel 2231 of the, the suction plug 2224 is sleeved on the lower portion of the upper pump rod 2222, the outer cylindrical surface of the suction plug 2224 is connected with the inner cylindrical surface of the pump chamber in a sliding and sealing manner, the upper compression spring 2223 is arranged on the upper pump rod 2222 between the suction plug 2224 and the upper limiting projection, a round hole is formed in the bottom of the upper pump rod 2222, the upper end of the lower pump rod 2225 is inserted into the upper pump rod 2222, the lower limiting projection is arranged in the middle of the lower pump rod 2225, the lower end of the lower pump rod 2225 is inserted into the lower compression spring 2226, and the lower end face of the lower limiting projection abuts against the upper end of the lower compression spring 2226.
Compared with the prior art, the utility model has the following effect:
1. the utility model discloses a secreted exosome storage bottle of NK cell is used for the storage of exosome freeze-dried powder or exosome suspension (containing cell factor), secreted exosome atomizer of NK cell is used for the spraying of exosome freeze-dried powder or exosome suspension (containing cell factor), exosome storage bottle body can respectively with exosome storage bottle lid and atomizer body threaded connection, when using exosome, only need to store the exosome freeze-dried powder or exosome suspension (containing cell factor) exosome storage bottle take out the back from the refrigerator, with exosome storage bottle body from exosome storage bottle lid screw down, adorn exosome storage bottle body spiral again in aseptic atomizer body lower part, the waste of exosome storage bottle body has been avoided. Injecting a certain amount of interferon and normal saline into the bottle from the spraying bottle mouth at the upper part of the sprayer bottle body, finally screwing the spraying head on the sterile sprayer bottle body, and shaking the exosome sprayer by hand when in use, thus realizing dilution of exosome freeze-dried powder or exosome suspension (containing cell factors). The utility model discloses saved the step that moves the liquid, avoided secondary pollution, practiced thrift medical matters such as syringes that move the liquid in-process and use in the past simultaneously, the utility model discloses a but sprayer body and atomising head used repeatedly after disinfecting, disinfecting has reduced medical cost, has improved work efficiency.
2. The utility model discloses a secreted exosome storage bottle of NK cell and exosome atomizer simple structure, convenient operation has better commonality.
Drawings
FIG. 1 is a schematic structural diagram of an exosome storage bottle secreted by NK cells of the present invention;
fig. 2 is a schematic structural view of the exosome storage bottle cap of the present invention;
FIG. 3 is a schematic structural view of the exosome storage bottle body of the present invention;
FIG. 4 is a schematic diagram of the construction of the NK cell secreting exosome nebulizer of the present invention;
FIG. 5 is a schematic structural view of the sprayer body of the present invention;
fig. 6 is a schematic structural view of the button of the present invention;
fig. 7 is a schematic structural view of the exosome spray bottle cap of the present invention;
fig. 8 is a schematic structural view of the spray pump device of the present invention.
Detailed Description
The first embodiment is as follows: the present embodiment is described with reference to fig. 1 to 3, and the NK cell secreted exosome storage bottle of the present embodiment includes an exosome storage bottle body 11 and an exosome storage bottle cap 12, the exosome storage bottle body 11 is of a hollow cylindrical structure, a storage bottle opening 111 is formed in an upper portion of the exosome storage bottle body 11, a first external thread 112 is formed in an outer circumference of an upper portion of the exosome storage bottle body 11, a first annular protrusion is radially outwardly extended from a lower portion of the outer circumference of the exosome storage bottle body 11, the exosome storage bottle cap 12 is of a hollow cylindrical structure, a storage cap opening 121 is formed in a lower portion of the exosome storage bottle cap 12, an inner diameter of the exosome storage bottle cap 12 is equal to an outer diameter of the exosome storage bottle body 11, a first internal thread 122 matched with the first external thread 112 of the exosome storage bottle body 11 is formed in an inner circumference of a lower portion of the exosome storage bottle cap 12, bottle lid 12 is stored to the exosome and exosome stores body 11 threaded connection, and the external diameter that exosome stored bottle lid 12 equals with the bellied external diameter of first annular of exosome storage body 11.
The second embodiment is as follows: the embodiment is described with reference to fig. 1 to 3, the secretion body storage bottle secreted by NK cells of the embodiment further includes a first O-ring 13, a first annular groove 123 corresponding to the storage bottle opening 111 of the secretion body storage bottle body 11 is disposed on a lower surface of an upper cover plate of the secretion body storage bottle cap 12, the first O-ring 13 is installed in the first annular groove 123, and the secretion body storage bottle cap 12 is in sealing fit with the secretion body storage bottle body 11 through the first O-ring 13. Other components and connections are the same as in the first embodiment.
The third concrete implementation mode: the present embodiment is described with reference to fig. 3 to 8, and the NK cell secreted exosome nebulizer of the present embodiment includes a nebulizer body 21, a nebulizing head 22 and an exosome storage body 11, the nebulizer body 21 is of a hollow cylindrical structure, an upper nebulizer bottle opening 211 is opened at the upper portion of the nebulizer body 21, a second external thread 212 matched with the nebulizing head 22 is arranged at the outer circumference of the upper portion of the nebulizer body 21, the nebulizing head 22 is arranged at the upper nebulizer bottle opening 211 of the nebulizer body 21, the nebulizing head 22 is in threaded connection with the nebulizer body 21, a lower nebulizer bottle opening 213 is opened at the lower portion of the nebulizer body 21, the inner diameter of the nebulizer body 21 is equal to the outer diameter of the exosome storage body 11, a second internal thread 214 matched with the first external thread 112 of the exosome storage body 11 is arranged at the inner circumference of the lower portion of the nebulizer body 21, the nebulizer body 21 is in threaded connection with the exosome storage body 11, the outer diameter of the sprayer body 21 is equal to the outer diameter of the first annular projection of the exosome-storing body 11. Other compositions and connections are the same as in the first or second embodiments.
The fourth concrete implementation mode: referring to fig. 4 and 5, the present embodiment is described, the exosome nebulizer secreted by NK cells of the present embodiment further includes a second O-ring seal 23, a second annular protrusion 215 extends radially inward from a lower portion of the inner cylindrical surface of the nebulizer body 21, a second annular groove 216 corresponding to the storage bottle opening 111 of the exosome storage body 11 is disposed on a lower surface of the second annular protrusion 215, the second O-ring seal 23 is mounted in the second annular groove 216, and the nebulizer body 21 is in sealing fit with the exosome storage body 11 through the second O-ring seal 23. Other compositions and connection relationships are the same as in the first, second or third embodiment.
The fifth concrete implementation mode: the present embodiment is described with reference to fig. 4 to 8, the spray head 22 of the present embodiment includes an exosome spray bottle cap 221, a spray pump device 222, a press head 223, an extension nozzle 224, a nozzle sleeve 225 and a liquid guiding tube 226, the exosome spray bottle cap 221 is a hollow cylindrical structure, a spray cap opening 2211 is formed at the lower part of the exosome spray bottle cap 221, a third internal thread 2212 matched with the second external thread 212 of the nebulizer body 21 is formed in the inner circle of the lower part of the exosome spray bottle cap 221, the exosome spray bottle cap 221 is spirally mounted at the upper spray bottle opening 211 of the nebulizer body 21, an upper cover plate of the exosome spray bottle cap 221 axially extends upward to form a cylindrical pump chamber upper cavity 2213, a circular hole is formed in a top plate of the pump chamber upper cavity 2213, a pump chamber internal thread is formed in the lower part of the inner cylindrical surface of the pump chamber 2213, the spray pump device 222 is spirally mounted on the pump chamber upper cavity 2213, a pressing sliding sleeve 2214 is, the press head 223 is slidably mounted inside the press sliding sleeve 2214, a liquid inlet channel 2231 is arranged inside the press head 223, the liquid outlet end of the spray pump device 222 is communicated with the liquid inlet channel 2231 of the press head 223, the liquid inlet end of the spray pump device 222 is connected with the upper end of the liquid guide pipe 226, an extension nozzle 224 is arranged on the press head 223, a liquid spray opening 2241 is arranged at the end part of the extension nozzle 224, a liquid spray channel 2242 which is used for being communicated with the liquid spray opening 2241 and the liquid inlet channel 2231 is arranged inside the extension nozzle 224, and a nozzle sleeve 225 is sleeved at the end part of the extension nozzle 224. So set up, atomising head 22 is used for realizing the spraying of exosome solution, and the design of 224 is chewed in the extension can directly spout medicine solution in the inside affected part position in patient's oral cavity, can not cause the waste of medicine solution. Other compositions and connection relationships are the same as those in the first, second, third or fourth embodiment.
The sixth specific implementation mode: referring to fig. 4 to 8, the present embodiment will be described, and the spray pump device 222 of the present embodiment includes a cylindrical pump chamber lower cavity 2221, an upper pump rod 2222, an upper compression spring 2223, a suction plug 2224, a lower pump rod 2225, a lower compression spring 2226, and a pump ball 2227, wherein an upper portion of an outer cylindrical surface of the cylindrical pump chamber lower cavity 2221 is provided with a pump chamber external thread matching with the pump chamber internal thread, the cylindrical pump chamber lower cavity 2221 is connected with the pump chamber upper cavity 2213 by a thread to form a pump chamber, a lower end of the cylindrical pump chamber lower cavity 2221 extends axially downward to form a hollow cylindrical protrusion having an annular step therein, a diameter of the annular step is smaller than a diameter of the pump ball 2227, the pump ball 2227 is disposed inside the hollow cylindrical protrusion, the lower compression spring 2226 is vertically disposed inside the hollow cylindrical protrusion, an upper end of the upper pump rod 2222 penetrates a circular hole of the pump chamber upper cavity 2213 and is inserted into a lower end of a liquid inlet passage, the middle of the upper pump rod 2222 is provided with an upper limit projection, the suction plug 2224 is sleeved on the lower portion of the upper pump rod 2222, the outer cylindrical surface of the suction plug 2224 is connected with the inner cylindrical surface of the pump chamber in a sliding and sealing manner, the upper pump rod 2222 between the suction plug 2224 and the upper limit projection is provided with an upper compression spring 2223, the bottom of the upper pump rod 2222 is provided with a round hole, the upper end of the lower pump rod 2225 is inserted into the upper pump rod 2222, the middle of the lower pump rod 2225 is provided with a lower limit projection, the lower end of the lower pump rod 2225 is inserted into the lower compression spring 2226, and the lower end surface of the lower limit projection is abutted against the upper end of. Other compositions and connection relationships are the same as in the first, second, third, fourth or fifth embodiment.
Principle of operation
The working principle of the present invention is explained with reference to fig. 1 to 8:
storage of exosomes: firstly, the exosome storage bottle is disinfected and sterilized, exosome freeze-dried powder or exosome suspension liquid (containing cell factors) secreted by separated and purified NK cells is filled into the exosome storage bottle body 11 according to parts, then the exosome storage bottle cap 12 is spirally installed on the exosome storage bottle body 11, and the exosome storage bottle body 11 is hermetically connected with the exosome storage bottle cap 12 through the first O-shaped sealing ring 13. And finally, putting an exosome storage bottle filled with exosome freeze-dried powder or exosome suspension (containing cell factors) secreted by NK cells into a refrigerated cabinet at 4 ℃ for refrigeration for standby application, and generally storing the exosome freeze-dried powder or the exosome suspension for one week.
Spraying of exosome (now prepared for use): firstly, disinfect to the exosome atomizer, take out the exosome storage bottle who is equipped with the exosome freeze-dried powder or exosome suspension (including cytokine) of NK cell secretion from the freezer, with exosome storage body 11 from exosome storage bottle lid 12 spiral-down, again with exosome storage body 11 spiral-wound dress at atomizer body 21, second O type sealing washer 23 has realized the sealing connection between exosome storage body 11 and atomizer body 21. A certain amount of interferon and normal saline are injected into the combined body of the exosome storage bottle body 11 and the atomizer bottle body 21, the atomizing head 22 is finally screwed on the atomizer bottle body 21, the exosome atomizer is shaken by hands before use, uniform mixing can be realized, and atomizing is realized by pressing the pressing head 223.
Claims (6)
1. An exosome storage bottle secreted by NK cells, characterized in that: the secretion body storage bottle for NK cell secretion comprises a secretion body storage bottle body (11) and a secretion body storage bottle cap (12), wherein the secretion body storage bottle body (11) is of a hollow cylindrical structure, a storage bottle opening (111) is formed in the upper portion of the secretion body storage bottle body (11), a first external thread (112) is arranged on the outer circle of the upper portion of the secretion body storage bottle body (11), a first annular bulge is radially and outwards extended from the lower portion of the outer cylindrical surface of the secretion body storage bottle body (11), the secretion body storage bottle cap (12) is of a hollow cylindrical structure, a storage cap opening (121) is formed in the lower portion of the secretion body storage bottle cap (12), the inner diameter of the secretion body storage bottle cap (12) is equal to the outer diameter of the secretion body storage bottle body (11), a first internal thread (122) matched with the first external thread (112) of the secretion body storage bottle body (11) is arranged in the lower portion of the secretion body storage bottle cap (12), and the secretion body storage bottle cap (12) is in threaded connection with the secretion body storage bottle body (11), the outer diameter of the exosome storage bottle cap (12) is equal to the outer diameter of the first annular bulge of the exosome storage bottle body (11).
2. The NK cell secreting exosome storage bottle of claim 1, characterized in that: NK cell secreted exosome storage bottle still includes first O type sealing washer (13), and the upper cover plate lower surface of exosome storage bottle lid (12) is equipped with first ring channel (123) that correspond with storage bottleneck (111) of exosome storage bottle body (11), and install in first ring channel (123) first O type sealing washer (13), and exosome storage bottle lid (12) are through first O type sealing washer (13) and exosome storage bottle body (11) sealed cooperation.
3. A nebulizer based on the NK cell secreting exosome storage bottle of claim 2, characterized in that: the exosome sprayer for NK cell secretion comprises a sprayer body (21), a spray head (22) and an exosome storage body (11), the sprayer body (21) is of a hollow cylindrical structure, an upper spraying bottle mouth (211) is formed in the upper portion of the sprayer body (21), a second external thread (212) matched with the spray head (22) is arranged on the outer circle of the upper portion of the sprayer body (21), the spray head (22) is arranged at the upper spraying bottle mouth (211) of the sprayer body (21), the spray head (22) is in threaded connection with the sprayer body (21), a lower spraying bottle mouth (213) is formed in the lower portion of the sprayer body (21), the inner diameter of the sprayer body (21) is equal to the outer diameter of the exosome storage body (11), a second internal thread (214) matched with the first external thread (112) of the exosome storage body (11) is formed in the inner circle of the lower portion of the sprayer body (21), the sprayer bottle body (21) is in threaded connection with the exosome storage bottle body (11), and the outer diameter of the sprayer bottle body (21) is equal to that of the first annular bulge of the exosome storage bottle body (11).
4. The NK cell secreting exosome nebulizer according to claim 3, characterized in that: the secretion body sprayer for NK cells further comprises a second O-shaped sealing ring (23), a second annular protrusion (215) radially and inwardly extends from the lower portion of the inner cylindrical surface of the sprayer body (21), a second annular groove (216) corresponding to the storage bottle opening (111) of the secretion body storage body (11) is formed in the lower surface of the second annular protrusion (215), the second O-shaped sealing ring (23) is installed in the second annular groove (216), and the sprayer body (21) is in sealing fit with the secretion body storage body (11) through the second O-shaped sealing ring (23).
5. The NK cell secreting exosome nebulizer according to claim 4, characterized in that: the spray head (22) comprises an exosome spray bottle cap (221), a spray pump device (222), a press head (223), a lengthened nozzle (224), a nozzle sleeve (225) and a liquid guiding pipe (226), the exosome spray bottle cap (221) is of a hollow cylindrical structure, a spray cap opening (2211) is formed in the lower portion of the exosome spray bottle cap (221), a third internal thread (2212) matched with a second external thread (212) of the nebulizer bottle body (21) is arranged in the inner portion of the exosome spray bottle cap (221), the exosome spray bottle cap (221) is spirally mounted at the upper spray bottle opening (211) of the nebulizer bottle body (21), an upper cover plate of the exosome spray bottle cap (221) axially extends upwards to form a cylindrical pump chamber upper cavity (2213), a circular hole is formed in a top plate of the pump chamber upper cavity (2213), a pump chamber internal thread is formed in the lower portion of the inner cylindrical surface of the pump chamber (2213) of the pump chamber, and the spray pump device (222) is spirally mounted on the pump, the pressing sliding sleeve (2214) is coaxially sleeved outside the upper cavity (2213) of the pump chamber, the pressing head (223) is slidably mounted inside the pressing sliding sleeve (2214), the liquid inlet channel (2231) is arranged inside the pressing head (223), the liquid outlet end of the spray pump device (222) is communicated with the liquid inlet channel (2231) of the pressing head (223), the liquid inlet end of the spray pump device (222) is connected with the upper end of the liquid guiding pipe (226), the lengthening nozzle (224) is arranged on the pressing head (223), the liquid spraying port (2241) is formed in the end of the lengthening nozzle (224), the liquid spraying channel (2242) communicated with the liquid spraying port (2241) and the liquid inlet channel (2231) is formed in the inside of the lengthening nozzle (224), and the nozzle sleeve (225) is sleeved at the end of the lengthening nozzle (224).
6. The NK cell secreting exosome nebulizer according to claim 5, characterized in that: the spray pump device (222) comprises a cylindrical pump chamber lower cavity (2221), an upper pump rod (2222), an upper compression spring (2223), a suction plug (2224), a lower pump rod (2225), a lower compression spring (2226) and a pump ball (2227), wherein the upper part of the outer cylindrical surface of the cylindrical pump chamber lower cavity (2221) is provided with a pump chamber external thread matched with the pump chamber internal thread, the cylindrical pump chamber lower cavity (2221) is in threaded connection with the pump chamber upper cavity (2213) to form a pump chamber, the lower end of the cylindrical pump chamber lower cavity (2221) axially and downwards extends to form a hollow cylindrical protrusion, the hollow cylindrical protrusion is internally provided with an annular step, the aperture of the annular step is smaller than the diameter of the pump ball (2227), the pump ball (2227) is arranged inside the hollow cylindrical protrusion, the lower compression spring (2226) is vertically arranged inside the hollow cylindrical protrusion, the upper end of the upper pump rod (2222) penetrates through a round hole in the top plate of the pump chamber upper cavity (2213) and is inserted into the lower end of, the middle of the upper pump rod (2222) is provided with an upper limiting convex block, the suction plug (2224) is sleeved on the lower portion of the upper pump rod (2222), the outer cylindrical surface of the suction plug (2224) is connected with the inner cylindrical surface of the pump chamber in a sliding and sealing manner, the upper pump rod (2222) between the suction plug (2224) and the upper limiting convex block is provided with an upper compression spring (2223), the bottom of the upper pump rod (2222) is provided with a round hole, the upper end of the lower pump rod (2225) is inserted into the upper pump rod (2222), the middle of the lower pump rod (2225) is provided with a lower limiting convex block, the lower end of the lower pump rod (2225) is inserted into the lower compression spring (2226), and the lower end face of the lower limiting convex block is abutted against the upper end of the.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021206706.0U CN213491226U (en) | 2020-06-24 | 2020-06-24 | Exosome storage bottle and atomizer of NK cell secretion |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021206706.0U CN213491226U (en) | 2020-06-24 | 2020-06-24 | Exosome storage bottle and atomizer of NK cell secretion |
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| CN213491226U true CN213491226U (en) | 2021-06-22 |
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| CN202021206706.0U Active CN213491226U (en) | 2020-06-24 | 2020-06-24 | Exosome storage bottle and atomizer of NK cell secretion |
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2020
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