CN213474017U

CN213474017U - Kit for individualized MRD detection of acute lymphocytic leukemia

Info

Publication number: CN213474017U
Application number: CN202022574063.1U
Authority: CN
Inventors: 张超; 李娜
Original assignee: Yantai Derui Biological Technology Co ltd
Current assignee: Yantai Derui Biological Technology Co ltd
Priority date: 2020-11-10
Filing date: 2020-11-10
Publication date: 2021-06-18
Anticipated expiration: 2030-11-10

Abstract

The utility model belongs to the kit field, concretely relates to a kit for acute lymphoblastic leukemia individuation MRD detects, comprises a box bod, sliding connection has the backup pad in the box body, the spout has been seted up to the inner wall of box body, be provided with the slider in the backup pad, sliding connection has the slider in the spout, the lower extreme of backup pad bonds and has the bracing piece, the lower extreme of bracing piece is provided with the closing plate, the bleeder vent has been seted up on the closing plate, the lower extreme of box body bonds and has the sleeve. The utility model discloses a set up the sleeve at the box body lower extreme, set up the spring in the sleeve, when the lid was closed, the clamp plate made the bracing piece pass through the closing plate with spring compression, opened the lid when taking out, spring reset for reagent pipe is convenient for take out, and through set up the bleeder vent on the closing plate, makes closing plate lower extreme admission speed receive the restriction, avoids raising the speed and leads to reagent pipe to pop out from the holding tank at the excessive speed.

Description

Kit for individualized MRD detection of acute lymphocytic leukemia

Technical Field

The utility model relates to a kit technical field specifically is a kit that is used for individualized MRD of acute lymphocytic leukemia to detect.

Background

Leukemia is a malignant tumor inhibiting normal hematopoietic system function due to malignant clonal proliferation of hematopoietic stem cells, is characterized by high heterogeneity, and comprises multiple subtypes, wherein the main four subtypes are acute lymphocytic leukemia, acute myelogenous leukemia, chronic lymphocytic leukemia and chronic myelogenous leukemia. Acute lymphoblastic leukemia mainly originates from B-line or T-line lymphoid progenitor cells, and leukemia cells abnormally proliferate and aggregate in bone marrow, so that the pathogenesis and pathogenesis of the acute lymphoblastic leukemia are not completely clear. Acute lymphoblastic leukemia is treated actively and effectively, and part of patients can be cured. Clinical evaluation of patients with acute lymphoblastic leukemia divided into different risk groups, after complete remission from treatment, < 5% of the leukemia cells could not be detected by conventional morphological methods (peripheral blood smears, bone marrow biopsies), but a small amount of leukemia cells remained in the patients, i.e. minimal residual cancer cell foci (MRD). Several early clinical trials have established that minimal residual cancer cell foci are associated with a high degree of prognosis during early leukemia therapy, reflecting the chemosensitivity of leukemia, and that MRD levels are an important indicator for assessing patients' signs of relapse. The detection of MRD is an internationally recognized indicator of the prognosis of ALL, the selection of treatment regimens, the assessment of the efficacy of treatment and the prediction of cancer recurrence. The current MRD detection methods include 3 detection methods, namely flow cytometry, RT-PCR-based leukemia related fusion gene quantification and RT-PCR-based IG/TCR gene rearrangement quantification.

At present, the many uses acute lymphoblastic leukemia individuation MRD detect reagent box detects the patient's condition, but in prior art, is arranged in the reagent box that acute lymphoblastic leukemia individuation MRD detected reagent pipe to get in the reagent box and puts the trouble, uses inconveniently, and simultaneously, the reagent box lid is fixed insecurely, when the reagent box drops, can make the lid pine take off, and the damage is fallen out to inside reagent pipe. Accordingly, there is a need for improvements in the art.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a kit for acute lymphoblastic leukemia individuation MRD detects, has solved the reagent pipe and has got in the kit and put trouble problem, has still solved the fixed not firm problem of lid.

In order to achieve the above object, the utility model provides a following technical scheme: a kit for acute lymphoblastic leukemia individualized MRD detection comprises a kit body, wherein a supporting plate is connected in the kit body in a sliding manner, a sliding groove is formed in the inner wall of the kit body, a sliding block is arranged on the supporting plate, a sliding block is connected in the sliding groove in a sliding manner, a supporting rod is bonded at the lower end of the supporting plate, a sealing plate is arranged at the lower end of the supporting rod, an air hole is formed in the sealing plate, a sleeve is bonded at the lower end of the kit body, the sealing plate is sleeved in the sleeve in a sliding manner, a spring is arranged in the sleeve, a foam block is bonded at the upper end of the supporting plate, a containing groove is formed in the upper end of the foam block, a reagent tube is sleeved in the containing groove in a sliding manner, a box cover is hinged at the upper end of the, the left end of lid articulates there is the connecting block, the right-hand member of connecting block is provided with the fixture block, the draw-in groove has been seted up to the box body left end, sliding sleeve has the fixture block in the draw-in groove, the left end of box body is provided with the supporting shoe, sliding sleeve has the spacer pin in the supporting shoe, the spacing groove has been seted up to the lower extreme of connecting block, sliding connection has the spacer pin in the spacing groove.

Preferably, there are four sliding chutes, and the four sliding chutes are symmetrically distributed on the inner sides of the left end and the right end of the box body.

Preferably, the number of the air holes is two, and the two air holes are symmetrically distributed on the sealing plate.

Preferably, one end of the spring is in contact connection with the sealing plate, and the other end of the spring is in contact connection with the box body.

Preferably, the lower end of the box cover is bonded with a rubber pad, and the lower end of the rubber pad is in contact connection with the box body.

Preferably, the outer side of the limit pin is provided with a convex ring, an annular groove is formed in the supporting block, and the convex ring is connected in the annular groove in a sliding manner.

Compared with the prior art, the beneficial effects of the utility model are as follows:

1. the utility model discloses a set up the sleeve at the box body lower extreme, set up the spring in the sleeve, when the lid was closed, the clamp plate made the bracing piece pass through the closing plate with spring compression, opened the lid when taking out, spring reset for reagent pipe is convenient for take out, and through set up the bleeder vent on the closing plate, makes closing plate lower extreme admission speed receive the restriction, avoids raising the speed and leads to reagent pipe to pop out from the holding tank at the excessive speed.

2. The utility model discloses a set up the supporting shoe at the box body left end, set up the spacer pin in the supporting shoe, through spacer pin and spacing groove cooperation for the connecting block is fixed more firm, and then makes the connection between box body and the lid more firm, and the lid is opened when avoiding the kit to drop, makes the reagent pipe in the box body fall out the damage.

Drawings

FIG. 1 is a schematic structural view of the present invention;

FIG. 2 is a top view of the cartridge of FIG. 1 according to the present invention;

FIG. 3 is an enlarged view of the point A of FIG. 1 according to the present invention;

fig. 4 is an enlarged view of the point B in fig. 1 according to the present invention.

In the figure: 1. a box body; 2. a support plate; 3. a chute; 4. a slider; 5. a support bar; 6. a sealing plate; 7. air holes are formed; 8. a sleeve; 9. a spring; 10. a foam block; 11. a containing groove; 12. a reagent tube; 13. a box cover; 14. a pressure spring; 15. pressing a plate; 16. a rubber pad; 17. connecting blocks; 18. a card slot; 19. a clamping block; 20. a support block; 21. a spacing pin; 22. a limiting groove; 23. a convex ring; 24. an annular groove.

Detailed Description

The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

Examples

Referring to fig. 1-4, a kit for acute lymphoblastic leukemia individualized MRD detection comprises a box body 1, a supporting plate 2 is slidably connected in the box body 1, a chute 3 is formed in the inner wall of the box body 1, a slider 4 is arranged on the supporting plate 2, a slider 4 is slidably connected in the chute 3, a supporting rod 5 is bonded at the lower end of the supporting plate 2, a sealing plate 6 is arranged at the lower end of the supporting rod 5, an air vent 7 is formed in the sealing plate 6, a sleeve 8 is bonded at the lower end of the box body 1, the sealing plate 6 is slidably sleeved in the sleeve 8, a spring 9 is arranged in the sleeve 8, a foam block 10 is bonded at the upper end of the supporting plate 2, a containing groove 11 is formed at the upper end of the foam block 10, a reagent tube 12 is slidably sleeved in the containing groove 11, a box cover 13 is hinged, the lower extreme contact of clamp plate 15 is connected with reagent pipe 12, the left end of lid 13 articulates there is connecting block 17, the right-hand member of connecting block 17 is provided with fixture block 19, draw-in groove 18 has been seted up to 1 left end of box body, sliding sleeve has in draw-in groove 18 had fixture block 19, the left end of box body 1 is provided with supporting shoe 20, sliding sleeve has spacing pin 21 in supporting shoe 20, spacing groove 22 has been seted up to the lower extreme of connecting block 17, sliding connection has spacing pin 21 in spacing groove 22.

Referring to fig. 2, there are four sliding chutes 3, and the four sliding chutes 3 are symmetrically distributed at the inner sides of the left and right ends of the box body 1. Through setting up a plurality of spouts 3, can connect a plurality of sliders 4 and support backup pad 2 for the lift of backup pad 2 is more stable.

Referring to fig. 3, there are two air holes 7, and the two air holes 7 are symmetrically distributed on the sealing plate 6. Air at the lower end of the sealing plate 6 can be exhausted by arranging the air holes 7.

Referring to fig. 3, one end of the spring 9 is connected to the sealing plate 6, and the other end of the spring 9 is connected to the case 1. The supporting rod 5 can automatically ascend by arranging the spring 9.

Referring to fig. 1, a rubber pad 16 is adhered to the lower end of the box cover 13, and the lower end of the rubber pad 16 is connected to the box body 1 in a contact manner. The rubber pad 16 is arranged to increase the sealing performance between the box body 1 and the box cover 13.

Referring to fig. 4, a convex ring 23 is disposed outside the limit pin 21, an annular groove 24 is disposed in the support block 20, and the convex ring 23 is slidably connected in the annular groove 24. The limit pin 21 is fixed in the supporting block 20 by arranging the convex ring 23 to be matched with the annular groove 24.

The utility model discloses the concrete implementation process as follows: when the reagent box is used, the reagent tube 12 is placed into the containing groove 11, the box cover 13 is closed, the pressing plate 15 moves downwards to enable the reagent tube 12 to move downwards, the reagent tube 12 drives the foam block 10 to move downwards, the foam block 10 drives the supporting plate 2 to move, the supporting plate 2 drives the supporting rod 5 to move, the supporting rod 5 drives the sealing plate 6 to move, the sealing plate 6 moves to enable the supporting rod 5 to compress the spring 9, after the box cover 13 is closed, the measuring clamping block 19 is inserted into the clamping groove 18, the supporting block 20 is arranged at the left end of the box body 1, the limiting pin 21 is arranged in the supporting block 20, the connecting block 17 is fixed more stably through the matching of the limiting pin 21 and the limiting groove 22, the connection between the box body 1 and the box cover 13 is further more stable, the box cover 13 is prevented from being opened when the reagent box falls off, the reagent tube 12 in the, so that the reagent tube 12 is convenient to take out, and the air inlet speed at the lower end of the sealing plate 6 is limited by arranging the air holes 7 on the sealing plate 6, and the reagent tube 12 is prevented from popping out of the accommodating groove 11 due to the fact that the rising speed is too high.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A kit for individualized MRD detection of acute lymphoblastic leukemia, comprising a cartridge (1), characterized in that: the reagent box is characterized in that a supporting plate (2) is connected in the box body (1) in a sliding manner, a sliding groove (3) is formed in the inner wall of the box body (1), a sliding block (4) is arranged on the supporting plate (2), the sliding block (4) is connected in the sliding groove (3) in a sliding manner, a supporting rod (5) is bonded at the lower end of the supporting plate (2), a sealing plate (6) is arranged at the lower end of the supporting rod (5), air holes (7) are formed in the sealing plate (6), a sleeve (8) is bonded at the lower end of the box body (1), the sealing plate (6) is sleeved in the sleeve (8) in a sliding manner, a spring (9) is arranged in the sleeve (8), a foam block (10) is bonded at the upper end of the supporting plate (2), a containing groove (11) is formed in the upper end of the foam block (, the lower extreme of lid (13) bonds and has pressure spring (14), the lower extreme of pressure spring (14) bonds and has clamp plate (15), the lower extreme contact connection of clamp plate (15) has reagent pipe (12), the left end of lid (13) articulates there is connecting block (17), the right-hand member of connecting block (17) is provided with fixture block (19), draw-in groove (18) have been seted up to box body (1) left end, sliding sleeve has fixture block (19) in draw-in groove (18), the left end of box body (1) is provided with supporting shoe (20), sliding sleeve has spacer pin (21) in supporting shoe (20), spacing groove (22) have been seted up to the lower extreme of connecting block (17), sliding connection has spacer pin (21) in spacing groove (22).

2. The kit for individualized MRD detection in acute lymphoblastic leukemia according to claim 1, characterized in that: the number of the sliding grooves (3) is four, and the four sliding grooves (3) are symmetrically distributed on the inner sides of the left end and the right end of the box body (1).

3. The kit for individualized MRD detection in acute lymphoblastic leukemia according to claim 1, characterized in that: the number of the air holes (7) is two, and the two air holes (7) are symmetrically distributed on the sealing plate (6).

4. The kit for individualized MRD detection in acute lymphoblastic leukemia according to claim 1, characterized in that: one end of the spring (9) is in contact connection with the sealing plate (6), and the other end of the spring (9) is in contact connection with the box body (1).

5. The kit for individualized MRD detection in acute lymphoblastic leukemia according to claim 1, characterized in that: the lower end of the box cover (13) is bonded with a rubber pad (16), and the lower end of the rubber pad (16) is connected with the box body (1) in a contact manner.

6. The kit for individualized MRD detection in acute lymphoblastic leukemia according to claim 1, characterized in that: the outer side of the limiting pin (21) is provided with a convex ring (23), an annular groove (24) is formed in the supporting block (20), and the convex ring (23) is connected in the annular groove (24) in a sliding mode.