CN213266450U - Exosome centrifugal processor - Google Patents
Exosome centrifugal processor Download PDFInfo
- Publication number
- CN213266450U CN213266450U CN202021565354.8U CN202021565354U CN213266450U CN 213266450 U CN213266450 U CN 213266450U CN 202021565354 U CN202021565354 U CN 202021565354U CN 213266450 U CN213266450 U CN 213266450U
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- fixedly connected
- exosome
- shaped plate
- gears
- universal joints
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- 210000001808 exosome Anatomy 0.000 title claims abstract description 25
- 238000012360 testing method Methods 0.000 abstract description 5
- 238000005119 centrifugation Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 230000033115 angiogenesis Effects 0.000 description 1
- 230000005809 anti-tumor immunity Effects 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 230000023402 cell communication Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 108091070501 miRNA Proteins 0.000 description 1
- 239000002679 microRNA Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- -1 ultrafiltration Substances 0.000 description 1
Images
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- Centrifugal Separators (AREA)
Abstract
The utility model discloses an exosome centrifugal processor, including the box, characterized by: the utility model relates to a biological equipment field, specifically say, relate to an exosome centrifugal processor, lower side fixed connection U-shaped plate two riser lower extremes in the box, U-shaped plate diaphragm upside fixed connection ring gear downside, U-shaped plate diaphragm downside middle part fixed connection motor, the utility model relates to a biological equipment field specifically says. The device can realize the rotation of the two round boxes under the driving of the two gears and the universal joint when the two round boxes rotate by taking the rotating rod as the circle center, so that the exosome in the test tube is more thoroughly centrifuged.
Description
Technical Field
The utility model relates to a biological equipment field, specifically say, relate to an exosome centrifugal processor.
Background
The exosome carries a large number of specific proteins (such as cytokines and growth factors) and functional bioactive substances such as mRNAs and miRNAs, participates in physiological processes such as cell communication, cell migration, angiogenesis promotion, anti-tumor immunity and the like in vivo, and is closely related to the occurrence and the process of various diseases. Due to the special structure and function of the exosome, the exosome has potential application value, can be used as a biological index for diagnosing various diseases on one hand, can also be used as a treatment means on the other hand, and can be possibly used as a natural carrier of a medicament for clinical treatment in the future. The separation and purification of exosomes are always the concerns of researchers, and the acquisition of high-purity exosomes is of great importance to the subsequent research. At present people adopt methods such as ultracentrifugation, immunomagnetic bead, ultrafiltration, sediment or kit to realize the extraction separation of exosome more, because exosome nature form is extremely viscous, traditional centrifugation mode is mostly put into the exosome to the box to a root axis is the centre of a circle high-speed rotation and is centrifuged, but this kind of method centrifugal speed is slower, and work efficiency is lower, so urgently need in the preparation of an exosome centrifugal processor.
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is to provide an exosome centrifugal processor for exosome centrifugation.
The utility model adopts the following technical scheme to realize the purpose of the invention:
the utility model provides an exosome centrifugal processor, includes the box, characterized by: the lower side in the box body is fixedly connected with the lower ends of two vertical plates of a U-shaped plate;
the upper side of the first transverse plate of the U-shaped plate is fixedly connected with the lower side of the gear ring, and the middle part of the lower side of the first transverse plate of the U-shaped plate is fixedly connected with the motor;
the output end of the motor penetrates through the first U-shaped plate, the upper end of the output end of the motor is fixedly connected with the lower end of the rotating rod, and the upper end of the rotating rod is fixedly connected with the middle part of the lower side of the second transverse plate of the U-shaped plate;
two ends of the upper side of the gear ring are respectively meshed with the lower sides of the corresponding gears, one ends of the two gear central shafts are respectively in bearing connection and penetrate through the lower parts of the two vertical plates of the U-shaped plate, one ends of the two gear central shafts are respectively and fixedly connected with one ends of the corresponding universal joints, and the other ends of the two universal joints are respectively and fixedly connected with the middle parts of the upper sides of the corresponding end covers;
the upper ends of the two round boxes are respectively in threaded connection with the corresponding end covers, and the lower sides in the two round boxes are respectively fixedly connected with the lower ends of a group of uniformly distributed cylinders.
As a further limitation of the present technical solution, both the universal joints are cross-shaped universal joints.
As a further limitation of the technical scheme, the inner walls of the two groups of cylinders are coated with rubber layers.
Compared with the prior art, the utility model discloses an advantage is with positive effect:
1. the device can realize the rotation of the two round boxes under the driving of the two gears and the universal joint when the two round boxes rotate by taking the rotating rod as the circle center, so that the exosome in the test tube is more thoroughly centrifuged.
2. The device can realize the simultaneous centrifugal operation of exosomes in two groups of test tubes, and improves the working efficiency.
3. The device has compact structure and convenient operation.
Drawings
Fig. 1 is a schematic view of a three-dimensional structure of the present invention.
Fig. 2 is a schematic view of a three-dimensional structure of the present invention.
Fig. 3 is a schematic three-dimensional structure diagram of the present invention.
Fig. 4 is a schematic view of a connection structure of parts according to the present invention.
Fig. 5 is a schematic view of a connection structure of parts according to the present invention.
Fig. 6 is a third schematic view of the connection structure of some parts of the present invention.
In the figure: 1. the device comprises a box body, 2, U-shaped plates II, 3, a universal joint, 4, an end cover, 5, a gear ring, 6, a round box, 7, a rotating rod, 8, a cylinder, 9, U-shaped plates I, 10, a gear, 11 and a motor.
Detailed Description
In the following, an embodiment of the present invention will be described in detail with reference to the drawings, but it should be understood that the scope of the present invention is not limited by the embodiment.
As shown in fig. 1-6, the utility model comprises a box body 1, wherein the lower side in the box body 1 is fixedly connected with the lower ends of two vertical plates of a U-shaped plate I9;
the upper side of the transverse plate of the U-shaped plate I9 is fixedly connected with the lower side of the gear ring 5, and the middle part of the lower side of the transverse plate of the U-shaped plate I9 is fixedly connected with a motor 11;
the output end of the motor 11 penetrates through the first U-shaped plate 9, the upper end of the output end of the motor 11 is fixedly connected with the lower end of the rotating rod 7, and the upper end of the rotating rod 7 is fixedly connected with the middle part of the lower side of the transverse plate of the second U-shaped plate 2;
two ends of the upper side of the gear ring 5 are respectively meshed with the lower sides of the corresponding gears 10, one ends of central shafts of the two gears 10 are respectively in bearing connection and penetrate through the lower parts of vertical plates of the U-shaped plates 2, one ends of the central shafts of the two gears 10 are respectively and fixedly connected with one ends of the corresponding universal joints 3, and the other ends of the two universal joints 3 are respectively and fixedly connected with the middle parts of the upper sides of the corresponding end covers 4;
the upper ends of the two round boxes 6 are respectively in threaded connection with the corresponding end covers 4, and the lower sides of the two round boxes 6 are respectively fixedly connected with the lower ends of a group of uniformly distributed cylinders 8.
The two universal joints 3 are both cross-shaped universal joints.
The inner walls of the two groups of cylinders 8 are coated with rubber layers.
The utility model discloses a work flow does: before using, the two end covers 4 are in a state of being parallel to the bottom plate of the box body 1 under the influence of self gravity, as shown in figure 1, when the device is used, the pipe bodies provided with exosomes are respectively inserted into the corresponding cylinders 8, one end cover 4 is stirred, one round box 6 is screwed on the corresponding end cover 4, the other round box 6 is screwed on the other end cover 4, due to the self gravity of the two round boxes 6, before starting, the lower sides of the two round boxes 6 are in a parallel state with the bottom plate of the box body 1, as shown in figure 2, a motor 11 is started, the motor 11 drives a U-shaped rod 2 to rotate by taking the rotating rod 7 as the center of a circle through the rotating rod 7, the U-shaped rod 2 drives the corresponding round box 6 to rotate by taking the rotating rod 7 as the center of a circle through two gears 10 and the universal joint 3, when the two round boxes 6 rotate, the two round boxes 6 drive one end of the corresponding universal joint 3 to swing through the influence, make two circle casees 6 tend to the level, as shown in fig. 3, simultaneously, two gears 10 are driven along the ring gear 5 slip of meshing with it to U-shaped pole two 2, two gears 10 are along the gliding rotation in the ring gear 5, two gears 10 drive the rotation of corresponding circle case 6 through corresponding universal joint 3, two circle cases 6 drive a set of drum 8 that corresponds and use bull stick 7 as the rotatory rotation in the centre of a circle, it is more thorough to make the exosome centrifugation in two sets of drum 8, after the centrifugation is ended, stop motor 11, unscrew two circle cases 6, take out every test tube respectively, put into new test tube, the operation process is the same, no longer describe, after using, stop motor 11.
The above disclosure is only one specific embodiment of the present invention, however, the present invention is not limited thereto, and any changes that can be considered by those skilled in the art should fall within the protection scope of the present invention.
Claims (3)
1. The utility model provides an exosome centrifugal processor, includes box (1), characterized by: the lower side in the box body (1) is fixedly connected with the lower ends of two vertical plates of a U-shaped plate I (9);
the upper side of the transverse plate of the U-shaped plate I (9) is fixedly connected with the lower side of the gear ring (5), and the middle part of the lower side of the transverse plate of the U-shaped plate I (9) is fixedly connected with a motor (11);
the output end of the motor (11) penetrates through the first U-shaped plate (9), the upper end of the output end of the motor (11) is fixedly connected with the lower end of the rotating rod (7), and the upper end of the rotating rod (7) is fixedly connected with the middle part of the lower side of the transverse plate of the second U-shaped plate (2);
the two ends of the upper side of the gear ring (5) are respectively meshed with the lower sides of the corresponding gears (10), one ends of central shafts of the two gears (10) are respectively in bearing connection and penetrate through the lower parts of vertical plates of the U-shaped plates (2), one ends of the central shafts of the two gears (10) are respectively and fixedly connected with one ends of corresponding universal joints (3), and the other ends of the two universal joints (3) are respectively and fixedly connected with the middle parts of the upper sides of the corresponding end covers (4);
the upper ends of the two round boxes (6) are respectively in threaded connection with the corresponding end covers (4), and the lower sides of the two round boxes (6) are respectively fixedly connected with the lower ends of a group of uniformly arranged cylinders (8).
2. An exosome centrifugal processor according to claim 1, characterised by: the two universal joints (3) are both cross-shaped universal joints.
3. An exosome centrifugal processor according to claim 2, characterised by: the inner walls of the two groups of cylinders (8) are coated with rubber layers.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021565354.8U CN213266450U (en) | 2020-07-31 | 2020-07-31 | Exosome centrifugal processor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021565354.8U CN213266450U (en) | 2020-07-31 | 2020-07-31 | Exosome centrifugal processor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN213266450U true CN213266450U (en) | 2021-05-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021565354.8U Active CN213266450U (en) | 2020-07-31 | 2020-07-31 | Exosome centrifugal processor |
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| CN (1) | CN213266450U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113731650A (en) * | 2021-09-08 | 2021-12-03 | 深圳市森盈生物科技有限公司 | Integrated centrifugal system and method for full-automatic sheet making machine |
-
2020
- 2020-07-31 CN CN202021565354.8U patent/CN213266450U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113731650A (en) * | 2021-09-08 | 2021-12-03 | 深圳市森盈生物科技有限公司 | Integrated centrifugal system and method for full-automatic sheet making machine |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20211129 Address after: 250102 room 2502, 25 / F, building a, Jinan pharmaceutical Valley R & D platform area, No. 1, north section of Gangxing Third Road, comprehensive free trade zone, Jinan area, China (Shandong) pilot Free Trade Zone, Jinan City, Shandong Province Patentee after: Shandong Jiekai Biotechnology Co.,Ltd. Address before: Room 1202, qiaomengyuan, gangxingsan Road, high tech Zone, Jinan City, Shandong Province Patentee before: Zhao Kai |
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| TR01 | Transfer of patent right |