CN213217845U

CN213217845U - Fixing device for assisting micro-injection in rat brain

Info

Publication number: CN213217845U
Application number: CN202020707930.1U
Authority: CN
Inventors: 席凯文; 边慧; 陈德多
Original assignee: Kunming Medical University
Current assignee: Kunming Medical University
Priority date: 2020-04-30
Filing date: 2020-04-30
Publication date: 2021-05-18
Anticipated expiration: 2030-04-30

Abstract

The utility model discloses a fixing device for assisting micro-injection in rat brain, including a square fixed station (1), its characterized in that: a neck fixing block (2) is arranged in the middle of the fixing table (1), the neck fixing block (2) is in a half-open and half-closed type consisting of an upper pressing block (21) and a lower pressing block (22), and semicircular upper grooves (211) and semicircular lower grooves (221) are symmetrically arranged in the centers of the upper pressing block (21) and the lower pressing block (22); a sliding block (3) is arranged in the front center of the neck fixing block (2), and a T-shaped fixing rod (4) is connected to the sliding block (3); the four-limb fixing belt (5) is symmetrically arranged on two sides of the rear portion of the neck fixing block (2), the device is simple in structure, convenient to operate and good in fixing effect, and the experiment efficiency is improved.

Description

Fixing device for assisting micro-injection in rat brain

Technical Field

The utility model relates to the technical field of medical experimental equipment, especially, relate to a fixing device for assisting microinjection in rat brain.

Background

Rat brain indwelling tube administration is a common method in neuroscience research, and the method is to inject some drugs which cannot pass through a blood brain barrier into a specific nucleus pulposus or ventricle and then carry out animal experimental research. During the experiment, the projection position of the nuclear mass on the skull bone surface is determined by the brain stereotaxic apparatus to embed the tube, and the ethological experiment is carried out by injecting micro-drugs after the tube is fixedly embedded. The common micro-injection method at present is to fix the neck of a rat by the left hand, open a catheter cap by the right hand, insert an injection needle into a catheter and inject medicine. In the administration process, because the rat is in an active state and the diameter of the catheter is small, the injection needle is not easy to insert into the catheter, and the operation of two persons is usually needed, so that the time and the labor are wasted. Meanwhile, the dosage in the brain is small, so that the dosage is possibly inaccurate due to the shaking of the head of a rat in the administration process. In addition, rats may suddenly become agitated during the administration process and bite the experimenter.

SUMMERY OF THE UTILITY MODEL

In order to solve the problems and deficiencies of the prior art, the utility model provides a fixing device for assisting micro-injection in rat brain.

The following design structure and design scheme are specifically adopted:

a fixing device for assisting micro-injection in the brain of a rat comprises a square fixing table (1), wherein a neck fixing block (2) is arranged in the middle of the fixing table (1), the neck fixing block (2) is formed by an upper pressing block (21) and a lower pressing block (22) into a half-open and half-closed type, and semicircular upper grooves (211) and semicircular lower grooves (221) are symmetrically arranged in the centers of the upper pressing block (21) and the lower pressing block (22); a sliding block (3) is arranged in the front center of the neck fixing block (2), and a T-shaped fixing rod (4) is connected to the sliding block (3); four limb fixing belts (5) are symmetrically arranged at two sides of the back of the neck fixing block (2).

Preferably, one side of the upper pressing block (21) and one side of the lower pressing block (22) are fixed through hinges, and the other side of the upper pressing block and the lower pressing block are provided with fixing buckles (7).

Preferably, protective cotton can be arranged on the inner sides of the upper groove (211) and the lower groove (221).

Preferably, the sliding block (3) can slide back and forth in the first sliding groove (31), an inner circular hole (32) is formed in the center of the sliding block (3), and the fixing rod (4) is connected to the inner circular hole (32).

Preferably, a square hole (411) is formed in the middle of the transverse rod (41) of the fixing rod (4).

Preferably, the limb fixing belt (5) comprises a forelimb fixing belt (51) and a hindlimb fixing belt (52), and the forelimb fixing belt (51) and the hindlimb fixing belt (52) can slide back and forth in the second sliding groove (6).

Preferably, the forelimb fixing belt (51) and the hindlimb fixing belt (52) can be adjusted in length.

The working principle of the utility model is introduced as follows: the utility model discloses during the use, place rat belly down on fixed station (1), the rat neck is placed on neck fixed block (2), it is fixed through last briquetting (21) and lower briquetting (22), the four limbs of rat adopt forelimb fixed band (51) and hind limb fixed band (52) respectively to fix, can adjust the position of forelimb fixed band (51) and hind limb fixed band (52) according to the size of rat, and can adjust forelimb fixed band (51) and hind limb fixed band (52), it is firm to fix the four limbs of rat; the slide block (3) is adjusted according to the position of the head of the rat, and then the upper jaw incisor of the rat is hung in the square hole (411) on the fixed rod (4), so that the head of the rat is fixed, and then intracerebral microinjection is carried out.

Compared with the prior art, the utility model produced beneficial effect is: the utility model discloses a neck of the fixed rat of neck fixed block adopts the four limbs of the fixed rat of four limbs fixed band, and the preceding of fixed rat, hind limb fixed band can be according to the size adjusting position of rat to through the palace incisor tooth of the fixed rat of quad slit on the dead lever, thereby fix the rat head, the device is fixed effectual, convenient operation, has improved injection efficiency.

Drawings

Fig. 1 is a schematic structural view of the present invention;

fig. 2 is a schematic structural view of the four-limb fixing band of the present invention;

FIG. 3 is a schematic structural view of the slider of the present invention;

FIG. 4 is a diagram illustrating the usage of the present invention;

reference numerals: 1-a fixed table; 2-neck fixing block; 21-pressing a block; 211-upper groove; 22-pressing block; 221-lower groove; 3, a sliding block; 31 — a first runner; 32-inner circular hole; 4, fixing a rod; 41-transverse bar; 411-square hole; 5, fixing the limbs; 51-forelimb fixing belt; 52-hind limb fixation band; 6-a second chute; 7, fixing and buckling.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention will be described in detail with reference to the accompanying drawings. It should be understood that the description is intended to be illustrative only and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.

As shown in the accompanying drawings 1-3, a fixing device for assisting micro-injection in the brain of a rat comprises a square fixing table 1, a neck fixing block 2 is arranged in the middle of the fixing table 1, the neck fixing block 2 is formed by an upper pressing block 21 and a lower pressing block 22 and is in a half-open and half-closed type, and semicircular upper grooves 211 and semicircular lower grooves 221 are symmetrically arranged in the centers of the upper pressing block 21 and the lower pressing block 22; a sliding block 3 is arranged in the front center of the neck fixing block 2, and a T-shaped fixing rod 4 is connected to the sliding block 3; four limb fixing belts 5 are symmetrically arranged at two sides of the back of the neck fixing block 2.

Furthermore, one side of the upper pressing block 21 and the lower pressing block 22 is fixed through the loose-leaf, and the other side is provided with a fixing buckle 7.

Further, protective cotton may be disposed on the inner sides of the upper groove 211 and the lower groove 221.

Further, the sliding block 3 can slide back and forth in the first sliding groove 31, an inner circular hole 32 is formed in the center of the sliding block 3, and the fixing rod 4 is connected to the inner circular hole 32.

Further, a square hole 411 is formed in the middle of the transverse rod 41 of the fixing rod 4.

Further, the limb fixing strap 5 includes a front limb fixing strap 51 and a rear limb fixing strap 52, and the front limb fixing strap 51 and the rear limb fixing strap 52 are slidable back and forth in the second slide slot 6.

Further, both the forelimb securing straps 51 and the hindlimb securing straps 52 are adjustable in length.

Examples

As shown in the attached fig. 4, the fixing table 1 is firstly placed in a horizontal position, then the abdomen of the rat is placed on the fixing table 1 downwards, the neck of the rat is placed in the upper groove 211 and the lower groove 221, and is fixed by the upper pressing block 21 and the lower pressing block 22 and is fixed by the fixing buckle 7; then adjusting the positions of the forelimb fixing belt 51 and the hindlimb fixing belt 52 according to the body type of the rat, fixing the limbs of the rat by the forelimb fixing belt 51 and the hindlimb fixing belt 52 respectively, adjusting the lengths of the forelimb fixing belt 51 and the hindlimb fixing belt 52, and fixing the limbs of the rat firmly; finally, the position of the sliding block 3 is adjusted according to the body type of the rat, the upper jaw of the rat is aligned, the upper jaw cutting teeth of the rat are placed in the square holes 411 on the transverse rod 41 of the fixing rod 4, the head of the rat is fixed, and subsequent intracerebral microinjection of the rat is performed.

It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modification, equivalent replacement, improvement and the like made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention. Further, it is intended that the appended claims cover all such variations and modifications as fall within the scope and boundaries of the appended claims or the equivalents of such scope and boundaries.

Claims

1. A fixing device for assisting micro-injection in rat brain comprises a square fixing table (1), and is characterized in that: a neck fixing block (2) is arranged in the middle of the fixing table (1), the neck fixing block (2) is in a half-open and half-closed type consisting of an upper pressing block (21) and a lower pressing block (22), and semicircular upper grooves (211) and semicircular lower grooves (221) are symmetrically arranged in the centers of the upper pressing block (21) and the lower pressing block (22); a sliding block (3) is arranged in the front center of the neck fixing block (2), and a T-shaped fixing rod (4) is connected to the sliding block (3); four limb fixing belts (5) are symmetrically arranged at two sides of the back of the neck fixing block (2).

2. The fixing device for assisting in the intracerebral microinjection of rats according to claim 1, wherein: one side of the upper pressing block (21) and one side of the lower pressing block (22) are fixed through hinges, and the other side of the upper pressing block and the lower pressing block are provided with fixing buckles (7).

3. The fixing device for assisting in the intracerebral microinjection of rats according to claim 1, wherein: the inner sides of the upper groove (211) and the lower groove (221) can be provided with protective cotton.

4. The fixing device for assisting in the intracerebral microinjection of rats according to claim 1, wherein: the sliding block (3) can slide back and forth in the first sliding groove (31), an inner circular hole (32) is formed in the center of the sliding block (3), and the inner circular hole (32) is connected with the fixing rod (4).

5. The fixing device for assisting in the intracerebral microinjection of rats according to claim 1, wherein: a square hole (411) is formed in the middle of the transverse rod (41) of the fixing rod (4).

6. The fixing device for assisting in the intracerebral microinjection of rats according to claim 1, wherein: the limb fixing belt (5) comprises a forelimb fixing belt (51) and a hindlimb fixing belt (52), and the forelimb fixing belt (51) and the hindlimb fixing belt (52) can slide forwards and backwards in the second sliding groove (6).

7. The fixing device for assisting in the intracerebral microinjection of rats according to claim 6, wherein: the forelimb fixing belt (51) and the hindlimb fixing belt (52) can be adjusted in length.