CN212882338U

CN212882338U - Granulating, drying, granulating and total mixing integrated machine

Info

Publication number: CN212882338U
Application number: CN202020948432.6U
Authority: CN
Inventors: 刘旭海; 王谷洪; 周友华; 王熠璐; 费翼城; 钟志坚; 熊静; 朱明辉; 周潭水
Original assignee: Jiangzhong Pharmaceutical Co Ltd
Current assignee: Jiangzhong Pharmaceutical Co Ltd
Priority date: 2020-05-29
Filing date: 2020-05-29
Publication date: 2021-04-06
Anticipated expiration: 2030-05-29

Abstract

The utility model discloses a granulating, drying, granulating and total mixing integrated machine, which comprises an air inlet system, a granulator, a temporary storage tank, a near-infrared detection device, an exhaust system, a lifter and a vacuum pump; the air inlet system passes through the intake stack and is connected with the granulator, the granulator discharge gate of granulator passes through the ejection of compact pipeline and is connected with the granulator feed inlet of granulator, be equipped with the finished product discharge gate on the ejection of compact pipeline, through will including devices such as air inlet system, granulator, jar, near infrared detection device, exhaust system, lifting machine and vacuum pump make up into complete one set of equipment, can realize that solid preparation accomplishes in proper order in equipment and pelletizes, dry, whole grain and always mix a plurality of processes such as waiting, and the production process need not the outside material that shifts, and its production is reliable high-efficient.

Description

Granulating, drying, granulating and total mixing integrated machine

Technical Field

The utility model relates to a pharmaceutical production preparation technical field, in particular to dry whole grain of pelletization and total machine that mixes.

Background

The production of solid preparation usually includes mixing, wet granulation, drying, granule finishing, total mixing and other processes, the prior art generally adopts split arrangement and single machine operation for different processes, the different processes are completed in different production workshops, during production, materials are easy to pollute the production workshops and influence the health of workers in the process of process transfer, meanwhile, the quality of the materials is not guaranteed in the process of transfer, and is easy to be polluted by other dust and impurities, and the transfer process influences the production efficiency and increases the time cost of the workers, so that a new technical scheme is necessary to be provided to improve the production efficiency.

SUMMERY OF THE UTILITY MODEL

The utility model aims at providing an all-in-one of production processes such as sustainable pelletization, drying, whole grain and always mix of production solid preparation.

The above technical purpose of the present invention can be achieved by the following technical solutions:

a granulating, drying, granulating and total mixing integrated machine comprises an air inlet system, a granulator, a temporary storage tank, a near-infrared detection device, an exhaust system, a lifter and a vacuum pump, wherein the equipment is integrally arranged on a steel platform; the air inlet system is connected with a granulator through an air inlet pipeline, a granulating discharge port of the granulator is connected with a granulator feed port of the granulator through a granulator feed pipeline, a finished product discharge port is arranged on the granulator feed pipeline, the granulator is installed on a lifting machine through a stand column, an upper cavity of the granulator is connected with a vacuum pump through a vacuum pipeline, the temporary storage tank is installed at the bottom of the granulator, a discharge port of the temporary storage tank is connected with a granulator feed interface of the granulator through a granulating feed pipe, and a granulating exhaust hole at the top of the granulator is connected with an exhaust system through a granulating exhaust pipeline; the near infrared detection device is arranged on the inner cavity wall of the granulator, wherein near infrared spectroscopy (NIR) has the advantages of simplicity, rapidness, low cost, no pollution, nondestructive and multicomponent simultaneous determination of samples and the like, and is widely applied to industries such as food, petroleum, chemical industry, medicine and the like. The resultant frequency and the frequency multiplication absorption of the vibration frequency of the groups such as C-H, N-H, O-H, C = O and the like in the substance molecule just fall in a near infrared region, so that the near infrared technology is more suitable for analyzing the components which are directly or indirectly related to the groups, and a near infrared detection device monitors the moisture, the content, the particle size and the like of the particles on line in real time and controls the adjustment of parameters such as air volume, temperature, liquid spraying amount and the like of the granulator according to data feedback.

Preferably, the air inlet system includes air intake, coarse filter section, the cold section of table, well effect filter section, heating zone and high efficiency filter section in proper order, and is preferred, coarse filter section, well effect filter section and high efficiency filter section are inside all to install pressure monitoring devices, and the pressure value that measures through each filter section pressure monitoring devices feeds back the circumstances such as filter jam, damage warning, the tail end of high efficiency filter section passes through the pelletization air intake connection of intake stack with the granulator, and its temperature and humidity that get into air in the granulator realize through the cold section of table and heating zone, and is further, temperature and humidity sensor is installed to the inner chamber of granulator for the humiture of monitoring entering granulator inner chamber air.

Preferably, the exhaust system is provided with a cyclone separator, a water curtain dust collector, an air outlet and an exhaust fan in sequence from the tail end of the granulating exhaust pipeline.

Preferably, an air inlet silencer is installed on the air inlet pipeline, an air exhaust silencer is installed on the pipeline between the cyclone separator and the water curtain dust collector, and a silencer device is adopted, so that noise generated in the production process is effectively reduced.

Preferably, a spray nozzle for adding the adhesive is arranged at the top of the inner cavity of the granulator.

Preferably, the air exhaust fan adopts a variable frequency motor, and the rotating speed of the motor can be accurately controlled by adopting the variable frequency motor, so that the air quantity is controlled.

Preferably, the granulator adopts the boiling granulator, and the granulator has the function of exploding closely, when exploding in the equipment, closes into, the air outlet, utilizes equipment self intensity to make the explosion take place in the cavity, does not harm external equipment facility and personnel.

To sum up, this patent has following beneficial effect:

1. the device comprises an air inlet system, a granulator, a temporary storage tank, a near-infrared detection device, an exhaust system, a lifter, a vacuum pump and the like, which are combined into a complete set of equipment, so that the solid preparation can sequentially complete a plurality of procedures such as granulation, drying, granule finishing, total mixing and the like in the equipment, no external material transfer is needed in the production process, and the production is reliable and efficient;

2. the near-infrared detection device is adopted to monitor the moisture, the content, the particle size and the like of the particles on line in real time and control the adjustment of parameters such as air quantity, temperature, liquid spraying amount and the like of the granulator according to data feedback, so that the quality of the product can be effectively controlled in a closed loop manner, and the product does not need to be taken out in the detection process, so that the detection is convenient and simple;

3. negative pressure is generated in the inner cavities of the granulator and the granulator of the equipment through a vacuum pump and an exhaust fan, so that the functions of material conveying and circular conveying are achieved;

4. through setting up the air inlet muffler and the muffler of airing exhaust, effectively reduce the noise of equipment.

Drawings

Fig. 1 is a schematic view of the overall structure of the present invention;

fig. 2 is a schematic structural view of a part of the air intake system of the present invention;

FIG. 3 is a schematic structural view of the pelletizer part of the present invention;

FIG. 4 is a schematic view of the structure of the granulator and temporary storage tank of the present invention;

fig. 5 is a schematic structural view of the exhaust system part of the present invention;

in the figure, an air inlet 1, a coarse filtration section 2, a surface cooling section 3, a middle efficiency filtration section 4, a heating section 5, a high efficiency filtration section 6, an air inlet silencer 7, an air inlet pipeline 8, a granulation exhaust hole 9, a spray head 10, a granulator 11, a granulation feed hole 12, a temperature and humidity sensor 13, a granulation air inlet 14, a granulation discharge hole 15, a finished product discharge hole 16, a near infrared detection device 17, a granulator feed interface 18, a granulation feed pipe 19, a temporary storage tank discharge hole 20, a temporary storage tank 21, a temporary storage tank feed inlet 22, a granulator discharge hole 23, a granulator 24, a granulator feed pipeline 25, a granulator cache cavity 26, a granulator feed inlet 27, a column 28, a lifting machine 29, a steel platform 30, a vacuum pump 31, a pipeline 32, a fan 33, a vacuum exhaust outlet 34, a water curtain dust remover 35, an exhaust silencer 36, a cyclone separator 37 and an exhaust pipeline 38 for granulation.

Detailed Description

The patent is described in further detail below with reference to the accompanying drawings.

As shown in fig. 1, fig. 3 and fig. 4, a granulating, drying, granulating and total mixing integrated machine comprises an air inlet system, a granulator 11, a granulator 25, a temporary storage tank 21, a near infrared detection device 17, an exhaust system, a lifter 29 and a vacuum pump 31, wherein the equipment is integrally installed on a steel platform 30; the air inlet system is connected with a granulator 11 through an air inlet pipeline 8, a granulating discharge port 15 of the granulator 11 is connected with a granulator feed port 27 of a granulator 24 through a granulator feed pipeline 25, a finished product discharge port 16 is arranged on the granulator feed pipeline 25, the granulator 24 is installed on a lifting machine 29 through an upright post 28, an upper cavity of the granulator 24 is connected with a vacuum pump 31 through a vacuum pipeline 32, a temporary storage tank 21 is installed at the bottom of the granulator 24, a granulator discharge port 23 at the bottom of the granulator 24 is communicated with a temporary storage tank feed port 22 at the top of the temporary storage tank 21, a temporary storage tank discharge port 20 is connected with a granulator feed interface 18 of the granulator 11 through a granulating feed pipe 19, and a granulating exhaust hole 9 at the top of the granulator 11 is connected with an exhaust system through a granulating exhaust pipeline 38; the near-infrared detection device 17 is installed on the inner cavity wall of the granulator 11, wherein the near-infrared detection device 17 monitors the moisture, the content, the particle size and the like of the particles on line in real time and controls the air volume, the temperature, the liquid spraying amount and other parameters of the granulator to adjust according to data feedback.

As shown in fig. 2, the air inlet system sequentially includes an air inlet 1, a coarse filter section 2, a surface cooling section 3, a middle filter section 4, a heating section 5 and a high efficiency filter section 6, preferably, pressure monitoring devices are installed inside the coarse filter section 2, the middle filter section 4 and the high efficiency filter section 6, and the pressure values measured by the pressure monitoring devices of the filter sections feed back the conditions of filter blockage, damage alarm and the like, the tail end of the high efficiency filter section 6 is connected with a granulating air inlet 14 of the granulator 11 through an air inlet pipeline 8, the temperature and humidity of air entering the granulator 11 are realized through the surface cooling section 3 and the heating section 5, and further, a temperature and humidity sensor 13 is installed in an inner cavity of the granulator 11 and is used for monitoring the temperature and humidity of the air entering the inner cavity of the granulator 11.

As shown in fig. 5, the exhaust system is provided with a cyclone separator 37, a water curtain dust collector 35, an exhaust outlet 34 and an exhaust fan 33 in sequence from the end of a granulation exhaust duct 38.

Furthermore, an air inlet silencer 7 is installed on the air inlet pipeline 8, an air exhaust silencer 36 is installed on the pipeline between the cyclone separator 37 and the water curtain dust collector 35, and a silencer device is adopted, so that noise generated in the production process is effectively reduced.

Preferably, the top of the inner cavity of the granulator is provided with a spray nozzle 10 for adding the adhesive.

Preferably, the exhaust fan 33 adopts a variable frequency motor, and the rotating speed of the motor can be accurately controlled by adopting the variable frequency motor, so that the air volume is controlled.

Preferably, the granulator 11 is a boiling granulator, and the granulator 11 has an explosion closing function, when an explosion occurs in the equipment, the air inlet and the air outlet are closed, the explosion occurs in the cavity by using the strength of the equipment, and external equipment facilities and personnel are not damaged.

Preferably, the near-infrared detection device (the following specifications of the device can be adopted: micro nir PAT-W/PAT-U/OnSite-W of the company VIAVI, sweden DA 7440; Antaris MX of the company saimmer, usa; GSA101/102/103 of the company shandong jingyung intelligent science and technology limited), and the operating principle of the near-infrared detection device is as follows: the near infrared device light source irradiates on the detected material to generate diffuse reflection effect, the reflected light returns to the device, the energy of chemical bonds of different detected substances is different, the reflected near infrared spectra are different, the spectra and laboratory detection data are related by a mathematical method to form a mathematical model, and the mathematical model can be used for detecting the moisture, content, particle size, mixing uniformity, coating thickness and the like of particles.

The working process is as follows: adding materials into a granulator 11 from a granulator feeding hole 12, processing the temperature and humidity of air entering the interior of equipment by an air inlet system, filtering impurities in the air, enabling the processed air to enter an inner cavity of the granulator 11 from an air inlet pipeline 8 and a granulation air inlet 14, enabling a nozzle 10 positioned at the top of the granulator 11 to quantitatively and frequently spray an adhesive into a granulation cavity in the granulation process of the granulator 11, enabling an exhaust fan 33 to work together, enabling hot air to pass through a bag-type dust collector in the inner cavity of the granulator 11, enter an exhaust system through a granulation exhaust hole 9 and a granulation exhaust pipeline 38, enabling a cyclone separator 37 and a water curtain dust collector 35 of the exhaust system to process exhaust air, and then discharging the exhaust air out of a device; in the granulating process, the moisture, the content, the particle size and the like of the particles are monitored on line in real time through the near infrared detection device 17, the air quantity, the temperature, the liquid spraying amount and other parameters of the granulator are controlled according to data feedback, qualified medicine particles enter a granulator cache cavity 26 at the upper end of a granulator 24 through a granulating discharge port 15 and a feeding pipeline of the granulator 25, the materials are conveyed through negative pressure generated by a vacuum pump 31, the height of the granulator 24 can be adjusted according to a lifting machine 29, a negative pressure generated inside the granulator 11 is enabled by an exhaust fan 33, the granulated materials are conveyed into an inner cavity of the granulator 11 from a granulating feed port 18 through a temporary storage tank discharge port 20 and a granulating feed pipe 19, when auxiliary materials need to be added, the auxiliary materials can be added through a temporary storage tank feed port 22, an air inlet system is controlled, and normal-temperature dry cool air is adopted to mix the materials in the inner cavity of the, mix the degree of consistency through near-infrared detection device 17 and detect, the granule after mixing qualified is discharged through finished product discharge gate 16 ejection of compact.

The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications to the present embodiment without inventive contribution as required after reading the present specification, but all of them are protected by patent laws within the scope of the claims of the present invention.

Claims

1. A granulating, drying, granulating and total mixing integrated machine is characterized in that: comprises an air inlet system, a granulator, a temporary storage tank, a near-infrared detection device, an exhaust system, a lifter and a vacuum pump; the air inlet system is connected with a granulator (11) through an air inlet pipeline (8), a granulating discharge hole (15) of the granulator (11) is connected with a granulator feed inlet (27) of a granulator (24) through a granulator feed pipeline (25), a finished product discharge hole (16) is formed in the granulator feed pipeline (25), the granulator (24) is installed on a lifting machine (29) through an upright post (28), an upper cavity of the granulator (24) is connected with a vacuum pump (31) through a vacuum pipeline (32), a temporary storage tank (21) is installed at the bottom of the granulator (24), a temporary storage tank discharge hole (20) is connected with a granulator feed interface (18) of the granulator (11) through a granulating feed pipe (19), and a granulating exhaust hole (9) in the top of the granulator (11) is connected with an exhaust system through a granulating exhaust pipeline (38); the near-infrared detection device (17) is arranged on the inner cavity wall of the granulator (11).

2. A granulating, dry finishing and total mixing all in one machine as claimed in claim 1, wherein: the air inlet system comprises an air inlet (1), a coarse filter section (2), a surface cooling section (3), a middle filter section (4), a heating section (5) and a high-efficiency filter section (6) in sequence, and the tail end of the high-efficiency filter section (6) is connected with a granulating air inlet (14) of a granulator (11) through an air inlet pipeline (8).

3. A granulating, dry finishing and total mixing all in one machine as claimed in claim 2, wherein: pressure monitoring devices are arranged in the coarse filtering section (2), the medium filtering section (4) and the high-efficiency filtering section (6).

4. A granulating, dry finishing and total mixing all in one machine as claimed in claim 2, wherein: and a temperature and humidity sensor (13) is arranged in the inner cavity of the granulator (11).

5. A granulating, dry-finishing and total-blending machine as claimed in claim 3 or 4, wherein: the exhaust system is sequentially provided with a cyclone separator (37), a water curtain dust collector (35), an air outlet (34) and an air exhaust fan (33) from the tail end of a granulating exhaust pipeline (38).

6. A granulating, dry finishing and total mixing all in one machine as claimed in claim 5, wherein: an air inlet silencer (7) is installed on the air inlet pipeline (8), and an air exhaust silencer (36) is installed on the pipeline between the cyclone separator (37) and the water curtain dust remover (35).

7. A granulating, dry finishing and total mixing all in one machine as claimed in claim 6, wherein: and a spray head (10) for adding the adhesive is arranged at the top of the inner cavity of the granulator (11).

8. A granulating, dry finishing and total mixing all in one machine as claimed in claim 7, wherein: the exhaust fan (33) adopts a variable frequency motor.

9. A granulating, dry finishing and total mixing all in one machine as claimed in claim 1, wherein: the granulator (11) adopts a boiling granulator.