CN212533023U - Micro-fluidic culture dish capable of being produced by one-time injection molding and demolding - Google Patents

Micro-fluidic culture dish capable of being produced by one-time injection molding and demolding Download PDF

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Publication number
CN212533023U
CN212533023U CN202020698481.9U CN202020698481U CN212533023U CN 212533023 U CN212533023 U CN 212533023U CN 202020698481 U CN202020698481 U CN 202020698481U CN 212533023 U CN212533023 U CN 212533023U
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China
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culture dish
micro
partition wall
inner ring
fluidic
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CN202020698481.9U
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Chinese (zh)
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彭兴跃
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Xiamen Qiyue Electronic Technology Co ltd
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Xiamen Qiyue Electronic Technology Co ltd
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Priority to CN202020698481.9U priority Critical patent/CN212533023U/en
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Priority to US17/921,347 priority patent/US20230313106A1/en
Priority to PCT/CN2021/081436 priority patent/WO2021218472A1/en
Priority to EP21797211.6A priority patent/EP4144829A1/en
Priority to JP2022566378A priority patent/JP7547503B2/en
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Abstract

The utility model discloses a micro-fluidic culture dish of drawing of patterns production can once mould plastics, through partition wall and the inner ring of integrated into one piece area passway in the culture dish, can make the culture dish that can be used to the micro-fluidic experiment, through setting up the oscillator on outer passageway, external drive power drive oscillator reciprocating motion can drive the fluid motion in the culture dish, is fit for the experiment of different tissues or cell, including stem cell's experiment.

Description

Micro-fluidic culture dish capable of being produced by one-time injection molding and demolding
Technical Field
The utility model relates to a culture dish field especially relates to a but micro-fluidic culture dish of once moulding plastics drawing of patterns production.
Background
A petri dish is a laboratory vessel for the cultivation of microorganisms or cells, consisting of a flat disc-shaped bottom and a lid, generally made of glass or plastic. The traditional culture dish is easy to demould and produce at one time, has very low cost and is widely applied to the research and application of life science. However, the traditional culture dish is unable to generate and control microflow, which results in great limitation in kinetic studies, especially in cell-to-cell correlation studies. The lab-on-a-chip technology for generating flow is expensive, and it is impossible to culture cells for a long time, and the manufacturing process is complicated, and the requirement for peripheral equipment is high, and it is inconvenient to use. If the cost of the microfluidic technology can be reduced, the microfluidic technology is convenient and practical to the level of a plastic culture dish, the cost of applying the lab-on-a-chip to life science research can be greatly reduced, and the revolution of a life science experimental method can be greatly promoted.
SUMMERY OF THE UTILITY MODEL
The utility model provides a micro-fluidic culture dish that drawing of patterns produced can once mould plastics to simplify manufacturing process, reduce cost and improve the convenient to use nature of product simultaneously.
The utility model provides a technical problem can adopt following technical scheme to realize:
the utility model provides a but micro-fluidic culture dish of drawing of patterns production once moulds plastics, includes the body, the bottom surface is equipped with the annular partition wall that upwards extends in the body, it has the passway mouth of two symmetries to open on the partition wall, the outer passway mouth department of partition wall is equipped with a oscillator, the oscillator is reciprocating motion under the drive of the outside driving body of culture dish outside setting.
Preferably, the device also comprises an inner ring, the inner ring and the body are integrally formed, the diameter of the inner ring is smaller than that of the partition wall, and the inner ring is only provided with one passage opening.
Preferably, the vibrator is a spherical magnet having a clear NS pole, the external driver is a rectangular magnet piece having a clear NS pole, and the rectangular magnet piece is placed flat in a drive coil.
The utility model discloses a partition wall and inner ring of integrated into one piece area passway mouth in the culture dish make the culture dish that can be used to the micro-fluidic experiment promptly, through set up the oscillator on outer passageway, external drive power drive oscillator reciprocating motion can drive the fluid motion in the culture dish, is fit for the experiment of different tissues or cell, including the experiment of stem cell.
Drawings
Fig. 1 is a schematic view of the entire structure of embodiment 1.
FIG. 2 is a schematic top view of embodiment 1.
FIG. 3 is a schematic view of a fluid produced after filling a liquid into a vibrator according to example 1.
FIG. 4 is a schematic view of the entire structure of embodiment 2.
Fig. 5 is a schematic view of a fluid generated after the vibrator is placed in example 2, and fig. 5a to d are flow directions of the inner ring in different placement states.
In the figure, 1 a main body, 2 partition walls, 3 inner rings, 4 outer rings, 5 vibrators, 6 inner rings, 11 bottom surfaces, 21 channel openings and 61 channel openings.
Detailed Description
The present invention will be described in further detail with reference to examples, but the present invention is not limited thereto.
Fig. 1 to 5 show the preferred embodiment of the present invention.
Example 1:
the utility model discloses a micro-fluidic culture dish includes body 1, and body 1 is the hollow cylinder who is equipped with bottom surface 11, upwards extends an annular partition wall 2 in its bottom surface 11, and partition wall 2 and body 1 integrated into one piece cut apart into body 1 and say 3 and two fluid regions of outer lane 4 in the inner loop, and the passway 21 has all been seted up to two symmetrical positions in the relative centre of a circle of partition wall 2. Fluid is filled in the culture dish, a vibrator 5 is placed on the outer side of the channel opening 21, namely the outer ring 4, and the vibrator is driven to reciprocate parallel to the bottom surface 11 at the channel opening 21 by an external driving body (not shown in the figure) arranged outside the culture dish, so that the fluid in the culture dish can be driven to flow, as shown in figure 3.
In this embodiment, the vibrator is a spherical magnet with a definite NS pole, the external driver is a rectangular magnet piece with a definite NS pole, the rectangular magnet piece is flatly placed in a driving coil, and square wave current is applied to the coil, so that the vibrator can be driven to perform regular reciprocating motion.
Example 2:
an inner ring 6 is arranged in the middle of the bottom surface 11 of the body 1, the inner ring 6 is also integrally formed with the body 1, the diameter of the inner ring 6 is smaller than that of the partition wall 2, and only one passage opening 61 is formed in the inner ring 6. Similarly put into a oscillator 5 on outer ring way 4, through external drive body drive oscillator be on a parallel with bottom surface 11 reciprocating motion in channel mouth 21 department, and then drive the fluid production of culture dish and flow, can see from figure 5, the inner ring 6 can be walked around to the fluid flow direction, can let the region in the inner ring structure form cell or the tissue culture microenvironment of relative confined, the direction that the channel mouth 61 of inner ring 6 set up is different, its inside and outside exchange velocity just is different, be fit for the experiment of different tissues or cells, including the experiment of stem cell.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the technical scope of the present invention, so that any slight modifications, equivalent changes and modifications made by the technical spirit of the present invention to the above embodiments still belong to the protection scope of the present invention.

Claims (3)

1. A micro-fluidic culture dish capable of being produced by one-time injection molding and demolding is characterized in that: the culture dish comprises a body, the bottom surface is equipped with the annular partition wall that upwards extends in the body, it has the passway of two symmetries to open on the partition wall, the outer passway department of partition wall is equipped with a oscillator, the oscillator is reciprocating motion under the drive of the outside driving body of culture dish outside setting.
2. The microfluidic culture dish capable of being produced by one-time injection and demolding according to claim 1, wherein the micro-fluidic culture dish is characterized in that: the partition wall is characterized by further comprising an inner ring, the inner ring and the body are integrally formed, the diameter of the inner ring is smaller than that of the partition wall, and the inner ring is only provided with one passage opening.
3. The microfluidic culture dish capable of being produced by one-time injection and demolding according to claim 1, wherein the micro-fluidic culture dish is characterized in that: the vibrator is a spherical magnet with a clear NS pole, the external driving body is a rectangular magnet piece with a clear NS pole, and the rectangular magnet piece is flatly placed in a driving coil.
CN202020698481.9U 2020-04-30 2020-04-30 Micro-fluidic culture dish capable of being produced by one-time injection molding and demolding Active CN212533023U (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN202020698481.9U CN212533023U (en) 2020-04-30 2020-04-30 Micro-fluidic culture dish capable of being produced by one-time injection molding and demolding
US17/921,347 US20230313106A1 (en) 2020-04-30 2021-03-18 Method for constructing slow microcyclic artificial cell niche and apparatus thereof
PCT/CN2021/081436 WO2021218472A1 (en) 2020-04-30 2021-03-18 Method for constructing slow microcyclic artificial cell niche and apparatus thereof
EP21797211.6A EP4144829A1 (en) 2020-04-30 2021-03-18 Method for constructing slow microcyclic artificial cell niche and apparatus thereof
JP2022566378A JP7547503B2 (en) 2020-04-30 2021-03-18 Method and device for constructing slow microcirculation artificial cell nest

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202020698481.9U CN212533023U (en) 2020-04-30 2020-04-30 Micro-fluidic culture dish capable of being produced by one-time injection molding and demolding

Publications (1)

Publication Number Publication Date
CN212533023U true CN212533023U (en) 2021-02-12

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021218472A1 (en) * 2020-04-30 2021-11-04 Peng Xingyue Method for constructing slow microcyclic artificial cell niche and apparatus thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021218472A1 (en) * 2020-04-30 2021-11-04 Peng Xingyue Method for constructing slow microcyclic artificial cell niche and apparatus thereof
JP2023528175A (en) * 2020-04-30 2023-07-04 彭興躍 Method and device for constructing slow microcirculation artificial cell nest
JP7547503B2 (en) 2020-04-30 2024-09-09 彭興躍 Method and device for constructing slow microcirculation artificial cell nest

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