CN212523096U

CN212523096U - Purification device for production of dehydroepiandrosterone by biotransformation method

Info

Publication number: CN212523096U
Application number: CN202021097414.8U
Authority: CN
Inventors: 李华; 郭秋爽; 刘宇鹏; 王刚; 杨生玉; 孙杨
Original assignee: Henan University
Current assignee: Henan University
Priority date: 2020-06-15
Filing date: 2020-06-15
Publication date: 2021-02-12
Anticipated expiration: 2030-06-15

Abstract

The utility model discloses a biological conversion method production dehydrogenation table androsterone changes production and uses purification device, including the cooling cylinder, the inside cooling chamber that is provided with of cooling cylinder, cooling chamber and cooling cylinder fixed connection, cooling chamber surface spiral wind have the cooling tube, and cooling cylinder top block has the top cap, fixedly connected with connecting axle in the middle of the top cap bottom, connecting axle, the equal fixedly connected with connecting rod in connecting axle both sides, the utility model discloses the beneficial effect who reaches is: through setting up the bellows pipe, the thermal cooling water of carrying hot solution flows from the cooling tube and is close to third transfer line one end, through the bellows pipe, the extension is at the flow time of cooling water in the pipe, the heat loss of carrying in the cooling water with higher speed, the heat that carries when avoiding the cooling water circulation to flow in the cooler bin causes the damage to the cooler bin, through setting up the scraper blade, make the scraper blade scrape the powder of cooling chamber inner wall and get, the powder drops in the top groove of bottom plate, take up the top cap, can collect the hydrogen table androsterone powder on the bottom plate, and convenient operation is simple.

Description

Purification device for production of dehydroepiandrosterone by biotransformation method

Technical Field

The utility model relates to a purification device, in particular to purification device is used in production of dehydrogenation epiandrosterone commentaries on classics of biotransformation method production, belongs to chemical production purification equipment technical field.

Background

When the dehydroepiandrosterone is produced, extraction and purification are needed to achieve the required purity, but due to the characteristics that the dehydroepiandrosterone is insoluble in water, can be dissolved in benzene, ethanol, diethyl ether, and is insoluble in chloroform and petroleum ether, the dehydroepiandrosterone cannot be extracted by ordinary heating evaporation purification, and after the dehydroepiandrosterone is mixed and dissolved by heat, the dehydroepiandrosterone is cooled to precipitate the dehydroepiandrosterone to complete the purification.

In the prior art, when the mixed hot-melt solvent of dehydroepiandrosterone is cooled, cooling water is generally used for rapid cooling, but the purity of the product obtained by rapid cooling is low; when the cooling water carries the heat of the hot solution to circulate in the cooling box quickly, the cooling box is easy to be damaged; attached to the inconvenient taking out of cooling device inner wall after the cooling, bring the trouble for the operator, consequently in order to solve the problem that above-mentioned exists, the utility model provides a purification device is used in production transfer of dehydroepiandrosterone of bioconversion method production.

SUMMERY OF THE UTILITY MODEL

The technical problem to be solved by the utility model is to overcome the defects of the prior art, and provide a purification device for the production of dehydroepiandrosterone by a biotransformation method, wherein by arranging a cooling pipe, a corrugated pipe and a scraper, the mixed hot-melt solvent of the dehydroepiandrosterone is effectively solved, and when being cooled, the mixed hot-melt solvent is generally cooled by cooling water, but the purification quality of the quick cooling is low; when the cooling water carries the heat of the hot solution to circulate in the cooling box quickly, the cooling box is easy to be damaged; the powder is attached to the inner wall of the cooling device after cooling and is not convenient to take out, which brings trouble to operators.

In order to solve the technical problem, the utility model provides a following technical scheme:

the utility model relates to a purification device for the production of dehydroepiandrosterone by a bioconversion method, which comprises a cooling cylinder, wherein a cooling cavity is arranged inside the cooling cylinder, the cooling cavity is fixedly connected with the cooling cylinder, the surface of the cooling cavity is spirally wound with a cooling pipe, the top of the cooling cylinder is clamped with a top cover, a connecting shaft is fixedly connected in the middle of the bottom of the top cover, the connecting shaft is fixedly connected with connecting rods on both sides of the connecting shaft, a scraper is fixedly connected with one end of the connecting rod far away from the connecting shaft, one end of the cooling pipe penetrates through the side wall on one side of the cooling cylinder and extends to the outside of the cooling cylinder, one end of the cooling pipe positioned outside the cooling cylinder is fixedly connected with a liquid outlet pipe, the liquid outlet pipe is far away from the output end of a circulating pump fixedly connected with one end of the cooling cylinder, the input, one end of the cooling box, which is far away from the first infusion tube, is fixedly connected with a second infusion tube, and one end of the second infusion tube, which is far away from the first infusion tube, is fixedly connected with a corrugated tube.

As an optimal technical scheme of the utility model, the one end that the drain pipe was kept away from to the cooling tube runs through cooling cylinder one side lateral wall and extends to the cooling chamber outside, drain pipe one end fixedly connected with third transfer line is kept away from to the cooling tube.

As a preferred technical scheme of the utility model, the connecting axle lower extreme is connected with the bottom plate, bottom plate and connecting axle fixed connection, the top groove has been seted up to the bottom plate upper end.

As an optimized technical proposal of the utility model, the top cover top middle connection has a handle, the handle is fixedly connected with the top cover, the surface of the handle is provided with screw threads.

As a preferred technical scheme of the utility model, cooling chamber one side lateral wall is connected with the feed liquor pipe, feed liquor pipe and cooling chamber fixed connection, the feed liquor pipe is kept away from cooling chamber one end and is extended to the cooling cylinder outside, the feed liquor pipe is located the outside one end fixedly connected with feed liquor valve of cooling cylinder.

As an optimized technical proposal of the utility model, the first valve is fixedly connected with the liquid outlet pipe, and the second valve is fixedly connected with the third liquid conveying pipe.

The utility model discloses the beneficial effect who reaches is: through setting up the cooling tube, the cooling water in the cooling box is gone into the cooling tube from the drain pipe by the pump, the cooling water flows and cools off the hot solution of cooling intracavity in the cooling tube, the cooling tube spiral is around connecing in the cooling chamber surface, the extension cooling time, the effect of improving the cooling is improved, improve product purity, through setting up the nodal pipe, the cooling water that carries the heat of hot solution flows near third transfer line one end from the cooling tube, through the nodal pipe, the extension is at the flow time of cooling water in the pipe, the heat of carrying in the cooling water runs off with higher speed, the heat that carries when avoiding the cooling water circulation to flow in the cooling box causes the damage to the cooling box, through setting up the scraper blade, make the powder of scraper blade to cooling intracavity inner wall scrape and get, the powder drops in the apical trough of bottom plate, take up the top cap, can collect the hydrogen table androsterone powder on the bottom plate promptly, and.

Drawings

The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention, and together with the description serve to explain the invention and not to limit the invention.

In the drawings:

fig. 1 is a schematic front view of the present invention;

FIG. 2 is a schematic sectional view of the cooling cylinder of the present invention;

FIG. 3 is a sectional view of the cooling chamber of the present invention;

fig. 4 is a schematic side view of the cooling cylinder of the present invention.

In the figure: 1. a cooling cylinder; 2. a cooling chamber; 3. a cooling tube; 4. a top cover; 5. a connecting shaft; 6. a connecting rod; 7. a squeegee; 8. a base plate; 9. a liquid outlet pipe; 10. a first valve; 11. a circulation pump; 12. a first infusion tube; 13. a cooling tank; 14. a second infusion tube; 15. a nodal tube; 16. a liquid inlet valve; 17. a liquid inlet pipe; 18. a third infusion tube; 19. a second valve; 20. a handle.

Detailed Description

The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are presented herein only to illustrate and explain the present invention, and not to limit the present invention.

Example 1

As shown in figures 1-4, the utility model relates to a purification device for production of dehydroepiandrosterone by bioconversion method, which comprises a cooling cylinder 1, a cooling cavity 2 is arranged inside the cooling cylinder 1, the cooling cavity 2 is fixedly connected with the cooling cylinder 1, a cooling pipe 3 is spirally wound on the surface of the cooling cavity 2, a top cover 4 is clamped on the top of the cooling cylinder 1, a connecting shaft 5 is fixedly connected in the middle of the bottom of the top cover 4, the connecting shaft 5 is fixedly connected with a connecting rod 6 on both sides of the connecting shaft 5, one end of the connecting rod 6 far away from the connecting shaft 5 is fixedly connected with a scraper 7, one end of the cooling pipe 3 penetrates through the side wall of one side of the cooling cylinder 1 and extends to the outside of the cooling cylinder 1, one end of the cooling pipe 3 located outside the cooling cylinder 1 is fixedly connected with a liquid outlet pipe 9, one end of the liquid outlet pipe 9 far away, one end of the first infusion tube 12, which is far away from the circulating pump 11, is fixedly connected with a cooling box 13, one end of the cooling box 13, which is far away from the first infusion tube 12, is fixedly connected with a second infusion tube 14, and one end of the second infusion tube 14, which is far away from the first infusion tube 12, is fixedly connected with a corrugated tube 15.

One end of the cooling pipe 3, which is far away from the liquid outlet pipe 9, penetrates through the side wall of one side of the cooling cylinder 1 and extends to the outside of the cooling cavity 2, one end of the cooling pipe 3, which is far away from the liquid outlet pipe 9, is fixedly connected with a third liquid conveying pipe 18, cooling water in a cooling box 13 cools the cooling cavity 2 and then flows into the third liquid conveying pipe 18 from one end of the cooling pipe 3, the lower end of the connecting shaft 5 is connected with a bottom plate 8, the bottom plate 8 is fixedly connected with the connecting shaft 5, the upper end of the bottom plate 8 is provided with a top groove, dehydroepiandrosterone powder is collected on the bottom plate 8 and is convenient to take out, the middle of the top cover 4 is connected with a handle 20, the handle 20 is fixedly connected with the top cover 4, the handle 20 is provided with threads on the surface, the top cover 4 is more convenient to take out, the side wall of the cooling cavity 2 is connected with a liquid inlet, hot solution can be injected into the cooling cavity 2 from the liquid inlet pipe 17 by opening the liquid inlet valve 16, the liquid outlet pipe 9 is fixedly connected with the first valve 10, the third liquid conveying pipe 18 is fixedly connected with the second valve 19, and liquid outlet and liquid inlet are more convenient.

Specifically, when the saturated hot solution of dehydroepiandrosterone is required to be purified, the hot solution of dehydroepiandrosterone is injected into the cooling cylinder 1 from the liquid inlet pipe 17, water is injected into the cooling box 13 to cool the water, the circulating pump 11 is started to pump the cooling water in the cooling box 13 into the cooling pipe 3 from the liquid outlet pipe 9, the cooling water flows in the cooling pipe 3 to cool the hot solution in the cooling cavity 2, the cooling pipe 3 is spirally wound on the surface of the cooling cavity 2 to prolong the cooling time and improve the cooling effect, the cooling water carrying the heat of the hot solution flows out of one end of the cooling pipe 3 close to the third liquid conveying pipe 18 and passes through the corrugated pipe 15 to prolong the flowing time of the cooling water in the pipe, so that the heat loss in the cooling water is accelerated, the damage to the cooling box 13 caused by the heat carried when the cooling water circularly flows into the cooling box 13 is avoided, and the cooling water enters the cooling box 13 again and is pumped into the cooling pipe 3, so reciprocating cycle for saturated hot solution is cooled off, the solubility of dehydroepiandrosterone reduces, the dehydroepiandrosterone powder is appeared, open top cap 4, hold handle 20, wave top cap 4, make scraper blade 7 scrape the powder of 2 inner walls in cooling chamber and get, the powder drops in the top groove of bottom plate 8, pick up top cap 4, collect the hydrogen epiandrosterone powder on the bottom plate 8 and carry out the drying and can accomplish the purification, this device has fine practicality and popularization nature, convenient to popularize and use.

Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments described in the foregoing embodiments, or equivalents may be substituted for elements thereof. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The utility model provides a purification device is used in production is changeed in production of bioconversion method production dehydroepiandrosterone, a serial communication port, including cooling cylinder (1), cooling cylinder (1) inside is provided with cooling chamber (2), cooling chamber (2) and cooling cylinder (1) fixed connection, cooling chamber (2) surface spiral round-trip has cooling tube (3), cooling cylinder (1) top block has top cap (4), fixedly connected with connecting axle (5) in the middle of top cap (4) bottom, connecting axle (5), the equal fixedly connected with connecting rod (6) in connecting axle (5) both sides, connecting rod (6) are kept away from connecting axle (5) one end and are all fixedly connected with scraper blade (7), cooling tube (3) one end runs through cooling cylinder (1) one side lateral wall and extend to cooling cylinder (1) outside, cooling tube (3) are located the outside one end fixedly connected with drain pipe (9) of cooling cylinder (1), the output of cooling cylinder (1) one end fixedly connected with circulating pump (11) is kept away from in drain pipe (9), the first transfer line of input fixedly connected with (12) of circulating pump (11), circulating pump (11) one end fixedly connected with cooling box (13) is kept away from in first transfer line (12), first transfer line (12) one end fixedly connected with second transfer line (14) is kept away from in cooling box (13), first transfer line (12) one end fixedly connected with nodal pipe (15) is kept away from in second transfer line (14).

2. The purification device for conversion production of dehydroepiandrosterone by bioconversion method according to claim 1, wherein: one end of the cooling pipe (3) far away from the liquid outlet pipe (9) penetrates through the side wall of one side of the cooling cylinder (1) and extends to the outside of the cooling cavity (2), and one end of the cooling pipe (3) far away from the liquid outlet pipe (9) is fixedly connected with a third liquid conveying pipe (18).

3. The purification device for conversion production of dehydroepiandrosterone by bioconversion method according to claim 1, wherein: the connecting shaft (5) lower extreme is connected with bottom plate (8), bottom plate (8) and connecting shaft (5) fixed connection, the top groove has been seted up to bottom plate (8) upper end.

4. The purification device for conversion production of dehydroepiandrosterone by bioconversion method according to claim 1, wherein: the handle (20) is connected with the middle of the top cover (4), the handle (20) is fixedly connected with the top cover (4), and threads are formed in the surface of the handle (20).

5. The purification device for conversion production of dehydroepiandrosterone by bioconversion method according to claim 1, wherein: cooling chamber (2) one side lateral wall is connected with feed liquor pipe (17), feed liquor pipe (17) and cooling chamber (2) fixed connection, cooling chamber (2) one end is kept away from in feed liquor pipe (17) and is extended to cooling cylinder (1) outside, feed liquor pipe (17) are located cooling cylinder (1) outside one end fixedly connected with feed liquor valve (16).

6. The purification device for conversion production of dehydroepiandrosterone by bioconversion method according to claim 2, wherein: a first valve (10) is fixedly connected to the liquid outlet pipe (9), and a second valve (19) is fixedly connected to the third liquid conveying pipe (18).