CN212417980U

CN212417980U - Liquid shunting device

Info

Publication number: CN212417980U
Application number: CN202020237689.0U
Authority: CN
Inventors: 曹青; 文大为; 何盛宝; 修远; 田林; 杨定忠; 何京; 窦民娜; 陈菲; 刘坤红; 李琛琛; 薛慧峰; 王建明
Original assignee: Beijing Chengda Instrument Co ltd; Petrochina Co Ltd
Current assignee: Beijing Chengda Instrument Co ltd; Petrochina Co Ltd
Priority date: 2019-10-28
Filing date: 2020-03-02
Publication date: 2021-01-29
Anticipated expiration: 2030-03-02

Abstract

The utility model discloses a liquid flow divider, including knockout, and the n way pipe that the backpressure equals. The n paths of guide pipes are respectively communicated with the liquid separator, wherein n is an integer more than or equal to 1. Furthermore, heating elements may also be provided. The liquid shunting device of the utility model has the advantages of low cost, and the shunting and solvent preheating can be combined, thereby achieving the purpose of simultaneously completing shunting and preheating; because the flow velocity difference in the n ducts is small, the solvent after being divided by the n ducts can be applied to a plurality of groups of parallel chromatographic column separation experiments.

Description

Liquid shunting device

Technical Field

The utility model relates to a liquid diverging device, in particular to liquid chromatogram mobile phase diverging preheating device.

Background

The shunting device is a commonly used technical element of a chromatographic instrument and aims to distribute one path of mobile phase output provided by an infusion pump to a plurality of liquid channels. In the prior art, a common mode is to use a rotary valve or an electromagnetic valve and other devices to split flow in a plurality of channels according to opening and closing time, but the device has higher cost.

The solvent preheating device is also a commonly used component module of a chromatographic instrument. The function of the device is to heat the mobile phase to the required temperature in advance and then flow into the chromatographic column, so as to ensure the uniformity and stability of the temperature on the chromatographic column. However, the current shunting device cannot be integrated with a preheating device, the preheating device is a serial module independent of the shunting device, and the device cost, the heat exchange efficiency and the shunting parallelism are all negatively affected.

SUMMERY OF THE UTILITY MODEL

In order to solve the problem, the utility model provides a liquid shunting device. The device is with low costs, and can preheat reposition of redundant personnel and solvent and combine, reaches the effect that can accomplish reposition of redundant personnel and preheat simultaneously.

The utility model provides a liquid flow divider, including n way pipes that knockout and backpressure equal. The n paths of guide pipes are respectively communicated with the liquid separator, wherein n is an integer more than or equal to 1.

In an embodiment, a heating element is also included.

In one embodiment, the heating element is a solid heating block, and the n-way conduit is wound on the heating element in a partition mode.

In one embodiment, a heat exchange box top cover is further arranged on the heating element.

In one embodiment, the device further comprises a fixing element for fixing the n-way conduit to the heating element.

In one embodiment, the fixing element is a metal sheet with a groove arranged on the heating element.

In one embodiment, the liquid separator is one or more three-way or multi-way tubes.

In one embodiment, the liquid distributor is a plurality of multi-way pipes, and the branch pipes have the same inner diameter and the same length.

In one embodiment, the n-way conduit is made of metal.

In one embodiment, the n-way conduit has an inner diameter of 0.05 to 0.5mm and an aspect ratio of 5000:1 to 50000: 1.

In one embodiment, the n-channel conduit has an inner diameter of 0.05-0.2 mm and an aspect ratio of 10000: 1-20000: 1.

The liquid shunting device of the utility model has the advantages of low cost, and the shunting and solvent preheating can be combined, thereby achieving the purpose of simultaneously completing shunting and preheating; because the flow velocity difference in the n ducts is small, the solvent after being divided by the n ducts can be applied to a plurality of groups of parallel chromatographic column separation experiments.

Drawings

Fig. 1 is a schematic view of a liquid diversion device according to an embodiment of the present invention.

Fig. 2 is a schematic view of a liquid diversion device according to another embodiment of the present invention.

FIG. 3 is a schematic view of a conduit zoned wound around a heating element.

Wherein, the reference numbers:

10 liquid separator

11 heating element

12 catheter

13 fixing element

14 Heat exchange Box Top cover

Detailed Description

In order to clearly understand the technical features, objects and advantages of the present invention, the following detailed description is given to the technical solution of the present invention, but the technical solution of the present invention is not limited to the limit of the implementable range of the present invention.

The utility model provides a liquid shunting device, including n way pipe 12 and the heating element 11 that knockout 10, backpressure equal. n paths of guide pipes 12 are respectively communicated with the liquid distributor 10, wherein n is an integer more than or equal to 1. The solvent is divided by the liquid separator 10 and the n-way conduit 12. In some embodiments, the heating element 11 is a solid heating block, and the n-way conduit 12 is wound on the heating element 11 in sections; of course, in other embodiments, the heating element 11 may also be in the form of an oil bath in which the n-way conduit 12 is immersed, and the present invention is not limited to the configuration or aspect of the heating element 11.

The liquid distributor 10 is one or more three-way or multi-way pipes for distributing liquid to the n-way pipes 12. When the liquid separator 10 is a plurality of multi-way pipes, the branch pipes have the same inner diameter and the same length. Thereby ensuring even flow distribution and equal flow velocity in each conduit 12.

Fig. 1 is a schematic view of a liquid diversion device according to an embodiment of the present invention. In the present embodiment, the liquid separator 10 is designed as three tee pipes: tee-1, tee-2 and tee-3, the tee has an inlet and two outlets. The solvent firstly passes through a tee joint-1, the solvent is divided into two branches, the two branches respectively pass through a tee joint-2 and a tee joint-3, and each branch passing through the tee joint-2 or the tee joint-3 is divided into two branches. The solvent is divided into four streams by the liquid separator 10 in this embodiment, and the four stream outlets communicate with the 4-way conduit 12.

As shown in fig. 2, it is a schematic view of a liquid diversion device according to another embodiment of the present invention. In the present embodiment, the liquid separator 10 is designed as a five-way tube having an inlet and four outlets. The solvent is directly divided into four streams by the liquid separator 10 in this embodiment, and the outlets of the four streams are communicated with the 4-way conduit 12. In this embodiment, the heating element 11 is an oil bath, and the 4-way pipe 12 is coiled and immersed in the oil bath.

However, the configuration of the dispenser 10 of the present invention is not limited to the above. The multi-way tube can be designed into other configurations when in use.

In some embodiments, because the metal has good pressure resistance and is easy to conduct heat, the n-way conduit 12 is preferably made of metal, and the n-way conduit 12 may also be made of other materials, which is not limited by the present invention. Wherein the inner diameter of the n-way conduit 12 is 0.05-0.5 mm, and the length-diameter ratio is 5000: 1-50000: 1; preferably, the n-way conduit 12 has an inner diameter of 0.05 to 0.2mm and an aspect ratio of 10000:1 to 20000: 1. Suitable inner diameter dimensions and aspect ratios prevent n-way conduit 12 from becoming blocked with solvent when the solvent is diverted unfiltered or otherwise viscous. When the inner diameter of the n-path guide pipe 12 is too small, the shunting device is easy to block; if the length-diameter ratio of the n-way conduit 12 is too low, the back pressure of the n-way conduit 12 is not large enough, which tends to cause uneven distribution of the liquid distribution device, and has a large influence on the back pressure of a subsequent chromatography system (not shown) of the liquid distribution device. The values of the inside diameter and the length to diameter ratio of the n-way conduit 12 have a greater influence. In use, the minimum inner diameter of the n-way conduit 12 may be selected based on the sample being analyzed without affecting flow and without clogging.

Referring to fig. 1 again, in the present embodiment, the heating element 11 shown in fig. 1 is a solid heating block, and the 4-way conduit 12 is wound on the heating element 11 in a partitioned manner. The diverted solvent enters conduit 12, is heated by heating element 11, and enters a chromatographic system (not shown) for separation. The heating element 11 heats the solvent to a temperature required for separation, thereby avoiding a problem of deviation of separation effect caused by the solvent not being heated to the required temperature.

In some embodiments, the heating element 11 is further provided with a fixing element 13 and a heat exchange box top cover 14.

Fig. 3 is a schematic view of a conduit being wound in sections around a heating element. The fixing element 13 arranged on the heating element 11 is a metal sheet with a groove, the 4-way guide pipe 12 is wound in the groove of the metal sheet, and the top cover 14 of the heat exchange box is covered on the groove. The fixing element 13 is used to fix the n-way conduit 12 on the heating element 11, so as to prevent the n-way conduit 12 from falling off from the heating element 11, and ensure that the solvent in the n-way conduit 12 is heated to a desired temperature by the heating element 11. The heat exchange box top cover 14 can perform the function of heat preservation on the n-way guide pipe 12 and the heating element 11, thereby reducing the production cost.

Through the utility model discloses a liquid diverging device can accomplish the reposition of redundant personnel to n individual passageways, and every passageway shunts passively. The back pressure of each channel can be represented as P1, P2, P3 … Pn, and when the infusion flow rate of the pump is defined as V, the infusion flow rate of each channel is correspondingly represented as V1, V2, V3 … Vn. The total back pressure P of the diversion channel can be calculated by the following equation:

P＝1/(1/P1+1/P2+1/P3+…+1/Pn)；

the per-channel infusion flow rate Vn can be calculated by the following equation 1:

equation 1: vn is V P/Pn

In particular, in the case of equal lengths of the shunt lines relative to each other, the equation can be converted using the line length for each channel, since the back pressure is proportional to the tube length.

Namely: l ═ 1/(1/L1+1/L2+1/L3+ … + 1/Ln);

then Vn is V L/Ln;

l1, L2, L3 … Ln denote the line length of each channel.

For the special case of multi-channel parallel splitting using equal length pipelines, there is formula 2: vn is V/n.

However, because of processing problems including, but not limited to, pipe intercept length, pipe end conditions, internal diameter uniformity, internal wall finish, etc., parallel multi-pass passive splitting, the splitting accuracy is affected by the parallelism of the pipe pressure. According to equation 1, the channel whose actual pressure is lower by Δ Pn has an approximately higher flow Δ Vn ═ V/n × Δ Pn @

(ii) a For channels with an actual pressure which is higher than Δ Pn, the flow is approximately lower than Δ Vn ═ V/n ═ Δ Pn-

The pressure deviation Δ Pn at a certain channel is much smaller than the average operating pressure of each channel

In time of (1), Δ Pn @

And the flow deviation is negligible close to 0, namely parallel flow division is realized.

For making each branch road backpressure equal, the utility model discloses in each branch road length, the pipe diameter be equal completely to recommend the internal diameter that adopts the multichannel to equal length be 0.05 ~ 0.5mm, draw ratio is 5000:1 ~ 50000: 1's pipe as multichannel liquid channel, the fluid of input is when flowing through these pipes, every passageway is because the pressure that the damping produced is far more than the pressure difference between different passageways, realize from this in every way metal with equal flow distribution, it is lower than the device cost that uses devices such as rotary valve or solenoid valve to carry out initiative reposition of redundant personnel according to the starting time simultaneously. The conduit of each channel can also be divided into a plurality of sections, and the sections are connected by using joints. The utility model provides a n way pipe 12 is because the internal diameter is little, and the draw ratio is big, twines n way pipe 12 subregion on fixed element 13 preferably.

The liquid shunting device of the utility model is particularly suitable for the mobile phase shunting of liquid chromatogram, and the preferable scheme is that the n-way guide pipe 12 is arranged inside the heating element 11, and the heating element 11 can use metal and heat exchange liquid such as oil bath, etc. to heat the solvent in the n-way guide pipe 12 to the temperature required by the actual analysis method. For a plurality of channels in parallel, if the condition of uneven flow distribution pressure exists, the channels with relatively high back pressure are subjected to low actual flow, the solvent has long retention time, sufficient heat exchange and higher temperature, so that the viscosity is reduced, the pressure is reduced, the flow distribution error problem caused by the pipeline processing parallelism can be partially compensated, and the flow consistency of each channel is further ensured. The fixing element 13 may be the heating element 11 itself, or the fixing element 13 with the catheter fixed thereto may be placed in the heating element 11.

Example 1:

in this example, 2 t-pipes having 1 inlet and 2 outlets were used as the liquid separators, and the mobile phase was divided into 4 paths as shown in fig. 1. The conduit is made of 316 stainless steel, the inner diameter is 0.05mm, the length-diameter ratio is 50000: 1. The back pressure difference of the chromatographic column used in the 4-way is 0.2MPa, and the flow rate difference of each flow path is not more than 2%.

Example 2:

in this embodiment, a five-way pipe having 1 inlet and 4 outlets is used as a liquid separator, and as shown in fig. 2, the mobile phase can be divided into 4 paths. The material of pipe is 316 stainless steel, internal diameter 0.1mm, draw ratio 15000: 1. When the back pressure difference of the chromatographic column used in the 4-way is 0.2MPa, the flow rate difference of each flow path is not more than 1%.

Example 3:

in this example, a five-way pipe having 1 inlet and 4 outlets was used as a liquid separator, and as shown in fig. 2, the mobile phase was divided into 4 paths, and the heating element used was an oil bath, and heat transfer was performed by winding the pipe and immersing it in the oil bath. The material of pipe is 316 stainless steel, and internal diameter 0.5mm, slenderness ratio 5000: 1. When the back pressure difference of the chromatographic column used in the 4-way is 0.2MPa, the flow rate difference of each flow path is not more than 1%.

Example 4:

in this embodiment, a five-way pipe with 1 inlet and 4 outlets is used as a liquid separator, as shown in fig. 2, the mobile phase can be divided into 4 paths, wherein the heating element used is a metal heater, and the heat conduction is performed in a manner of metal direct contact. The material of pipe is 316 stainless steel, internal diameter 0.1mm, draw ratio 15000: 1. As shown in fig. 3, the conduit is coiled around the fixing element of the metal heater surface, and the groove design on the fixing element 3 can separate 4 pipelines. A heat exchange box top cover is arranged above the metal heater and is made of stainless steel and can be buckled with the metal heater. In fig. 3, the top cover is shown removed for clarity. When the back pressure difference of the chromatographic column used in the 4-way is 0.2MPa, the flow rate difference of each flow path is not more than 1%.

Example 5:

in this embodiment, a five-way pipe having 1 inlet and 4 outlets is used as a liquid separator, and as shown in fig. 2, the mobile phase can be divided into 4 paths, wherein the heating module used is a metal heater, and the heat conduction is performed in a manner of direct metal contact. The material of pipe is 316 stainless steel, and internal diameter 0.8mm, slenderness ratio 4000: 1. When the difference in column back pressure used in the 4 channels was 0.15MPa, the difference in flow rate between the channels was 3%.

Comparative example 1:

in this comparative example, a five-way pipe having 1 inlet and 4 outlets was used as a liquid separator, and as shown in fig. 2, the mobile phase was divided into 4 paths, and the heating module used was a metal heater for heat conduction in direct contact with metal. The conduit is made of 316 stainless steel, the inner diameter is 0.04mm, the length-diameter ratio is 50000: 1. In practice, it has been found that this liquid diversion device is prone to clogging when unfiltered or highly viscous solvents are used, due to the small internal diameter of the conduit.

Naturally, the present invention can be embodied in many other forms without departing from the spirit or essential attributes thereof, and it should be understood that various changes and modifications can be made by one skilled in the art without departing from the spirit or essential attributes thereof, and it is intended that all such changes and modifications be considered as within the scope of the appended claims.

Claims

1. A liquid diversion apparatus, comprising:

a liquid separator;

n conduits with equal back pressure are respectively communicated with the liquid separator, wherein n is an integer greater than or equal to 1; and

a heating element in thermally conductive contact with the n-way conduit.

2. The fluid diversion device of claim 1, wherein said heating element is a solid heating block, and said n conduits are zoned wound around said heating element.

3. The fluid diversion device of claim 1, wherein said heating element is a heat exchange fluid and said n conduits are immersed in said heat exchange fluid.

4. The fluid diversion device of claim 1, wherein a heat exchange box top cover is further provided on said heating element.

5. The fluid diversion apparatus of claim 2, further comprising a securing element for securing said n-way conduit to said heating element.

6. The fluid distribution device of claim 5, wherein the securing element is a grooved metal sheet disposed on the heating element.

7. The fluid diversion apparatus of claim 1, wherein said fluid separator is one or more tee or higher multi-ported tubes.

8. The fluid distribution device of claim 7, wherein the manifold is a plurality of multi-ported tubes, and wherein the manifolds have the same inner diameter and the same length.

9. The fluid diversion device of claim 1, wherein said n conduits are metal.

10. The liquid diversion device of claim 1, wherein the n-way conduit has an inner diameter of 0.05-0.5 mm and an aspect ratio of 5000: 1-50000: 1.

11. The liquid diversion device according to claim 10, wherein the n-way conduit has an inner diameter of 0.05 to 0.2mm and an aspect ratio of 10000:1 to 20000: 1.