CN212345028U - Acute periosteum syndrome animal model - Google Patents
Acute periosteum syndrome animal model Download PDFInfo
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- CN212345028U CN212345028U CN202021959499.6U CN202021959499U CN212345028U CN 212345028 U CN212345028 U CN 212345028U CN 202021959499 U CN202021959499 U CN 202021959499U CN 212345028 U CN212345028 U CN 212345028U
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Abstract
The utility model discloses an acute periosteum syndrome animal model, include: the pressure control air pump is connected with the transfusion assembly of the experimental animal, and the pressurizing liquid bag assembly is connected between the pressure control air pump and the transfusion assembly; the pressure control air pump includes: the pressure control air pump box body is arranged in the pressure control air pump box body, the pressure control air pump power supply and the pressure controller are arranged in the pressure control air pump box body, the vent hole is arranged on the pressure control air pump box body, the air outlet and the air inlet which extend out of the pressure control air pump box body, the vent valve is arranged between the air outlet and the air inlet, and the driving assembly is connected between the vent valve and the pressure control air pump power supply and the pressure controller; the utility model can realize stable and controllable pressure, and the pressure can reach a higher level; therefore, real-time monitoring of the pressure in the fascia chamber is realized, and the severity of the periosteum syndrome model is evaluated in real time.
Description
Technical Field
The utility model relates to an animal experiment field, especially an acute periosteum syndrome animal model.
Background
Aiming at the current animal research of limb acute periosteum syndrome, an intramuscular injection liquid method, an external cuff pressurization method and a blood flow blocking method are available.
The method for injecting liquid into the fascia tissue through muscle has been reported in two ways, one is that liquid is injected into the fascia tissue intermittently, namely a certain amount of liquid is injected into the fascia tissue chamber, because the liquid is usually normal saline, and the pressure in the fascia tissue chamber is gradually reduced due to the liquid flow in the fascia tissue chamber, the pressure in the fascia tissue chamber is ensured to be stable by the model, the liquid needs to be injected for multiple times, and the tissue is damaged by additional acupuncture through multiple injections; and the other is similar to infusion apparatus, one side of the needle head is inserted into the tissue by an indwelling needle head or a hose, constant pressure is provided for the tissue by utilizing a liquid bag with fixed height, the model provides rapidly increased pressure in a fascia chamber in a short time and maintains a certain constant level, and the model can provide limited pressure in the fascia chamber due to the limited space height of a conventional laboratory.
The blood flow blocking method only blocks and recovers blood supply vessels of tissues in the fascial ventricle to simulate the tissue ischemia process in the process of the periosteal compartment syndrome, but has small influence on the pressure in the fascial ventricle, and the model has poor simulation effect on the acute periosteal compartment syndrome.
External cuff compression compresses the limb by inflating the cuff around the outside of the limb to reduce the volume of the compartment, which in turn increases the pressure within the compartment. The model is externally pressurized, thus allowing the intra-fascial pressure to reach a high level, such as 300 mmHg. However, the model is only suitable for simulating the periosteum syndrome caused by the reduction of the volume of the fascial chamber, such as the periosteum syndrome caused by too tight iatrogenic gypsum or the periosteum syndrome after burn, but the clinical periosteum syndrome is often caused by the increase of the content in the fascial chamber due to the edema of tissues in the fascial chamber after trauma and the like, so that the pressure in the fascial chamber is increased.
Therefore, the intramuscular injection method can better simulate the pathological change process of the clinical periosteum syndrome. However, the intramuscular injection method is difficult to achieve the stable pressure in the fascial chamber and a higher level at present due to the simple liquid injection method; all methods in the market lack real-time monitoring of the pressure in the fascial compartment and cannot evaluate the severity of the periosteal compartment syndrome model in real time. The fundamental characteristic of the compartment syndrome is an increase in the intra-fascial pressure, so intra-fascial pressure measurements are also important criteria for assessing whether and how serious the compartment syndrome is. At present, all models do not contain real-time monitoring of the pressure in the fascia chamber, and an additional pressure monitoring device is often needed to be matched.
The market needs an animal model making method with controllable and stable pressure and the pressure can reach a larger level, and the utility model solves the problems.
SUMMERY OF THE UTILITY MODEL
For solving prior art's not enough, the utility model aims to provide an acute periosteum syndrome animal model can realize that the pressure stability is controllable, and pressure can reach higher level, can carry out real-time supervision to the indoor pressure of manadesma, assesss the severity of periosteum syndrome model in real time.
In order to achieve the above object, the utility model adopts the following technical scheme:
an animal model of acute periosteum syndrome comprising: the pressure control air pump is connected with the transfusion assembly of the experimental animal, and the pressurizing liquid bag assembly is connected between the pressure control air pump and the transfusion assembly; the pressure control air pump includes: the pressure control air pump box body, set up pressure control air pump power, the pressure controller in the pressure control air pump box body, set up the blow vent on the pressure control air pump box body, extend in gas outlet, the air inlet of pressure control air pump box body, set up the breather valve between gas outlet, the air inlet, connect the drive assembly between breather valve and pressure control air pump power, pressure controller.
The aforesaid acute periosteum syndrome animal model, the infusion subassembly includes: the device comprises an infusion apparatus connected with a pressurizing liquid bag assembly, an indwelling needle connected with the infusion apparatus and connected with the experimental animal, and an infusion apparatus switch arranged on the infusion apparatus.
In the acute periosteum syndrome animal model, the three-way valve is arranged between the infusion apparatus and the indwelling needle, and the three-way valve is connected with the pressure gauge.
In the above animal model of acute periosteum syndrome, the pressurizing fluid bag assembly comprises: an air bag connected with the pressure control air pump, and a sterile liquid bag arranged in the air bag and connected with the infusion assembly.
The animal model of acute periosteum syndrome comprises a balloon which comprises: the inflatable airbag comprises an inflatable airbag body, an inflation inlet arranged on the inflatable airbag body, an airbag external fixing sleeve bag arranged outside the inflatable airbag body, and a fixed connecting piece arranged on the airbag external fixing sleeve bag.
The animal model of acute periosteum syndrome comprises a driving component and a driving component, wherein the driving component comprises: a moving shaft connected with the vent valve, and an electromagnet connected with the moving shaft and connected with a pressure controller and a power supply of the pressure control air pump.
The utility model discloses an useful part lies in:
the pressure control air pump maintains the pressure in the sterile water bag, so that the pressure in the sterile liquid bag can maintain high pressure at the same horizontal position of the animal; the pressure-controlled air pump is used for controlling the increasing speed of the pressure in the air bag, then the increasing speed of the pressure in the water bag is controlled, and finally the increasing speed of the pressure in the fascia chamber is controlled; the pressure-controlled pressure-measuring water injection method of the utility model provides a higher-range pressurization range, and the correlation between the pressure in the three-way pressure-measuring meter at the near end of water injection and the pressure in the fascia chamber is excellent; therefore, the pressure in the fascia chamber can be monitored in real time, and the severity of the periosteum syndrome model can be evaluated in real time;
the pressure in the fascia chamber can be indicated by the pressure gauge, so that tissue damage caused by repeated acupuncture pressure measurement of the traditional pressure measurement method and fascia indoor pressure fluctuation caused by liquid injection in the pressure measurement process are avoided.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of an animal model of the present invention;
FIG. 2 is a schematic diagram of an external structure of an embodiment of the pressure-controlled air pump of the present invention (A: the rear side view of the pressure-controlled air pump, B: the side view of the pressure-controlled air pump, C: the lower side view of the pressure-controlled air pump, and D: the upper side view of the pressure-controlled air pump);
FIG. 3 is a schematic diagram of the internal structure of an embodiment of the pressure-controlled air pump of the present invention (A: the schematic diagram of the pressure-controlled air pump when air is sucked in, B: the schematic diagram of the pressure-controlled air pump when air is discharged);
FIG. 4 is a schematic view of the internal structure of an embodiment of the airbag of the present invention (A: front view of the airbag, B: external fixation of the airbag, C: usage of the airbag, D: front view of the pressurizing liquid bag assembly, E: side view of the pressurizing liquid bag assembly);
fig. 5 is a relationship between the pressure of the pressure-controlled pressure-measuring water-injection air pump and the pressure of the three-way pressure-measuring meter;
fig. 6 is the relationship between the pressure of the three-way pressure gauge of the pressure-controlled pressure-measuring water-injection method and the pressure in the fascia chamber;
fig. 7 is a relationship between the pressure of the pressure-controlled pressure-measuring water-injection air pump and the pressure in the fascia chamber;
FIG. 8 is a graph showing the relationship between the height of a conventional intramuscular water-infusion bag and the pressure applied.
The meaning of the reference symbols in the figures:
the air pump comprises an experimental animal 1, a pressure control air pump 2, a sterile liquid bag 3, an infusion apparatus 4, an air bag 5, a medical silicone tube 6, an infusion apparatus switch 7, a three-way valve 8, a remaining needle 9, a pressure gauge 10, a pressure control air pump power supply 11, a pressure controller 12, a pressure control air pump box body 13, a vent hole 14, a vent hole 15, a rear cover 16, an air inlet 17, an electromagnet 20, a motion shaft 21, a vent valve 22, an inflatable air bag body 23, an inflation inlet 24, an external airbag fixing sleeve bag 25 and a magic tape 26.
Detailed Description
The present invention will be described in detail with reference to the accompanying drawings and specific embodiments.
As shown in fig. 1, 2 and 3, an acute periosteum syndrome animal model comprises: the pressure control air pump 2 is connected with the transfusion component of the experimental animal 1, and the pressurizing liquid bag component is connected between the pressure control air pump 2 and the transfusion component; the pressure control air pump 2 includes: the pressure control air pump comprises a pressure control air pump box body 13, a pressure control air pump power supply 11 and a pressure controller 12 which are arranged in the pressure control air pump box body 13, an air vent 14 and a rear cover 16 which are arranged on the pressure control air pump box body 13, an air outlet 15 and an air inlet 17 which extend to the pressure control air pump box body 13, a vent valve 22 which is arranged between the air outlet 15 and the air inlet 17, and a driving assembly which is connected between the vent valve 22 and the pressure control air pump power supply 11 and the pressure controller 12.
As shown in fig. 1, the infusion set comprises: an infusion apparatus 4 connected with the pressurizing liquid bag component, an indwelling needle 9 connected with the infusion apparatus 4 and connected with the experimental animal 1, and an infusion apparatus switch 7 arranged on the infusion apparatus 4. A three-way valve 8 is arranged between the transfusion device 4 and the indwelling needle 9, and a pressure gauge 10 is connected on the three-way valve 8.
The pressurized fluid bag assembly includes: an air bag 5 connected with the pressure control air pump 2, and a sterile liquid bag 3 arranged in the air bag 5 and connected with the infusion set. The sterile liquid bag is filled with sterile normal saline injection. A medical silicone tube 6 is arranged between the pressure control air pump 2 and the air bag 5.
As shown in fig. 4, the airbag 5 includes: the inflatable airbag comprises an inflatable airbag body 23, an inflation inlet 24 arranged on the inflatable airbag body 23, an airbag external fixing sleeve bag 25 arranged outside the inflatable airbag body 23, and a fixing connecting piece arranged on the airbag external fixing sleeve bag 25. As a preference, the fixing connector is a magic tape 26, and other fixing connectors besides the magic tape 26 may be used, such as: zippers, buttons, adhesives, and the like.
The drive assembly includes: a moving shaft connected to the air vent valve 22, and an electromagnet 20 connected to the moving shaft and connected to the pressure controller 12 and the pressure control air pump power supply 11. The pressure controller 12 and the pressure control air pump power supply 11 are matched to control the input electric power, and the movement of the moving shaft is controlled, so that the air outlet and inlet amount is controlled. Drive assembly is unrestricted, also can give vent to anger with other methods control and admit air what, for example set up 5 stifled gas ports of gasbag in inside and give vent to anger and the control of admitting air, perhaps be the accurate cooperation through guide rail and baffle, as long as can both be applied to accurate control the utility model discloses.
In order to verify the value of the device in the construction of an animal periosteum syndrome model, the pressure-controlled pressure-measuring water injection method of the utility model is used for comparing the water injection pressure control range and the quality with the traditional intramuscular water injection method;
firstly, establishing an animal model for a pressure control type pressure measurement water injection method, wherein the manufacturing method comprises the following steps:
1. the experimental preparation process comprises the following steps:
1) the animals are fasted 12h before the experiment, and water is not forbidden;
2) during the experiment, animals are weighed, and are anesthetized by injecting sodium pentobarbital in an abdominal cavity, wherein the concentration of the sodium pentobarbital is 3 percent, and the dosage is 40-50 mg/kg; sodium pentobarbital maintained the anesthetic state during the experiment;
3) fixing the animal, shaving the lower limb of the animal, and exposing the operation part;
4) connecting the sterile liquid bag 3 and the infusion apparatus 4, and exhausting air in the infusion apparatus 4;
5) the front end of the transfusion device 4 is connected with a pressure gauge 10 through a three-way valve 8;
6) the air bag 5 of the pressure control air pump 2 is wrapped on the periphery of the sterile liquid bag 3 and is connected with a pressure control air pump power supply 11;
7) the sterile liquid bag 3, the infusion apparatus 4 and the pressure gauge 10 are placed at the same level with the lower limbs of the animals.
2. The establishment process of the acute periosteum syndrome model comprises the following steps:
1) using 9 heads of an indwelling needle of an infusion apparatus 4 to enter the needle from the lower end position of the fascia chamber at an angle of 45 degrees with the skin, entering the fascia chamber and then parallel to the fasciae, then pulling out a needle core, and indwelling an infusion hose in the fascia chamber;
2) the switch 7 of the infusion apparatus is turned on, so that the liquid in the sterile liquid bag 3 can flow into the fascia chamber;
3) the pressure control air pump 2 sets pressure and pressurizing speed;
4) during the experiment, the pressure in the fascia chamber is monitored by using a pressure gauge 10 at the front end of the infusion apparatus 4;
5) setting the pressure maintaining time of the pressure control air pump 2;
6) and after the pressure duration is over, closing the pressure control air pump 2, closing the infusion apparatus 4 and pulling out the indwelling tube.
7) In the experimental process, if the duration of the pressure gauge 10 is more than or equal to 30mmHg and is more than 2 hours, the model is successfully established.
The experimental process comprises the following steps:
experimental materials: 3 male SD rats of 250g to 270 g.
The experimental process comprises the following steps: the periosteum syndrome model is built on both lower limbs, the traditional intramuscular water injection method is used on the left side, and the new pressure-controlled pressure-measuring water injection method is used on the right side. The traditional intramuscular water injection method needs to provide pressure through a high hanging water bag, and the provided pressure is related to the height of the water bag. The height of the conventional intramuscular water infusion bag and the pressure provided are recorded and the pressure inside the fascial chamber is measured. Recording the pressure of the new pressure-controlled pressure-measuring water-injection pressure-controlling air pump, the pressure of the three-way pressure-measuring gauge and measuring the pressure in the fascia chamber.
The results of the experiment are shown in FIGS. 5-8;
and (4) analyzing results: the height of the water bag in the traditional intramuscular water injection method is proportional to the provided pressure, and the water bag can provide 74.14mmH pressure for every 1m of increase. The new pressure-controlled manometric flooding operating platform level can provide 282mmHg internal pressure. The pressure in the pressure-controlled pump is positively correlated with the pressure in the water bag and the pressure in the fascia chamber, and the numerical values of the pressure-controlled pump, the water bag and the fascia chamber are close to each other: pressure-controlled pump internal pressure and water bag internal pressure R20.9958, K0.9661; pressure in pressure-controlled pump and pressure in fascia chamber R20.9963, K0.9836. Therefore, the new pressure-controlled water injection method provides a higher range of pressure increase range. The correlation between the pressure in the water injection proximal three-way pressure gauge and the pressure in the fascia chamber is excellent, the pressure in the fascia chamber can be indicated by the pressure of the pressure gauge, and tissue damage and fascia indoor pressure fluctuation caused by liquid injection in the pressure measuring process caused by repeated acupuncture pressure measurement by the traditional pressure measuring method are avoided.
The pressure control air pump maintains the pressure in the sterile water bag, so that the pressure in the sterile liquid bag can maintain high pressure at a horizontal position; the pressure-controlled air pump is used for controlling the increasing speed of the pressure in the air bag, then the increasing speed of the pressure in the water bag is controlled, and finally the increasing speed of the pressure in the fascia chamber is controlled; a higher pressurization range can be provided, and the correlation between the pressure in the water injection near-end three-way pressure measuring meter and the pressure in the fascia chamber is excellent; therefore, the pressure in the fascial chamber can be monitored in real time, and the severity of the periosteal chamber syndrome model can be evaluated in real time.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It should be understood by those skilled in the art that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by adopting equivalent replacement or equivalent transformation fall within the protection scope of the present invention.
Claims (6)
1. An animal model of acute periosteum syndrome, comprising: the pressure control air pump is connected with the transfusion assembly of the experimental animal, and the pressurizing liquid bag assembly is connected between the pressure control air pump and the transfusion assembly; the pressure control air pump includes: the pressure control air pump box body, set up pressure control air pump power, the pressure controller in the pressure control air pump box body, set up the blow vent on the pressure control air pump box body, extend in gas outlet, the air inlet of pressure control air pump box body, set up in breather valve between gas outlet, the air inlet connects the drive assembly between breather valve and pressure control air pump power, pressure controller.
2. The animal model of acute periosteal syndrome according to claim 1, wherein the infusion set comprises: the device comprises an infusion apparatus connected with a pressurizing liquid bag assembly, an indwelling needle connected with the infusion apparatus and connected with the experimental animal, and an infusion apparatus switch arranged on the infusion apparatus.
3. The animal model of acute periosteum syndrome according to claim 2, wherein a three-way valve is arranged between the infusion apparatus and the indwelling needle, and a pressure gauge is connected to the three-way valve.
4. The animal model of claim 1, wherein the pressurized fluid bag assembly comprises: an air bag connected with the pressure control air pump, and a sterile liquid bag arranged in the air bag and connected with the infusion assembly.
5. The animal model of claim 4, wherein the balloon comprises: the inflatable airbag comprises an inflatable airbag body, an inflation inlet arranged on the inflatable airbag body, an airbag external fixing sleeve bag arranged outside the inflatable airbag body, and a fixed connecting piece arranged on the airbag external fixing sleeve bag.
6. The animal model of claim 1, wherein the drive assembly comprises: a moving shaft connected with the vent valve, and an electromagnet connected with the moving shaft and connected with a pressure controller and a power supply of the pressure control air pump.
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| CN202021959499.6U CN212345028U (en) | 2020-09-09 | 2020-09-09 | Acute periosteum syndrome animal model |
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| CN202021959499.6U CN212345028U (en) | 2020-09-09 | 2020-09-09 | Acute periosteum syndrome animal model |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112075385A (en) * | 2020-09-09 | 2020-12-15 | 浙江大学 | Acute periosteum syndrome animal model and manufacturing method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112075385A (en) * | 2020-09-09 | 2020-12-15 | 浙江大学 | Acute periosteum syndrome animal model and manufacturing method thereof |
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