CN212308015U - Isolated human impedance detection device - Google Patents
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- CN212308015U CN212308015U CN201921436122.XU CN201921436122U CN212308015U CN 212308015 U CN212308015 U CN 212308015U CN 201921436122 U CN201921436122 U CN 201921436122U CN 212308015 U CN212308015 U CN 212308015U
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Abstract
The utility model discloses an isolated human impedance detection device, including impulse generator, data processing unit, data display element, one or more treatment electrode and a passageway or two impedance acquisition units, impulse generator's output and treatment electrode's input are connected, and impedance acquisition unit's collection input still is connected with treatment electrode's output respectively, impedance acquisition unit's collection output with data processing unit's input is connected, through the check point of one or more voltage detection electrode and the human body of current detection electrode contact, obtains voltage trigger signal and current trigger signal; and respectively preprocessing the voltage trigger signal and the current trigger signal, and then sending the preprocessed signals into a data processing unit for calculation. The utility model discloses can carry out human impedance and detect, guarantee the electroporation effect, can play real-time supervision and melt the effect, reduce the volume and the weight of check out test set circuit.
Description
Technical Field
The utility model belongs to the technical field of human impedance measures, concretely relates to isolated human impedance detection device.
Background
The tumor ablation treatment technology is characterized in that under the guidance of images, energy such as radio frequency, microwave, freezing, laser, electric field and the like is extremely accurately punctured to a target area of a tumor, an accurate minimally invasive ablation operation is implemented, the tumor is inactivated in situ, and the method is a brand-new accurate minimally invasive operation. Thermal ablation destroys tumor cells by heating or freezing the tissue. The physical ablation technology widely applied in clinic at present comprises argon-helium knife cryoablation, radio frequency, microwave and laser thermal ablation and the like. Although these ablation techniques have a definite therapeutic effect and outstanding advantages, the main disadvantage is that the destruction of the tissue is not selective, i.e. the normal tissue organs such as blood vessels, nerves, bile ducts, pancreatic ducts, etc. are completely destroyed in the ablation zone except the tumor tissue. The defect is the main reason causing complications after the ablation, such as massive hemorrhage after the ablation, damage of a bile duct system, perforation of an intestinal canal, nerve dysfunction and the like which are common in clinic. This non-selective tissue destruction by thermal ablation greatly increases the risk of clinical use of this technique and severely limits its range of clinical use. In addition, because the blood flow can take away heat, the heat ablation effect is seriously influenced by blood perfusion, and the heat ablation causes tissue necrosis and is not easy to be discharged out of the body.
The nano-knife ablation is to transmit a high-voltage electric field to tumor cells in the form of micro-pulses, change the transmembrane potential of the cells, cause nanometer pores on lipid bilayer cell membranes, increase the permeability of the cell membranes, cause irreversible electroporation of the tumor cells in a target area, and finally cause tumor death. The nanometer knife ablates living cells, theoretically reserved cell matrixes and structures around the cells have small influence on tissues such as blood vessels, bile ducts, nerves and the like in a treatment area, generally only have recoverable damage, and still keep complete on structure and function. And because the nano-knife ablation is non-thermal ablation and is not influenced by blood flow, complete cell death can be generated around blood vessels.
The nanoprobe ablation process, if the applied electric field exceeds a certain threshold, will result in permanent destruction of the cell membrane structure and cellular homeostasis, causing an immune response, leading to apoptosis. According to different tumors, the pulse electric field intensity is 1.5kV/cm, the pulse width is 20-1000 mus, the pulse amplitude determines the volume of single ablation, the larger the volume of single ablation with amplitude is, the maximum output current can reach 50A, the pulse amplitude is 3kV, and the pulse power can reach 150 kW; the pulse amplitude is 4.5kV and the pulse power will reach 225 kW. In the treatment process, when irreversible electroporation occurs to the tissue, the impedance of the biological tissue continuously changes along with the treatment process, the impedance of a human body needs to be calculated, the electroporation effect is ensured, and the ablation effect is monitored in real time. At present, unipolar square wave pulses are adopted clinically, the intensity of the used pulse electric field is 1.5kV/cm, the pulse width is 100 mus, and the pulse amplitude is 3kV square waves. Because the impedance of the biological tissue is continuously changed along with the treatment process, the impedance between the treatment electrodes can be reduced to 60 omega, the safety of directly measuring the impedance of the human body is low, namely, if a short-circuit fault occurs, the energy is completely released to a patient, and disastrous results are caused
SUMMERY OF THE UTILITY MODEL
The to-be-solved technical problem of the utility model is not enough to prior art exists, provides an isolated human impedance detection device, according to the utility model discloses a detection circuitry can carry out human impedance and detect, guarantees the electroporation effect, plays real-time supervision and melts the effect to adopt isolated AD conversion technology, improved the electrical safety of irreversible electroporation equipment circuit, reduced the volume and the weight of electroporation equipment circuit. In order to realize the purpose, the utility model discloses a technical scheme as follows:
according to the utility model discloses an aspect provides an isolated human impedance detection device, including impulse generator, data processing unit, data display element, one or more treatment electrode and a passageway or two passageways more than just be used for gathering human impedance's impedance acquisition unit, impulse generator's output respectively with one or more treatment electrode's input is connected, impedance acquisition unit's collection input respectively with treatment electrode's output is connected, impedance acquisition unit's collection output with data processing unit's input is connected, this data processing unit's output with data display element connects to treatment electrode is as the check point, and the voltage and the electric current of the treatment pulse signal of check point are gathered to impedance acquisition unit's collection input.
Preferably, each impedance collecting unit at least comprises a voltage collecting unit and a current collecting unit, the therapeutic electrode comprises a voltage detecting electrode and a current detecting electrode, the output end of the pulse generator is respectively connected with the input end of the voltage detecting electrode and the input end of the current detecting electrode, the voltage collecting unit comprises a voltage low-pass filter circuit, a voltage peak holding circuit, a voltage signal attenuation circuit and a voltage isolation type a/D converter, the output end of the voltage detecting electrode is connected with the input end of the voltage peak holding circuit through the voltage low-pass filter circuit, and the output end of the voltage peak holding circuit is connected with the first detecting input end of the data processing unit through the voltage signal attenuation circuit and the voltage isolation type a/D converter; the current acquisition unit comprises a current low-pass filter circuit, a current peak value holding circuit, a current signal attenuation circuit and a current isolation type A/D converter, the output end of the current detection electrode is connected with the input end of the current peak value holding circuit through the current low-pass filter circuit, and the output end of the current peak value holding circuit is connected with the second detection input end of the data processing unit through the current signal attenuation circuit and the current isolation type A/D converter.
Preferably, the voltage low-pass filter circuit includes a resistor R1 and a capacitor C1, the voltage peak holding circuit includes a first operational amplifier U1, a rectifier diode S1 and a capacitor C2, the voltage signal attenuation circuit includes a resistor R2, a resistor R3 and a second operational amplifier U2, one end of the resistor R1 is connected to the output end of the voltage detection electrode, the other end of the resistor R1 is connected to one end of the capacitor C1 and the positive input end of the first operational amplifier U1, the output end of the first operational amplifier U1 is connected to the anode of the rectifier diode S1, the cathode of the rectifier diode S1 is connected to one end of the capacitor C2, one end of the resistor R2 and the negative input end of the first operational amplifier U1, the other end of the resistor R2 is connected to one end of the resistor R3 and the positive input end of the second operational amplifier U2, the output end of the second operational amplifier U2 is connected to the cathode of the second operational amplifier U2 and the voltage isolation input end of the second operational amplifier U2 The acquisition input end of the separate A/D converter is connected, the acquisition output end of the voltage isolation A/D converter is connected with the first detection input end of the data processing unit U, and the other end of the capacitor C1, the other end of the capacitor C2 and the other end of the resistor R3 are respectively connected with the ground.
Preferably, the isolated A/D converter adopts an AMC1303MX converter chip.
Preferably, the amplitude of the voltage pulse output by the detection electrode is 5V-3000V.
Preferably, a plurality of the detection electrodes are arranged and fixed on a substrate in a spiral or circular ring shape, each detection electrode is 8-12 mm, each electrode forms spiral distribution on a human body or is annularly surrounded on the human body, when the impedance of deep tissues of the human body is detected, an additional detection electrode is not independently used, but the detection is carried out through a treatment electrode, the secondary damage to the human body is avoided, the size and the weight of a detection equipment circuit are reduced, each electrode is respectively contacted with the human body to form a detection point, the resolution precision of impedance detection is improved, and the impedance sum between the detection points of the human body corresponding to each resistor is detected.
To sum up, the utility model discloses owing to adopted above technical scheme, beneficial effect lies in:
(1) the utility model discloses a detection circuitry can carry out human impedance and detect, guarantees the electroporation effect, can play real-time supervision and melt the effect to adopt isolated AD conversion technique, improved the electrical safety of irreversible electroporation equipment circuit, reduced the volume and the weight of electroporation equipment circuit.
(2) The utility model discloses a peak holding circuit can keep the pulse peak value of about 100 mus pulse width to 300 mus pulse width of every passageway, and peak holding circuit keeps the peak value after the pulse shaping for a period of time, as follow-up signal attenuation circuit's input. High frequency signal carries out AD data conversion after signal attenuation through signal attenuation module, carries out the isolation to human impedance detection above all, the utility model discloses an isolated human impedance detects, not only observes the electroporation effect, also has the isolation moreover.
Drawings
In order to illustrate the embodiments of the present invention or the technical solutions in the prior art more clearly, the drawings required in the description of the embodiments or the prior art will be briefly introduced below, it is obvious that the drawings in the following description are only some examples of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive step.
FIG. 1 is a schematic block diagram of an isolated human body impedance detection device of the present invention;
fig. 2 is a schematic circuit diagram of an isolated human body impedance detection device of the present invention;
fig. 3 is a flow chart of the isolated human body impedance detection of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the examples of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
According to one aspect of the present invention, referring to FIG. 1, the present invention provides an isolated human body impedance detecting device, which comprises a pulse generator, a data processing unit, a data display unit, one or more treatment electrodes, and an impedance collecting unit for collecting human body impedance, the output end of the pulse generator is respectively connected with the input ends of one or more treatment electrodes, the acquisition input end of the impedance acquisition unit is respectively connected with the output end of the treatment electrode, the acquisition output end of the impedance acquisition unit is connected with the input end of the data processing unit, the output end of the data processing unit is connected with the data display unit, the therapeutic electrode is used as a detection point, and the acquisition input end of the impedance acquisition unit acquires the voltage and the current of the therapeutic pulse signal of the detection point. In the present invention, each impedance collecting unit at least comprises a voltage collecting unit and a current collecting unit, the therapy electrode comprises a voltage detection electrode and a current detection electrode, the output end of the pulse generator is respectively connected with the input end of the voltage detection electrode and the input end of the current detection electrode, the voltage collecting unit comprises a voltage low-pass filter circuit, a voltage peak holding circuit, a voltage signal attenuation circuit and a voltage isolation type a/D converter, the output end of the voltage detection electrode is connected with the input end of the voltage peak holding circuit through the voltage low-pass filter circuit, and the output end of the voltage peak holding circuit is connected with the first detection input end of the data processing unit through the voltage signal attenuation circuit, the voltage isolation type a/D converter; the current acquisition unit comprises a current low-pass filter circuit, a current peak value holding circuit, a current signal attenuation circuit and a current isolation type A/D converter, the output end of the current detection electrode is connected with the input end of the current peak value holding circuit through the current low-pass filter circuit, and the output end of the current peak value holding circuit is connected with the second detection input end of the data processing unit through the current signal attenuation circuit and the current isolation type A/D converter.
In the present invention, as shown in fig. 1 and fig. 2, the voltage low-pass filter circuit includes a resistor R1 and a capacitor C1, the voltage peak holding circuit includes a first operational amplifier U1, a rectifier diode S1 and a capacitor C2, the voltage signal attenuation circuit includes a resistor R2, a resistor R3 and a second operational amplifier U2, one end of the resistor R1 is connected to the output end of the voltage detection electrode, the other end of the resistor R1 is connected to one end of the capacitor C1 and the positive input end of the first operational amplifier U1, the output end of the first operational amplifier U1 is connected to the anode of the rectifier diode S1, the cathode of the rectifier diode S1 is connected to one end of the capacitor C2, one end of the resistor R2 and the negative input end of the first operational amplifier U1, the other end of the resistor R2 is connected to one end of the resistor R3 and the positive input end of the second operational amplifier U2, the output end of the second operational amplifier U2 is connected to the negative input end of the second operational amplifier U2 and the acquisition input end of the voltage isolation type a/D converter, the acquisition output end of the voltage isolation type a/D converter is connected to the first detection input end of the data processing unit U4, and the other end of the capacitor C1, the other end of the capacitor C2 and the other end of the resistor R3 are connected to ground. In the present invention, as shown in fig. 2, the circuit structure principle of the current low-pass filter circuit, the current peak holding circuit, the current signal attenuation circuit and the current isolation type a/D converter in the current collection unit is the same as the structure principle of the voltage low-pass filter circuit, the voltage peak holding circuit and the voltage signal attenuation circuit in the voltage collection unit, the current low-pass filter circuit includes a resistor R11 and a capacitor C11, the current peak holding circuit includes a second operational amplifier U11, a rectifier diode S11 and a capacitor C12, the current signal attenuation circuit includes a resistor R12, a resistor R13 and a third operational amplifier U12, one end of the resistor R11 is connected to the output end of the current detection electrode, the other end of the resistor R11 is connected to one end of the capacitor C11 and the positive input end of a second operational amplifier U11, the output end of the second operational amplifier U11 is connected to the anode of the rectifier diode S11, the negative electrode of the rectifier diode S11 is connected to one end of a capacitor C12, one end of a resistor R12, and the negative input end of a second operational amplifier U11, the other end of the resistor R12 is connected to one end of the resistor R13 and the positive input end of a third operational amplifier U12, the output end of the third operational amplifier U12 is connected to the negative input end of the third operational amplifier U12 and the acquisition input end of a current isolation type a/D converter U13, the acquisition output end of the current isolation type a/D converter U13 is connected to the second detection input end of the data processing unit U4, and the other end of the capacitor C11, the other end of the capacitor C12, and the other end of the resistor R13 are connected to ground.
The working principle of the voltage acquisition unit is further explained below, the voltage pulse amplitude output by the voltage detection electrode is 5V-3000V, the voltage peak holding circuit is composed of a first operational amplifier U1, a rectifier diode S1 and a capacitor C2, and a low-pass filter is composed of a resistor R1 and a capacitor C1 to filter the pulse wave output by the detection electrode and eliminate noise interference; the voltage attenuator is composed of a resistor R2 and a resistor R3, the input voltage is attenuated to be within a range of 250mv so as to prevent the voltage isolation type A/D converter U3 from exceeding the measuring range, the isolation type A/D converter U3 is borne by an AMC1303MX chip, and the chip realizes two functions, namely the isolation effect on human body impedance detection and AD data conversion. The output of the voltage attenuator is sent into an AINN port of a voltage isolation type A/D converter U3 after passing through an operation follower formed by a second operational amplifier, and is connected in parallel by a capacitor C3 and a capacitor C4, and the nominal voltage provided by an analog power supply 5V AVDD port is filtered; the output of isolated A/D converter U3 is the digital end of isolation, and the digital signal of modulation is exported by the DOUT port, and parallelly connected by electric capacity C5 and electric capacity C6, filters the power that digital power supply 5V DVDD digital port provided, in the utility model discloses in, the digital signal of AMC1303 MX's output DOUT is as the data input signal of data processing unit, adopts 32 position floating point formula microprocessor U3 to handle and the analysis as the core processor to the signal of gathering, and shows the result of handling at data display unit, and microprocessor U3 adopts TMS320F28 2837X treater chip to calculate, and isolated human impedance detection circuitry adopts the AMC1303MX chip, and this chip is input and output for high accuracy modulator isolation. If the switch has short-circuit fault, the output end is isolated from the input end, and the energy can be blocked to be released to a patient, so that the safety of the patient is protected, and the AMC1303MX chip can be used for not only AD data conversion, but also the most important thing is that the isolation effect on human body impedance detection is carried out, so that the safety of the human body is ensured. AMC1303MX is a high-precision delta-sigma (Δ Σ) modulator, and the output and input circuits are isolated by capacitive double isolation gates with high magnetic field immunity. The isolation barrier is certified to provide enhanced isolation up to 7000V peak according to DINV DE V0884-10 (semiconductor device-magnetic capacitive coupler standard for safety insulation), UL1577 (rating Standards for device dielectric withstand voltage, voltage breakdown rating), and CSA standard (Canadian Standards Association). When used with an isolated power supply, the isolated modulator prevents noise currents on the common mode high voltage line from entering the local system ground, thereby interfering with or damaging the low voltage circuit and preventing damage to lower voltage devices. At the same time, isolated modulator AMC1303MX is optimized for direct-connect shunt resistors or other low voltage class signal sources, while having excellent DC and AC performance. By decimating the bit stream using an appropriate digital filter, a 16-bit resolution of 85dB (13.8ENOB) dynamic range can be achieved at a 78kSPS data rate. On the high side, the modulator is powered by a 5V (avdd) nominal voltage, while the isolated digital interface is powered by a 3.3V or 5V power supply (DVDD) nominal voltage. When the impedance detection is started, the signal detected by the detection electrode is a square wave pulse, and the pulse width of the square wave pulse determines the output pulse width on the electrode. The peak holding circuit holds the pulse peak value of the pulse width of about 100 mu s of each channel to the pulse width of 300 mu s, and the peak holding circuit holds the peak value after pulse forming for a period of time as the input of a subsequent signal attenuation circuit. After the high-frequency signal is subjected to signal attenuation by the signal attenuation module and is used as the input of the isolated A/D converter, the AMC1303MX chip can not only perform AD data conversion, but also perform isolation on human body impedance detection most importantly, and the human body impedance is calculated according to the resistance which is voltage/current. The utility model discloses an isolated human impedance detects, not only can observe the electroporation effect, also has the isolation moreover.
The utility model discloses in, combine fig. 1, fig. 2 and fig. 3, utilize isolated human impedance detection device carries out the flow that detects includes following step:
step S1, using the therapeutic electrode as the detection point, collecting the voltage trigger signal and the current trigger signal (voltage and current of the therapeutic pulse signal) of the detection point at least by a voltage collecting unit and a current collecting unit, the therapeutic electrode includes a voltage detecting electrode and a current detecting electrode, contacting the voltage detecting electrode and the current detecting electrode with the detection point of the human body, then applying a trigger signal source to the voltage detecting electrode and the current detecting electrode, making the voltage detecting electrode and the current detecting electrode obtain the voltage trigger signal and the current trigger signal respectively; the utility model can apply a trigger signal source to the voltage detection electrode and the current detection electrode through one or more voltage detection electrodes and current detection electrodes contacting the detection point of the human body, so that the voltage detection electrode and the current detection electrode respectively obtain a voltage trigger signal and a current trigger signal; the voltage detection electrodes and the current detection electrodes are spirally or circularly arranged and fixed on a substrate, each detection electrode is 8-12 mm, each electrode is used as a detection point, repeated measurement is carried out for multiple times through the detection points, and trigger signals of 128 or 256 sampling points are acquired each time; continuously measuring the same detection point for 10s, so that the measured human body impedance value is more accurate;
step S2, sending the voltage trigger signal and the current trigger signal to an isolated a/D converter after signal attenuation, low-pass filtering, peak holding, and signal re-attenuation, respectively, to obtain a voltage digital signal and a current digital signal, as shown in fig. 3; the applied trigger signal source is a nanometer knife pulse generator which generates electric pulses, the pulse waveform, amplitude, repetition frequency, pulse width and pulse frequency directly influence the treatment effect, and therefore, the voltage trigger signal and the current trigger signal can be sent to signal isolation and A/D conversion after attenuation, peak value holding and signal attenuation again so as to obtain voltage data output and current data output; due to the ablation process at the nanoptome, if the applied electric field exceeds a certain threshold, it will cause permanent damage to the cell membrane structure and cellular homeostasis, causing an immune response, leading to apoptosis. Therefore, irreversible electroporation (IRE) is generated on a phospholipid or phospholipoprotein membrane of a mammal by an electric pulse technology, the typical value of a mammal cell is as high as 2.5kV/cm, therefore, the electric field intensity of a pulse output by a nano knife pulse generator is required to be high enough to ensure the electroporation effect, when the irreversible electroporation is performed on the mammal cell, the nano knife pulse generator adopts a square wave output waveform, the constant voltage range applied to a detection electrode (a treatment electrode 1 and a treatment electrode 2) is 500V-5000V, the repetition frequency is between 1 Hz and 2Hz, the pulse width is generally 1 mu s to hundreds mu s, and the pulse frequency is between 1 to 199 times, therefore, when the nano knife ablation is performed on a human body through the detection electrode, the impedance detection is performed on the human body to obtain the voltage data and the current data during the ablation, so as to ensure the electroporation effect and can play a role in monitoring the ablation effect in real time;
and step S3, sending the voltage digital signal and the current digital signal into a data processing unit, calculating the voltage digital signal and the current digital signal by using a preset resistance-voltage/current calculation model, calculating the measured human body impedance value, and displaying the calculated human body impedance value on a data display unit.
In the utility model, one or more voltage detection electrodes and current detection electrodes are contacted with the human body, a preset trigger signal source is applied to one or more voltage detection electrodes and current detection electrodes, continuous measurement is carried out in a preset time to obtain a plurality of sampling point values of voltage trigger signals and current trigger signals, then the plurality of sampling point values and a preset resistance voltage/current calculation model are calculated to obtain an average value, the measured impedance value of the human body is calculated, a plurality of voltage detection electrodes and current detection electrodes are arranged and fixed on a substrate in a spiral or circular ring shape, each detection electrode is 8mm-12mm, the same detection point is continuously measured for 10s, sampling is carried out for a plurality of times in the measuring time to obtain 128 or 256 sampling points, and then the average value is calculated and obtained through the resistance voltage/current calculation model, the measured human body impedance value is more accurate.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not intended to limit the present invention, and all modifications, equivalents, improvements and the like that are made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (6)
1. An isolated human impedance detection device, its characterized in that: the impedance acquisition unit comprises a pulse generator, a data processing unit, a data display unit, one or more treatment electrodes and one or more than two channels and is used for acquiring human body impedance, wherein the output end of the pulse generator is respectively connected with the input ends of the one or more treatment electrodes, the acquisition input end of the impedance acquisition unit is respectively connected with the output end of the treatment electrode, the acquisition output end of the impedance acquisition unit is connected with the input end of the data processing unit, and the output end of the data processing unit is connected with the data display unit.
2. The isolated human impedance detection device of claim 1, wherein: each impedance acquisition unit at least comprises a voltage acquisition unit and a current acquisition unit, the treatment electrode comprises a voltage detection electrode and a current detection electrode, the output end of the pulse generator is respectively connected with the input end of the voltage detection electrode and the input end of the current detection electrode, the voltage acquisition unit comprises a voltage low-pass filter circuit, a voltage peak holding circuit, a voltage signal attenuation circuit and a voltage isolation type A/D converter, the output end of the voltage detection electrode is connected with the input end of the voltage peak holding circuit through the voltage low-pass filter circuit, and the output end of the voltage peak holding circuit is connected with the first detection input end of the data processing unit through the voltage signal attenuation circuit and the voltage isolation type A/D converter; the current acquisition unit comprises a current low-pass filter circuit, a current peak value holding circuit, a current signal attenuation circuit and a current isolation type A/D converter, the output end of the current detection electrode is connected with the input end of the current peak value holding circuit through the current low-pass filter circuit, and the output end of the current peak value holding circuit is connected with the second detection input end of the data processing unit through the current signal attenuation circuit and the current isolation type A/D converter.
3. An isolated human body impedance detection device according to claim 2, wherein: the voltage low-pass filter circuit comprises a resistor R1 and a capacitor C1, the voltage peak holding circuit comprises a first operational amplifier U1, a rectifier diode S1 and a capacitor C2, the voltage signal attenuation circuit comprises a resistor R2, a resistor R3 and a second operational amplifier U2, one end of the resistor R1 is connected with the output end of the voltage detection electrode, the other end of the resistor R1 is respectively connected with one end of the capacitor C1 and the positive input end of the first operational amplifier U1, the output end of the first operational amplifier U1 is connected with the anode of the rectifier diode S1, the cathode of the rectifier diode S1 is respectively connected with one end of the capacitor C2, one end of the resistor R2 and the negative input end of the first operational amplifier U1, the other end of the resistor R2 is respectively connected with one end of the resistor R3 and the positive input end of the second operational amplifier U2, and the output end of the second operational amplifier U2 is respectively connected with the cathode A of the second operational amplifier U2 and the voltage isolation type input end A The acquisition input end of the voltage isolation type A/D converter is connected, the acquisition output end of the voltage isolation type A/D converter is connected with the first detection input end of the data processing unit U, and the other end of the capacitor C1, the other end of the capacitor C2 and the other end of the resistor R3 are respectively connected with the ground.
4. An isolated human body impedance detection device according to claim 2 or 3, wherein: the isolated A/D converter employs an AMC1303MX converter chip.
5. An isolated human body impedance detection device according to claim 2 or 3, wherein: the amplitude of the voltage pulse output by the detection electrode is 5V-3000V.
6. An isolated human body impedance detection device according to claim 5, wherein: the plurality of detection electrodes are spirally or circularly arranged and fixed on one substrate, and each detection electrode is 8-12 mm.
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| CN110448374B (en) * | 2019-09-01 | 2024-05-03 | 上海健康医学院 | Isolated human body impedance detection circuit and detection method |
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