CN212260095U - Sterile and gnotobiotic animal isolation cage - Google Patents
Sterile and gnotobiotic animal isolation cage Download PDFInfo
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- CN212260095U CN212260095U CN202020346875.8U CN202020346875U CN212260095U CN 212260095 U CN212260095 U CN 212260095U CN 202020346875 U CN202020346875 U CN 202020346875U CN 212260095 U CN212260095 U CN 212260095U
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Abstract
The utility model provides an isolation cage for aseptic and gnotobiotic animals, which comprises an isolation cabin fixedly supported by a bracket, wherein the top of the isolation cabin is connected with an air supply pipeline through an arranged air supply high-efficiency filter, the back of the lower part of the isolation cabin is connected with an exhaust pipeline through an arranged exhaust high-efficiency filter, and the air supply pipeline is communicated with the exhaust pipeline through a proportion adjusting valve; the air supply pipeline is provided with an air inlet, and an air supply fan is arranged inside the air supply pipeline; the exhaust duct is provided with an air outlet, and an exhaust fan is arranged inside the exhaust duct. The sterile and gnotobiotic animal isolation cage can create a locally closed positive pressure ventilation space, inhibit microorganisms from entering, and meet the ethical welfare of experimental animals.
Description
Technical Field
The utility model relates to an experimental animals facility especially relates to an aseptic and gnotobiotic animal isolation cage.
Background
The experimental animal is the basis and the important supporting condition of life science and medical science research, and the quality of the experimental animal plays an important role in the quality of biological products. With the progress of human and the development of society, experimental animals are more and more emphasized by all countries in the world, and the development and application degree of the experimental animals are one of important marks for measuring the scientific and technical level of a country and a region. With the development of the science of experimental animals and the soundness of various laws and regulations in China, researchers of scientific research gradually recognize the influence of environmental factors on experimental results and the harm to the health of personnel, and pay attention to the environmental control of experimental animals.
As a special device capable of effectively carrying out biological isolation, the sterile and gnotobiotic isolation cage (hereinafter referred to as the isolation cage) can meet the requirement that the sterile and gnotobiotic animals cannot detect microorganisms and parasites.
Maintaining sterility inside the isolation cage is critical due to the high market value of sterile and gnotobiotic animals. The existing market isolation cage has poor sterilization effect and sterility maintenance, lacks of cognition on welfare ethics of experimental animals, lacks of consideration on equipment operation safety, and has the following specific defects:
1) the isolation cage channel sealing effect is poor, the risk that microorganisms enter the interior of the isolation cage is large, the requirement on the background environment required by the sterility of the isolation cage is high, and the plant cost is high.
2) The inside sterile treatment of cage is verifiable poor.
3) The interior of the isolation cage is not easy to be thoroughly cleaned, and is easy to accumulate dirt and grow bacteria.
4) The energy consumption of the ventilation system required for sterile maintenance is high.
5) The animal has sensitive sense of hearing, the common isolation cage lacks the comprehensive control to the noise, and only controls the noise outside the isolation cage but not controls the noise inside the isolation cage.
6) Only the illumination intensity is considered, and the wavelength, the illumination time or the light and shade alternation time are not controlled, so that the body and the physiology of the experimental animal are influenced.
7) For sudden power outages, the device itself has no security provisions.
In order to solve the problems, a sterile and gnotobiotic animal isolation cage is developed.
SUMMERY OF THE UTILITY MODEL
The utility model provides an aseptic and gnotobiotic animal isolation cage has solved the problem among the background art, its technical scheme as follows:
an isolation cage for sterile and gnotobiotic animals comprises an isolation cabin fixedly supported by a bracket, wherein the top of the isolation cabin is connected with an air supply pipeline through an arranged air supply efficient filter, the back of the lower part of the isolation cabin is connected with an exhaust pipeline through an arranged exhaust efficient filter, and the air supply pipeline is communicated with the exhaust pipeline through a proportion adjusting valve; the air supply pipeline is provided with an air inlet, and an air supply fan is arranged inside the air supply pipeline; the exhaust duct is provided with an air outlet, and an exhaust fan is arranged inside the exhaust duct.
The isolation cabin is a full-welding cabin body, the square toughened glass and the isolation cabin are sealed by adopting an inflatable sealing strip, the inside of the isolation cabin is polished, and the edge inside the cabin body is in circular transition.
The toughened glass is transparent toughened glass and is provided with isolating gloves.
The isolation cabin is provided with a PLC control system which is connected with the illuminating lamp, the touch screen and the wireless signal device and realizes control through the touch screen.
The PLC control system is connected with the air exhaust fan and the air supply fan, and the air pressure of the air exhaust fan and the air supply fan is controlled through the frequency converter through power supply Hertz control.
The bottom of the isolation cabin is provided with a drain valve and a VHP sterilizer.
And an RTP (real-time transport protocol) rapid transfer valve is arranged on the side surface of the isolation cabin and used for realizing the tightness in the process of transferring articles to the isolation cage.
The inside of isolation cabin is provided with the washing squirt, and the water inlet of washing squirt is located the back of isolation cabin, washs isolation cabin inner surface.
The inside of isolation cabin is provided with the baffle, the baffle is located the inside below of isolation cabin to be higher than the height of air exit.
The size of the isolation cage can be customized, and multiple isolation cabins can be connected in parallel.
The sterile and gnotobiotic animal isolation cage can create a locally closed positive pressure ventilation space, inhibit microorganisms from entering, and meet the ethical welfare of experimental animals.
Drawings
FIG. 1 is a schematic structural view of the sterile and Sydney animal isolation cage;
fig. 2 is a side schematic view of fig. 1.
Detailed Description
As shown in figure 1, the sterile and Sydner animal isolation cage comprises an isolation cabin 6, and the lower part of the isolation cabin 6 is fixedly supported by a support 1. The material of the support 1 and the isolation capsule 6 is stainless steel 304.
The isolation cabin 6 is a full-welding cabin body, the toughened glass and the isolation cabin 6 are sealed by adopting an inflatable sealing strip, so that the whole cabin body is sealed without leakage, the entering of microorganisms can be effectively blocked, and the whole equipment can be used in a D-level clean environment. The inside of the isolation cabin 6 is polished, and the edge inside the cabin body is in circular transition, so that the isolation cabin is free of dead angle and easy to clean.
The front of the isolation cabin 6 is made of transparent toughened glass, and personnel operate the isolation cabin through isolation gloves 5 arranged on the toughened glass.
A drain valve 11 is mounted at the bottom of the isolation chamber 6. The bottom of the isolation cabin 6 is also provided with a VHP sterilizer 2 and a UPS power supply 3. The VHP sterilizer 2 is connected to the isolation cabin 6, so that the inside of the isolation cage can be sterilized in place, and the VHP sterilizer 2 gasifies a 30% -35% H2O2 solution and then injects the gasified solution into the inside of the isolation cage 6 for diffusion sterilization by a fan. After sterilization, the system has the functions of H2O2 concentration degradation and residue elimination. Furthermore, sterilization needs to be developed through a sterilization process, and a corresponding chemical indicator is adopted for distribution. The sterilization effect needs to be verified, and a challenge experiment is carried out by adopting a corresponding biological indicator.
The UPS 3 can provide power protection for the system and has certain cruising ability.
The left side of the isolation cabin 6 is provided with an RTP rapid transit valve 4, and the RTP rapid transit valve 4 is used for the tightness of the process of transferring articles by the isolation cage.
The inside of isolation cabin 6 is provided with washing squirt 7, baffle 13, and the water inlet of washing squirt 7 is located the back of isolation cabin 6, can wash isolation cabin 6 internal surface. The partition 13 is located below the interior of the isolation capsule 6.
Referring to fig. 2, the top of the isolation cabin 6 is provided with an illuminating lamp 8, a touch screen 9, a wireless signal device 10, an air outlet 15, a proportional control valve 16, an air supply blower 17, an air inlet 18 and an air supply high-efficiency filter 19. The back of the isolation cabin 6 is provided with an exhaust high-efficiency filter 12 and an exhaust fan 14.
The air supply fan 17 is positioned in an air supply pipeline between the air inlet 18 and the air supply high-efficiency filter 19, and the air supply pipeline is communicated with the inside of the isolation cabin 6 through the air supply high-efficiency filter 19. An exhaust high-efficiency filter 12 is arranged on the back of the lower part of the isolation cabin 6, and an exhaust fan 14 in an exhaust pipeline is used for exhausting part of air of the isolation cabin 6 to the outside through an exhaust outlet 15, and the other part of air is sent to an air supply pipeline through a proportion adjusting valve 16. The air flow of the equipment is designed to be 70-80% of circulating air, 20-30% of clean fresh air, and the air flow is realized by the opening and closing of the proportion adjusting valve 16.
The air inlet of the isolation cage is blocked by the air inlet high-efficiency filter 19, the air exhaust of the isolation cage is blocked by the air exhaust high-efficiency filter 12, and the entering of microorganisms can be effectively blocked.
Further, the utility model discloses a configuration is aired exhaust high efficiency filter 12, is advanced air high efficiency filter 19, can the separation air exhaust fan 14, the noise that air supply fan 17 produced, and the noise in the isolation cabin 6 will be minimum.
The isolation cabin 6 is provided with a PLC control system, and the control is realized through the touch screen 9 at the top, so that various control requirements of the system can be met. The PLC control system is connected to the wireless signal device 10, and is configured to wirelessly transmit the pod status data or receive the control signal.
The PLC control system controls the intensity, wavelength, illumination time or light and shade alternation time of the illumination lamp 8, so that the body and physiology of the experimental animal reach normal states.
The PLC control system regulates and controls the power supply Hertz through the frequency converter to increase the wind pressure of the exhaust fan 14 and the air supply fan 17, and the service life of the filter can be prolonged.
The size of the isolation cage can be customized, and a plurality of isolation cabins 6 can be connected in parallel.
The sterile and gnotobiotic animal isolation cage can create a locally closed positive pressure ventilation space, inhibit microorganisms from entering, and meet the ethical welfare of experimental animals.
Claims (10)
1. An aseptic and gnotobiotic animal isolation cage which is characterized in that: the air supply device comprises an isolation cabin fixedly supported by a bracket, wherein the top of the isolation cabin is connected with an air supply pipeline through an arranged air supply efficient filter, the back of the isolation cabin below is connected with an exhaust pipeline through an arranged exhaust efficient filter, and the air supply pipeline is communicated with the exhaust pipeline through a proportion adjusting valve; the air supply pipeline is provided with an air inlet, and an air supply fan is arranged inside the air supply pipeline; the exhaust duct is provided with an air outlet, and an exhaust fan is arranged inside the exhaust duct.
2. The sterile and gnotobiotic isolation cage of claim 1, wherein: the isolation cabin is a full-welding cabin body, the square toughened glass and the isolation cabin are sealed by adopting an inflatable sealing strip, the inside of the isolation cabin is polished, and the edge inside the cabin body is in circular transition.
3. The sterile and gnotobiotic isolation cage of claim 2, wherein: the toughened glass is transparent toughened glass and is provided with isolating gloves.
4. The sterile and gnotobiotic isolation cage of claim 1, wherein: the isolation cabin is provided with a PLC control system which is connected with the illuminating lamp, the touch screen and the wireless signal device and realizes control through the touch screen.
5. The sterile and gnotobiotic isolation cage of claim 4, wherein: the PLC control system is connected with the air exhaust fan and the air supply fan, and the air pressure of the air exhaust fan and the air supply fan is controlled through the frequency converter through power supply Hertz control.
6. The sterile and gnotobiotic isolation cage of claim 1, wherein: the bottom of the isolation cabin is provided with a drain valve and a VHP sterilizer.
7. The sterile and gnotobiotic isolation cage of claim 1, wherein: and an RTP (real-time transport protocol) rapid transfer valve is arranged on the side surface of the isolation cabin and used for realizing the tightness in the process of transferring articles to the isolation cage.
8. The sterile and gnotobiotic isolation cage of claim 1, wherein: the inside of isolation cabin is provided with the washing squirt, and the water inlet of washing squirt is located the back of isolation cabin, washs isolation cabin inner surface.
9. The sterile and gnotobiotic isolation cage of claim 1, wherein: the inside of isolation cabin is provided with the baffle, the baffle is located the inside below of isolation cabin to be higher than the height of air exit.
10. The sterile and gnotobiotic isolation cage of claim 1, wherein: the size of the isolation cage can be customized, and multiple isolation cabins can be connected in parallel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020346875.8U CN212260095U (en) | 2020-03-18 | 2020-03-18 | Sterile and gnotobiotic animal isolation cage |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202020346875.8U CN212260095U (en) | 2020-03-18 | 2020-03-18 | Sterile and gnotobiotic animal isolation cage |
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| Publication Number | Publication Date |
|---|---|
| CN212260095U true CN212260095U (en) | 2021-01-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202020346875.8U Active CN212260095U (en) | 2020-03-18 | 2020-03-18 | Sterile and gnotobiotic animal isolation cage |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113207844A (en) * | 2021-03-19 | 2021-08-06 | 温州医科大学 | Parasite protection device for IVC system |
| CN113519402A (en) * | 2021-06-08 | 2021-10-22 | 中国人民解放军南部战区总医院 | Multifunctional experimental animal isolator |
-
2020
- 2020-03-18 CN CN202020346875.8U patent/CN212260095U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113207844A (en) * | 2021-03-19 | 2021-08-06 | 温州医科大学 | Parasite protection device for IVC system |
| CN113519402A (en) * | 2021-06-08 | 2021-10-22 | 中国人民解放军南部战区总医院 | Multifunctional experimental animal isolator |
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