CN212246845U

CN212246845U - Crystallization, filtration and drying integrated machine for beta cyclodextrin production

Info

Publication number: CN212246845U
Application number: CN202020862221.0U
Authority: CN
Inventors: 孔维銮; 童平; 曹文超
Original assignee: Qufu Tianli Medical Supplements Co ltd
Current assignee: Qufu Tianli Medical Supplements Co ltd
Priority date: 2020-05-21
Filing date: 2020-05-21
Publication date: 2020-12-29
Anticipated expiration: 2030-05-21

Abstract

The utility model relates to a beta cyclodextrin production is with crystallization filtration drying all-in-one, belong to pharmaceutic adjuvant processing field, including a jar body, internal stirring portion and the filter of being provided with of jar, its characterized in that, stirring portion includes upper stirring portion and lower stirring portion, upper stirring portion and lower stirring portion are connected with the drive division that drives the main shaft rotation through a common main shaft, upper stirring portion sets up to the stirring rake structure, lower stirring portion sets up to the scraper structure, still be provided with the filter in the jar body, the filter sets up below lower stirring portion, be provided with the discharge gate on the lateral wall of jar body of filter upside; a jacket is arranged outside the tank body; the top of the tank body is provided with a feed inlet, a solvent inlet and an exhaust port, and the outer end of the exhaust port is connected with a vacuum part through a first gas path; a liquid outlet is arranged at the bottom of the tank body, and a drying air inlet part is connected to the bottom of the tank body; has better stirring, filtering and drying effects, less equipment damage and higher yield of the obtained beta-cyclodextrin.

Description

Crystallization, filtration and drying integrated machine for beta cyclodextrin production

Technical Field

The utility model relates to a pharmaceutic adjuvant processing technology field, concretely relates to beta cyclodextrin production is with crystallization filter drying all-in-one.

Background

Cyclodextrin (CD for short) is a general name of a series of cyclic oligosaccharides generated by amylose under the action of Cyclodextrin glucosyltransferase generated by bacillus, generally contains 6-12D-glucopyranose units, is in the form of oligosaccharide crystalline powder, has the general property of starch, is widely used as a filler of medicines, and has wide application prospects in the field of medical industry. The structure of the cyclodextrin is formed by connecting a plurality of molecules end to end by alpha-1, 4-glycosidic bonds, the cyclodextrin molecules have a slightly conical hollow cylindrical three-dimensional annular structure, and the beta-cyclodextrin has moderate molecular holes, wide application range and low production cost, and is a cyclodextrin product which is most used in industry.

The production process of the beta-cyclodextrin generally comprises the working procedures of hydrolysis, extraction, decoloration, filtration, purification, drying, pulverization and the like, wherein a plurality of devices such as an extraction tank, a filter, a dryer, a crusher and the like are required to be used respectively, and the sequence needs to be changed for a plurality of times in the production process, the patent application document with the publication number of CN101628190A in the prior art discloses a filtering and drying integrated device, the filtering and drying operation does not need to be changed by adopting the filtering and drying integrated device, however, the stirrer in the structure is a stirrer with a single structure, and the beta-cyclodextrin has the characteristic of being thick in texture, which is put into an integrated device, filtered beta-cyclodextrin is adhered on a filter plate and is not easy to stir, therefore, when the stirrer with the single structure is used for beta-cyclodextrin, poor stirring effect is easy to occur, and even the motor of the stirrer is damaged. In addition, the filtration and drying integrated device with the structure is not suitable for the production of beta-cyclodextrin, and has the problem of low product yield.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve the technical problem that to prior art not enough, provide a stirring, filtration, drying effect is better, the little beta cyclodextrin production is with crystallization filter drying all-in-one of equipment damage, and gained beta cyclodextrin productivity is higher.

The utility model provides an above-mentioned technical problem's technical scheme as follows: a crystallization, filtration and drying integrated machine for producing beta cyclodextrin comprises a tank body, wherein a stirring part and a filter plate are arranged in the tank body, and the crystallization, filtration and drying integrated machine is characterized in that the stirring part comprises an upper stirring part and a lower stirring part, the upper stirring part and the lower stirring part are connected with a driving part for driving a main shaft to rotate through a common main shaft, the upper stirring part is of a stirring paddle structure, the lower stirring part is of a scraper structure, the filter plate is also arranged in the tank body, the filter plate is arranged below the lower stirring part, and a discharge port is formed in the side wall of the tank body on the upper side of; a jacket is arranged outside the tank body, and a heat exchange medium flows through the jacket; the top of the tank body is provided with a feed inlet, a solvent inlet and an exhaust port, and the outer end of the exhaust port is connected with a vacuum part through a first gas path; the bottom of the tank body is provided with a liquid outlet, the liquid outlet is connected with the vacuum part through a second gas path, the bottom of the tank body is connected with a drying air inlet part, and the drying air inlet part is communicated with the bottom of the filter plate through a third gas path.

The dry air inlet portion adopts the forced draught blower, and the forced draught blower exit end sets up an electric heat piece, the electric heat piece adopts mica electric heat piece for blow hot-blast to the filter bottom, the filter surface is equipped with the filtration pore, hot-blast upwards blows through a plurality of intensive filtration pores, then be used for solving the easy problem of blockking up of filtration pore after the suction filtration, two then be arranged in the drying process and cooperate gas vent evacuation and stirring portion to play the boiling effect, realize the boiling through direct breather pipe than current, can improve drying efficiency greatly, three then be used for crushing in-process, increase the disturbance of powder, improve crushing effect, avoid the powder to block up the filtration pore, reduce material loss.

The driving part comprises a driving motor and a speed reducer matched with the driving motor, the output end of the driving part is connected with the main shaft through a sealing piece, and a cooling part is arranged outside the sealing piece.

A medium inlet is arranged at the upper part of the jacket, a medium outlet is arranged at the lower part of the jacket, and a heat exchange medium (hot water or cold water) flows through the jacket and is used for controlling the temperature of the integrated machine under different processes; a feed inlet and a solvent inlet at the top of the tank body are used for feeding beta cyclodextrin extracting solution and crystallization solvent into the tank body; the vacuum part is connected with a liquid outlet at the bottom and is used for suction filtration of materials in the tank body; the vacuum part is connected with the exhaust port at the top and used for adjusting the negative pressure in the tank body, and the vacuum part is matched with the drying air inlet part to blow hot air to the bottom end of the filter plate and used for negative pressure drying of materials in the tank body; the stirring part in the tank body is applied to the processes of cooling crystallization, filtration and drying, the special design of the stirring part is that the upper stirring part of the stirring paddle structure and the lower stirring part of the scraper structure are cooperated, the lower stirring part plays a role in instantly rotating the beta-cyclodextrin deposited and adhered on the filter plate, the rapid and uniform stirring is realized by cooperating with the upper stirring part, the stirring effect is good, and the load of the driving part is prevented from being increased.

And a first air exhaust valve is arranged on the first air path, a second air exhaust valve is arranged on the second air path air valve, and an air supply valve is arranged on the third air path and is respectively used for independently controlling the corresponding air paths.

Still be provided with the filter on the first gas circuit for filter the material of taking out through the gas vent, reduce material loss.

And a liquid outlet is arranged on the second gas circuit and used for discharging the filtrate during suction filtration.

Further, stirring portion includes at least two sets of stirring scrapers of arranging along the main shaft direction down, stirring scraper and main shaft fixed connection, and the stirring scraper of bottom sets up on the filter, and the length of these at least two sets of stirring scrapers is in proper order degressively along the orientation by supreme down, and the horizontal angle of stirring scraper sets up to 30. According to the technical scheme, the length of the stirring scraper is designed in a descending manner, and the design of the horizontal angle of the stirring scraper is matched, so that on one hand, when the main shaft rotates, the driven stirring scraper at the lower part can quickly rotate the material from the filter plate, and simultaneously give an upward thrust to the material, so that the material is quickly contacted with the stirring paddle at the upper part, the purpose of quick stirring is further achieved, the stirring effect is improved, particularly in the crushing stage, the crushing effect can be improved, and the particle size of the crushed material is more uniform; on the other hand, in the discharging process after drying and crushing, the material on the upper part smoothly slides down to the discharging port on one side of the filter plate, so that quick discharging is realized, and inconvenience in operation of cleaning the material by workers is avoided.

Further, go up stirring portion including at least two sets of stirring rakes of arranging along the main shaft direction, threaded connection's mode is set to the inner of the stirring rake of bottom and main shaft, and the inner of the stirring rake of bottom is provided with the internal thread, and the lower part is provided with one section and this stirring rake matched with external screw thread in the main shaft, and the upper limit of this external screw thread is located the bottom of last stirring rake, and the lower limit is located the top of stirring portion down, and other stirring rakes except this stirring rake are fixed connection with the main shaft. Adopt this technical scheme, cooperation drive division adopts positive and negative rotation driving motor, under the existence condition of this ropy material of jar internal beta cyclodextrin, the positive and negative rotation of drive division can drive this stirring rake respectively and realize its up-and-down motion along the main shaft direction, and then realize the amalgamation and part of this bottom stirring rake rather than the upper portion stirring rake, be applicable to when initial stirring under the amalgamation state or filter the internal beta cyclodextrin resistance too high condition of later stage jar, each stirring rake is comparatively dispersed under the detached state, be applicable to the even stirring after the stirring is stabilized.

Further, at least two supports are further arranged in the tank body, the supports are sleeved outside the main shaft, and the end portions of the supports are fixed on the inner wall of the tank body. One of the supports is arranged between the upper stirring part and the lower stirring part, the other support is arranged on the upper side of the upper stirring part, specifically, a shaft sleeve is sleeved outside the main shaft, and the outside of the shaft sleeve is fixedly connected with the supports and used for increasing the stability of the main shaft during rotation.

Furthermore, the bottom of the tank body is also connected with a high-pressure spraying part which adopts a high-pressure spraying machine, the high-pressure spraying machine is commercially available, the output end of the high-pressure spraying machine is provided with a spray head which faces the bottom end of the filter plate and is used for cleaning the filter plate, the structure does not need to disassemble the filter plate, the automatic cleaning is realized, the operation is convenient, and the problems of complexity and low efficiency of manual cleaning are avoided; in addition, the drying air inlet part and the drying air inlet part are organically combined to form a form of sprayed bubble water, so that the efficiency and the cleaning effect of the cleaning filter plate can be greatly improved.

The utility model has the advantages that:

1. the device is used for secondary crystallization, filtration, drying and crushing in the production process of beta-cyclodextrin to form integrated equipment through the arranged jacket, the stirring part, the filter plate, the vacuum part and the drying air inlet part, and is beneficial to improving the effects and efficiency of the procedures of stirring, filtration, drying and the like in the tank body; the special design of the stirring part is that the upper stirring part of the stirring paddle structure and the lower stirring part of the scraper structure are cooperated, the lower stirring part plays a role of instantly rotating beta-cyclodextrin deposited and adhered on the filter plate, the rapid and uniform stirring is realized by cooperating with the upper stirring part, the stirring effect is good, and the load of the driving part is prevented from being increased;

2. the lower stirring part comprises at least two groups of stirring scrapers which are arranged along the direction of the main shaft, the lengths of the stirring scrapers are sequentially reduced from bottom to top, and the horizontal angle of the stirring scrapers is set to be 30 degrees, so that when the main shaft rotates, the driven lower stirring scraper can quickly rotate the material from the filter plate and simultaneously give an upper thrust to the material, the material is quickly contacted with the stirring paddle on the upper part, the aim of quickly stirring is further fulfilled, and the stirring effect is improved; on the other hand, in the discharging process after drying and crushing, the material on the upper part can smoothly slide down to the discharging port on one side of the filter plate, so that quick discharging is realized, and the inconvenience in material cleaning operation of workers is avoided;

3. the utility model discloses a crystallization filtering and drying all-in-one is used for beta-cyclodextrin's secondary crystallization and drying, crushing, and the result productivity improves greatly.

Drawings

FIG. 1 is a schematic structural diagram of the crystallization, filtration and drying integrated machine of the present invention;

in the figure: 1. the vacuum drying device comprises a tank body, 2 parts of a stirring part, 21 parts of an upper stirring part, 22 parts of a lower stirring part, 3 parts of a filter plate, 4 parts of a main shaft, 41 parts of external threads, 5 parts of a driving part, 51 parts of a driving motor, 52 parts of a speed reducer, 53 parts of a sealing part, 54 parts of a cooling part, 6 parts of a discharge port, 7 parts of a jacket, 71 parts of a medium inlet, 72 parts of a medium outlet, 81 parts of a feed port, 82 parts of a solvent inlet, 9 parts of an exhaust port, 10 parts of a vacuum part, 11 parts of a first gas path, 111 parts of a first gas suction valve, 112 parts of a filter, 12 parts of a second gas path, 121 parts of a second gas suction valve, 122 parts of a liquid discharge port, 13 parts of a third gas path, 131 parts of a blast valve, 14 parts of.

Detailed Description

The principles and features of the present invention will be described with reference to the drawings, which are provided for illustration purposes only and are not intended to limit the scope of the present invention.

As shown in fig. 1, the crystallization, filtration and drying integrated machine for producing beta-cyclodextrin of the present embodiment comprises a tank body 1, a stirring part 2 and a filter plate 3 are arranged in the tank body 1, the stirring part 2 comprises an upper stirring part 21 and a lower stirring part 22, the upper stirring part 21 and the lower stirring part 22 are connected to a driving part 5 for driving a main shaft 4 to rotate through a common main shaft 4, the upper stirring part 21 is arranged in a stirring paddle structure, the lower stirring part 22 is arranged in a scraper structure, the tank body 1 is also provided with the filter plate 3, the filter plate 3 is arranged below the lower stirring part 22, and a discharge port 6 is arranged on the side wall of the tank body 1 on the upper side of the filter plate; a jacket 7 is arranged outside the tank body 1, a heat exchange medium flows through the jacket 7, a medium inlet 71 is arranged at the upper part of the jacket 7, and a medium outlet 72 is arranged at the lower part of the jacket 7; the top of the tank body 1 is provided with a feed inlet 81, a solvent inlet 82 and an exhaust port 9, and the outer end of the exhaust port 9 is connected with a vacuum part 10 through a first gas path 11; the bottom of the tank body 1 is provided with a liquid outlet 14, the liquid outlet 14 is connected with a vacuum part 10 through a second air passage 12, the bottom of the tank body 1 is connected with a drying air inlet part 15, and the drying air inlet part 15 is communicated with the bottom of the filter plate 3 through a third air passage 13.

The drying air inlet part 15 adopts a blower, the outlet end of the blower is provided with an electric heating sheet, the electric heating sheet adopts a mica electric heating sheet, and the surface of the filter plate 3 is provided with filter holes.

The driving part 5 comprises a driving motor 51 and a speed reducer 52 adapted to the driving motor, the output end of the driving motor is connected with the main shaft 4 through a sealing piece 53, and a cooling part 54 is arranged outside the sealing piece 53.

The lower stirring part 22 of this embodiment includes at least two groups of stirring scrapers arranged along the direction of the main shaft 4, the stirring scrapers are fixedly connected with the main shaft 4, the stirring scraper at the bottom end is arranged on the filter plate 3, and the lengths of the at least two groups of stirring scrapers are gradually decreased from bottom to top; the clearance between the stirring scraper and the filter plate 3 is set within 2mm, and the horizontal angle of the stirring scraper is set to be 30 degrees.

Go up stirring portion 21 include at least two sets of stirring rakes of arranging along 4 directions of main shaft, the mode of threaded connection is set to with main shaft 4 in the stirring rake of bottom, and the stirring rake of bottom is provided with the internal thread, and the lower part is provided with one section and this stirring rake matched with external screw thread 41 in 4 of main shaft, other stirring rakes except this stirring rake are fixed connection with main shaft 4.

In this embodiment, the tank body 1 is further provided with at least two brackets 16, the brackets 16 are sleeved outside the main shaft 4, and the end portions of the brackets 16 are fixed on the inner wall of the tank body 1.

This embodiment 1 bottom of the jar body still be connected with high pressure and spray portion 17, high pressure spray portion 17 adopts the high pressure to spray the machine, and the output that the high pressure sprayed the machine is provided with the shower nozzle of direction towards filter 3 bottom.

Claims

1. The crystallization, filtration and drying integrated machine for producing beta cyclodextrin comprises a tank body (1), wherein a stirring part (2) and a filter plate (3) are arranged in the tank body (1), and is characterized in that the stirring part (2) comprises an upper stirring part (21) and a lower stirring part (22), the upper stirring part (21) and the lower stirring part (22) are connected with a driving part (5) for driving a main shaft (4) to rotate through a common main shaft (4), the upper stirring part (21) is arranged into a stirring paddle structure, the lower stirring part (22) is arranged into a scraper structure, the tank body (1) is also internally provided with the filter plate (3), the filter plate (3) is arranged below the lower stirring part (22), and a discharge hole (6) is formed in the side wall of the tank body (1) on the upper side of the filter plate (3); a jacket (7) is arranged outside the tank body (1), and a heat exchange medium flows through the jacket (7); the top of the tank body (1) is provided with a feed inlet (81), a solvent inlet (82) and an exhaust port (9), and the outer end of the exhaust port (9) is connected with a vacuum part (10) through a first gas path (11); the bottom of the tank body (1) is provided with a liquid outlet (14), the liquid outlet (14) is connected with the vacuum part (10) through a second air passage (12), the bottom of the tank body (1) is connected with a drying air inlet part (15), and the drying air inlet part (15) is communicated with the bottom of the filter plate (3) through a third air passage (13).

2. The integrated crystallizing, filtering and drying machine for producing beta-cyclodextrin according to claim 1, wherein the lower stirring part (22) comprises at least two groups of stirring scrapers arranged along the direction of the main shaft (4), the stirring scrapers are fixedly connected with the main shaft (4), the stirring scraper at the bottommost end is arranged on the filter plate (3), and the lengths of the at least two groups of stirring scrapers are gradually decreased from bottom to top; the clearance between stirring scraper and filter (3) sets up within 2mm, the horizontal angle of stirring scraper sets up to 30.

3. The integrated crystallizing, filtering and drying machine for producing beta-cyclodextrin according to claim 1, wherein the upper stirring part (21) comprises at least two groups of stirring paddles arranged along the direction of the main shaft (4), the inner end of the stirring paddle at the bottommost end is in threaded connection with the main shaft (4), the inner end of the stirring paddle at the bottommost end is provided with internal threads, the middle lower part of the main shaft (4) is provided with a section of external threads (41) matched with the stirring paddle, and the other stirring paddles except the stirring paddle are fixedly connected with the main shaft (4).

4. The integrated crystallizing, filtering and drying machine for producing beta-cyclodextrin according to claim 1, wherein the tank body (1) is further provided with at least two brackets (16), the brackets (16) are sleeved outside the main shaft (4), and the end parts of the brackets (16) are fixed on the inner wall of the tank body (1).

5. The integrated crystallizing, filtering and drying machine for producing beta-cyclodextrin according to claim 1, wherein a medium inlet (71) is arranged at the upper part of the jacket (7), and a medium outlet (72) is arranged at the lower part of the jacket (7).

6. The integrated crystallizing, filtering and drying machine for producing beta-cyclodextrin according to claim 1, wherein the bottom of the tank body (1) is further connected with a high-pressure spraying part (17), the high-pressure spraying part (17) adopts a high-pressure spraying machine, and the output end of the high-pressure spraying machine is provided with a spray head which faces the bottom end of the filter plate (3).