CN212128148U - A separator for nerve cell - Google Patents
A separator for nerve cell Download PDFInfo
- Publication number
- CN212128148U CN212128148U CN201922444476.5U CN201922444476U CN212128148U CN 212128148 U CN212128148 U CN 212128148U CN 201922444476 U CN201922444476 U CN 201922444476U CN 212128148 U CN212128148 U CN 212128148U
- Authority
- CN
- China
- Prior art keywords
- filter screen
- left end
- end cover
- hand member
- nerve cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Abstract
The utility model relates to the technical field of medical equipment, concretely relates to a separator for nerve cell. This separator is including dismantling left end housing and the right-hand member lid of connecting as an organic whole, and left end housing and right-hand member lid pass through threaded connection, and the right-hand member lid is the back taper, and its head end is equipped with and is circular-arc filter screen support, and its end is equipped with the sealing plug, installs the filter screen on the filter screen support, constitutes the sample chamber between filter screen and the sealing plug, and left end housing bottom is equipped with the drain pipe, constitutes waste liquid chamber between the inside and the filter screen of left end housing, and the filtration pore diameter of filter screen is less than nerve cell. The utility model discloses to prior art not enough, provide a simple structure is reasonable a separator for nerve cell, solved current device and caused damage and the incomplete problem of cell separation to the cell in nerve cell separation process.
Description
Technical Field
The utility model relates to the technical field of medical equipment, concretely relates to a separator for nerve cell.
Background
Nerve cells refer to a class of cells derived from or capable of differentiating into nerve tissues, having self-renewal ability and multipotentiality, and in recent years, nerve cell research and cell therapy have become hot spots for treating neurodegenerative diseases and central nervous system injury. One of the most fundamental problems in cell research and cell therapy is the isolation of neural cells. In the prior art, microporous membrane filtration and suction equipment is usually adopted to directly suck mixed liquid, small particles and certain liquid are discharged through a filter screen under the action of negative pressure, and large and medium particles and large-diameter cells are intercepted, so that the separation of the large-diameter cells and the small particles is realized. However, the disadvantage is that the filtration pore size of the microporous membrane is small during negative pressure suction, and if the negative pressure is too large during operation, the strength of the membrane is not enough and the membrane is easy to break, so that the membrane pores of the microporous membrane are often blocked due to too many small particles in the mixed liquid, and incomplete separation or separation failure is easily caused.
SUMMERY OF THE UTILITY MODEL
The utility model discloses to prior art not enough, provide a simple structure is reasonable a separator for nerve cell, solved current device and caused damage and the incomplete problem of cell separation to the cell in nerve cell separation process.
The technical scheme of the utility model is realized like this: the utility model provides a separator for nerve cell, is including dismantling left end cover and right-hand member lid of connection as an organic whole, a serial communication port, left end cover and right-hand member lid pass through threaded connection, the right-hand member lid is the back taper, and its head end is equipped with and is circular-arc filter screen support, and its end is equipped with the sealing plug, install the filter screen on the filter screen support, constitute the sample chamber between filter screen and the sealing plug, left end cover bottom is equipped with the drain pipe, constitutes the waste liquid chamber between the inside and the filter screen of left end cover, the filtration pore diameter of filter screen is less than nerve cell's diameter.
The filter screen support is characterized in that a clamping groove is formed in the inner wall of the right end cover, and the filter screen support is fixed in the clamping groove through a buckle.
The filter screen is made of polyethylene, polycarbonate or polypropylene materials, the thickness of the filter screen is 0.5-0.8 mm, the diameter of a filter hole of the filter screen is 20-100 mu m, and the porosity is 45-70%.
And a fixed support is arranged on the outer side of the right end cover.
The left end cover is provided with a transparent viewing port, and the tail end of the liquid outlet pipe is provided with a liquid outlet plug.
The cross sections of the left end cover and the right end cover are circular or rectangular.
The utility model provides an existing defect among the background art, have following beneficial effect:
the utility model provides a separator for nerve cell simple structure is reasonable, has solved current device and has caused damage and the incomplete problem of cell separation to the cell in nerve cell separation process. The utility model discloses a under the effect of centrifugal force and fluid propulsion, waste liquids such as moisture in the separating medium and biological granule see through the worry hole entering waste liquid intracavity of filter screen, discharge through the drain pipe at last, and useful nerve cell can keep away from the filter screen and subside in the sample chamber under the effect of centrifugal force to can not block up the filtration pore, make the filter process continuously smooth and easy. The filtering holes of the filter screen are set to be smaller than the size of the nerve cells, so that the nerve cells are isolated and retained in the sampling cavity, and water and other small biological molecules flow to the waste liquid cavity. Through being the back taper with the right-hand member lid, filter screen support establishes to circular-arc, and such structure can increase filter area and filter screen intensity for the cell deposits in the sample chamber better, prevents that the filtration pore from blockking up.
Drawings
Fig. 1 is a schematic structural view of the present invention;
in the figure: 1-fixed support, 2-left end cover, 3-right end cover, 4-sampling cavity, 5-filter screen bracket, 6-sealing plug, 7-filter screen, 8-waste liquid cavity, 9-liquid outlet pipe, 10-liquid outlet plug, 11-buckle and 12-observation opening.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.
An embodiment of a separation device for nerve cells as shown in fig. 1, including dismantling left end cover 2 and right end cover 3 of connecting as an organic whole, left end cover 2 and right end cover 3 pass through threaded connection, right end cover 3 is the back taper, its head end is equipped with and is circular-arc filter screen support 5, its end is equipped with sealing plug 6, install filter screen 7 on the filter screen support 5, constitute sample chamber 4 between filter screen 7 and the sealing plug 6, 2 bottoms of left end cover are equipped with drain pipe 9, constitute waste liquid chamber 8 between 2 insides of left end cover and the filter screen 7, the filtration pore diameter of filter screen 7 is less than nerve cells's diameter. The inner wall of the right end cover 3 is provided with a clamping groove, and the filter screen bracket 5 is fixed in the clamping groove through a buckle 11. The filter screen 7 is made of polyethylene, polycarbonate or polypropylene materials, the thickness of the filter screen is 0.5-0.8 mm, the diameter of a filter hole is 20-100 mu m, and the porosity is 45-70%. The outer side of the right end cover 3 is provided with a fixed support 1. The left end cover 2 is provided with a transparent viewing port 12, and the tail end of the liquid outlet pipe 9 is provided with a liquid outlet plug 10. The cross sections of the left end cover 2 and the right end cover 3 are circular or rectangular.
The utility model discloses a working process is: when the separation device works, the nerve cell separation solution is added into the sampling cavity 4 of the separation device, and then the sealing plug 6 is inserted for sealing. And then placed on a centrifuge for centrifugation. Under the effect of centrifugal force and liquid propulsion, waste liquids such as micromolecule moisture and biological particles penetrate through the filter holes of the filter screen 7 to enter the waste liquid cavity 8, and are discharged to a waste liquid collecting bag through the liquid outlet pipe 9, so that the waste liquid collecting process is simple and easy to operate. And the nerve cells can be far away from the filter screen 7 and settle in the sampling cavity 4 under the action of centrifugal force, so that the filter holes can not be blocked, and the filtering process is continuous and smooth. After the centrifugation is finished, the operator can directly take away the separation collector to obtain the separated nerve cells. The filtering holes of the filtering net 7 are set to be 20-100 um in diameter and smaller than the size of cells to be separated, so that the nerve cells are isolated and retained in the sampling cavity 4, and water and other biological small molecules flow to the waste liquid cavity 8. Through being the back taper with right-hand member lid 3, filter screen support 5 sets up to circular-arc, and such structure can increase filter area and filter screen intensity for the cell deposits in sample chamber 4 better, makes it be difficult to block up to filtration pore department.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. The utility model provides a separator for nerve cell, is including dismantling left end lid (2) and right-hand member lid (3) of connection as an organic whole, a serial communication port, left end lid (2) and right-hand member lid (3) pass through threaded connection, right-hand member lid (3) are the back taper, and its head end is equipped with and is circular-arc filter screen support (5), and its end is equipped with sealing plug (6), install filter screen (7) on filter screen support (5), constitute sample chamber (4) between filter screen (7) and sealing plug (6), left end lid (2) bottom is equipped with drain pipe (9), constitutes waste liquid chamber (8) between left end lid (2) inside and filter screen (7), the filtration pore diameter of filter screen (7) is less than nerve cell's diameter.
2. The separation device for nerve cells according to claim 1, characterized in that: the filter screen support is characterized in that a clamping groove is formed in the inner wall of the right end cover (3), and the filter screen support (5) is fixed in the clamping groove through a buckle (11).
3. The separation device for neural cells according to claim 1 or 2, wherein: the filter screen (7) is made of polyethylene, polycarbonate or polypropylene materials, the thickness of the filter screen is 0.5-0.8 mm, the diameter of a filter hole of the filter screen is 20-100 mu m, and the porosity of the filter screen is 45-70%.
4. The separation device for nerve cells according to claim 3, wherein: and a fixed support (1) is arranged on the outer side of the right end cover (3).
5. The separation device for nerve cells according to claim 4, wherein: a transparent viewing port (12) is arranged on the left end cover (2), and a liquid outlet plug (10) is arranged at the tail end of the liquid outlet pipe (9).
6. The separation device for nerve cells according to claim 5, wherein: the cross sections of the left end cover (2) and the right end cover (3) are circular or rectangular.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922444476.5U CN212128148U (en) | 2019-12-30 | 2019-12-30 | A separator for nerve cell |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922444476.5U CN212128148U (en) | 2019-12-30 | 2019-12-30 | A separator for nerve cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212128148U true CN212128148U (en) | 2020-12-11 |
Family
ID=73676537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922444476.5U Expired - Fee Related CN212128148U (en) | 2019-12-30 | 2019-12-30 | A separator for nerve cell |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212128148U (en) |
-
2019
- 2019-12-30 CN CN201922444476.5U patent/CN212128148U/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information |
Inventor after: Hu Weiyan Inventor after: Zhang Rongping Inventor after: Yu Haofei Inventor after: Li Ju Inventor after: Zhang Lanchun Inventor after: Li Yuan Inventor after: Geng Yijuan Inventor before: Hu Weiyan Inventor before: Zhang Rongping Inventor before: Yu Haofei Inventor before: Li Ju Inventor before: Zhang Lanchun Inventor before: Li Yuan Inventor before: Geng Zhijuan |
|
| CB03 | Change of inventor or designer information | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20201211 Termination date: 20211230 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |