CN212084420U - Serial brain tissue retractor - Google Patents
Serial brain tissue retractor Download PDFInfo
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- CN212084420U CN212084420U CN202020577675.3U CN202020577675U CN212084420U CN 212084420 U CN212084420 U CN 212084420U CN 202020577675 U CN202020577675 U CN 202020577675U CN 212084420 U CN212084420 U CN 212084420U
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Abstract
A serial brain tissue retractor comprises a series of brain tissue retracting units, each brain tissue retracting unit comprises a respective expanding saccule and a catheter, the catheter is communicated with the expanding saccule, and the catheter is provided with a liquid injection interface; the expansion balloon adopts a non-compliant balloon; all brain tissue retracting units are sequenced from small to large according to the expanded diameters of the expanding saccule to form the front and back sequence in the operation, and the saccule expansion diameters of the brain tissue retracting units are increased progressively. The utility model has the advantages that: the brain tissue is flexibly pulled in a balloon expansion mode, so that the brain tissue cannot be cut, the integrity of the brain tissue is flexibly pulled and stored, and the postoperative tissue recovery is facilitated.
Description
Technical Field
The utility model relates to a brain tissue leads out device.
Background
Traditional brain tissue retraction and operation channel establishment mainly depends on brain pressure plates (stainless steel sheets) to retract brain tissue by using anatomical structures of cranium and brain through human hands, and mainly depends on professional skills, experience and patience of operation operators. In addition, cerebral vessels and nerves are easily damaged in the process of retracting brain tissues, the brain traction wound is visible everywhere, and the expanded channel is easy to shrink and become small due to the latent deformation characteristic of the brain tissues after retraction, so that the operation is influenced. The brain pressing plate is used for directly retracting the bone window, so that the operation is performed, the wound is large, the infection is easy, the recovery time of the patient is long, and the patient is suffered from great pain and heavy economic burden.
For the operation requiring brain parenchyma retraction, a brain pressing plate is useless, and an electrocoagulation knife is required for cutting, and the electrocoagulation knife can easily cause irreversible damage to nerves and blood vessels in brain tissues to cause partial brain function loss, and even cause death of patients.
CN201610334312.5 discloses a brain tissue retraction device, which comprises a flexible retraction assembly, including an expansion balloon, a support tube, a connection seat, a locking mechanism locked and matched with the connection seat, and a stamping device connector for expanding or contracting the expansion balloon; the brain pressing plate is sleeved at the far end of the flexible retracting component and enters the retracting channel to enable the retracting channel to be in a retracting state. The disadvantages of this brain tissue retraction device are: the expansion saccule is a compliance saccule or a semi-compliance saccule, liquid is injected into the expansion saccule before craniotomy, the saccule is expanded, and brain tissue is continuously retracted, so that a retraction channel for operation is established.
The disadvantages of this brain tissue retraction device are: the balloon in the brain tissue is squeezed by external force by using the compliance or semi-compliance balloon, but the balloon part outside the brain tissue has no squeezing effect, and when liquid is injected, the balloon outside the retraction channel is expanded, and the liquid amount in the retraction channel is less than that outside the retraction channel. That is to say, when injecting liquid into the expansion balloon, most of the liquid is located outside the retraction channel, and does not actually play a role in retracting brain tissue, so that when the expansion balloon establishes the retraction channel, even if the liquid injection amount is accurately controlled, the size of the retraction channel cannot be accurately controlled, and the time for establishing the retraction channel cannot be accurately controlled. When the craniotomy is performed, the time for establishing the retracting channel and obtaining the minimally invasive surgery channel is limited, the establishing time of the channel is usually controlled within 10-15 minutes, if the establishing time of the channel cannot be accurately controlled, the instrument is likely to be discarded in the surgery, or even if the instrument is used, the surgery time is prolonged, and the surgery risk is increased.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide a brain tissue draws device and training to establish the preoperative simulation method of operation passageway in the operation of craniotomy, aim at solving how to reduce among the prior art brain tissue and draw and cause the destruction to brain tissue internal nerve and blood vessel in the operation, ensure the accurate control that the operation passageway was established and shorten the settling time, and make the operation of craniotomy normally go on.
A brain tissue retractor comprises an expansion balloon, a catheter and an injection interface, wherein the catheter is communicated with the expansion balloon. The conduit being in communication with the dilation balloon means that liquid within the conduit is able to enter the dilation balloon. When the device is used, the injection interface is connected with devices or equipment which can input liquid, such as an injector, a pump and the like, and the liquid enters the expansion saccule from the catheter, so that the expansion saccule expands to further retract brain tissues.
The utility model provides a brain tissue retractor which is composed of saccules with different expansion diameters and the same length.
A tethered brain tissue retraction device, comprising: the brain tissue retracting device comprises a series of brain tissue retracting units, each brain tissue retracting unit comprises an expanding saccule and a catheter, the catheters are communicated with the expanding saccule and are provided with liquid injection interfaces; the expansion balloon adopts a non-compliant balloon; all brain tissue retracting units are sequenced from small to large according to the expanded diameters of the expanding saccule to form the front and back sequence in the operation, and the saccule expansion diameters of the brain tissue retracting units are increased progressively.
Preferably, the catheter diameters of all the brain tissue retracting units are the same, and the expansion balloon of each brain tissue retracting unit has a respective balloon expansion diameter and inflation point pressure value. For example, the diameter of the catheter is 1.3mm, and the expanded diameter of the expansion balloon of the minimum-sized brain tissue retraction unit is 2mm, which corresponds to the pressure value of the first expansion point; the expanded diameter of the next gauge of the dilatation balloon is 4mm, corresponding to the second inflation point pressure value, and so on.
During operation, the brain tissue retracting unit with the minimum specification is inserted into a brain tissue gap, then liquid is injected, the expansion balloon is expanded, and the operation is kept for a period of time, such as 0.5 min. Withdrawing the brain tissue retracting unit with the minimum specification, inserting the brain tissue retracting unit with the next specification into the brain tissue gap, injecting liquid, expanding the expansion saccule, and keeping for a period of time, such as 0.5 min. Usually a 12mm diameter retraction channel is required, the brain tissue retraction units are used in stages until the desired size of the retraction channel is obtained. The dilatation balloon maintains the dilatation state, squeezes the brain tissue while draining the cerebrospinal fluid. Therefore, after the expansion balloon is withdrawn, the brain tissue does not immediately recover, and the retraction channel obtained at the previous stage is maintained.
Or the diameter of the catheter of the next-stage brain tissue retracting unit is the expanded size of the expansion balloon of the previous-stage brain tissue retracting unit, and the expansion balloon of each brain tissue retracting unit has the respective balloon expansion diameter. In this way, the diameter of each grade of brain tissue retracting unit increased during expansion of the expansion balloon is the same, and although catheters with different sizes need to be manufactured, the use sequence of the brain tissue retracting units is favorably distinguished.
Preferably, the brain tissue retraction device comprises an expansion retention tube having the same size as the expanded size of the expansion balloon of the largest brain tissue retraction unit.
Preferably, the dilation holding tube is a soft tube, and supports, holds and protects the dilated surgical passage during surgery.
The utility model discloses in with the mode of expansion step by step, tractive to during the size entering brain tissue clearance of pipe, the pipe diameter is within 2mm, preferably sets up to 1.3mm ~1.83mm, makes the pipe both have intensity and rigidity, and the size is as far as possible little again, gets into in the tissue clearance easily. After the catheter enters the tissue gap, injecting liquid into the catheter to expand the expansion balloon, gradually and intermittently expanding the balloon to expand the retraction channel in a stepping manner, keeping a given time for each expansion to enable the brain tissue to adapt to the retraction force, keeping the intracranial pressure in a safe range, and considering the establishment time of the retraction channel and the protection of the brain tissue. Taking the case that the retracting channel is gradually expanded to 12mm from 2mm, the stepping diameter is 2mm, and the pause time of each stage is 0.5min, the establishment time of the retracting channel can be controlled within 10-15 min.
The utility model has the advantages that:
1. the brain tissue is flexibly pulled in a balloon expansion mode, so that the brain tissue cannot be cut, the integrity of the brain tissue is flexibly pulled and stored, and the postoperative tissue recovery is facilitated.
2. The retracting channel is established in a mode of reaming from small to large step by step, so that brain tissues can have sufficient time to adapt to the retracting action, the time of each expansion of the saccule is controllable, the pressure maintaining time after the expansion is controllable, and the time for establishing the retracting channel is accurate and controllable.
3. The balloon has simple structure and can be made of the existing medical materials.
4. The soft tubular device can be folded and compressed to be placed when being placed, and does not contact with brain tissues in the placing process. After being placed, the utility model has the functions of supporting, keeping and protecting the retracted brain tissue.
Drawings
Fig. 1 is a schematic view of a brain tissue retracting device composed of a series of brain tissue retracting units, wherein a represents a schematic view in which the catheter sizes of all the brain tissue retracting units are the same; b shows a schematic view of a brain tissue retraction unit with progressively increasing catheter size.
Fig. 2 is a schematic view of a brain tissue retraction device with a single layer balloon being progressively expanded.
FIG. 3 is a schematic view of a flexible tubular device.
Detailed Description
Balloon catheter
The balloon catheter 2 is a soft balloon catheter 2 with an inflatable balloon 1 at the head end, and is used for expanding narrow hollow organs such as blood vessels, digestive tracts, urinary tracts, tissue gaps and the like in a human body under the guidance of images. When the saccule 1 is not expanded, the saccule conduit 2 enters a target position, and after the treatment is finished, the saccule 1 retracts so that the saccule conduit 2 is withdrawn to the outside of the body. The catheter body material of the balloon catheter 2 is a medical polymer material, and the medical polymer material includes, but is not limited to, polyurethane, silicone rubber, polyester fiber, polyvinylpyrrolidone, polyetheretherketone, polymethylmethacrylate, polyvinyl alcohol, polylactic acid, polyethylene, and the like.
Compliant balloon
Compliance refers to the value of the volume change per unit pressure change. For most balloon catheters 2, the length of the balloon 1 is not changed by increasing the pressure, and therefore, the change in volume is mainly reflected in the change in diameter of the balloon 1. The diameter of the compliant balloon 1 will vary with pressure. The advantages of the compliant balloon 1 are: the balloon can be well attached to the surface of the tissue, and the shape of the balloon 1 is changed along with the cavity or the tissue gap.
Non-compliant balloon
The diameter of the non-compliant balloon 1 increased very little until the rupture point was reached, with a substantially negligible increase in diameter. The pressure inside the balloon 1 reaches the inflation point and the diameter of the balloon 1 expands directly to the specified value. The balloon 1 may rupture when the balloon 1 itself exceeds the tension limit. When the internal pressure of the balloon 1 does not reach the expansion point, the balloon 1 keeps contracting, and the diameter of the balloon 1 is basically equal to that of the balloon catheter 2. The non-compliant balloon 1 can be made of a copolymer or blend of a rigid segment of PET, nylon, or the like copolymerized with a flexible segment of olefin, a lipid chain, or the like.
Connection of balloon catheter and dilatation balloon
The balloon catheter 2 is wrapped in the expansion balloon 1, and the near end and the far end of the expansion balloon 1 are respectively provided with a binding piece for fixing the balloon 1 and the supporting tube. The purpose of the strapping is to form a closed capsule. The near end and the far end of the expansion balloon 1 are respectively fastened and fixed, when liquid is injected, the near end and the far end of the expansion balloon 1 are fixed, so that the expansion balloon 1 can only be radially inflated and expanded, the impact of the balloon 1 on the tissues in front is avoided, and all the injected liquid is concentrated in a designated area (the area between the near end binding piece and the far end binding piece), and the support strength of the balloon 1 is favorably maintained. Most importantly, the distal tie attaches the balloon 1 to the balloon catheter 2 tightly, and fluid cannot enter further than the distal tie. The tying member is a rope or a reducing ring. When the rope or the reducing ring is assembled, the saccule 1 and the supporting tube are tightly combined by external force to form a closed sac body. The balloon catheter 2 is provided with a through hole which is arranged between the two binding pieces and is close to the binding piece at the near end and far away from the binding piece at the far end. When the internal pressure reaches the expansion point pressure, the liquid is injected into the dilatation balloon 1 through the through holes.
Serial suite type brain tissue retractor
A brain tissue retractor comprises a series of brain tissue retracting units, each brain tissue retracting unit comprises an expanding sacculus 1 and a sacculus catheter 2, the sacculus catheter 2 is communicated with the expanding sacculus 1, and the sacculus catheter 2 is provided with a liquid injection interface; the expansion balloon adopts a non-compliant balloon 1; all brain tissue retracting units are sequenced from small to large according to the expanded diameters of the expanding saccule 1 to form the front and back sequence in the operation, and the expanding diameters of the saccule 1 of the brain tissue retracting units are increased progressively.
In some embodiments, the balloon catheters 2 of all brain tissue retraction units have the same diameter, and the dilation balloon 1 of each brain tissue retraction unit has a respective balloon 1 dilation diameter and inflation point pressure value. For example, the diameter of the balloon catheter 2 is 1.3mm, and the expanded diameter of the expansion balloon 1 of the minimum-sized brain tissue retraction unit is 2mm, which corresponds to the pressure value of the first expansion point; the expanded diameter of the next gauge of the dilatation balloon 1 is 4mm corresponding to the second inflation point pressure value, and so on.
During operation, the brain tissue retracting unit with the minimum specification is inserted into a brain tissue gap, then liquid is injected, the expansion balloon 1 is expanded, and the operation is kept for a period of time, such as 0.5 min. And (3) withdrawing the brain tissue retracting unit with the minimum specification, inserting the brain tissue retracting unit with the next specification into the brain tissue gap, injecting liquid, expanding the expansion balloon 1, and keeping for a period of time, such as 0.5 min. Usually a 12mm diameter retraction channel is required, the brain tissue retraction units are used in stages until the desired size of the retraction channel is obtained. The expansion saccule 1 keeps the expansion state, and the brain tissue is squeezed to dehydrate the tissue, so after the expansion saccule 1 is withdrawn, the brain tissue does not immediately recover, and the retraction channel obtained at the previous stage is kept.
Alternatively, in some embodiments, the diameter of the balloon catheter 2 of the posterior brain tissue retraction unit is the post-dilation dimension of the dilation balloon 1 of the anterior brain tissue retraction unit, the dilation balloon 1 of each brain tissue retraction unit having a respective balloon 1 dilation diameter. In this way, the expanded balloon 1 of each grade of brain tissue retraction unit has the same increased diameter size when being expanded, and although the balloon catheter 2 with different sizes needs to be manufactured, the method is favorable for distinguishing the use sequence of the brain tissue retraction unit.
In some embodiments, the brain tissue retraction device further comprises an expansion holding tube 5 in addition to the series of brain tissue retraction units, the size of the expansion holding tube 5 being the same as the post-expansion size of the expansion balloon 1 of the largest brain tissue retraction unit.
In some embodiments, after incremental reaming, the expanded retaining tube 5 is placed in the retracted position in a collapsed state and the expanded retaining tube 5 is expanded. The folding compression is put in, and the brain tissue is not contacted in the process of putting. After being placed, the utility model has the functions of supporting, keeping and protecting the retracted brain tissue.
Brain tissue retractor of single balloon catheter
Brain tissue retractor, including expansion sacculus 1, sacculus pipe 2 and injection interface, sacculus pipe 2 and expansion sacculus 1 intercommunication, expansion sacculus 1 is non-compliance sacculus 1, and expansion sacculus 1 has 1 diameters of multistage expansion back sacculus. The expansion balloon 1 is expanded step by step from the minimum expansion diameter, and the diameter of the balloon 1 is kept for a given time, such as 0.5min, after each step of expansion.
A form of dilatation balloon: the expansion sacculus 1 is a single-layer non-compliant sacculus 1, the expansion sacculus 1 has multi-stage expansion point pressure intensity, and each stage of expansion point pressure intensity corresponds to the diameter of the sacculus 1 after one stage of expansion. For example, the pressure in the balloon 1 reaches the pressure of a first-stage expansion point, the balloon 1 is expanded and maintained, the diameter of the expanded balloon 1 is the diameter (such as 2 mm) of the first-stage balloon 1, and the balloon is maintained for a given time (such as 0.5 min); injecting liquid into the saccule 1, pressurizing until the pressure in the saccule 1 reaches the pressure of a second-stage expansion point, expanding and maintaining the pressure of the saccule 1, wherein the diameter of the saccule 1 after expansion is the diameter (such as 4 mm) of the second-stage saccule 1, … …, and pressurizing and retracting step by step until the size of a retracting channel which can be entered by a surgical instrument is obtained.
The brain tissue retractor comprises an expansion holding tube 5, the expansion holding tube 5 is a soft tube, and the size of the soft tube is the same as or slightly larger than that of the expanded balloon 1 of the largest brain tissue retractor unit. The soft tubular device is made of elastic high polymer materials, and is sent into a channel expanded by the saccule 1 through the conveying device 3 and released after being folded and compressed. The conveying device 3 consists of a pipe and a push rod.
The utility model discloses with the mode of expansion step by step, tractive to among the size entering brain tissue clearance of sacculus pipe 2, sacculus pipe 2 diameter is within 2mm, preferably sets up to 1.3mm ~1.83mm, makes sacculus pipe 2 both have intensity and rigidity, and the size is little as far as possible again, gets into in the tissue clearance easily. After the balloon catheter 2 enters a tissue gap, liquid is injected into the balloon catheter 2, so that the expansion balloon 1 is expanded, the balloon 1 is expanded step by step and intermittently, the stepping reaming of the retraction channel is realized, the given time is kept for each expansion, the brain tissue adapts to the retraction force, the retraction pressure on the brain tissue is reduced, and the establishment time of the retraction channel and the protection on the brain tissue are considered. Taking the case that the retracting channel is gradually expanded to 12mm from 2mm, the stepping diameter is 2mm, and the pause time of each stage is 0.5min, the establishment time of the retracting channel can be controlled within 10-15 min.
Methods of using brain tissue retraction devices
A method for using the brain tissue retracting device is characterized in that an object needing to establish a retracting channel is defined, a balloon catheter 2 with an expanding balloon 1 is obtained, the balloon catheter 2 is inserted into the object, a liquid injection joint of the balloon catheter 2 is connected with a liquid source, liquid is injected into the balloon catheter 2, the pressure in the balloon catheter 2 reaches the pressure of an expansion point, and the pressure is maintained after the expanding balloon 1 is expanded; and expanding the diameter of the retracting conduction step by step in a gradual expanding and pressure maintaining mode until a retracting channel with a given size is obtained.
The object for establishing the retraction channel can be a human brain tissue model which is used for preoperative training of doctors or simulation operation training.
In some embodiments, the brain tissue retracting device is composed of a series of brain tissue retracting units, after the expanding saccule 1 of the previous brain tissue retracting unit is expanded and pressure maintaining is completed, liquid in the saccule conduit 2 is pumped out, the current expanding saccule 1 is withdrawn, the brain tissue retracting unit of the next specification is replaced as the current brain tissue retracting unit, liquid is injected until the expanding saccule 1 is expanded, and pressure maintaining is performed; each brain tissue retraction unit is used in stages in this manner until a retraction channel of a given size is obtained.
In some embodiments, the brain tissue retracting device is the same set of the balloon catheter 2 and the expansion balloon 1, the expansion balloon 1 reaches the pressure of a primary expansion point, and the pressure is maintained after the expansion balloon 1 is expanded; pressurizing again after pressure maintaining is finished until the expansion balloon 1 reaches the pressure of the next-stage expansion point, maintaining the pressure, injecting liquid after pressure maintaining is finished, and continuously and circularly pressurizing, expanding the balloon 1 and maintaining the pressure until a retracting channel with a given size is obtained.
By using the set of using method, preoperative simulation, doctor skill training and simulation tests can be carried out to obtain the optimal retracting stepping diameter, pressure maintaining time, the expansion diameter of the balloon 1, the size of the balloon catheter 2 and screening of the material of the balloon catheter 2 and the material of the expansion balloon 1. The human brain tissue simulant or the purchased animal brain tissue (such as pig brain purchased from a vegetable field) can be used as the object needing to establish the retracting channel. Is favorable for improving the technical proficiency of surgeons and the success rate of clinical operations.
All patents and publications mentioned in the specification of the invention are indicative of the state of the art to which this invention pertains and of the technology disclosed herein as being applicable. All patents and publications cited herein are hereby incorporated by reference to the same extent as if each individual publication was specifically and individually indicated to be incorporated by reference. The invention described herein may be practiced in the absence of any element or elements, limitation or limitations, which limitation is not specifically disclosed herein. The terms and expressions which have been employed herein are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described, but it is recognized that various modifications and changes may be made within the scope of the invention and the claims which follow. It is to be understood that the embodiments described herein are preferred embodiments and features and that modifications and variations may be made by one skilled in the art in light of the teachings of the present disclosure, and are to be considered within the purview of this disclosure and scope of the invention as defined by the appended claims and the independent claims.
Claims (4)
1. A tethered brain tissue retraction device, comprising: the brain tissue retracting device comprises a series of brain tissue retracting units, each brain tissue retracting unit comprises an expanding saccule and a catheter, the catheters are communicated with the expanding saccule and are provided with liquid injection interfaces; the expansion balloon adopts a non-compliant balloon; all brain tissue retracting units are sequenced from small to large according to the expanded diameters of the expanding saccule to form the front and back sequence in the operation, and the saccule expansion diameters of the brain tissue retracting units are increased progressively.
2. The series of brain tissue retraction device according to claim 1, wherein: the catheter diameters of all the brain tissue retracting units are the same, and the expanding saccule of each brain tissue retracting unit has the respective saccule expanding diameter and the pressure value of the expansion point.
3. The series of brain tissue retraction device according to claim 1, wherein: the diameter of the catheter of the posterior brain tissue retracting unit is the expanded size of the expansion balloon of the anterior brain tissue retracting unit, and the expansion balloon of each brain tissue retracting unit has the respective balloon expansion diameter.
4. The series of brain tissue retraction device according to any one of claims 1 to 3, wherein: the brain tissue retracting device comprises an expansion maintaining tube, and the size of the expansion maintaining tube is the same as the expanded size of the expansion balloon of the largest brain tissue retracting unit.
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| CN2020101410456 | 2020-03-03 | ||
| CN202010141045 | 2020-03-03 |
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| CN202010306008.6A Pending CN111369858A (en) | 2020-03-03 | 2020-04-17 | Method for simulating retraction of brain tissue |
| CN202020577698.4U Active CN212342072U (en) | 2020-03-03 | 2020-04-17 | Brain tissue retractor |
| CN202020577675.3U Active CN212084420U (en) | 2020-03-03 | 2020-04-17 | Serial brain tissue retractor |
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| CN202010306008.6A Pending CN111369858A (en) | 2020-03-03 | 2020-04-17 | Method for simulating retraction of brain tissue |
| CN202020577698.4U Active CN212342072U (en) | 2020-03-03 | 2020-04-17 | Brain tissue retractor |
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| CN116687495B (en) * | 2023-07-24 | 2023-11-03 | 上海宏普医疗器械有限公司 | Implanted saccule |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN201958929U (en) * | 2010-12-30 | 2011-09-07 | 孙波 | Medical brain-tissue passage-manufacturing device |
| CN102416218A (en) * | 2011-10-09 | 2012-04-18 | 东南大学 | Adjustable-diameter esophagus balloon catheter |
| CN203539853U (en) * | 2012-12-14 | 2014-04-16 | 常州乐奥医疗科技有限公司 | Novel bile duct expansion sacculus |
| CN204698504U (en) * | 2015-06-03 | 2015-10-14 | 上海英诺伟医疗器械有限公司 | A kind of multipurpose ureteroscope sacculus silk-guiding |
| CN207055725U (en) * | 2016-12-23 | 2018-03-02 | 上海英诺伟医疗器械有限公司 | A kind of sacculus dilating catheter |
| CN107280717A (en) * | 2017-07-17 | 2017-10-24 | 泗洪县正心医疗技术有限公司 | A kind of adjustable operation path pipe of caliber |
| CN207886223U (en) * | 2017-08-26 | 2018-09-21 | 贵州医科大学 | Self-expanding no-station pole canopy keyhole surgery lane device |
| CN108992768B (en) * | 2018-08-29 | 2024-05-31 | 郑州大学第一附属医院 | Brain operation dilator and brain channel establishment method using same |
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| CN111369858A (en) | 2020-07-03 |
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Effective date of registration: 20230817 Address after: Room 406, Building 1, North Zone, Zhejiang Industrial Park, No. 7, Changzhuang 4th Road, West Zone, Economic Development Zone, Xuecheng District, Zaozhuang City, Shandong Province, 277000 Patentee after: Easy Test (Shandong) Medical Technology Co.,Ltd. Address before: Room 401, building 1, North District, Zhejiang Industrial Park, No.7, Changzhuang 4th Road, West District, Xuecheng Economic Development Zone, Zaozhuang City, Shandong Province 277000 Patentee before: Enwei (Shandong) Medical Technology Co.,Ltd. |