CN212017031U

CN212017031U - Film filtering device for medicine sterile detection

Info

Publication number: CN212017031U
Application number: CN202020698295.5U
Authority: CN
Inventors: 林小晖; 刘雪; 宋菁景
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-29
Filing date: 2020-04-29
Publication date: 2020-11-27
Anticipated expiration: 2030-04-29

Abstract

The utility model relates to a membrane filtration device of aseptic detection of medicine, include: the filter cartridge is of a sealed cylinder structure and comprises an upper filter cartridge and a lower filter cartridge which are connected through a membrane component; the filtering and separating device is arranged in the upper filter cylinder, a space is arranged between part of the outer side wall and the inner side wall of the upper filter cylinder, so that the upper space and the lower space of the filtering and separating device are communicated, and part of the top structure is provided with a filter screen plate; the liquid inlet pipe is positioned above the filter screen plate and is communicated and connected with the filter screen plate, the edge of the liquid inlet pipe is positioned outside the filter screen plate, the edge of the liquid inlet pipe is hermetically connected with the upper end surface of the filtering and separating device, and the liquid inlet pipe is hermetically connected with the side wall of the upper filter cylinder; the air inlet pipe extends into the position right above the filter screen plate from the side wall of the liquid inlet pipe, the central shaft of the pipe orifice of the air inlet pipe is arranged downwards, and the central shaft of the pipe orifice and the filter screen plate form an included angle. The film detection process is more accurate, and the film blockage is better avoided.

Description

Film filtering device for medicine sterile detection

Technical Field

The utility model belongs to the film filtering device field, concretely relates to film filtering device of aseptic detection of medicine.

Background

The information in this background section is only for enhancement of understanding of the general background of the invention and is not necessarily to be construed as an admission or any form of suggestion that this information forms the prior art that is already known to a person of ordinary skill in the art.

The microporous filter membrane in the membrane filtration method can effectively intercept bacteria, thereby realizing the inspection of a sample, and can successfully detect the polluted mixed bacteria contained in the sample aiming at the screening and filtration of soluble components in a drug sample. But impurity and insoluble component in the medicine can lead to the decline of membrane filtration ability, and the membrane can be blockked up to insoluble component after long time, and in the prior art, set up the inlet of sample in the position of next to the membrane, utilize the scouring force of liquid, clear away the piling up on membrane surface, avoid blockking up. However, the inventors believe that this method only scours one side of the membrane and may cause the other side of the membrane to accumulate, which is not conducive to long-term membrane filtration.

SUMMERY OF THE UTILITY MODEL

To the problem that exists among the above-mentioned prior art, the utility model aims at providing a membrane filter equipment that medicine sterility testing exists.

In order to solve the technical problem, the technical scheme of the utility model is that:

a membrane filtration device for sterility testing of a drug, comprising:

the filter cartridge is of a sealed cylinder structure, the cylinder body is divided into an upper filter cartridge and a lower filter cartridge, the upper filter cartridge and the lower filter cartridge are connected through a membrane component, and the membrane component is connected with the side wall of the filter cartridge in a sealing manner;

the filtering and separating device is arranged in the upper filter cylinder, a square cavity structure with a closed upper end and an open lower end is connected and fixed with the upper filter cylinder, a space is arranged between part of the outer side wall and the inner side wall of the upper filter cylinder, so that the upper space and the lower space of the filtering and separating device are communicated, and part of the structure at the top is a filter screen plate;

one end of the liquid inlet pipe extends into the cavity structure through the side wall of the upper filter cylinder, is positioned above the filter screen plate and is communicated with the filter screen plate, the edge of the liquid inlet pipe is positioned outside the filter screen plate, the edge of the liquid inlet pipe is hermetically connected with the upper end surface of the filtering and separating device, and the liquid inlet pipe is hermetically connected with the side wall of the upper filter cylinder;

the intake pipe, one end gets into by the top of last filter cartridge, stretches into directly over the filter plate by the lateral wall of feed liquor pipe, and the orificial center pin of intake pipe sets up downwards, and orificial center pin has the contained angle with filter plate, sealing connection between the lateral wall of intake pipe and feed liquor pipe.

The utility model provides a membrane filtration device of aseptic detection of medicine, liquid carry out the prefiltration through the filter plate at filtering separation device top earlier, filter the impurity in the liquid through filtering the otter board, impurity includes granule and some undissolved substances, reduces the jam of film to in filterable time, the leading-in a certain amount of aseptic gas of intake pipe plays the effect of disturbance liquid, avoids liquid to receive the influence of filtering on the otter board impurity to lead to flowing not smooth, makes the smooth filtration otter board of passing through of liquid.

The utility model has the advantages that:

the utility model provides a carry out membrane filter equipment of process that medicine aseptic technique detected can make the filtration process of liquid medicine (liquid), the more accurate condition that contains the fungus that obtains.

To heterogeneous medicine, because contain more kinds of composition in the medicine, the nature of every kind of composition has certain difference, probably contains insoluble component or granule after making liquid, through the utility model discloses a device tentatively filters insoluble component and granule, can eliminate the jam of insoluble component and granule to the film as far as possible, avoids the membrane filtration unsmooth, and the separation that can not realize bacterium and liquid that leads to.

Drawings

The accompanying drawings, which form a part hereof, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate exemplary embodiments of the disclosure and together with the description serve to explain the invention and not to limit the invention unduly.

FIG. 1 is a diagram of a membrane filtration device for sterility testing of drugs according to the present invention;

FIG. 2 is a top view of the filtering and separating device of the present invention;

the filter comprises a gas inlet pipe 1, a gas inlet pipe 2, a liquid inlet pipe 3, a filter screen plate 4, a filtering and separating device 5, a gas outlet 6, a gas filtering device 7, an air pumping hole 8, a membrane component 9, an air release hole 10, an upper filter cylinder 11 and a lower filter cylinder.

Detailed Description

It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs.

It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present disclosure. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.

The utility model discloses a membrane filtration device of aseptic detection of medicine, including straining a section of thick bamboo, be divided into and strain a section of thick bamboo 10 and strain a section of thick bamboo 11 down, the inside of straining a section of thick bamboo 10 on sets up filtering separation device 4, and feed liquor pipe 2, intake pipe 1 stretch into and strain a section of thick bamboo 10, filtering separation device 4 and feed liquor pipe 2 are connected, and intake pipe 1 is connected with feed liquor pipe 2, and membrane module 8 is located and strains a section of thick bamboo 10 and strain down between the section of thick bamboo 11 on.

The membrane module 8 is referred to as a patent with application number 200520018139.5, the membrane module 8 is a membrane module in this patent document, the membrane module 8 comprises membranes, a support plate, a membrane unloading plate and other structures, and the membrane module 8 is connected with the upper filter cartridge and the lower filter cartridge through a fixing and connecting device to realize the mutual fixed and sealed connection among the upper filter cartridge, the lower filter cartridge and the membrane module. The liquid falls onto the membrane and then flows from below the membrane module into the lower cartridge 11. The detachment of the membrane can be achieved. It will be appreciated that the bottom opening of the upper cartridge 10 and the top opening of the lower cartridge 11 form a sealed structure. The sealing means that the sealing is realized except for the opened air suction port and the opened air exhaust port.

The filtering and separating device 4 is positioned above the membrane component 8, liquid flows down to the surface of the membrane component 8 through the filtering and separating device 4, the membrane filters the liquid, bacteria are trapped, and then the bacteria on the membrane are detected.

The liquid inlet pipe 2 is communicated with the filter screen plate 3, liquid can flow onto the filter screen plate 3 from the liquid inlet pipe 2, the edge of the liquid inlet pipe 2 is positioned at the outer side of the filter screen plate 3 and is in sealing connection with the upper end surface (top) of the filtering and separating device, so that the liquid inlet pipe can completely cover the part of the filter screen plate 3, the liquid can not flow outside and can be filtered along the filter screen plate 3, and after sealing connection, gas can not escape from the liquid inlet pipe 2.

The filtering and separating device is fixedly connected with the upper filtering cylinder, and a space is arranged between the inner side walls of the filtering cylinders 10 on part of the outer side walls, so that the filtering and separating device is fixedly connected with the upper filtering cylinder 10, the stability of the filtering and separating device is realized, and meanwhile, a gap is kept between part of the outer side walls and the inner side walls of the upper filtering cylinder 10, so that the air flow up and down of the filtering and separating device can be realized. That is, a part of the outer side wall of the filtering and separating device is connected with the inner wall of the upper filter cartridge 10, and a part of the outer side wall of the filtering and separating device is kept clearance with the inner wall of the upper filter cartridge 10. For example, the upper filter cartridge is square, and the filtering and separating device is also square, so that the filtering and separating device is smaller than the filter cartridge, can only occupy a part of the horizontal direction in the upper filter cartridge, and does not form a complete seal with the inner wall of the upper filter cartridge, and the filtering and separating device can be located at a corner position, or a position at one side of the axis, or a position in the middle in the upper filter cartridge, when located in the middle, two ends of the filtering and separating device are connected with the inner wall of the upper filter cartridge, and the other two ends of the filtering and separating device are not connected with the inner wall of the upper filter cartridge.

In the prior art, as the liquid contains impurities including some insoluble substances and particles, the membrane is easy to block, the filtering effect is reduced, the separation of bacteria, the liquid and the impurities cannot be realized, and the detection result is reduced.

The utility model discloses a filtering separation device 4 combines with the feed liquor pipe, and liquid realizes prefiltering after filtering separation device 4, and filter plate compares in the film, can filter some impurity, can avoid blockking up the film like this, and filtering separation device 4's lower extreme opening, liquid can freely fall, has certain distance between filtering separation device 4 and the membrane module 8, can realize the separation of whole gas or partial gas and liquid.

The gas inlet pipe enters from the side wall of the liquid inlet pipe instead of the top, so that the gas can disturb the liquid from the side surface.

The specific filtration process is described as follows:

as shown in fig. 1 or fig. 2, the utility model discloses in, the feed liquor pipe in membrane module 8's top realizes the feed liquor, realize admitting air from the intake pipe, admit air can be inert gas such as aseptic nitrogen or aseptic air, the air input ratio is smaller, be equivalent to in a small amount of bubbles enter into liquid, play disturbance liquid can, it gets into in the liquid earlier to admit air, then flow down along with liquid, in-process and liquid separation that flow down, or partly filter away along with liquid via the membrane, gaseous entering is strained the membrane top of a section of thick bamboo after, the atmospheric pressure of membrane top risees gradually, the filtration rate of just beginning membrane is slower, after the atmospheric pressure of membrane top crescent, the filtration rate of membrane can accelerate gradually, at this moment can open the gassing mouth of straining a section of thick bamboo top and take out a part of gas, reduce atmospheric pressure regulation filtration rate. When the liquid filtering speed is low at the beginning, air can be extracted through the air extraction opening on the side wall of the device below the film, so that the filtering speed is increased.

The air pumping process can be realized by an air pump, and part or all of the side wall of the filter cylinder is made of transparent materials, so that the filtering speed can be observed.

Therefore, the smooth filtration of the liquid is realized in the whole process, the blockage is avoided, and the filtration of bacteria in the liquid is conveniently realized.

The detailed structure of the present invention will be explained below.

Further, the top of the upper filter cylinder 10 is provided with an air release port 9, the lower part of the membrane is provided with an air suction port 7 on the side wall of the lower filter cylinder 11.

The air release opening and the air suction opening can be sealed when not used, and a sealing plug or a sealing cap can be used and can be connected with the air suction pipe when used.

Further, a gas filtering device 6 is arranged at the part of the air inlet pipe 1 positioned at the outer side of the upper filter cylinder.

If the inlet air contains bacteria, the air filter helps to remove the bacteria in the air and maintain the sterile environment inside the filter cartridge. The gas filtering device 6 may be a common device having a gas sterilizing function, such as an air filter.

Furthermore, the included angle between the central axis of the pipe orifice of the air inlet pipe and the filter screen plate is less than 70 degrees.

The central axis of the pipe orifice of the air inlet pipe is arranged downwards and forms an included angle with the filter screen plate, and because the inlet pipe enters from the side wall of the liquid inlet pipe, the liquid can be disturbed from the side by the gas in the bending direction of the air inlet pipe. The lower end of the air inlet pipe can be a hose, so that the pipe orifice can be conveniently bent at a certain angle. As shown in figure 1, the air inlet pipe enters from the top of the upper filter cylinder, the lower end of the air inlet pipe is connected with the side wall of the liquid inlet pipe, and the pipe orifice is positioned right above the filter screen plate, so that the disturbance of liquid passing through the filter screen plate can be realized.

The liquid inlet pipe 2 can be conveyed by a water pump, and the sterile environment can be ensured in the process.

Furthermore, the one end of feed liquor pipe 2 sets up the terminal surface of slope, and the lower extreme of intake pipe 1 passes the terminal surface of slope, and the sealed setting between the feed liquor pipe.

Set up the terminal surface of slope, can ensure the linkage of being connected with intake pipe 1, more be favorable to making the orificial center pin of intake pipe 1 set up downwards, if the orificial setting upwards, carry out the disturbance to the liquid of orifice top.

Also can guarantee that gaseous side from feed liquor pipe 2 gets into, realize making gaseous side from feed liquor pipe 2 blow in the bubble, have the little effort in the aspect of a side to the water, can play the effect of disturbance, avoid liquid to receive the barrier effect of filter plate, because filter plate last time can persist partly impurity, gaseous disturbance can make liquid flow more smooth and easy.

Further, the liquid inlet pipe 2 is horizontally arranged or is obliquely arranged from top to bottom. The angle setting of feed liquor pipe 2 is more nimble, because feed liquor pipe 2 carries liquid through the water pump, liquid has power, if for the slope setting, liquid from top to bottom flows, has the power of self-flowing.

Furthermore, the filtering and separating device 4 is of a square structure and comprises two first side walls and two second side walls, the two opposite first side walls of the filtering and separating device 4 are connected with the inner side wall of the upper filtering cylinder 10, the two opposite second side walls are respectively spaced from the inner wall of the upper filtering cylinder 10, and the sum of the distances between the two opposite second side walls and the inner wall of the upper filtering cylinder is less than or equal to the distance between the two second side walls.

It will be understood that the filtering and separating device 4 is of a square configuration and therefore has four side walls and an upper and a lower side wall, the lower side wall being of an open configuration, the two first side walls being connected to the upper cartridge, so as to ensure the stability of the filtering and separating device 4.

As can be seen from the top view 2, the side wall of the filtering and separating device 4 is spaced from the side wall of the upper filter cartridge, so that the gas flowing out from the lower part of the filtering and separating device 4 can be ensured to enter the upper part of the filtering and separating device 4, the gas flow above the membrane is ensured, and the pressure is basically kept consistent.

Furthermore, two ends of the filtering and separating device 4 corresponding to the two first side walls are respectively arranged to be in a step-shaped structure, the lower side walls of the two first side walls are connected with the inner wall of the upper filter cylinder, the inside of the filtering and separating device 4 is divided into an upper section cavity and a lower end cavity, and the filter screen plate is positioned at the top of the upper section cavity.

The cavity structure inside the filtering and separating device provides a space for gas-liquid separation, the cavity structure is arranged to be a step-shaped structure, the inside of the filtering and separating device is divided into an upper cavity structure and a lower cavity structure, the lower portion of the first side wall is connected with the inner wall of the upper filter cylinder 10, the upper portion of the first side wall retracts upwards inside the upper filter cylinder 10, the space of the upper cavity and the space of the lower cavity are different in size, the space of the lower cavity is larger, a gas-liquid mixture enters the lower cavity from the upper cavity, and after the space is enlarged, the gas-liquid separation is facilitated.

The lower part of the filtering and separating device is provided with an opening, and the liquid can directly fall downwards without obstruction.

Further, the top of the upper section cavity and the lower section cavity of the filtering and separating device 4 are both provided with a plurality of air outlets 5, and the air outlets 5 at the top of the upper section cavity are positioned outside the liquid inlet pipe 2. The gas outlet 5 is used for discharging gas and leading the gas to enter the cavity of the upper filter cylinder, so that gas-liquid separation can be realized in the filtering and separating device 4

Further, the area of the filter screen plate at the top of the filtering and separating device 4 exceeds 1/2 of the area of the top of the cavity of the whole upper section. The area of the filter screen plate can mainly ensure a larger filter area.

The filter screen plate 3 can be made of metal and has meshes with a certain density, and the outer side edge of the filter screen plate can be connected with the filter separation device 3 in a welding way.

A liquid outlet can be arranged at the bottom of the lower filter cartridge 11 below the film, liquid below the film can be discharged through the liquid outlet, and the liquid outlet is connected with the lower filter cartridge in a sealing manner.

The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The utility model provides a membrane filter equipment of medicine sterility testing which characterized in that: the method comprises the following steps:

the filter cartridge is of a sealed cylinder structure and comprises an upper filter cartridge and a lower filter cartridge, the upper filter cartridge and the lower filter cartridge are connected through a membrane component, and the membrane component is connected with the side wall of the filter cartridge in a sealing manner;

2. The membrane filtration device for the sterility testing of drugs according to claim 1, wherein: the top of the upper filter cylinder is provided with an air release port, and the side wall of the lower filter cylinder is provided with an air suction port below the film.

3. The membrane filtration device for the sterility testing of drugs according to claim 1, wherein: and a gas filtering device is arranged on the outer side of the part of the gas inlet pipe connected with the upper filter cylinder.

4. The membrane filtration device for the sterility testing of drugs according to claim 1, wherein: the included angle between the central axis of the pipe orifice of the air inlet pipe and the filter screen plate is less than 70 degrees.

5. The membrane filtration device for the sterility testing of drugs according to claim 1, wherein: one end of the liquid inlet pipe is provided with an inclined end face, and the lower end of the air inlet pipe penetrates through the inclined end face and is arranged between the air inlet pipe and the liquid inlet pipe in a sealing mode.

6. The membrane filtration device for the sterility testing of drugs according to claim 1, wherein: the liquid inlet pipe is horizontally arranged or is obliquely arranged from top to bottom.

7. The membrane filtration device for the sterility testing of drugs according to claim 1, wherein: the filtering and separating device is of a square structure and comprises two opposite first side walls and two opposite second side walls, the two opposite first side walls of the filtering and separating device are connected with the inner side walls of the filtering and separating device, the two opposite second side walls are respectively spaced from the inner wall of the upper filter cylinder, and the sum of the distances between the two opposite second side walls and the inner wall of the upper filter cylinder is smaller than or equal to the distance between the two second side walls.

8. The membrane filtration device for the sterility testing of drugs according to claim 7, wherein: two ends of the filtering and separating device, which correspond to the two first side walls, are respectively provided with a step-shaped structure, the lower side walls of the two first side walls are connected with the inner wall of the filter cylinder, the inside of the filtering and separating device is divided into an upper section cavity and a lower end cavity, and the filter screen plate is positioned at the top of the upper section cavity.

9. The membrane filtration device for the sterility testing of drugs according to claim 8, wherein: the top of the upper section cavity and the top of the lower section cavity of the filtering and separating device are both provided with a plurality of air outlets, and the air outlets at the top of the upper section cavity are positioned outside the liquid inlet pipe.

10. The membrane filtration device for the sterility testing of drugs according to claim 8, wherein: the area of the filter screen plate at the top of the filtering and separating device exceeds 1/2 of the whole upper section cavity top area.